| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiyuan Zhang, Yu Lin, Lili Xiao, Eryou Feng, Wulian Wang, Liqiong Li. The effects of icariine concentration on osteoclasts bone resorption induced by titanium particles in vitro. Regenerative biomaterials. vol 2. issue 3. 2016-01-28. PMID:26816641. |
at 48 h after treatment, the expression level of receptor activator of nf-kb (rank) was detected by elisa, and messenger rna (mrna) levels of tartrate-resistant acid phosphatase (trap), matrix metalloproteinase 9 (mmp-9), carbonic anhydrase ii (caii) and cathepsin k (ctsk) were determined by real-time polymerase chain reaction. |
2016-01-28 |
2023-08-13 |
Not clear |
| Y Xue, L Wang, D Xia, Q Li, S Gao, M Dong, T Cai, S Shi, L He, K Hu, T Mao, X Dua. Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations. Journal of dental research. vol 94. issue 5. 2015-06-30. PMID:25731711. |
cathepsin k (ctsk) is an important protease responsible for degrading type i collagen, osteopontin, and other bone matrix proteins. |
2015-06-30 |
2023-08-13 |
Not clear |
| Usman A Khan, Saeed M Hashimi, Shershah Khan, Jingjing Quan, Mahmoud M Bakr, Mark R Forwood, Nigel M Morriso. Differential expression of chemokines, chemokine receptors and proteinases by foreign body giant cells (FBGCs) and osteoclasts. Journal of cellular biochemistry. vol 115. issue 7. 2015-01-10. PMID:24500983. |
tartrate-resistant acid phosphatase (trap), matrix metallo proteinase 9 (mmp9), nuclear factor of activated t cells 1 (nfatc1), cathepsin k (ctsk) and rank were significantly lower in fbgcs compared to osteoclasts. |
2015-01-10 |
2023-08-12 |
Not clear |
| Heiani Touaitahuata, Gaelle Cres, Sylvain de Rossi, Virginie Vives, Anne Blang. The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth. Developmental biology. vol 393. issue 1. 2014-11-06. PMID:24992711. |
in vitro, we show that dock5(-/-) osteoclasts do present acidic compartments at the ventral plasma membrane and produce normal amounts of active mmp9, trap and ctsk for matrix protein degradation but they are unable to solubilize minerals. |
2014-11-06 |
2023-08-13 |
mouse |
| Faiza Sharif, Merijn A G de Bakker, Michael K Richardso. Osteoclast-like Cells in Early Zebrafish Embryos. Cell journal. vol 16. issue 2. 2014-07-01. PMID:24567948. |
genes involved in bone and tissue remodelling in the vertebrates include matrix metalloproteinase-9 (mmp-9), receptor activator of necrosis factor κ-β (rank), cathepsin-k (ctsk) and tartrate-resistant acid phosphatase (tracp). |
2014-07-01 |
2023-08-12 |
zebrafish |
| Weon-Jong Yoon, Kil-Nam Kim, Soo-Jin Heo, Sang-Chul Han, Jihyeon Kim, Yeong-Jong Ko, Hee-Kyoung Kang, Eun-Sook Yo. Sargachromanol G inhibits osteoclastogenesis by suppressing the activation NF-κB and MAPKs in RANKL-induced RAW 264.7 cells. Biochemical and biophysical research communications. vol 434. issue 4. 2013-08-27. PMID:23611776. |
additionally, the expression of osteoclastic marker genes, such as tartrate-resistant acid phosphatase (trap), cathepsin k (ctsk), matrix metalloproteinase 9 (mmp9), and calcitonin receptor (ctr), was strongly inhibited. |
2013-08-27 |
2023-08-12 |
Not clear |
| Sutada Lotinun, Riku Kiviranta, Takuma Matsubara, Jorge A Alzate, Lynn Neff, Anja Lüth, Ilpo Koskivirta, Burkhard Kleuser, Jean Vacher, Eero Vuorio, William C Horne, Roland Baro. Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. The Journal of clinical investigation. vol 123. issue 2. 2013-05-13. PMID:23321671. |
cathepsin k (ctsk) is secreted by osteoclasts to degrade collagen and other matrix proteins during bone resorption. |
2013-05-13 |
2023-08-12 |
mouse |
| Yan Zhang, Jie Li, Ji Zhu, Guangdong Zhou, Wen Jie Zhang, Yilin Cao, Wei Li. Enhanced cartilage formation by inhibiting cathepsin K expression in chondrocytes expanded in vitro. Biomaterials. vol 33. issue 30. 2012-12-18. PMID:22818652. |
furthermore, over-expression of ctsk led to reduced matrix production in cultured human chondrocytes in vitro and poor formation of engineered cartilage in vivo. |
2012-12-18 |
2023-08-12 |
human |
| Patricia K Russell, Michele V Clarke, Jarrod P Skinner, Tammy P S Pang, Jeffrey D Zajac, Rachel A Dave. Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice. Journal of molecular endocrinology. vol 49. issue 1. 2012-09-26. PMID:22525354. |
the osteoblast genes col1a1 and bglap and the osteoclast genes ctsk and rankl (tnfs11) were upregulated in the bones of mobl-arkos, consistent with the increased matrix synthesis, mineralization, and bone resorption observed previously in these mice. |
2012-09-26 |
2023-08-12 |
mouse |
| Leping Ye, Binghai Zhao, Kaiming Yuan, Yanhui Chu, Changchong Li, Connie Zhao, Qing-Quan Lian, Ren-Shan G. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicology letters. vol 209. issue 3. 2012-04-16. PMID:22237054. |
the other genes were primarily included in the categories of cytoskeletal structure (tpm1, tnnt2, actn3, myoz2, tmod1, and mfap5), extracellular matrix (ckm, lum, tnnc1, art3, dcn, col17a1, aspn, ctsk, itm2a, spock2 and orm1), transporting (cox8h, cox6a2 and scnn1a) and secreted proteins (scgb3a1, nppb and spp1). |
2012-04-16 |
2023-08-12 |
rat |
| Yang Xue, Tao Cai, Songtao Shi, Weiguang Wang, Yanli Zhang, Tianqiu Mao, Xiaohong Dua. Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011. Orphanet journal of rare diseases. vol 6. 2011-10-18. PMID:21569238. |
ctsk mutations result in total loss or inactivity of the ctsk protein, which causes abnormal degradation of bone matrix proteins such as type i collagen. |
2011-10-18 |
2023-08-12 |
mouse |
| Michelle D Combs, Caitlin M Braitsch, Alexander W Lange, Jeanne F James, Katherine E Yutze. NFATC1 promotes epicardium-derived cell invasion into myocardium. Development (Cambridge, England). vol 138. issue 9. 2011-07-01. PMID:21447555. |
in osteoclasts, calcineurin-mediated activation of nfatc1 by receptor activator of nfκb ligand (rankl) signaling induces cathepsin k (ctsk) expression for extracellular matrix degradation and cell invasion. |
2011-07-01 |
2023-08-12 |
mouse |
| X Yan, M Takahara, L Xie, Y Oda, T Nakahara, H Uchi, S Takeuchi, Y Tu, Y Moroi, M Furu. Stromal expression of cathepsin K in squamous cell carcinoma. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 25. issue 3. 2011-05-26. PMID:20524946. |
cathepsin k (ctsk), a cysteine protease with strong collagenolytic and elastolytic properties involved in extracellular matrix turnover, may be produced by neoplastic cells as well as stromal macrophages and fibroblasts. |
2011-05-26 |
2023-08-12 |
Not clear |
| Lining Xie, Yoichi Moroi, Sayaka Hayashida, Gaku Tsuji, Satoshi Takeuchi, Baoen Shan, Takeshi Nakahara, Hiroshi Uchi, Masakazu Takahara, Masutaka Furu. Cathepsin K-upregulation in fibroblasts promotes matrigel invasive ability of squamous cell carcinoma cells via tumor-derived IL-1α. Journal of dermatological science. vol 61. issue 1. 2011-04-21. PMID:21146373. |
cathepsin k (ctsk), a cysteine protease with strong collagenolytic properties, is involved in extracellular matrix turnover. |
2011-04-21 |
2023-08-12 |
Not clear |
| Garima Garg, A R Pradeep, Manoj Kumar Thora. Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis. Archives of oral biology. vol 54. issue 11. 2010-04-08. PMID:19782963. |
cathepsin k (ctsk), predominantly expressed in osteoclasts, is a potent extracellular matrix degrading enzyme that plays a critical role in osteoclast-mediated bone resorption. |
2010-04-08 |
2023-08-12 |
Not clear |
| Darja Bitenc Logar, Radko Komadina, Janez Prezelj, Barbara Ostanek, Zoran Trost, Janja Mar. Expression of bone resorption genes in osteoarthritis and in osteoporosis. Journal of bone and mineral metabolism. vol 25. issue 4. 2007-08-30. PMID:17593491. |
real-time rt-pcr was used to quantify ctsk (cathepsin k), mmp-9 (matrix metalloproteinase 9), acp5 (trap), tnfsf11 (rankl), tnfrsf11b (opg), and bglap (osteocalcin) mrnas. |
2007-08-30 |
2023-08-12 |
Not clear |
| Miyuki Suguro, Hiroyuki Tagawa, Yoshitoyo Kagami, Masataka Okamoto, Koichi Ohshima, Hiroshi Shiku, Yasuo Morishima, Shigeo Nakamura, Masao Set. Expression profiling analysis of the CD5+ diffuse large B-cell lymphoma subgroup: development of a CD5 signature. Cancer science. vol 97. issue 9. 2006-10-18. PMID:16856881. |
the cd5 signature included downregulated extracellular matrix genes such as postn, sparc, col1a1, col3a1, ctsk, mmp9 and lamb3, and comprised upregulated genes including trpm4. |
2006-10-18 |
2023-08-12 |
Not clear |
| Riku Kiviranta, Jukka Morko, Sari L Alatalo, Roisin NicAmhlaoibh, Juha Risteli, Tiina Laitala-Leinonen, Eero Vuori. Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone. vol 36. issue 1. 2005-07-05. PMID:15664014. |
previous reports indicate that mice deficient for cathepsin k (ctsk), a key protease in osteoclastic bone resorption, develop osteopetrosis due to their inability to properly degrade organic bone matrix. |
2005-07-05 |
2023-08-12 |
mouse |
| Frank Bühling, Christoph Röcken, Frank Brasch, Roland Hartig, Yoshiyuki Yasuda, Paul Saftig, Dieter Brömme, Tobias Welt. Pivotal role of cathepsin K in lung fibrosis. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161653. |
ctsk(-/-) mice deposited significantly more extracellular matrix than control mice. |
2004-07-08 |
2023-08-12 |
mouse |
| Frank Bühling, Christoph Röcken, Frank Brasch, Roland Hartig, Yoshiyuki Yasuda, Paul Saftig, Dieter Brömme, Tobias Welt. Pivotal role of cathepsin K in lung fibrosis. The American journal of pathology. vol 164. issue 6. 2004-07-08. PMID:15161653. |
interestingly, ctsk(+/+) control mice revealed an increased expression of catk in fibrotic lung regions suggesting a protective role of catk to counter the excessive deposition of collagen matrix in the diseased lung. |
2004-07-08 |
2023-08-12 |
mouse |