| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aaron D Thome, David G Standaert, Ashley S Harm. Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease. PloS one. vol 10. issue 10. 2016-06-14. PMID:26469270. |
in models of alzheimer's disease (ad), multiple sclerosis (ms) and neurotoxin models of pd, the chemokine cx3cl1 (fractalkine) and its receptor (cx3cr1) have important roles in modulating neuroinflammation. |
2016-06-14 |
2023-08-13 |
Not clear |
| Jenny Dworzak, Benoît Renvoisé, Johnny Habchi, Emma V Yates, Christophe Combadière, Tuomas P Knowles, Christopher M Dobson, Craig Blackstone, Ole Paulsen, Philip M Murph. Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity. PloS one. vol 10. issue 6. 2016-02-22. PMID:26038823. |
cx3cr1, the receptor for the chemokine cx3cl1 (fractalkine), has been implicated in the progression and severity of alzheimer's disease-like pathology in mice, but the underlying mechanisms remain unclear. |
2016-02-22 |
2023-08-13 |
mouse |
| Clotilde Lauro, Myriam Catalano, Flavia Trettel, Cristina Limatol. Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? Annals of the New York Academy of Sciences. vol 1351. 2016-01-26. PMID:26084002. |
the expression of cx3cl1 on neurons and of its receptor cx3cr1 on microglia facilitates a privileged interaction, playing important roles in regulating the function and maturation of these cells. |
2016-01-26 |
2023-08-13 |
human |
| Yong Liu, Xiao-Mei Wu, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke, Zhong-Ming Qia. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:25966946. |
the exact roles of activated microglia and fractalkine (cx3cl1)/fractalkine receptor (cx3cr1) signaling are not fully understood in brain ischemic injury and the findings reported are controversial. |
2015-12-30 |
2023-08-13 |
mouse |
| Yong Liu, Xiao-Mei Wu, Qian-Qian Luo, Suna Huang, Qing-Wu Qian Yang, Fa-Xiang Wang, Ya Ke, Zhong-Ming Qia. CX3CL1/CX3CR1-mediated microglia activation plays a detrimental role in ischemic mice brain via p38MAPK/PKC pathway. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:25966946. |
here, we investigated the effects of cx3cr1 sirna on the expression of cx3cr1, p38 mitogen-activated protein kinase (p38mapk), protein kinase c (pkc) and inflammatory cytokines, microglia activation, white matter lesions, and cognitive function in mice treated with bilateral common carotid artery stenosis (bcas) in vivo as well as effects of exogenous cx3cl1, cx3cr1 sirna, and sb2035080 on expression of inflammatory cytokines in bv2 microglia treated with oxygen-glucose deprivation (ogd) in vitro. |
2015-12-30 |
2023-08-13 |
mouse |
| Shan Sun, Huiqian Yu, Hui Yu, Mei Honglin, Wenli Ni, Yanping Zhang, Luo Guo, Yingzi He, Zhen Xue, Yusu Ni, Jin Li, Yi Feng, Yan Chen, Ruijin Shao, Renjie Chai, Huawei L. Inhibition of the activation and recruitment of microglia-like cells protects against neomycin-induced ototoxicity. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24781382. |
our results demonstrate that cx3cl1-induced mlc activation plays an important role in the induction of hc death and provide evidence for cx3cl1 and cx3cr1 as promising new therapeutic targets for the prevention of hearing loss. |
2015-10-20 |
2023-08-13 |
mouse |
| Jin Fu, Yun-Lu Jiao, Zheng-Wei Li, Yong-Hua J. Spinal 5-HT3AR contributes to BmK I-induced inflammatory pain in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 67. issue 3. 2015-09-10. PMID:26109301. |
finally, the expression level of cx3cl1 and cx3cr1 was reduced by intrathecal pre-treatment with ondansetron. |
2015-09-10 |
2023-08-13 |
rat |
| In-Soo Oh, Dong-Whan Suh, Sung-Ryeoll Park, Kee-Yong H. Fractalkine receptor chemokine (CX3CR1) influences on cervical and lumbar disc herniation. Indian journal of orthopaedics. vol 49. issue 2. 2015-05-27. PMID:26015616. |
we evaluated the expression of cx3cl1 and cx3cr1 in patients with disc herniation to clarify the role of cx3cl1 and cx3cr1 in the disc degeneration and to compare between cervical and lumbar hnp. |
2015-05-27 |
2023-08-13 |
Not clear |
| Ming Duan, Honghong Yao, Yu Cai, Ke Liao, Pankaj Seth, Shilpa Buc. HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NF-κBYY1 pathway. Current HIV research. vol 12. issue 3. 2015-04-01. PMID:24862326. |
interaction between cx3cl1 (fractalkine) and fkn receptor (cx3cr1) is highly functional in the brain, and is known to regulate a complex network of paracrine and autocrine interactions between neurons and microglia. |
2015-04-01 |
2023-08-13 |
mouse |
| Elisa Ferretti, Vito Pistoia, Anna Corcion. Role of fractalkine/CX3CL1 and its receptor in the pathogenesis of inflammatory and malignant diseases with emphasis on B cell malignancies. Mediators of inflammation. vol 2014. 2014-12-18. PMID:24799766. |
the biological activities of cx3cl1 are mediated by cx3cr1, that is expressed on different cell types such as nk cells, cd14(+) monocytes, cytotoxic effector t cells, b cells, neurons, microglia, smooth muscle cells, and tumor cells. |
2014-12-18 |
2023-08-13 |
human |
| Chao Bian, Zhe-Chen Wang, Jia-Le Yang, Ning Lu, Zhi-Qi Zhao, Yu-Qiu Zhan. Up-regulation of interleukin-23 induces persistent allodynia via CX3CL1 and interleukin-18 signaling in the rat spinal cord after tetanic sciatic stimulation. Brain, behavior, and immunity. vol 37. 2014-11-04. PMID:24362237. |
similar to il-23 signaling, an increase in il-18 and its receptor, il-18r, as well as cx3cl1 and its receptor, cx3cr1, was simultaneously observed in the spinal dorsal horn after tss. |
2014-11-04 |
2023-08-12 |
rat |
| Dariusz Szukiewicz, Jan Kochanowski, Tarun Kumar Mittal, Michal Pyzlak, Grzegorz Szewczyk, Krzysztof Cendrowsk. CX3CL1 (fractalkine) and TNFα production by perfused human placental lobules under normoxic and hypoxic conditions in vitro: the importance of CX3CR1 signaling. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 63. issue 3. 2014-10-04. PMID:24270813. |
tumor necrosis factor alpha (tnfα) induces cx3cl1, influencing a mechanism of cx3cl1 autoregulation by cx3cr1 expression. |
2014-10-04 |
2023-08-12 |
human |
| Teresita L Briones, Julie Woods, Magdalena Wadowsk. Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. Journal of neuroinflammation. vol 11. 2014-09-16. PMID:24447880. |
a major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine cx3cl1 (fractalkine) and its receptor, cx3cr1. |
2014-09-16 |
2023-08-12 |
human |
| Julia Grizenkova, Shaheen Akhtar, Sebastian Brandner, John Collinge, Sarah E Lloy. Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. BMC neuroscience. vol 15. 2014-08-27. PMID:24655482. |
in the central nervous system the chemokine cx3cl1 (fractalkine) is expressed by neurons and its exclusive receptor cx3cr1 is expressed solely on microglia. |
2014-08-27 |
2023-08-12 |
mouse |
| Cristina Limatola, Richard M Ransohof. Modulating neurotoxicity through CX3CL1/CX3CR1 signaling. Frontiers in cellular neuroscience. vol 8. 2014-08-25. PMID:25152714. |
the pivotal description of the localization of the unique cx3cl1 receptor, cx3cr1, on microglial cells, firmed up by the generation of cx3cr1(gfp/gfp) mice, opened the road to the hypothesis of some specific key interactions between microglia and neurons mediated by this pair. |
2014-08-25 |
2023-08-13 |
mouse |
| Rosa Chiara Paolicelli, Kanchan Bisht, Marie-Ève Trembla. Fractalkine regulation of microglial physiology and consequences on the brain and behavior. Frontiers in cellular neuroscience. vol 8. 2014-06-24. PMID:24860431. |
as part of this special issue on cytokines as players of neuronal plasticity and sensitivity to environment in healthy and pathological brain, our review focuses on the fractalkine signaling pathway, involving the ligand cx3cl1 which is mainly expressed by neurons, and its receptor cx3cr1 that is exclusively found on microglia within the healthy brain. |
2014-06-24 |
2023-08-13 |
mouse |
| Wenjun Zhu, Crystal Acosta, Brian MacNeil, Claudia Cortes, Howard Intrater, Yuewen Gong, Mike Namak. Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. BioMed research international. vol 2013. 2014-06-09. PMID:24175290. |
elevated expression of fractalkine (cx3cl1) and fractalkine receptor (cx3cr1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. |
2014-06-09 |
2023-08-12 |
Not clear |
| Wenjun Zhu, Crystal Acosta, Brian MacNeil, Claudia Cortes, Howard Intrater, Yuewen Gong, Mike Namak. Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. BioMed research international. vol 2013. 2014-06-09. PMID:24175290. |
an experimental autoimmune encephalomyelitis (eae) model of ms was utilized to assess time dependent gene and protein expression changes of cx3cl1 and cx3cr1. |
2014-06-09 |
2023-08-12 |
Not clear |
| Wenjun Zhu, Crystal Acosta, Brian MacNeil, Claudia Cortes, Howard Intrater, Yuewen Gong, Mike Namak. Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. BioMed research international. vol 2013. 2014-06-09. PMID:24175290. |
results revealed significant increases in mrna and the protein expression of cx3cl1 and cx3cr1 in the dorsal root ganglia (drg) and spinal cord (sc) 12 days after eae induction compared to controls. |
2014-06-09 |
2023-08-12 |
Not clear |
| A E El-Shazly, H C Doloriert, B Bisig, P P Lefebvre, P Delvenne, N Jacob. Novel cooperation between CX3CL1 and CCL26 inducing NK cell chemotaxis via CX3CR1: a possible mechanism for NK cell infiltration of the allergic nasal tissue. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 43. issue 3. 2013-08-08. PMID:23414540. |
novel cooperation between cx3cl1 and ccl26 inducing nk cell chemotaxis via cx3cr1: a possible mechanism for nk cell infiltration of the allergic nasal tissue. |
2013-08-08 |
2023-08-12 |
Not clear |