| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zackary A Cope, Johnny A Kenton, Arpi Minassian, Maureen V Martin, William Perry, Christoffer Bundgaard, Jørn Arnt, Jordy van Enkhuizen, Mark A Geyer, Jared W Youn. Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice. Behavioural brain research. vol 405. 2021-09-02. PMID:33577882. |
bipolar disorder is a life-threatening disorder linked to dopamine transporter (dat) polymorphisms, with reduced dat levels seen in positron emission tomography and postmortem brains. |
2021-09-02 |
2023-08-13 |
mouse |
| Valentina Carpentieri, Luca Cerniglia, Silvia Cimino, Mariangela Pucci, Esterina Pascale, Claudio D'Addario, Walter Adrian. Epigenetic regulation of DAT gene promoter modulates the risk of externalizing and internalizing behaviors on a normative population: An explorative study. Behavioural brain research. vol 406. 2021-09-02. PMID:33745985. |
we recently proposed to study methylation dynamics of two cpg motifs within the 5'-utr of dopamine transporter (dat) gene. |
2021-09-02 |
2023-08-13 |
human |
| Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorth. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. vol 408. 2021-09-02. PMID:33794225. |
dopamine (da) transporter (dat) is dynamically regulated by several protein kinases and the thr53 phosphorylation of dat (pt53-dat) is documented in heterologous cell models and in rat brain. |
2021-09-02 |
2023-08-13 |
mouse |
| Frederic Sampedro, Juan Marín-Lahoz, Saul Martínez-Horta, Valle Camacho, Diego-Alfonso Lopez-Mora, Javier Pagonabarraga, Jaime Kulisevsk. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease. Neurobiology of aging. vol 97. 2021-09-01. PMID:33212336. |
striatal dopamine transporter (dat) uptake assessment through i |
2021-09-01 |
2023-08-13 |
Not clear |
| Shalonda M Ingram, Tanu Rana, Ashley M Manson, Faisal M Yayah, Evan G B Jackson, Christopher Anderson, Benem-Orom Davids, J Shawn Goodwi. Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane. The Journal of biological chemistry. vol 296. 2021-08-31. PMID:34015332. |
the dopamine transporter (dat) is essential for the reuptake of the released neurotransmitter dopamine (da) in the brain. |
2021-08-31 |
2023-08-13 |
Not clear |
| Shreyas Bhat, Daryl A Guthrie, Ameya Kasture, Ali El-Kasaby, Jianjing Cao, Alessandro Bonifazi, Therese Ku, JoLynn B Giancola, Thomas Hummel, Michael Freissmuth, Amy Hauck Newma. Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters. ACS pharmacology & translational science. vol 4. issue 2. 2021-08-29. PMID:33860180. |
ibogaine and its active metabolite noribogaine correct folding defects in the dopamine transporter (dat), but they rescue only a very limited number of folding-deficient dat mutant proteins, which give rise to infantile parkinsonism and dystonia. |
2021-08-29 |
2023-08-13 |
Not clear |
| Arunkumar Singh Koijam, Aruna Chanu Hijam, Asem Surindro Singh, Preeti Jaiswal, Kanchan Mukhopadhyay, Usha Rajamma, Reena Haoba. Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur. Journal of molecular neuroscience : MN. vol 71. issue 1. 2021-08-27. PMID:32557146. |
dopamine transporter (dat) or solute carrier family 6 member 3 (slc6a3) is a transmembrane protein regulating dopaminergic neurotransmission. |
2021-08-27 |
2023-08-13 |
Not clear |
| Tatiana Sorkina, Mary Hongying Cheng, Tarique R Bagalkot, Callen Wallace, Simon C Watkins, Ivet Bahar, Alexander Sorki. Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity. The Journal of biological chemistry. vol 296. 2021-08-27. PMID:33610553. |
dopamine transporter (dat) mediates the reuptake of synaptically released dopamine, and thus controls the duration and intensity of dopamine neurotransmission. |
2021-08-27 |
2023-08-13 |
Not clear |
| Tatiana Sorkina, Mary Hongying Cheng, Tarique R Bagalkot, Callen Wallace, Simon C Watkins, Ivet Bahar, Alexander Sorki. Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity. The Journal of biological chemistry. vol 296. 2021-08-27. PMID:33610553. |
surprisingly, a corresponding quadruple dat mutant displays altered dopamine transport kinetics and increased cocaine-analog binding. |
2021-08-27 |
2023-08-13 |
Not clear |
| Jared T Hinkle, Kelly A Mills, Kate Perepezko, Gregory M Ponton. Bidirectional Correlations Between Dopaminergic Function and Motivation in Parkinson's Disease. Journal of geriatric psychiatry and neurology. 2021-08-26. PMID:33622073. |
to test the hypothesis that striatal dopamine function influences motivational alterations in parkinson disease (pd), we compared vesicular monoamine transporter 2 (vmat2) and dopamine transporter (dat) imaging data in pd patients with impulse control disorders (icds), apathy, or neither. |
2021-08-26 |
2023-08-13 |
Not clear |
| Caline S Karam, Brenna L Williams, Sandra K Jones, Jonathan A Javitc. The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila. Neurochemical research. 2021-08-26. PMID:33630236. |
the dopamine transporter (dat) mediates the inactivation of released dopamine (da) through its reuptake, and thereby plays an important homeostatic role in dopaminergic neurotransmission. |
2021-08-26 |
2023-08-13 |
drosophila_melanogaster |
| Eray Esendir, Verena Burtscher, Jonathan A Coleman, Rong Zhu, Eric Gouaux, Michael Freissmuth, Walter Sandtne. Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34118233. |
ligands that discriminate between sert and its close relative, the dopamine transporter dat, differ in their association rate constant rather than their dissociation rate. |
2021-08-26 |
2023-08-13 |
Not clear |
| Tingting Yu, Guangdi Zhou, Zhenzhen Cai, Wei Liang, Yatao Du, Weiye Wan. Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). vol 238. 2021-08-24. PMID:34340000. |
after exposure to pfoa for 7 days, the locomotor activity of zebrafish was decreased; the mrna levels of nuclear receptor subfamily 4 group a member 2b (nr4a2b), paired box 2 and 5 (pax2, pax5), tyrosine hydroxylase 1/2 (th1/th2) and dopamine transporter (dat) were increased; mrna and protein level of mesencephalic astrocyte-derived neurotrophic factor (manf) were decreased. |
2021-08-24 |
2023-08-13 |
human |
| Molly A Kwiatkowski, Benjamin Z Roberts, Jordy van Enkhuizen, Baohu Ji, Xianjin Zhou, Jared W Youn. Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33191077. |
hyperdopaminergia may result from insufficient activity of the dopamine transporter (dat), the primary mediator of synaptic dopamine clearance. |
2021-08-20 |
2023-08-13 |
mouse |
| Cian-Ling Jhang, Hom-Yi Lee, Jin-Chung Chen, Wenlin Lia. Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder. Human molecular genetics. vol 29. issue 14. 2021-08-18. PMID:32588892. |
our results showed that loss of cdkl5 decreases the proportion of phosphorylated dopamine transporter (dat) in the rostral striatum, leading to increased levels of extracellular dopamine and hyperlocomotion. |
2021-08-18 |
2023-08-13 |
mouse |
| Kaavya Jayaramayya, Mahalaxmi Iyer, Dhivya Venkatesan, Venkatesh Balasubramanian, Arul Narayanasamy, Mohana Devi Subramaniam, Ssang Goo Cho, Balachandar Vellingir. Unraveling correlative roles of dopamine transporter (DAT) and Parkin in Parkinson's disease (PD) - A road to discovery? Brain research bulletin. vol 157. 2021-08-17. PMID:32035946. |
unraveling correlative roles of dopamine transporter (dat) and parkin in parkinson's disease (pd) - a road to discovery? |
2021-08-17 |
2023-08-13 |
Not clear |
| Kaavya Jayaramayya, Mahalaxmi Iyer, Dhivya Venkatesan, Venkatesh Balasubramanian, Arul Narayanasamy, Mohana Devi Subramaniam, Ssang Goo Cho, Balachandar Vellingir. Unraveling correlative roles of dopamine transporter (DAT) and Parkin in Parkinson's disease (PD) - A road to discovery? Brain research bulletin. vol 157. 2021-08-17. PMID:32035946. |
dopamine transporter (dat) is essential for reuptake of da into the presynaptic terminal, thereby controlling the availability and spatial activity of released da. |
2021-08-17 |
2023-08-13 |
Not clear |
| Maxime Fougère, Cornelis Immanuel van der Zouwen, Joël Boutin, Dimitri Ryczk. Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8-A13. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:32869307. |
here, we used in mice a cell fate mapping strategy based on reporter protein expression (zsgreen) consecutive to previous expression of the vesicular glutamate transporter 2 (vglut2) gene, coupled with immunofluorescence experiments against tyrosine hydroxylase (th) or dopamine transporter (dat). |
2021-08-16 |
2023-08-13 |
mouse |
| Bree A Humburg, Chloe J Jordan, Hai-Ying Zhang, Hui Shen, Xiao Han, Guo-Hua Bi, Briana Hempel, Ewa Galaj, Michael H Baumann, Zheng-Xiong X. Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33538103. |
a specific adeno-associated viral vector carrying a channelrhodopsin gene was microinjected into the ventral tegmental area (vta) to express light-sensitive channelrhodopsin in dopamine (da) neurons of transgenic dopamine transporter (dat)-cre mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Megumi Sato, Sayaka Miki, Ryuji Sakakibar. [Parkinson's Disease, Dementia with Lewy Bodies and Brain-Gut Interactions]. Brain and nerve = Shinkei kenkyu no shinpo. vol 73. issue 8. 2021-08-12. PMID:34376592. |
neuroimaging such as metaiodobenzylguanidine (mibg) scintigraphy and dopamine transporter (dat) scan provide a way to detect the early stage of lewy body constipation. |
2021-08-12 |
2023-08-13 |
Not clear |