| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Biagio Palmisano, Alessandro Del Vecchio, Alfredo Passaretti, Alessia Stefano, Giovanna Miracolo, Giorgia Farinacci, Alessandro Corsi, Mara Riminucci, Umberto Romeo, Andrea Cicconett. Potential of combined red and near-infrared photobiomodulation to mitigate pro-osteoclastic and inflammatory gene expression in human mandibular osteogenic cells. Lasers in medical science. vol 39. issue 1. 2024-10-01. PMID:39349883. |
however, a statistically significant reduction was observed in the transcripts of col1a1 and mmp13, two important genes involved in the bone matrix homeostasis. |
2024-10-01 |
2024-10-03 |
human |
| Marzieh Neykhonji, Fereshteh Asgharzadeh, Marjaneh Farazestanian, Abdulridha Mohammed Al-Asady, Maziar Kaffashbashi, Seyed Alireza Parizadeh, Mahsa Attarian, Seyedeh Elnaz Nazari, Farzad Rahmani, Moein Eskandari, Amir Avan, Malihe Hasanzadeh, Mikhail Ryzhikov, Majid Khazaei, Seyed Mahdi Hassania. Oenothera biennis improves pregnancy outcomes by suppressing inflammation and fibrosis in an intra-uterine adhesion rat model. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333188. |
epo administration decreased extracellular matrix accumulation, evidenced by the down-regulation of tissue col1a1 and col3a1 expression. |
2024-09-27 |
2024-10-01 |
rat |
| Aiqun Xiang, Zixuan Peng, Hong He, Xuyun Meng, Yanting Luo, Junming Yang, Fang Zeng, Xiaolian Chen, Xingwu Zhon. The potential of brimonidine for myopia treatment: Targeting MMP-2 to regulate choroidal thickness and control eye growth. Heliyon. vol 10. issue 18. 2024-09-24. PMID:39309849. |
here, we investigated the effects of various brimonidine administration routes and concentrations on form-deprivation myopia (fdm) progression, matrix metalloproteinase-2 (mmp-2), and collagen alpha1 chain of type i (col1a1) expression in the retinal pigment epithelial (rpe)-choroid complex and sclera of guinea pigs. |
2024-09-24 |
2024-09-26 |
Not clear |
| Jacinta I Kalisch-Smith, Nusaybah Ehtisham-Uddin, Helena Rodriguez-Car. Feto-placental and coronary endothelial genes implicated in miscarriage, congenital heart disease and stillbirth, a systematic review and meta-analysis. Placenta. vol 156. 2024-09-14. PMID:39276426. |
the most common genes for chd (notch, dst, fbn1, jag1, chd4), miscarriage (col1a1, herc1), and stillbirth (akap9, mylk), were involved in blood vessel and cardiac valve formation, with roles in endothelial differentiation, angiogenesis, extracellular matrix signaling, growth factor binding and cell adhesion. |
2024-09-14 |
2024-09-18 |
human |
| Syeda Masooma Naqvi, Laura M O'Sullivan, Hollie Allison, Vincent J Casey, Jessica Schiavi-Tritz, Laoise M McNamar. Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency. JBMR plus. vol 8. issue 9. 2024-08-28. PMID:39193115. |
however, in long-term estrogen deficiency, we report increased expression of genes associated with extracellular matrix deposition (spp1, col1a1, col1a2, ocn) and mechanotransduction (cx43) compared with age-matched controls and short-term estrogen deficiency. |
2024-08-28 |
2024-08-30 |
rat |
| Syeda Masooma Naqvi, Laura M O'Sullivan, Hollie Allison, Vincent J Casey, Jessica Schiavi-Tritz, Laoise M McNamar. Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency. JBMR plus. vol 8. issue 9. 2024-08-28. PMID:39193115. |
these changes coincided with increased heterogeneity of mineral-to-matrix ratio and collagen maturity, to which extracellular matrix markers col1a1 and col1a2 were positively correlated. |
2024-08-28 |
2024-08-30 |
rat |
| Charlene Echague, Minnie Malik, Paul Driggers, William H Catherin. Coenzyme Q-10 reduced the aberrant production of extracellular matrix proteins in uterine leiomyomas through transforming growth factor beta 3. F&S science. 2024-07-14. PMID:39004304. |
to evaluate the impact of coenzyme q-10 (coq-10) on the dysregulated synthesis of extracellular matrix proteins mediated by transforming growth factor beta 3 (tgf-ß3) in uterine leiomyomas design: laboratory study subjects: none interventions: treatment of immortalized uterine myometrial and leiomyoma cells to tgf-ß3 and coq-10 main outcome measures: protein concentration of collagen 1a1 (col1a1), collagen 3a1 (col3a1), collagen 11a1 (col11a1), and fibronectin (fn1) was assessed through western blot analysis after treatment of immortalized uterine myometrial and leiomyoma cells with both tgf-ß3 and concentrations of coq-10 at 10, 50, and 100 μm concurrently for 24 hours. |
2024-07-14 |
2024-07-18 |
human |
| Yusuke Ogura, Hiroaki Miyoshi, Shiro Yoshida, Fumiko Arakawa, Mai Takeuchi, Kenjiro Nakama, Mitsuhiro Matsuura, Hirofumi Takada, Yoshiaki Yamanaka, Koji Hiraoka, Koichi Ohshim. Comprehensive gene expression analysis using RNA sequencing between male and female patients with idiopathic carpal tunnel syndrome. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-06-10. PMID:38855962. |
we identified 26 genes with significantly different expressions between male and female patients, in which postn, col1a1, and col3a1, which are involved in extracellular matrix organization, and igf1, an important fibrotic factor, were significantly upregulated in male patients. |
2024-06-10 |
2024-06-14 |
Not clear |
| Saikanth Varma, Archana Molangiri, Sreedhar Mudavath, Rajendran Ananthan, Ajumeera Rajanna, Asim K Duttaroy, Sanjay Basa. Exposure to BPA and BPS during pregnancy disrupts the bone mineralization in the offspring. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-05-31. PMID:38821392. |
the expression of extracellular matrix proteins such as alpl, col1a1, dmp1, and fn1 were downregulated (p<0.05). |
2024-05-31 |
2024-06-02 |
rat |
| Qiong Zhou, Geng Chen. Ampelopsin facilitates diabetic wound healing and keratinocyte cell progression by inhibiting the NLRP3 inflammasome pathway in macrophages. General physiology and biophysics. vol 43. issue 3. 2024-05-22. PMID:38774919. |
amp notably facilitated platelet endothelial cell adhesion molecule-31 (cd31), collagen type i alpha 1 chain (col1a1), and alpha-smooth muscle actin (α-sma), and inhibited matrix metallopeptidase 9 (mmp9) and cyclooxygenase 2 (cox2) expression in diabetic wounds. |
2024-05-22 |
2024-05-27 |
mouse |
| Beren Karaosmanoglu, Gozde Imren, Meral Uner, Diclehan Orhan, Safak Gucer, Ozlem Boybeyi Turer, Pelin Ozlem Simsek Kiper, Eda Utine, Ekim Z Taskiran, Feridun Cahit Tanyel, Tutku Soye. AP-1-dependent fibrosis: Exploring its potential role in the pathogenesis of placental transmogrification of the lung (PTL) via tissue-level transcriptome analysis. Pathology, research and practice. vol 258. 2024-05-08. PMID:38718468. |
additionally, genes associated with the extracellular matrix and connective tissue, such as col1a1, mmp2, and sparc, were significantly altered, indicating possible fibrotic changes. |
2024-05-08 |
2024-05-27 |
Not clear |
| Tara K Crawford, Brittany N Lafaver, Charlotte L Phillip. Extra-Skeletal Manifestations in Osteogenesis Imperfecta Mouse Models. Calcified tissue international. 2024-04-19. PMID:38641703. |
approximately 85% of the pathogenic variants responsible for oi are in the type i collagen genes, col1a1 and col1a2, with the remaining pathogenic oi variants spanning at least 20 additional genetic loci that often involve type i collagen post-translational modification, folding, and intracellular transport as well as matrix incorporation and mineralization. |
2024-04-19 |
2024-04-22 |
mouse |
| Meng-Hsuan Cheng, Hsuan-Fu Kuo, Chia-Yuan Chang, Jui-Chi Chang, I-Fan Liu, Chong-Chao Hsieh, Chih-Hsin Hsu, Chia-Yang Li, Shu-Chi Wang, Yung-Hsiang Chen, Chuang-Rung Chang, Tsung-Ying Lee, Yu-Ru Liu, Chi-Yuan Huang, Szu-Hui Wu, Wei-Lun Liu, Po-Len Li. Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-16. PMID:38626519. |
human pulmonary fibroblasts were transfected with mir-29a-3p, and rt-qpcr, immunostaining, and western blotting were performed to determine the expression of dnmt3a and extracellular matrix collagen-1 (col1a1) and fibronectin-1 (fn1) levels. |
2024-04-16 |
2024-04-19 |
mouse |
| Meng-Hsuan Cheng, Hsuan-Fu Kuo, Chia-Yuan Chang, Jui-Chi Chang, I-Fan Liu, Chong-Chao Hsieh, Chih-Hsin Hsu, Chia-Yang Li, Shu-Chi Wang, Yung-Hsiang Chen, Chuang-Rung Chang, Tsung-Ying Lee, Yu-Ru Liu, Chi-Yuan Huang, Szu-Hui Wu, Wei-Lun Liu, Po-Len Li. Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-16. PMID:38626519. |
ccm in increased the expression of mir-29a-3p in the lung tissue and inhibited the dnmt3a to reduce the col1a1 and fn1 levels leading to pulmonary extracellular matrix remodeling. |
2024-04-16 |
2024-04-19 |
mouse |
| Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larre. BET inhibitor nanotherapy halts kidney damage and reduces chronic kidney disease progression after ischemia-reperfusion injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-03-27. PMID:38537579. |
this success not only improved early the kidney function, as evidenced by decreased serum levels of bun and creatinine in jq1-nps-treated mice, along with reduced tissue expression of the damage marker, ngal, but also halted the production of extracellular matrix proteins (fsp-1, fn-1, α-sma and col1a1) and the fibrosis development. |
2024-03-27 |
2024-03-30 |
mouse |
| Carlotta Ceniti, Anna Di Vito, Rosa Luisa Ambrosio, Aniello Anastasio, Jessica Bria, Domenico Britti, Emanuela Chiarell. Food Safety Assessment and Nutraceutical Outcomes of Dairy By-Products: Ovine Milk Whey as Wound Repair Enhancer on Injured Human Primary Gingival Fibroblasts. Foods (Basel, Switzerland). vol 13. issue 5. 2024-03-13. PMID:38472796. |
specifically, wounds treated with 0.1% and 10% milk whey showed better migratory capabilities compared to those treated with 0.01% and 1% milk whey after 24 and 48 h. in addition, ovine milk whey stimulates extracellular matrix deposition, as evidenced by the increasing levels of cd44 antigen density evaluated through facs analysis, as well as col1a1 expression measured both via rt-qpcr and immunofluorescence. |
2024-03-13 |
2024-03-15 |
human |
| Stefania Oliveto, Paolo Ritter, Giorgia Deroma, Annarita Miluzio, Chiara Cordiglieri, Mauro Roberto Benvenuti, Luciano Mutti, Manuela Teresa Raimondi, Stefano Biff. The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells. Genes. vol 15. issue 2. 2024-02-24. PMID:38397189. |
among these genes responsible for collagen formation, col1a1 and col5a1 exhibited elevated expression, suggesting changes in matrix stiffness. |
2024-02-24 |
2024-02-26 |
human |
| Nan Gu, Yao Wang, Gengtian Sun, He Zou, Nan Yang, Xin Sun, Zhihui Li. Exploring wound management in dental pulp: Utilizing single-cell RNA sequencing for global transcriptomic analysis in healthy and inflamed pulpal tissues. International wound journal. vol 21. issue 3. 2024-02-22. PMID:38385817. |
in addition, substantial increase inexpression of critical genes including col1a1, fn1, il-1b, il-6 and tnc was detected, indicating that the extracellular matrix (ecm) was actively remodelled and that a robust inflammatory response was present, both of which are vital for tissue repair. |
2024-02-22 |
2024-02-24 |
Not clear |
| Jiangxia Li, Ke Xu, Yunqing Cui, Tianyuan Xu, Wenchao Fei, Cuiting Lyu, Yinjue Yu, Lina Yang, Yang Hong, Gong Yan. ECM1-associated miR-1260b promotes osteogenic differentiation by targeting GDI1. Acta histochemica. vol 126. issue 1. 2024-01-24. PMID:38266317. |
overexpression of mir-1260b promoted the osteogenic differentiation of u2os and mg63 cells, as demonstrated by increased alkaline phosphatase (alp) activity, matrix mineralization, and runt-related transcription factor 2 (runx2), osteopontin (opn), collagen i (col1a1), and osteocalcin (ocn) protein expressions, whereas low expression of mir-1260b had the opposite effect. |
2024-01-24 |
2024-01-27 |
Not clear |
| Yiqing Zhao, Ce Li, Siyang Hu, Chunya Wang, Xueru Bian, Hong Kang, Ping Zhou, Guangjie Ba. Heliyon. vol 10. issue 1. 2024-01-09. PMID:38192844. |
the expression of extracellular matrix genes (type i collagen (col1a1), type ii collagen(col2), glycosaminoglycan (gag)), chondrogenic differentiation gene sox9 and pluripotency gene oct4 were detected by rt-qpcr. |
2024-01-09 |
2024-01-10 |
human |