| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zhang, Haonan Li, Fang Qi, Qian Yu, Hong Jiang, Buyi Lin, Hexuan Dong, Hongzhi Li, Jun Y. T-2 toxin induces chondrocyte extracellular matrix degradation by regulating the METTL3-mediated Ctsk m6A modification. International immunopharmacology. vol 143. issue Pt 2. 2024-10-19. PMID:39426235. |
t-2 toxin induces chondrocyte extracellular matrix degradation by regulating the mettl3-mediated ctsk m6a modification. |
2024-10-19 |
2024-10-22 |
Not clear |
| Jianyong Han, Tianshuang Xia, Yiping Jiang, Weiqing Fan, Nani Wang, Yue Zhang, Aijun Liu, Kai Zhao, Hailiang Xi. Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate. Cell biochemistry and biophysics. 2024-07-21. PMID:39033477. |
moreover, xan could even promote bone formation by effectively enhancing expression of runx2 and opg, while inhibit bone resorption with depressing matrix metalloproteinase-9 (mmp-9), mmp-13 and ctsk expression, reducing rankl secretion, and abating the ratio of rankl/opg. |
2024-07-21 |
2024-07-24 |
rat |
| Feng-Yu Huang, Wan-Yi Guo, Pei-Ping Chen, Xin-Zhuo Zhang, Zhuo-Hang Li, He-Lan Huang, Na Lin, Xiao-Hui Su, Xiang-Ying Kon. [Mechanism of bulleyaconitine A in inhibiting bone destruction of rheumatoid arthritis via Src/PI3K/Akt signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 6. 2024-04-15. PMID:38621927. |
the result of the experiment indicated that bulleyaconitine a not only dose-dependently inhibited the mrna expression levels of osteoclast differentiation-related genes cathepsin k(ctsk) and matrix metalloproteinase-9(mmp-9)(p<0.01), but also significantly reduced the expression of p-c-src, pi3k, as well as p-akt in vitro osteoclasts(p<0.01). |
2024-04-15 |
2024-04-18 |
Not clear |
| Xiaoxiao Zhang, Yin Luo, Huanmeng Hao, Juno M Krahn, Guowei Su, Robert Dutcher, Yongmei Xu, Jian Liu, Lars C Pedersen, Ding X. Heparan sulfate selectively inhibits the collagenase activity of cathepsin K. Matrix biology : journal of the International Society for Matrix Biology. 2024-03-28. PMID:38548090. |
ctsk is highly expressed by bone-resorbing osteoclasts and plays an essential role in resorption of bone matrix. |
2024-03-28 |
2024-03-31 |
Not clear |
| Alice Moroni, Evelise Brizola, Alessia Di Cecco, Morena Tremosini, Marta Sergiampietri, Alberto Bianchi, Barbara Tappino, Maria Piana, Maria Gnol. Pathological mandibular fracture complicated by osteonecrosis in an adult patient with pycnodysostosis: Clinical report and review of the literature. European journal of medical genetics. 2023-12-23. PMID:38141876. |
pycnodysostosis is caused by biallelic loss of function variants in ctsk gene, coding the lysosomal protease cathepsin k. ctsk is involved in the degradation of bone matrix proteins, such as type i and type ii collagen. |
2023-12-23 |
2023-12-25 |
Not clear |
| Fei Fang, Tang Feng, Jianwei Li, Huaiyi Zhang, Qin Wang, Yidan Chen, Guixue Wang, Yang Shen, Xiaoheng Li. Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton-NF-κB pathway. Genes & diseases. vol 10. issue 2. 2023-05-24. PMID:37223522. |
as a mediator for extracellular matrix protein degradation, cathepsin k (ctsk) was directly regulated by hemodynamics and contributed to atherosclerosis. |
2023-05-24 |
2023-08-14 |
mouse |
| Myeong-Hyun Nam, Hee-Jung Park, Young-Kwon Se. Reduction of Osteoclastic Differentiation of Raw 264.7 Cells by EMF Exposure through TRPV4 and p-CREB Pathway. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834470. |
emf-irradiated cells exhibited reduced mrna levels of osteoclastic differentiation markers cathepsin k (ctsk), tartrate-resistant acid phosphatase (trap), and matrix metalloproteinase 9 (mmp-9). |
2023-02-25 |
2023-08-14 |
Not clear |
| Hai-Yan Xue, Ming-Wei Liu, Guang Yan. Resveratrol suppresses lipopolysaccharide-mediated activation of osteoclast precursor RAW 264.7 cells by increasing miR-181a-5p expression. International journal of immunopathology and pharmacology. vol 37. 2023-02-01. PMID:36723677. |
mrna expression levels of mir-181a-5p, traf6, specific gene calcitonin receptor (ctr), activated t nuclear factor 1 (nfatc1), cathepsin k (ctsk), and matrix metalloproteinase (mmp)-9 were determined via a real-time polymerase chain reaction. |
2023-02-01 |
2023-08-14 |
Not clear |
| Claire J Houchen, Bethany Castro, Portia Hahn Leat, Nashwa Mohammad, Faith Hall-Glenn, Erin E Buman. Treatment with an Inhibitor of Matrix Metalloproteinase 9 or Cathepsin K Lengthens Embryonic Lower Jaw Bone. Orthodontics & craniofacial research. 2023-01-21. PMID:36680416. |
our objective was to determine the effect of inhibiting osteoclast-secreted proteolytic enzymes on lower jaw bone length of avian embryos by pharmacologically inhibiting matrix metalloproteinase-9 (mmp9) or cathepsin k (ctsk). |
2023-01-21 |
2023-08-14 |
Not clear |
| Jakub Chwastek, Marta Kędziora, Małgorzata Borczyk, Michał Korostyński, Katarzyna Starowic. Inflammation-Driven Secretion Potential Is Upregulated in Osteoarthritic Fibroblast-Like Synoviocytes. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233118. |
moreover, the translation of proteolytic enzymes [matrix metalloprotease 3 (mmp3), cathepsin k (ctsk), and cathepsin s (ctss)] by fls-oa is increased under inflammatory conditions. |
2022-10-14 |
2023-08-14 |
Not clear |
| Qi Zhang, Sijing Hu, Yuqiong He, Zile Song, Yi Shen, Zihui Zhao, Quanlong Zhang, Luping Qin, Qiaoyan Zhan. Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway. Nutrients. vol 14. issue 19. 2022-10-14. PMID:36235631. |
mon significantly inhibited the expression of the nuclear factor of activated t-cells c1 (nfatc1) and the immediate early gene (c-fos) and nuclear translocation of nfatc1 in lps-treated ocs, thereby inhibiting the expression of matrix metalloproteinase-9 (mmp-9), cathepsin k (ctsk), and trap. |
2022-10-14 |
2023-08-14 |
mouse |
| Ning Wu, YouZhi Wang, KeKe Wang, BoQiang Zhong, YiHao Liao, JiaMing Liang, Ning Jian. Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer. Cell death & disease. vol 13. issue 9. 2022-09-22. PMID:36138018. |
cathepsin k (ctsk) is a cysteine protease that usually has a strong activity of degrading extracellular matrix and is related to osteoclast-mediated bone destruction. |
2022-09-22 |
2023-08-14 |
Not clear |
| Hongyan Liu, Saichun Zhang, Ting Wu, Zhaohui Lv, Jianming Ba, Weijun Gu, Yiming M. Expression and clinical significance of Cathepsin K and MMPs in invasive non-functioning pituitary adenomas. Frontiers in oncology. vol 12. 2022-09-02. PMID:36052250. |
cathepsin k (ctsk) is a protease that degrades type i collagen and extracellular matrix, thereby contributing to bone resorption and tumor invasion. |
2022-09-02 |
2023-08-14 |
Not clear |
| Die Qian, Lisha He, Qing Zhang, Wenqing Li, Dandan Tang, Chunjie Wu, Fei Yang, Ke Li, Hong Zhan. Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005209. |
ctsk, a well-known key enzyme in the bone resorption process and most studied for its roles in the effective degradation of the bone extracellular matrix, is expressed in various organs. |
2022-08-25 |
2023-08-14 |
Not clear |
| Nanyu Zou, Ran Liu, Changjun L. Cathepsin K Frontiers in cell and developmental biology. vol 10. 2022-08-01. PMID:35912093. |
cathepsin k cathepsin k (ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. |
2022-08-01 |
2023-08-14 |
Not clear |
| Yang Xie, Xiang Jiang, Ping Wang, Xi Zheng, Jing Song, Mingxin Bai, Yundi Tang, Xiangyu Fang, Yuan Jia, Zhanguo Li, Fanlei H. SR-A neutralizing antibody: potential drug candidate for ameliorating osteoclastogenesis in rheumatoid arthritis. Clinical and experimental immunology. vol 207. issue 3. 2022-05-13. PMID:35553634. |
anti-sr-a neutralizing antibodies significantly inhibited oc differentiation and bone absorption in vitro in patients with ra, but not in healthy individuals, dampening the expression of oc-specific genes such as tartrate-resistant acid phosphatase (trap), cathepsin k (ctsk), and matrix metalloproteinase-9 (mmp-9). |
2022-05-13 |
2023-08-13 |
mouse |
| Fanyuan Yu, Fengli Huo, Feifei Li, Yanqin Zuo, Chenglin Wang, Ling Y. Aberrant NF-κB activation in odontoblasts orchestrates inflammatory matrix degradation and mineral resorption. International journal of oral science. vol 14. issue 1. 2022-01-27. PMID:35082271. |
specifically, we uncovered that nuclear factor-kappa b (nf-κb) signaling orchestrated tumor necrosis factor α (tnf-α)-induced matrix metalloproteinases (mmps) and cathepsin k (ctsk) functions in ods to enhance matrix degradation and tissue resorption. |
2022-01-27 |
2023-08-13 |
Not clear |
| Ye Yuan, Supriya Jagga, Janaina S Martins, Rakshya Rana, Paola Divieti Pajevic, Eva S Li. Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH. PloS one. vol 16. issue 5. 2021-10-22. PMID:34043707. |
the osteocyte enriched rna isolated from tibiae in vdrf/f;dmp1cre+ and npt2ako mice have enhanced expression of matrix resorption genes that are classically expressed by osteoclasts (ctsk, acp5, atp6v0d2, nhedc2). |
2021-10-22 |
2023-08-13 |
mouse |
| R T Ormsby, A R Zelmer, D Yang, N J Gunn, Y Starczak, S P Kidd, R Nelson, L B Solomon, G J Atkin. Evidence for osteocyte-mediated bone-matrix degradation associated with periprosthetic joint infection (PJI) European cells & materials. vol 41. 2021-10-11. PMID:34622431. |
increased expression of known collagenases, such as matrix metallopeptidase (mmp) 13, mmp1 and cathepsin k (ctsk), was measured in infected bone compared to non-infected bone. |
2021-10-11 |
2023-08-13 |
human |
| Yaongamphi Vashum, Zenith Khashi. Obesity and Cathepsin K: A Complex Pathophysiological Relationship in Breast Cancer Metastases. Endocrine, metabolic & immune disorders drug targets. vol 20. issue 8. 2021-08-04. PMID:32368981. |
cathepsin k (ctsk), a cysteine protease, effectively degrades several components of the extracellular matrix and has the ability to differentiate adipocytes from bone marrow lineage. |
2021-08-04 |
2023-08-13 |
Not clear |