| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle Tokarz, Janaina S Martins, Elizabeth T Petit, Charles P Lin, Marie B Demay, Eva S Li. Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 33. issue 3. 2019-10-09. PMID:29083055. |
these studies demonstrate that hyp mice have larger osteocyte lacunae in both the tibia and calvaria, accompanied by enhanced osteocyte mrna and protein expression of matrix metalloproteinase 13 (mmp13) and genes classically used by osteoclasts to resorb bone, such as cathepsin k (ctsk). |
2019-10-09 |
2023-08-13 |
mouse |
| Qiang Guo, Zhen Cao, Bo Wu, Fangxiao Chen, Jennifer Tickner, Ziyi Wang, Heng Qiu, Chao Wang, Kai Chen, Renxiang Tan, Qile Gao, Jiake X. Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption. Journal of cellular physiology. vol 234. issue 1. 2019-10-02. PMID:30078210. |
using reverse transcription-polymerase chain reaction and western blot analysis, we found that kavain downregulates the expression of osteoclast marker genes, such as nuclear factor of activated t cells, cytoplasmic 1 (nfatc1), v-atpase d2 (atp6v0d2), dendrocyte expressed seven transmembrane protein (dcstamp), matrix metallopeptidase 9 (mmp9), cathepsin k (ctsk), and acp5. |
2019-10-02 |
2023-08-13 |
mouse |
| Yu-Qiong He, Qi Zhang, Yi Shen, Ting Han, Quan-Long Zhang, Jian-Hua Zhang, Bing Lin, Hong-Tao Song, Hsien-Yeh Hsu, Lu-Ping Qin, Hai-Liang Xin, Qiao-Yan Zhan. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochemical and biophysical research communications. vol 506. issue 4. 2019-05-17. PMID:30392907. |
in addition, rbm downregulated the expression of osteoclast-related proteins, including nuclear factor of activated t cells cytoplasmic 1 (nfatc1), cellular oncogene fos (c-fos), matrix metallopeptidase 9 (mmp-9) and cathepsin k (ctsk) as shown by western blot. |
2019-05-17 |
2023-08-13 |
Not clear |
| Gregory P L Thomas, Shailendra A Magdum, Nad R Saeed, David Johnso. Multisuture Craniosynostosis and Papilledema in Pycnodysostosis: A Paradox? The Journal of craniofacial surgery. vol 30. issue 1. 2019-03-13. PMID:30394969. |
loss of ctsk impairs the ability of osteoclasts to degrade bone extracellular matrix. |
2019-03-13 |
2023-08-13 |
Not clear |
| Dongfeng Zhao, Xiaofeng Li, Yongjian Zhao, Ping Qiao, Dezhi Tang, Yan Chen, Chunchun Xue, Chenguang Li, Shufen Liu, Jing Wang, Sheng Lu, Qi Shi, Yan Zhang, Yufeng Dong, Yongjun Wang, Bing Shu, Xu Fen. Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis. Journal of pharmacological sciences. vol 137. issue 1. 2018-09-05. PMID:29703642. |
moreover, oa significantly suppresses the expression of rankl-activated osteoclast genes encoding matrix metalloproteinase 9 (mmp9), cathepsin k(ctsk), tartrate-resistant acid phosphatase (trap) and carbonic anhydrase ii (car2). |
2018-09-05 |
2023-08-13 |
mouse |
| Qiang Wang, Yongjian Zhao, Nannan Sha, Yan Zhang, Chenguang Li, Hao Zhang, Dezhi Tang, Sheng Lu, Qi Shi, Yongjun Wang, Bing Shu, Dongfeng Zha. The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis. Journal of pharmacological sciences. vol 136. issue 3. 2018-08-13. PMID:29501580. |
gsk also inhibited bone resorbed genetic expression of matrix metalloproteinase 9 (mmp9), cathepsin k (ctsk), trap and carbonic anhydrase ii (car2). |
2018-08-13 |
2023-08-13 |
mouse |
| Jing Cheng, Jifu Zheng, Ninghong Guo, Fuming Z. I‑BET151 inhibits osteoclastogenesis via the RANKL signaling pathway in RAW264.7 macrophages. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983590. |
mrna expression levels of osteoclast specific genes tracp, matrix metalloproteinase‑9 (mmp9), cathepsin k (ctsk) and proto‑oncogene tyrosine‑protein kinase src (c‑src) were measured using the reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr). |
2018-06-26 |
2023-08-13 |
Not clear |
| Daniela M Sousa, Francisco Conceição, Diana I Silva, Luís Leitão, Estrela Neto, Cecília J Alves, Inês S Alencastre, Herbert Herzog, Paulo Aguiar, Meriem Lamghar. Ablation of Y1 receptor impairs osteoclast bone-resorbing activity. Scientific reports. vol 6. 2018-06-04. PMID:27646989. |
interestingly, functional studies revealed that these giant y1r(-/-) multinucleated cells produce poorly demineralized eroded pits, which were associated to reduce expression of osteoclast matrix degradation markers, such as tartrate-resistant acid phosphatase-5b (tracp5b), matrix metalloproteinase-9 (mmp-9) and cathepsin-k (ctsk). |
2018-06-04 |
2023-08-13 |
Not clear |
| Matthew Prideaux, Christine Schutz, Asiri R Wijenayaka, David M Findlay, David G Campbell, Lucian B Solomon, Gerald J Atkin. Isolation of osteocytes from human trabecular bone. Bone. vol 88. 2017-12-18. PMID:27109824. |
in addition, genes associated with osteocyte perilacunar remodelling, including matrix metallopeptidase-13 (mmp13), cathepsin k (ctsk) and carbonic anhydrase 2 (car2) were expressed. |
2017-12-18 |
2023-08-13 |
mouse |
| A Bernhardt, K Koperski, M Schumacher, M Gelinsk. Relevance of osteoclast-specific enzyme activities in cell-based in vitro resorption assays. European cells & materials. vol 33. 2017-09-29. PMID:28098926. |
based on these data a different regulation of trap and ctsk secretion is hypothesised for the resorption of inorganic calcium phosphate compared to the resorption of collagenous mineralised matrix. |
2017-09-29 |
2023-08-13 |
human |
| Tao Jiang, Fen Liu, Wei-Guang Wang, Xin Jiang, Xuan Wen, Kai-Jin Hu, Yang Xu. Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. PloS one. vol 12. issue 1. 2017-08-08. PMID:28095448. |
cathepsin k (ctsk) is a member of cysteine proteinase family, and is predominantly expressed in osteoclastsfor degradationof bone matrix proteins. |
2017-08-08 |
2023-08-13 |
mouse |
| Tao Jiang, Fen Liu, Wei-Guang Wang, Xin Jiang, Xuan Wen, Kai-Jin Hu, Yang Xu. Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. PloS one. vol 12. issue 1. 2017-08-08. PMID:28095448. |
thereforeitis necessary to study the metabolic role of ctsk in tooth matrix proteins. |
2017-08-08 |
2023-08-13 |
mouse |
| Jiang Wang, Hongbo You, Jun Qi, Caihong Yang, Ye Ren, Hao Chen. Autocrine and paracrine STIP1 signaling promote osteolytic bone metastasis in renal cell carcinoma. Oncotarget. vol 8. issue 10. 2017-08-01. PMID:28199984. |
increased cathepsin k (ctsk), the key enzyme secreted by osteoclasts to degrade collagen and other matrix proteins during bone resorption was further detected in the differentiated osteoclasts. |
2017-08-01 |
2023-08-13 |
human |
| Jian Zhang, Xiaofeng Meng, Chong Ding, Li Xie, Pengfei Yang, Peng Shan. Regulation of osteoclast differentiation by static magnetic fields. Electromagnetic biology and medicine. vol 36. issue 1. 2017-02-10. PMID:27355421. |
almost all the osteoclastogenic genes were highly expressed under 500 nt and 0.2 t, including rank, matrix metalloproteinase 9 (mmp9), v-atpase, carbonic anhydrase ii (car2) and cathepsin k (ctsk), whereas they were decreased under 16 t. in addition, 16 t disrupted actin formation with remarkably decreased integrin β3 expression. |
2017-02-10 |
2023-08-13 |
Not clear |
| M Zhang, Y Wang, X L Sun, L L Ren, L J Zhang, H Q L. Effects of 10-hydroxycamptothecin on differentiation of RAW264.7 cells into osteoclasts. Journal of biological regulators and homeostatic agents. vol 30. issue 3. 2017-02-02. PMID:27655499. |
mrna expression of osteoclast-specific genes, such as trap, cathepsin k (ctsk) and matrix metalloproteinase protease 9 (mmp-9), was detected by real-time polymerase chain reaction (pcr). |
2017-02-02 |
2023-08-13 |
Not clear |
| Hiroki Koizumi, Hideaki Suzuki, Shoji Ikezaki, Toyoaki Ohbuchi, Koichi Hashida, Akinori Saka. Osteoclasts are not activated in middle ear cholesteatoma. Journal of bone and mineral metabolism. vol 34. issue 2. 2016-12-13. PMID:25796629. |
the sample was then subjected to quantitative reverse transcription polymerase chain reaction for receptor activator of nuclear factor κb (rank), tartrate-resistant acid phosphatase (trap), cathepsin k (ctsk), osteoclast-associated receptor (oscar), calcitonin receptor (calcr), matrix metalloproteinase 9 (mmp9), receptor activator of nuclear factor κb ligand (rankl), and osteoprotegerin (opg). |
2016-12-13 |
2023-08-13 |
Not clear |
| Hye Jung Ihn, Doohyun Lee, Taeho Lee, Sang-Hyun Kim, Hong-In Shin, Yong Chul Bae, Jung Min Hong, Eui Kyun Par. Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway. PloS one. vol 10. issue 11. 2016-06-21. PMID:26536233. |
kp-a159 also dramatically inhibited the expression of marker genes related to osteoclast differentiation, including trap (acp5), cathepsin k (ctsk), dendritic cell-specific transmembrane protein (dcstamp), matrix metallopeptidase 9 (mmp9), and nuclear factor of activated t-cells, cytoplasmic 1 (nfatc1). |
2016-06-21 |
2023-08-13 |
mouse |
| Andre Kubler, Christer Larsson, Brian Luna, Bruno B Andrade, Eduardo P Amaral, Michael Urbanowski, Marlene Orandle, Kevin Bock, Nicole C Ammerman, Laurene S Cheung, Kathryn Winglee, Marc Halushka, Jin Kyun Park, Alan Sher, Jon S Friedland, Paul T Elkington, William R Bisha. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. The Journal of infectious diseases. vol 213. issue 4. 2016-06-09. PMID:26416658. |
five type i collagenases were overrepresented: cathepsin k (ctsk), mast cell chymase-1 (cma1), matrix metalloproteinase 1 (mmp-1), mmp-13, and mmp-14. |
2016-06-09 |
2023-08-13 |
human |
| Lavinia Raimondi, Angela De Luca, Nicola Amodio, Mauro Manno, Samuele Raccosta, Simona Taverna, Daniele Bellavia, Flores Naselli, Simona Fontana, Odessa Schillaci, Roberto Giardino, Milena Fini, Pierfrancesco Tassone, Alessandra Santoro, Giacomo De Leo, Gianluca Giavaresi, Riccardo Alessandr. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. vol 6. issue 15. 2016-04-19. PMID:25944696. |
mm cell-derived exosomes play a significant pro-differentiative role in murine raw264.7 cells and human primary osteoclasts, inducing the expression of osteoclast markers such as cathepsin k (ctsk), matrix metalloproteinases 9 (mmp9) and tartrate-resistant acid phosphatase (trap). |
2016-04-19 |
2023-08-13 |
human |
| Vishwa Deepak, Abe Kasonga, Marlena C Kruger, Magdalena Coetze. Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-κB and MAPK pathways. Connective tissue research. vol 56. issue 3. 2016-02-29. PMID:25405641. |
rankl-induced expression of osteoclast-specific marker genes such as trap, cathepsin k (ctsk) and matrix metalloproteinase-9 (mmp-9) was remarkably downregulated by eugenol. |
2016-02-29 |
2023-08-13 |
Not clear |