| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosaria Formisano, Katarzyna D Rosikon, Abhyudai Singh, Harbinder S Dhillo. The dopamine membrane transporter plays an active modulatory role in synaptic dopamine homeostasis. Journal of neuroscience research. 2021-11-11. PMID:34747520. |
in addition, the dopamine membrane transporter (dat), which is responsible for clearance of dopamine from the synaptic cleft, is suspected to play an active role in modulating release of dopamine. |
2021-11-11 |
2023-08-13 |
caenorhabditis_elegans |
| I-Mei Liao, Jin-Chung Che. Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response. Behavioural brain research. vol 396. 2021-11-09. PMID:32971195. |
here, we evaluated the potential role of d4r in regulating hyperdopaminergia-induced behavioral hyperactivity in meth behavioral sensitization and dopamine transporter (dat) knockdown (kd) mice. |
2021-11-09 |
2023-08-13 |
mouse |
| Katy A van Galen, Jan Booij, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Eric Fliers, Gary J Schwartz, Ralph J DiLeone, Kasper W Ter Horst, Susanne E la Fleur, Mireille J Serli. The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity. Metabolism: clinical and experimental. vol 123. 2021-11-09. PMID:34331964. |
we therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (sert) and striatal dopamine transporter (dat) availability in lean subjects and subjects with obesity. |
2021-11-09 |
2023-08-13 |
human |
| Ümit Özgür Akdemir, Ayşe Bora Tokçaer, Lütfiye Özlem Ata. Dopamine transporter SPECT imaging in Parkinson’s disease and parkinsonian disorders Turkish journal of medical sciences. vol 51. issue 2. 2021-11-08. PMID:33237660. |
dopamine transporter spect imaging in parkinson’s disease and parkinsonian disorders the dopamine transporter (dat) imaging provides an objective tool for the assessment of dopaminergic function of presynaptic terminals which is valuable for the differential diagnosis of parkinsonian disorders related to a striatal dopaminergic deficiency from movement disorders not related a striatal dopaminergic deficiency. |
2021-11-08 |
2023-08-13 |
human |
| Ümit Özgür Akdemir, Ayşe Bora Tokçaer, Lütfiye Özlem Ata. Dopamine transporter SPECT imaging in Parkinson’s disease and parkinsonian disorders Turkish journal of medical sciences. vol 51. issue 2. 2021-11-08. PMID:33237660. |
dat imaging with single-photon emission computed tomography (spect) can be used to confirm or exclude a diagnosis of dopamine deficient parkinsonism in cases where the diagnosis is unclear. |
2021-11-08 |
2023-08-13 |
human |
| Don Gueu Park, Jae Whan Kim, Young-Sil An, Jaerak Chang, Jung Han Yoo. Plasma neurofilament light chain level and orthostatic hypotension in early Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 12. 2021-11-08. PMID:34568970. |
other clinical parameters such as rbd, unified parkinson's disease rating scale (updrs), cognition, cross-cultural smell identification test (ccsit), white matter hyperintensity (wmh), cardiac metaiodobenzylguanidine (mibg) and striatal dopamine transporter (dat) uptake were assessed. |
2021-11-08 |
2023-08-13 |
Not clear |
| Maurizio Oggiano, Clelia Buccheri, Enrico Alleva, Walter Adrian. Dopaminergic modulation of the circadian activity and sociability: Dissecting parental inheritance versus maternal styles as determinants of epigenetic influence. Behavioural brain research. vol 417. 2021-11-08. PMID:34624423. |
a useful research approach is to exploit animal models that carry a functional silencing of slc6a3 gene, encoding the dopamine transporter (dat). |
2021-11-08 |
2023-08-13 |
human |
| Qiaoli Zeng, Fan Ning, Shanshan Gu, Qiaodi Zeng, Riling Chen, Liuquan Peng, Dehua Zou, Guoda Ma, Yajun Wan. The 10-Repeat 3'-UTR VNTR Polymorphism in the Frontiers in genetics. vol 12. 2021-11-08. PMID:34646314. |
the 10-repeat 3'-utr vntr polymorphism in the the dopamine transporter (dat) is encoded by the slc6a3 gene and plays an important role in the regulation of the neurotransmitter dopamine. |
2021-11-08 |
2023-08-13 |
Not clear |
| Kyoungjune Pak, Seongho Seo, Myung Jun Lee, Keunyoung Kim, Sunghwan Suh, Hyung-Jun Im, In Joo Ki. Striatal DAT availability does not change after supraphysiological glucose loading dose in humans. Endocrine connections. vol 10. issue 10. 2021-11-05. PMID:34491899. |
brain dopamine neurotransmission is regulated by the dopamine transporter (dat), which drives reuptake of extracellular dopamine into the presynaptic neurons. |
2021-11-05 |
2023-08-13 |
human |
| Allison N White, Joshua D Gross, Shane W Kaski, Kristen R Trexler, Kim A Wix, William C Wetsel, Steven G Kinsey, David P Siderovski, Vincent Setol. Genetic deletion of Journal of psychopharmacology (Oxford, England). vol 34. issue 12. 2021-11-04. PMID:32842837. |
we have shown that rgs12 loss diminishes locomotor responses of c57bl/6j mice to dopamine transporter (dat)-targeting psychostimulants. |
2021-11-04 |
2023-08-13 |
mouse |
| Andrea N Belovich, Jenny I Aguilar, Samuel J Mabry, Mary H Cheng, Daniele Zanella, Peter J Hamilton, Daniel J Stanislowski, Aparna Shekar, James D Foster, Ivet Bahar, Heinrich J G Matthies, Aurelio Gall. A network of phosphatidylinositol (4,5)-bisphosphate (PIP Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31796894. |
numerous human pet-fmri studies establish a link between midbrain dopamine (da) release, da transporter (dat) availability, and reward responses. |
2021-11-02 |
2023-08-13 |
human |
| Kai-Chun Yang, Bang-Hung Yang, Jiing-Feng Lirng, Mu-N Liu, Li-Yu Hu, Ying-Jay Liou, Li-An Chan, Yuan-Hwa Cho. Interaction of dopamine transporter and metabolite ratios underpinning the cognitive dysfunction in patients with carbon monoxide poisoning: A combined SPECT and MRS study. Neurotoxicology. vol 82. 2021-10-29. PMID:33171150. |
this study examined dopamine transporter (dat) and metabolite ratios concurrently and their relationships with cognitive dysfunction in co poisoning. |
2021-10-29 |
2023-08-13 |
human |
| Shanshan Cao, Jie Tang, Chunyi Liu, Yi Fang, Linyang Ji, Yingjiao Xu, Zhengping Che. Synthesis and Biological Evaluation of [ Molecular imaging and biology. vol 23. issue 5. 2021-10-29. PMID:33851345. |
synthesis and biological evaluation of [ the dopamine transporter (dat) is a marker of the occurrence and development of parkinson's disease (pd) and other diseases with nigrostriatal degeneration. |
2021-10-29 |
2023-08-13 |
Not clear |
| Olof R Hjorth, Andreas Frick, Malin Gingnell, Johanna M Hoppe, Vanda Faria, Sara Hultberg, Iman Alaie, Kristoffer N T Månsson, Kurt Wahlstedt, My Jonasson, Mark Lubberink, Gunnar Antoni, Mats Fredrikson, Tomas Furmar. Expression and co-expression of serotonin and dopamine transporters in social anxiety disorder: a multitracer positron emission tomography study. Molecular psychiatry. vol 26. issue 8. 2021-10-28. PMID:31822819. |
the aim of this multitracer pet study was to evaluate the regional expression and co-expression of the transporter proteins for serotonin (sert) and dopamine (dat) in patients with social anxiety disorder (sad). |
2021-10-28 |
2023-08-13 |
Not clear |
| Paul J Gasse. Organic Cation Transporters in Brain Catecholamine Homeostasis. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:33987762. |
most studies of catecholamine clearance have focused on the presynaptic high-affinity, low-capacity dopamine (dat), and norepinephrine (net) transporters, which are members of the uptake |
2021-10-28 |
2023-08-13 |
Not clear |
| Anna Marie Buchanan, Brenna Parke, Parastoo Hashem. Experimental Methods for Investigating Uptake 2 Processes In Vivo. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34196807. |
uptake 1 describes uptake of the monoamine via its designated transporter (sert for serotonin, net for norepinephrine, and dat for dopamine), whereas uptake 2 details multiple transporter types on neurons and glia taking up different types of modulators, not necessarily specific to the monoamine. |
2021-10-28 |
2023-08-13 |
human |
| Lynette C Daw. Organic Cation Transporters in Psychiatric Disorders. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34282486. |
other classes of antidepressant work by blocking the norepinephrine or dopamine transporters (net and dat), the high-affinity, low-capacity uptake-1 transporters for norepinephrine and dopamine, or by blocking combinations of sert, net, and dat. |
2021-10-28 |
2023-08-13 |
Not clear |
| Marilia Alves Dos Reis, Ary Gadelha, André C Felício, Marcelo Queiroz Hoexter, Ilza Rosa Batista, Pedro Braga-Neto, Mariana Calzavara, Daniel Alves Cavagnolli, Cinthia Higuchi, Melissa Furlaneto Lellis Leite, Solange Amorim Nogueira, Jairo Wagner, Mario Luiz Vieira Castiglioni, Ming Chi Shih, Rodrigo Affonseca Bressa. Evaluation of dopamine transporter density in healthy Brazilians using Tc-99m TRODAT-1 SPECT. Medicine. vol 100. issue 39. 2021-10-27. PMID:34596116. |
the presynaptic dopamine transporter (dat) modulates the uptake of dopamine by regulating its concentration in the central nervous system. |
2021-10-27 |
2023-08-13 |
human |
| Jenny I Aguilar, Mary Hongying Cheng, Josep Font, Alexandra C Schwartz, Kaitlyn Ledwitch, Amanda Duran, Samuel J Mabry, Andrea N Belovich, Yanqi Zhu, Angela M Carter, Lei Shi, Manju A Kurian, Cristina Fenollar-Ferrer, Jens Meiler, Renae Monique Ryan, Hassane S Mchaourab, Ivet Bahar, Heinrich Jg Matthies, Aurelio Gall. Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia. eLife. vol 10. 2021-10-26. PMID:34002696. |
dopamine (da) transporter (dat) deficiency syndrome (dtds) is a distinct type of infantile parkinsonism-dystonia that shares key clinical features with pd, including motor deficits (progressive bradykinesia, tremor, hypomimia) and altered da neurotransmission. |
2021-10-26 |
2023-08-13 |
human |
| Giovanni Palermo, Sara Giannoni, Gabriele Bellini, Gabriele Siciliano, Roberto Ceravol. Dopamine Transporter Imaging, Current Status of a Potential Biomarker: A Comprehensive Review. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681899. |
in this review we provide an update on the dopamine transporter (dat) imaging in pd and translate recent findings to potentially valuable clinical practice applications. |
2021-10-26 |
2023-08-13 |
Not clear |