| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong Wang, Yan Guo, Xiao-Wei Shi, Yang Gao, Jia-Yi Zhang, Chun-Jiu Wang, Xue Yang, Qi Shu, Xi-Lin Chen, Xin-Yi Fu, Wen-Shan Xie, Yi Zhang, Bin Li, Chang-Qing Gu. Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-03. PMID:34335838. |
further, acupotomy suppressed osteoclast activity and enhanced osteoblast activity in koa subchondral bone, showing a significantly decreased expression of tartrate-resistant acid phosphatase (trap), matrix metalloproteinases-9 (mmp-9), and cathepsin k (ctsk) and a significantly increased expression of osteocalcin (ocn); this regulation may be mediated by blocking the decrease in osteoprotegerin (opg) and the increase in nf- |
2021-08-03 |
2023-08-13 |
Not clear |
| Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Che. Aloperine improves osteoporosis in ovariectomized mice by inhibiting RANKL-induced NF-κB, ERK and JNK approaches. International immunopharmacology. vol 97. 2021-07-30. PMID:33945918. |
in addition, it is found that aloperine can inhibit the expression of osteoclast specific marker genes, including nuclear factor of activated t cells cytoplasmic 1 (nfatc1), tartrate resistant acid phosphatase (tracp), matrix metallopeptidase 9 (mmp9), cathepsin k (ctsk), v-atpase d2 and calcitonin receptor. |
2021-07-30 |
2023-08-13 |
mouse |
| Christopher D Kegelman, Jennifer C Coulombe, Kelsey M Jordan, Daniel J Horan, Ling Qin, Alexander G Robling, Virginia L Ferguson, Teresita M Bellido, Joel D Boercke. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 35. issue 1. 2021-07-28. PMID:31610061. |
consistent with recent studies identifying tgf-β as a key inducer of osteocyte expression of matrix-remodeling enzymes, yap/taz deletion in vivo decreased osteocyte expression of matrix proteases mmp13, mmp14, and ctsk. |
2021-07-28 |
2023-08-13 |
mouse |
| Guangju Zha. Clinical relevance of biochemical and metabolic changes in osteoarthritis. Advances in clinical chemistry. vol 101. 2021-07-09. PMID:33706891. |
however, the two subpathways of the tgf-β signaling-tgf-β and bone morphogenetic proteins (bmp) subpathways, lose their balance in oa, resulting an increased expression of cartilage degradation enzymes including matrix metallopeptidase 13 (mmp13), cathepsin b (ctsb), and cathepsin k (ctsk) and a decreased expression of aggrecan (acan). |
2021-07-09 |
2023-08-13 |
Not clear |
| Katarzyna Hetmańczyk-Sawicka, Roksana Iwanicka-Nowicka, Anna Fogtman, Jarosław Cieśla, Paweł Włodarski, Barbara Żyżyńska-Granica, Mirella Filocamo, Andrea Dardis, Paolo Peruzzo, Małgorzata Bednarska-Makaruk, Marta Koblowska, Agnieszka Ługowsk. Changes in global gene expression indicate disordered autophagy, apoptosis and inflammatory processes and downregulation of cytoskeletal signalling and neuronal development in patients with Niemann-Pick C disease. Neurogenetics. vol 21. issue 2. 2021-05-27. PMID:31927669. |
comparison of npc to control samples revealed upregulation of genes involved in inflammation (mmp3, thbs4), cytokine signalling (mmp3), extracellular matrix degradation (mmp3, ctsk), autophagy and apoptosis (ctsk, gpnmb, ptgis), immune response (akr1c3, rcan2, ptgis) and processes of neuronal development (rcan2). |
2021-05-27 |
2023-08-13 |
Not clear |
| Jose Alejandro Guerrero, Raquel Souto Silva, Izabella Lucas de Abreu Lima, Bianca Cristina Duffles Rodrigues, Breno Rocha Barrioni, Flávio Almeida Amaral, André Petenuci Tabanez, Gustavo Pompermaier Garlet, Diego Alexander Garzon Alvarado, Tarcília Aparecida Silva, Estevam Barbosa de Las Casas, Soraia Macar. Maxillary suture expansion: A mouse model to explore the molecular effects of mechanically-induced bone remodeling. Journal of biomechanics. vol 108. 2021-05-14. PMID:32635995. |
rme yielded increased expression of bone remodeling markers as osteocalcin (ocn), dentin matrix acidic phosphoprotein-1 (dmp1), runt-related transcription factor 2 (runx2), collagen type i alpha 1 (col1a1), alkaline phosphatase (alp), receptor activator of nuclear factor kappa b (rank), receptor activator of nuclear factor kappa b ligand (rankl), osteoprotegerin (opg), cathepsin k (ctsk), matrix metalloproteinases 9 and 13 (mmp9 and 13), transforming growth fator beta 1, 2 and 3 (tgfb 1, tgfb 2 and tgfb3), bone morphogenetic protein 2 (bmp-2), sclerostin (sost), beta-catenin-like protein 1 (ctnnbl) and wnt signaling pathways 3, 3a and 5a (wnt 3, wnt 3a and wnt 5a). |
2021-05-14 |
2023-08-13 |
mouse |
| Soon Chul Heo, Yu Na Kim, YunJeong Choi, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Ki. Elevated Expression of Cathepsin K in Periodontal Ligament Fibroblast by Inflammatory Cytokines Accelerates Osteoclastogenesis via Paracrine Mechanism in Periodontal Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-02. PMID:33445732. |
cathepsin k (ctsk) is a cysteine protease that is mainly produced from mature osteoclasts and contributes to the destruction of connective tissues and mineralized matrix as a consequence of periodontal disease (pd). |
2021-04-02 |
2023-08-13 |
human |
| Dongfeng Zhao, Bing Shu, Chenglong Wang, Yongjian Zhao, Weidong Cheng, Nannan Sha, Chenguang Li, Qiang Wang, Sheng Lu, Yongjun Wan. Oleanolic acid exerts inhibitory effects on the late stage of osteoclastogenesis and prevents bone loss in osteoprotegerin knockout mice. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31318102. |
furthermore, oa suppresses the activities of osteoclast genes, such as tartrate resistant acid phosphatase (trap), cathepsink (ctsk), and matrix metalloproteinase 9 (mmp9). |
2021-02-22 |
2023-08-13 |
mouse |
| Weiyan Mo, Haoyuan Luo, Juan Wu, Na Xu, Fuping Zhang, Qihong Qiu, Wenjun Zhu, Min Lian. Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells. Journal of molecular histology. vol 51. issue 2. 2021-01-18. PMID:32193744. |
real-time reverse transcription polymerase chain reaction analysis demonstrated that gingipains upregulated osteoclastic genes including the protease cathepsin k (ctsk), matrix metalloprotein 9 (mmp9), nuclear factor of activated t cells 1 (nfatc1) and acid phosphatase 5, tartrate resistant (acp5) in a time-dependent manner. |
2021-01-18 |
2023-08-13 |
Not clear |
| Zhihang Zhou, Xinwei Chen, Xuzhuo Chen, An Qin, Yi Mao, Yichuan Pang, Shiqi Yu, Shanyong Zhan. PP121 suppresses RANKL-Induced osteoclast formation in vitro and LPS-Induced bone resorption in vivo. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31972221. |
\it was found that pp121 could suppress the formation of osteoclasts from bone marrow macrophages (bmms) without causing cytotoxicity, inhibit bone resorption and downregulate the mrna level of osteoclast-specific markers, including calcitonin receptor (ctr), tartrate resistant acid phosphatase (trap), cathepsin k (ctsk), matrix metalloproteinase 3 (mmp3), cellular oncogene fos (c-fos) and nuclear factor of activated t-cells cytoplasmic 1 (nfatc1). |
2020-11-09 |
2023-08-13 |
Not clear |
| Meipeng Zhu, Hui Liu, Kai Sun, Jian Liu, Yan Mou, Dahu Qi, Chuankun Zhou, Maihaiti Abudunaibi, Bahebieergan Tasiken, Jianwen Li, Hao Cheng, Hui Huan. Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-03. PMID:31846839. |
vinp also suppressed the expression of osteoclast-specific genes, including nfatc1, c-fos, tartrate-resistant acid phosphatase (trap), matrix metalloproteinase-9 (mmp-9), and cathepsin k (ctsk) at both the mrna and protein levels. |
2020-11-03 |
2023-08-13 |
Not clear |
| Chongwen Ma, Bin Geng, Xiaohui Zhang, Rui Li, Xinxin Yang, Yayi Xi. Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-09-29. PMID:31914120. |
we examined the expression of nuclear factor of activated t cells c1 (nfatc1) in raw264.7 cells and its downstream factors, including cathepsin k (ctsk), tartrate-resistant acid phosphatase (trap), matrix metalloproteinases-9 (mmp-9) and their relationship with erk5. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mo Zhu, Binqin Yu, Jiaxiang Bai, Ximing Wang, Xiaobin Guo, Yu Liu, Jiayi Lin, Su Hu, Wen Zhang, Yunxia Tao, Chunhong Hu, Huilin Yang, Yaozeng Xu, Dechun Gen. Cannabinoid Receptor 2 Agonist Prevents Local and Systemic Inflammatory Bone Destruction in Rheumatoid Arthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 34. issue 4. 2020-07-15. PMID:30508319. |
in addition, jwh133 treatment attenuated osteoclast formation and osteoclastic bone resorption, and reduced the expression of receptor activators of the nuclear factor-κb (nf-κb) ligand (rankl), matrix metallopeptidase-9 (mmp-9), tartrate-resistant acid phosphatase (trap), cathepsin k (ctsk), and nuclear factor of activated t-cells 1 (nfat-1) in cia mice and osteoclast precursors, which were obviously blocked by pretreatment with sr144528. |
2020-07-15 |
2023-08-13 |
mouse |
| Yu Xiao, Kai Li, Ziyi Wang, Fangsheng Fu, Siyuan Shao, Fangming Song, Jinmin Zhao, Weiwei Chen, Qian Liu, Jiake X. Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30633330. |
in terms of mechanism, pec inhibited the expression of the osteoclastogenesis-related gene, including cathepsin k (ctsk), matrix metalloproteinase 9 (mmp9), and tracp (acp5). |
2020-05-18 |
2023-08-13 |
mouse |
| Kai Chen, Yu Yuan, Ziyi Wang, Dezhi Song, Jinmin Zhao, Zhen Cao, Junhao Chen, Qiang Guo, Li Chen, Jennifer Tickner, Jiake X. Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30341897. |
this inhibition was followed by the dramatically decreased expression of nfatc1-targeted genes including ctr (encoding calcitonin receptor), acp5 (encoding tartrate-resistant acid phosphatase [tracp]), ctsk (encoding cathepsin k), atp6v0d2 (encoding the vacuolar h+ atpase v0 subunit d2 [v-atpase-d2]) and mmp9 (encoding matrix metallopeptidase 9) which are osteoclastic-specific genes required for osteoclast formation and function. |
2020-03-30 |
2023-08-13 |
Not clear |
| Qiuyue Peng, Aishu Luo, Zihao Zhou, Wenhua Xuan, Ming Qiu, Qin Wu, Lingxiao Xu, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wan. Interleukin 29 inhibits RANKL-induced osteoclastogenesis via activation of JNK and STAT, and inhibition of NF-κB and NFATc1. Cytokine. vol 113. 2020-02-19. PMID:30001863. |
although il-29 did not affect the viability and apoptosis of raw264.7 cells, it inhibited multinucleated cells in the differentiation of osteoclastogenesis, the bone-resorbing activity of mature osteoclasts and osteoclastic specific genes expression including trap, cathepsin k (ctsk), nuclear factor of activated t-cells, cytoplasmic 1 (nfatc1), c-fos and matrix metallopeptidase 9 (mmp-9). |
2020-02-19 |
2023-08-13 |
human |
| Jae-Hyun Kim, Minsun Kim, Hyuk-Sang Jung, Youngjoo Soh. Leonurus sibiricus L. ethanol extract promotes osteoblast differentiation and inhibits osteoclast formation. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524244. |
as a result, ls suppressed the expression of osteoclast‑associated genes, such as matrix metallopeptidase‑9 (mmp‑9), cathepsin k (ctsk), tartrate‑resistant acid phosphatase (trap), osteoclast‑associated immunoglobulin‑like receptor (oscar), c‑src, c‑myc, osteoclast stimulatory transmembrane protein (oc‑stamp) and atpase h+ transporting v0 subunit d2 (atp6v0d2). |
2020-02-04 |
2023-08-13 |
mouse |
| Peng Xue, Xiangxiang Hu, James Powers, Nicole Nay, Emily Chang, Jane Kwon, Sing Wai Wong, Lichi Han, Tai-Hsien Wu, Dong-Joon Lee, Henry Tseng, Ching-Chang K. CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response. Biochemical and biophysical research communications. vol 511. issue 3. 2020-01-21. PMID:30826055. |
furthermore, suppressed the expression of osteoclast differentiation-associated genes, tartrate-resistant acid phosphatase (trap), cathepsin k (ctsk), matrix metalloproteinase-9 (mmp-9) and dendritic cell-specific transmembrane protein (dc-stamp) were observed after prolonged exposures (5 days) to the compounds. |
2020-01-21 |
2023-08-13 |
Not clear |
| Kai Li, Yu Xiao, Ziyi Wang, Fangsheng Fu, Siyuan Shao, Fangming Song, Jinmin Zhao, Xixi Lin, Qian Liu, Jiake X. Tiliroside is a new potential therapeutic drug for osteoporosis in mice. Journal of cellular physiology. 2019-11-20. PMID:30815860. |
molecular mechanism studies reveal that tle reduces rankl-induced activation of mitogen-activated protein kinase and t-cell nuclear factor 1 pathways, and osteoclastogenesis-related marker gene expression, including cathepsin k (ctsk), matrix metalloproteinase 9, tartrate-resistant acid phosphatase (acp5), and atp6v0d2. |
2019-11-20 |
2023-08-13 |
mouse |
| Sandra Pohl, Alexandra Angermann, Anke Jeschke, Gretl Hendrickx, Timur A Yorgan, Georgia Makrypidi-Fraune, Anita Steigert, Sonja C Kuehn, Tim Rolvien, Michaela Schweizer, Till Koehne, Mona Neven, Olga Winter, Renata Voltolini Velho, Joachim Albers, Thomas Streichert, Jan M Pestka, Christina Baldauf, Sandra Breyer, Ralf Stuecker, Nicole Muschol, Timothy M Cox, Paul Saftig, Chiara Paganini, Antonio Rossi, Michael Amling, Thomas Braulke, Thorsten Schink. The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 33. issue 12. 2019-11-01. PMID:30075049. |
however, whereas the cysteine protease ctsk is directly involved in the degradation of bone matrix proteins, the molecular function of acp5 in osteoclasts is still unknown. |
2019-11-01 |
2023-08-13 |
Not clear |