| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsin-Ling Shih, Kuan-Hsiang Cheng, Chin-Hao Chen, Jang-Yang Chang, Kuei-Sen Hs. Upregulation of Cathepsin S Expression Contributes to Neuronal Damage Following Kainic Acid-Induced Status Epilepticus. Journal of neurochemistry. vol 169. issue 3. 2025-03-05. PMID:40042007. |
an increase in chemokine cx3c motif ligand 1 (cx3cl1) immunoreactivity on microglia was observed following ka-induced se, and cx3c motif chemokine receptor 1 (cx3cr1) antagonist azd8797 treatment significantly attenuated se-induced microglia activation and neuronal damage. |
2025-03-05 |
2025-03-07 |
mouse |
| Lin Jiang, Xu Zhang, Shun Wang, Jiangkuan Zhang, Junyang Chen, Jiachuan Lu, Liting Yao, Weiwei Jin, Nan Li, Qing L. Functional Monomers Equipped Microgel System for Managing Parkinson's Disease by Intervening Chemokine Axis-mediated Nerve Cell Communications. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-12-25. PMID:39721010. |
meanwhile, the dopamine (da) released from pda can facilitate da storage and neurogenesis, inhibiting cx3cl1 release and the cx3cr1 receptor on microglia and further regulating the cx3cl1/cx3cr1-nf-κb-nlrp3 signaling pathway in microglia to inhibit neuroinflammation. |
2024-12-25 |
2024-12-29 |
Not clear |
| Pei-Pei Liu, Xiao-Hui Liu, Ming-Jing Ren, Xiao-Tong Liu, Xiao-Qing Shi, Ming-Li Li, Shu-Ang Li, Yang Yang, Dian-Dian Wang, Yue Wu, Fan-Xiang Yin, Yan-Hong Guo, Run-Zhou Yang, Meng Cheng, Yong-Juan Xin, Jian-Sheng Kang, Bing Huang, Kai-Di Re. Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease. Aging cell. 2024-10-25. PMID:39453382. |
transcriptome and fluorescence-activated cell sorting (facs) results revealed that ctss overexpression in neurons aggravated brain inflammatory milieu with microglia activation to m1 pro-inflammatory phenotype, activation of chemokine c-x3-c-motif ligand 1 (cx3cl1)-chemokine c-x3-c-motif receptor 1 (cx3cr1) axis and janus kinase 2 (jak2)-signal transducer and activator of transcription 3 (stat3) pathway. |
2024-10-25 |
2024-10-28 |
mouse |
| Pei-Pei Liu, Xiao-Hui Liu, Ming-Jing Ren, Xiao-Tong Liu, Xiao-Qing Shi, Ming-Li Li, Shu-Ang Li, Yang Yang, Dian-Dian Wang, Yue Wu, Fan-Xiang Yin, Yan-Hong Guo, Run-Zhou Yang, Meng Cheng, Yong-Juan Xin, Jian-Sheng Kang, Bing Huang, Kai-Di Re. Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease. Aging cell. 2024-10-25. PMID:39453382. |
as cx3cl1 is secreted by neurons and acts on the cx3cr1 in microglia, our results revealed for the first time the role of neuron ctss in neuron-microglia "crosstalk." |
2024-10-25 |
2024-10-28 |
mouse |
| Mateusz Wątroba, Anna D Grabowska, Dariusz Szukiewic. Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062768. |
fractalkine (cx3cl1) has unique properties as an adhesion molecule and chemoattractant, and by acting on its only receptor, cx3cr1, it regulates the activity of microglia in physiological states and neuroinflammation. |
2024-07-27 |
2024-07-29 |
Not clear |
| Yangyang Ge, Xiaoke Dou, Pu Chen, Jiayi Chen, Maosha Dai, Shanglong Yao, Yun Li. Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway. Molecular neurobiology. 2024-06-17. PMID:38886327. |
western blot detected cx3cl1 and cx3cr1 protein expression, while immunofluorescence observed these proteins, neurogenesis in the subventricular zone (svz), rostral migratory stream (rms), and dentate gyrus (dg), along with iba1 and cd68 co-expression. |
2024-06-17 |
2024-06-21 |
mouse |
| Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang, Yisheng Zhon. CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model. Inflammation and regeneration. vol 44. issue 1. 2024-06-08. PMID:38844990. |
cx3cr1, the only receptor of cx3cl1, is specifically expressed on retinal microglia, whose activation plays a role in the pathological process of optic nerve injury. |
2024-06-08 |
2024-06-10 |
Not clear |
| Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang, Yisheng Zhon. CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model. Inflammation and regeneration. vol 44. issue 1. 2024-06-08. PMID:38844990. |
this study aimed to evaluate whether cx3cl1 exerts optic neuroprotection by affecting the activation of microglia by combining with cx3cr1. |
2024-06-08 |
2024-06-10 |
Not clear |
| Samuel Bridge, Sophia N Karagiannis, Alessandra Borsin. The complex role of the chemokine CX3CL1/Fractalkine in major depressive disorder: A narrative review of preclinical and clinical studies. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706575. |
our narrative review focuses on the role of the chemokine fractalkine (fkn) (also known as cx3cl1), which has gained increasing interest for its ability to induce changes to microglial phenotypes through interaction with its corresponding receptor (cx3cr1) that may impact neurophysiological processes relevant to mdd. |
2024-05-06 |
2024-05-08 |
mouse |
| Chunmei Zhang, Yusi Zhang, Ran Zhuang, Kun Yang, Lihua Chen, Boquan Jin, Ying Ma, Yun Zhang, Kang Tan. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38674036. |
cx3cl1 signals are transmitted through its unique receptor, cx3cr1, primarily expressed in the microglia of the central nervous system (cns). |
2024-04-27 |
2024-04-29 |
human |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
based on the cx3c chemokine ligand 1(cx3cl1)-cx3c chemokine receptor 1(cx3cr1) axis, this study explored the potential mechanism by which zuogui jiangtang jieyu formula(zgjtjy) improved neuroinflammation and enhanced neuroprotective effect in a rat model of diabetes mellitus complicated with depression(dd). |
2023-12-19 |
2023-12-23 |
rat |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
western blot was used to measure the expression levels of cx3cl1, cx3cr1, a2a adenosine receptor(a2ar), glutamate receptor 2a(nr2a), glutamate receptor 2b(nr2b), and brain-derived neurotrophic factor(bdnf) in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |
| Z W Huang, Y Y Liu, X M Chen, C L Yu, H Y He, Y H Den. Attenuating Neuronal Autophagy Alleviates Inflammatory Injury in OGDDeprived Co-culture of HT22 with BV2. Acta naturae. vol 15. issue 3. 2023-11-01. PMID:37908770. |
neuronal cx3cl1 suppressed microglial inflammation by binding to its receptor cx3cr1 expressed on microglia. |
2023-11-01 |
2023-11-08 |
Not clear |
| Matilda Iemmolo, Giulio Ghersi, Giulia Bivon. The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175729. |
cx3cl1, as an adhesion molecule, on the one hand, plays an inhibiting role in the pro-inflammatory response in the central nervous system (cns) and shows neuroprotective effects by binding its membrane receptor (cx3cr1) present into microglia cells and maintaining them in a quiescent state; on the other hand, the scx3cl1 isoform seems to promote neurodegeneration. |
2023-05-14 |
2023-08-14 |
Not clear |
| Zhihua Lu, Aihua Zhang, Yan Da. CX3CL1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in LPS-treated MC3T3-E1 cells via its receptor CX3CR1. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-11-27. PMID:36436718. |
cx3cl1 deficiency ameliorates inflammation, apoptosis and accelerates osteogenic differentiation, mineralization in lps-treated mc3t3-e1 cells via its receptor cx3cr1. |
2022-11-27 |
2023-08-14 |
Not clear |
| Anna Bagó-Mas, Andrea Korimová, Meritxell Deulofeu, Enrique Verdú, Núria Fiol, Viktorie Svobodová, Petr Dubový, Pere Boadas-Vaell. Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056079. |
then, gliosis, erk phosphorylation and the expression of ccl2 and cx3cl1 chemokines and their receptors, ccr2 and cx3cr1, were analyzed in the spinal cord. |
2022-09-02 |
2023-08-14 |
mouse |
| Yangyang Ge, Li Wang, Chenchen Wang, Jiayi Chen, Maosha Dai, Shanglong Yao, Yun Li. CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke. Life sciences. 2022-04-24. PMID:35461837. |
the chemokine cx3cl1 and its receptor cx3cr1 play a fundamental role in the pathophysiology of ischemic stroke. |
2022-04-24 |
2023-08-13 |
mouse |
| Cankun Zheng, Wanling Xuan, Zhenhuan Chen, Rui Zhang, Xiaoxia Huang, Yingqi Zhu, Siyuan Ma, Kaitong Chen, Lu Chen, Mingyuan He, Hairuo Lin, Wangjun Liao, Jianping Bin, Yulin Lia. CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome. Frontiers in pharmacology. vol 13. 2022-04-04. PMID:35370759. |
in the two diabetic mouse models, knockout of cx3cl1 receptor cx3cr1 or treatment with an cx3cl1 neutralizing antibody significantly improved cardiorenal dysfunction by inhibiting apoptosis, mitochondrial dysfunction, and fibrosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Sh. Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice. Neuroscience bulletin. 2022-03-30. PMID:35352285. |
tia promoted the interaction of anxa1 and cx3cr1, increased the membrane distribution of cx3cr1 in microglia, and thus enhanced the cx3cr1 and cx3cl1 interaction. |
2022-03-30 |
2023-08-13 |
mouse |
| Jing Cao, Hui Gan, Han Xiao, Hui Chen, Dan Jian, Dan Jian, Xuan Zha. Key protein-coding genes related to microglia in immune regulation and inflammatory response induced by epilepsy. Mathematical biosciences and engineering : MBE. vol 18. issue 6. 2021-12-09. PMID:34814358. |
meanwhile, several genes, including cx3cr1, cx3cl1, gpr183, fpr1, p2ry13, p2ry12 and lpar5, were associated with microglial activation and migration, providing novel candidate targets for immunotherapy in epilepsy and laying the foundation for further research. |
2021-12-09 |
2023-08-13 |
mouse |