| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel J Kramer, Erin E Aisenberg, Polina Kosillo, Drew Friedmann, David A Stafford, Angus Yiu-Fai Lee, Liqun Luo, Dirk Hockemeyer, John Ngai, Helen S Bateu. Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations. Cell reports. vol 35. issue 6. 2021-11-24. PMID:33979604. |
here, we establish a mouse line with flpo recombinase expressed from the endogenous slc6a3 (dopamine active transporter [dat]) locus. |
2021-11-24 |
2023-08-13 |
mouse |
| Dennis T Rogers, Francois Pomerleau, Zachary Kelley, Dustin Brown, Bert Lynn, Greg A Gerhardt, John Littleto. Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures. Journal of biotechnology. vol 342. 2021-11-23. PMID:34648893. |
the dopamine transporter (dat) is targeted in substance use disorders (suds), and "non-classical"" dat inhibitors with low abuse potential are therapeutic candidates. |
2021-11-23 |
2023-08-13 |
human |
| Peng-Ju Yan, Zhao-Xiang Ren, Zhi-Feng Shi, Chun-Lei Wan, Chao-Jun Han, Liu-Shuai Zhu, Ning-Ning Li, John L Waddington, Xue-Chu Zhe. Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice. Acta pharmacologica Sinica. 2021-11-23. PMID:34811513. |
it is generally accepted that meth exerts rewarding effects via competitive inhibition of the dopamine transporter (dat), but the molecular mechanism of meth addiction remains largely unknown. |
2021-11-23 |
2023-08-13 |
mouse |
| Yang Hyun Lee, Sangwon Lee, Seok Jong Chung, Han Soo Yoo, Jin Ho Jung, Kyoungwon Baik, Byoung Seok Ye, Young H Sohn, Mijin Yun, Phil Hyu Le. The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism. Parkinsonism & related disorders. vol 82. 2021-11-22. PMID:33220520. |
to determine whether vascular parkinsonism (vap) patients with visually normal dopamine transporter (dat) scans have presynaptic dopaminergic depletion. |
2021-11-22 |
2023-08-13 |
Not clear |
| Juan L Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M Wright, Dondre L Marable, Lionel A Rodriguez, Sherry Lam, Meghan L Carlton, Randall J Ellis, Chloe J Jordan, Guo-Hua Bi, Oscar Solis, Marco Pignatelli, Michael J Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelide. Synaptic Zn Translational psychiatry. vol 11. issue 1. 2021-11-20. PMID:34750356. |
synaptic zn cocaine binds to the dopamine (da) transporter (dat) to regulate cocaine reward and seeking behavior. |
2021-11-20 |
2023-08-13 |
Not clear |
| Yuan-Shuo Hsueh, Chih-Ying Lin, Nan-Tsing Chiu, Yen Kuang Yang, Po See Chen, Hui Hua Chan. Changes in striatal dopamine transporters in bipolar disorder and valproate treatment. European psychiatry : the journal of the Association of European Psychiatrists. vol 64. issue 1. 2021-11-19. PMID:33413711. |
here, we aimed to investigate the role of the striatal dopamine transporter (dat) in bd patients and in social defeat (sd) mice treated with vpa. |
2021-11-19 |
2023-08-13 |
mouse |
| Liang Xu, Liao Y Che. Association of sigma-1 receptor with dopamine transporter attenuates the binding of methamphetamine via distinct helix-helix interactions. Chemical biology & drug design. vol 97. issue 6. 2021-11-19. PMID:33754484. |
dopamine transporter (dat) and sigma-1 receptor (σ1r) are potential therapeutic targets to reduce the psychostimulant effects induced by methamphetamine (meth). |
2021-11-19 |
2023-08-13 |
drosophila_melanogaster |
| Andrea Di Nisio, Micaela Pannella, Stefania Vogiatzis, Stefania Sut, Stefano Dall'Acqua, Maria Santa Rocca, Angelo Antonini, Andrea Porzionato, Raffaele De Caro, Mario Bortolozzi, Luca De Toni, Carlo Forest. Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals. Environment international. vol 158. 2021-11-19. PMID:34781208. |
in addition, cells at dp3 phase exposed to pfoa showed a severe reduction in the expression of the dopamine transporter (dat), functionally involved in pre-synaptic dopamine reuptake. |
2021-11-19 |
2023-08-13 |
human |
| Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimot. Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome. Brain research bulletin. vol 177. 2021-11-18. PMID:34560239. |
mptp caused the reduction of dopamine transporter (dat) and tyrosine hydroxylase (th) in the striatum, and increases in phosphorylated α-synuclein (p-α-syn) in the striatum and colon. |
2021-11-18 |
2023-08-13 |
mouse |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
thus, effects of mcat on 1) striatal dopamine (da) transporter (dat); and 2) striatal and hippocampal serotonin transporter (sert) function, as determined in tissues from adult male rats, were assessed. |
2021-11-17 |
2023-08-13 |
rat |
| Emma A Honkanen, Mikael Eklund, Simo Nuuttila, Tommi Noponen, Elina Jaakkola, Elina Mäkinen, Risto Hirvilammi, Marko Seppänen, Kari Lindholm, Filip Scheperjans, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34482280. |
to evaluate possible differences between brain dopamine transporter (dat) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. |
2021-11-17 |
2023-08-13 |
human |
| Simo Nuuttila, Mikael Eklund, Juho Joutsa, Elina Jaakkola, Elina Mäkinen, Emma A Honkanen, Kari Lindholm, Tommi Noponen, Toni Ihalainen, Kirsi Murtomäki, Tanja Nojonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasine. Diagnostic accuracy of glabellar tap sign for Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 11. 2021-11-16. PMID:34328563. |
gr was performed on 161 patients with pd, 47 patients with essential tremor (et) and 40 healthy controls immediately prior to dopamine transporter (dat) [ |
2021-11-16 |
2023-08-13 |
Not clear |
| Atsuo Nakahara, Renpei Sengoku, Tadashi Umehara, Hiromasa Matsuno, Mikihiro Yamazaki, Hisayoshi Ok. Frontal lobe dysfunction is associated with reduced DAT-SPECT accumulation in Lewy body disease. Journal of the neurological sciences. vol 430. 2021-11-16. PMID:34601357. |
recent reports indicate that the dopamine transporter (dat), which can be imaged using single-photon emission computed tomography ( |
2021-11-16 |
2023-08-13 |
Not clear |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
multimodal dopamine transporter (dat) imaging and magnetic resonance imaging (mri) to characterise early parkinson's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
currently, in early idiopathic pd, dopamine transporter (dat)-specific imaging assesses the extent of striatal dopaminergic deficits, and conventional magnetic resonance imaging (mri) of the brain excludes the presence of significant ischaemic load in the basal ganglia as well as signs indicative of other forms of parkinsonism. |
2021-11-15 |
2023-08-13 |
Not clear |
| Piniel Alphayo Kambey, Ma Chengcheng, Guo Xiaoxiao, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Ga. The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33507465. |
we first demonstrated that amodiaquine treatment ameliorated behavioural deficits in 6-ohda parkinson's disease mouse model, and it promoted dopaminergic neurons protection signified by tyrosine hydroxylase (th) and dopamine transporter (dat) mrna; tyrosine hydroxylase (th) protein expression level and the immunoreactivity in the substantia nigra compacta. |
2021-11-12 |
2023-08-13 |
mouse |
| Tripti Grover, Ranjan Gupta, Geetanjali Arora, Chandra Shekhar Bal, Atul Ambekar, Subrata Basu Ray, Meera Vaswani, Arundhati Sharm. Dopamine transporter availability in alcohol and opioid dependent subjects - a Psychiatry research. Neuroimaging. vol 305. 2021-11-11. PMID:32947183. |
dopamine transporter availability in alcohol and opioid dependent subjects - a drug dependence associated with increased dopamine neurotransmission and neuroplastic changes is influenced by dopamine transporters (dat) which are modulated by genetic and epigenetic factors. |
2021-11-11 |
2023-08-13 |
human |
| Padmanabhan Mannangatti, Durairaj Ragu Varman, Sammanda Ramamoorthy, Lankupalle D Jayanth. Neurokinin-1 Antagonism Distinguishes the Role of Norepinephrine Transporter from Dopamine Transporter in Mediating Amphetamine Behaviors. Pharmacology. vol 106. issue 11-12. 2021-11-11. PMID:34515205. |
amphetamine (amph) and other psychostimulants act on the norepinephrine (ne) transporter (net) and the dopamine (da) transporter (dat) and enhance ne and da signaling. |
2021-11-11 |
2023-08-13 |
Not clear |
| Serena Venezia, Walter A Kaufmann, Gregor K Wenning, Nadia Stefanov. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34530328. |
the facilitated propagation of α-synuclein is associated with early loss of dopamine transporter (dat) signal in the striatum and loss of dopaminergic neurons in substantia nigra pars compacta of tlr4 deficient mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Arda Könik, Navid Zeraatkar, Kesava S Kalluri, Benjamin Auer, Timothy J Fromme, Yulun He, Micaehla May, Lars R Furenlid, Phillip H Kuo, Michael A Kin. Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing. IEEE transactions on radiation and plasma medical sciences. vol 5. issue 6. 2021-11-11. PMID:34746540. |
spect imaging of dopamine transporters (dat) in the brain is a widely utilized study to improve the diagnosis of parkinsonian syndromes, where conventional (parallel-hole and fan-beam) collimators on dual-head scanners are commonly employed. |
2021-11-11 |
2023-08-13 |
Not clear |