| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Slevin, Michael Conall Dennedy, Eanna P Connaughton, Andreia Ribeiro, Rhodri Ceredig, Matthew D Griffin, Laurence J Ega. Infliximab Selectively Modulates the Circulating Blood Monocyte Repertoire in Crohn's Disease. Inflammatory bowel diseases. vol 22. issue 12. 2018-01-23. PMID:27824651. |
infliximab (ifx), an anti-tumour necrosis factor alpha (tnfα) monoclonal antibody, provides clinical benefits in treating crohn's disease (cd) but its mechanisms of action are not fully elucidated. |
2018-01-23 |
2023-08-13 |
Not clear |
| Robbert Q Kim, Willem J van Dijk, Titia K Sixm. Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role. Journal of structural biology. vol 195. issue 1. 2018-01-03. PMID:27183903. |
we provide a crystal structure of usp7(cd123) and show that cd and ubl123 are connected via an extended charged alpha helix. |
2018-01-03 |
2023-08-13 |
Not clear |
| Xiaowen Zheng, Feng Chen, Qian Zhang, Yulan Liu, Peng You, Shan Sun, Jiuxiang Lin, Ning Che. Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease. Protein & cell. vol 8. issue 9. 2017-12-26. PMID:28523434. |
through gene ontology analysis, we found that proteasome subunit alpha type 7 (psma7) showed especially marked differences between patients with ibd and the healthy controls, in that its expression level was much higher in the cd and uc groups. |
2017-12-26 |
2023-08-13 |
human |
| Paulo Gustavo Kotze, Mansur Paulo Saab, Bárbara Saab, Lorete Maria da Silva Kotze, Marcia Olandoski, Lilian Vital Pinheiro, Carlos Augusto Real Martinez, Maria de Lourdes Setsuko Ayrizono, Daniela de Oliveira Magro, Claudio Saddy Rodrigues Co. Tumor Necrosis Factor Alpha Inhibitors Did Not Influence Postoperative Morbidity After Elective Surgical Resections in Crohn's Disease. Digestive diseases and sciences. vol 62. issue 2. 2017-07-10. PMID:27933472. |
the real impact of anti-tumor necrosis alpha (tnf) therapy in postoperative complications after intestinal resections in crohn's disease (cd) still needs to be determined. |
2017-07-10 |
2023-08-13 |
Not clear |
| Da-Chuan Piao, Yoon-Seok Lee, Jin-Duck Bok, Chong-Su Cho, Zhong-Shan Hong, Sang-Kee Kang, Yun-Jaie Cho. Production of soluble truncated spike protein of porcine epidemic diarrhea virus from inclusion bodies of Escherichia coli through refolding. Protein expression and purification. vol 126. 2017-06-30. PMID:27260969. |
the cd spectrum of s25-229 showed the characteristic pattern of alpha helical structure. |
2017-06-30 |
2023-08-13 |
mouse |
| Shyla Saini, Tiegang Liu, James Yo. TNF-α stimulates colonic myofibroblast migration via COX-2 and Hsp27. The Journal of surgical research. vol 204. issue 1. 2017-06-30. PMID:27451881. |
mfb is a known target of tumor necrosis factor alpha (tnf-α), a proinflammatory cytokine strongly implicated in the pathophysiology of cd. |
2017-06-30 |
2023-08-13 |
Not clear |
| Marcin Włodarczyk, Jakub Fichna, Aleksandra Sobolewska-Włodarczy. Pharmacology and metabolism of infliximab biosimilars - A new treatment option in inflammatory bowel diseases. Pharmacological reports : PR. vol 68. issue 4. 2017-06-19. PMID:27162107. |
biological therapy with monoclonal antibodies to tumor necrosis factor alpha (tnf-α) was shown in large clinical trials to be effective in inducing and maintaining clinical remission in patients with moderate to severe crohn's disease (cd) and ulcerative colitis (uc). |
2017-06-19 |
2023-08-13 |
Not clear |
| Turban Kar, Pijush Basak, Rittik Kumar Ghosh, Maitree Bhattacharyy. Protective effects of curcumin against gamma ray induced conformational change of human serum albumin. International journal of biological macromolecules. vol 99. 2017-05-09. PMID:28274864. |
cd and ftir spectroscopy indicated significant decrease in the alpha helix content of hsa from 57% to 15% with increasing radiation doses. |
2017-05-09 |
2023-08-13 |
human |
| Yue Wang, Qingxia Li, Yunhua Zheng, Gang Li, Wei Li. Systematic biochemical characterization of the SAM domains in Eph receptor family from Mus Musculus. Biochemical and biophysical research communications. vol 473. issue 4. 2017-05-05. PMID:27086853. |
using cd (circular dichroism) spectrometry, we found that the secondary structure of all the sam domains was typically alpha helical folded and remarkably similar. |
2017-05-05 |
2023-08-13 |
mouse |
| Minhal Abidi, Afshin Iram, Mohammad Furkan, Aabgeena Naee. Secondary structural alterations in glucoamylase as an influence of protein aggregation. International journal of biological macromolecules. vol 98. 2017-04-17. PMID:28137466. |
alpha helices being the main key player relocates glucoamylase native environment as evident by cd, ftir and tem. |
2017-04-17 |
2023-08-13 |
Not clear |
| Tsuyoshi Hata, Tsunekazu Mizushima, Hideki Osawa, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Masakazu Ikenaga, Kiyokazu Nakajima, Hirofumi Yamamoto, Kohei Murata, Yuichiro Doki, Masaki Mor. Short-term outcomes of laparoscopic surgery for Crohn's disease patients treated with anti-tumor necrosis factor alpha agents. Surgery today. vol 47. issue 3. 2017-03-16. PMID:27372080. |
the impact of anti-tumor necrosis factor alpha (tnfα) treatment for crohn's disease (cd) on surgical outcomes is still controversial. |
2017-03-16 |
2023-08-13 |
Not clear |
| P Fallahi, I Ruffill. Contact dermatitis and interferon-γ dependent chemokines. La Clinica terapeutica. vol 167. issue 5. 2017-01-17. PMID:27845488. |
recently it has been shown that interferon (ifn)-γ, and the ifn-γ dependent chemokines, monokine induced by ifn-γ (mig), ifn-γ-induced protein 10 (ip-10), and ifn-inducible t cell alpha chemoattractant (i-tac), play an important role in cd. |
2017-01-17 |
2023-08-13 |
Not clear |
| Christopher Ma, Candace L Beilman, Vivian W Huang, Darryl K Fedorak, Karen I Kroeker, Levinus A Dieleman, Brendan P Halloran, Richard N Fedora. Anti-TNF Therapy Within 2 Years of Crohn's Disease Diagnosis Improves Patient Outcomes: A Retrospective Cohort Study. Inflammatory bowel diseases. vol 22. issue 4. 2016-12-23. PMID:26818419. |
although biological agents targeting tumor necrosis factor (tnf) alpha are effective in the management of crohn's disease (cd), use of anti-tnf agents is often delayed until after failure of other treatment modalities, resulting in potentially long delays between diagnosis and initiation of infliximab or adalimumab. |
2016-12-23 |
2023-08-13 |
Not clear |
| Azaj Ahmed, Anas Shamsi, Bilqees Ban. Purification and biochemical characterization of phytocystatin from Brassica alba. Journal of molecular recognition : JMR. vol 29. issue 5. 2016-12-21. PMID:26748819. |
cd spectral analysis shows that it possesses 17.11% alpha helical content. |
2016-12-21 |
2023-08-13 |
Not clear |
| Ghader Hosseinzadeh, Ali Maghari, Ali A Saboury, Ali A Moosavi-Movahed. Unfolding of insulin at the surface of ZnO quantum dots. International journal of biological macromolecules. vol 86. 2016-12-13. PMID:26812116. |
cd spectroscopy results also confirmed this unfolding and show a reduction in alpha helices content of insulin in contact with zno qds and their conversion to random coils. |
2016-12-13 |
2023-08-13 |
Not clear |
| Aditya Joshi, Raza Bajwa, Nandita Bhattacharjee, Rajasekhar Bodicharl. Bowel Perforation Associated With Infliximab Use in a Pediatrics Patient. WMJ : official publication of the State Medical Society of Wisconsin. vol 115. issue 2. 2016-06-16. PMID:27197343. |
biologic agents like infliximab (ifx) that target tumor necrosis factor alpha (tnf-α), have emerged as important medications for treating refractory cd. |
2016-06-16 |
2023-08-13 |
Not clear |
| Abdul Rouf Mir, Moin Uddin, Farzana Khan, Khursheed Alam, Asif Al. Dicarbonyl Induced Structural Perturbations Make Histone H1 Highly Immunogenic and Generate an Auto-Immune Response in Cancer. PloS one. vol 10. issue 8. 2016-06-09. PMID:26317779. |
far uv cd measurements showed di-carbonyl induced enhancement of the alpha structure and the induction of beta sheet conformation; and thermal denaturation (tm) studies confirmed the thermal stability of the modified histone. |
2016-06-09 |
2023-08-13 |
Not clear |
| Steven Ross, Nicolaos Scoutaris, Dimitrios Lamprou, David Mallinson, Dennis Douroumi. Inkjet printing of insulin microneedles for transdermal delivery. Drug delivery and translational research. vol 5. issue 4. 2016-05-09. PMID:26242687. |
circular discroism (cd) analysis of rehydrated films showed that insulin's alpha helices and β-sheet were well preserved for thl and sol. |
2016-05-09 |
2023-08-13 |
Not clear |
| Csaba Váradi, Zsolt Holló, Szilárd Póliska, László Nagy, Zoltán Szekanecz, Andrea Váncsa, Károly Palatka, András Guttma. Combination of IgG N-glycomics and corresponding transcriptomics data to identify anti-TNF-α treatment responders in inflammatory diseases. Electrophoresis. vol 36. issue 11-12. 2016-03-15. PMID:25639738. |
the aim of this study was to investigate the changes of serum igg glycoforms in crohn's disease (cd) and rheumatoid arthritis patients in response to antitumor necrosis factor alpha (anti-tnf-α) treatment. |
2016-03-15 |
2023-08-13 |
Not clear |
| Caterina Strisciuglio, Erasmo Miele, Francesca P Giugliano, Serena Vitale, Marialuisa Andreozzi, Alessandra Vitale, Maria R Catania, Annamaria Staiano, Riccardo Troncone, Carmen Gianfran. Bifidobacteria Enhance Antigen Sampling and Processing by Dendritic Cells in Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases. vol 21. issue 7. 2016-03-04. PMID:25895109. |
moreover, a marked tumor necrosis factor alpha release was observed in dc from cd after exposure to e. coli particles, whereas the probiotic did not affect the production of this proinflammatory cytokine. |
2016-03-04 |
2023-08-13 |
Not clear |