| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Usman Feroze Khatana, Ali Qamar, Mohammad B Ashfa. Infliximab-Associated Acneiform Eruption in a Patient With Inflammatory Bowel Disease. Cureus. vol 13. issue 9. 2021-10-28. PMID:34703704. |
notably tumor necrosis factor (tnf) alpha antagonists are particularly useful in inflammatory bowel disease (ibd) such as crohn's disease (cd) and ulcerative colitis (uc). |
2021-10-28 |
2023-08-13 |
Not clear |
| Shadi Hamdeh, Muhammad Aziz, Osama Altayar, Mojtaba Olyaee, Mohammad Hassan Murad, Stephen B Hanaue. Early vs Late Use of Anti-TNFa Therapy in Adult Patients With Crohn Disease: A Systematic Review and Meta-Analysis. Inflammatory bowel diseases. vol 26. issue 12. 2021-10-26. PMID:32064534. |
while anti-tumor necrosis factor alpha (anti-tnfa) therapies for crohn disease (cd) were initially introduced in 1998 for biologic therapies are often introduced after a minimum of 6 years after diagnosis. |
2021-10-26 |
2023-08-13 |
Not clear |
| Hui Li, Hui Xing, Chen Hu, Bai-Yang Sun, Shuang Wang, Wan-Ying Li, Bo Q. Hemorrhagic pericardial effusion following treatment with infliximab: A case report and literature review. World journal of clinical cases. vol 9. issue 25. 2021-10-08. PMID:34616831. |
infliximab (ifx) is an anti-tumor necrosis factor alpha (tnf-α) agent that is widely used for the management of a variety of autoimmune and inflammatory diseases, including crohn's disease (cd). |
2021-10-08 |
2023-08-13 |
Not clear |
| Dominika Salamon, Tomasz Gosiewski, Agnieszka Krawczyk, Agnieszka Sroka-Oleksiak, Mariusz Duplaga, Krzysztof Fyderek, Kinga Kowalska-Duplag. Quantitative changes in selected bacteria in the stool during the treatment of Crohn's disease. Advances in medical sciences. vol 65. issue 2. 2021-09-03. PMID:32590155. |
the aim of this study was to determine quantitative changes in selected species of bacteria (bacteroides fragilis, lactobacillus fermentum, lactobacillus rhamnosus, serratia marcescens) in the stool of patients with crohn's disease (cd) in the course of induction treatment with exclusive enteral nutrition (een) or anti-tumor necrosis factor alpha (infliximab, ifx) vs. healthy controls (hc). |
2021-09-03 |
2023-08-13 |
Not clear |
| Teruyuki Takeda, Masahiro Kishi, Noritaka Takatsu, Yasumichi Takada, Tsuyoshi Beppu, Masaki Miyaoka, Takashi Hisabe, Toshiharu Ueki, Hisatomi Arima, Fumihito Hirai, Kenshi Ya. Long-term outcomes of endoscopic balloon dilation for intestinal strictures in patients with Crohn's disease during maintenance treatment with anti-tumor necrosis factor alpha antibodies. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. 2021-07-19. PMID:34185921. |
efficacy of endoscopic balloon dilation (ebd) for intestinal strictures in patients with crohn's disease (cd) receiving anti-tumor necrosis factor alpha antibodies (anti-tnf) as maintenance therapy is unclear. |
2021-07-19 |
2023-08-13 |
Not clear |
| Yong Wang, Niels Wessel, Franziska Kohse, Adnan Khan, Heinz-Peter Schultheiss, Maria da Consolaҫão V Moreira, Thomas Walthe. Measurement of multiple cytokines for discrimination and risk stratification in patients with Chagas' disease and idiopathic dilated cardiomyopathy. PLoS neglected tropical diseases. vol 15. issue 3. 2021-06-29. PMID:33755669. |
none of the cytokines could demonstrate any prognostic potency in cd patients, and only mif and stromal derived factor-1 alpha (cxcl12) showed significance in predicting mortality and necessity for heart transplant in dcm patients. |
2021-06-29 |
2023-08-13 |
human |
| B A Almayah. Alpha particle rates and heavy metal concentrations in cosmetics available in the Najaf markets. Heliyon. vol 7. issue 5. 2021-05-28. PMID:34041406. |
this study focuses to measure the emission of alpha particle rates (eapr) and heavy metal concentrations (cd, pb, zn, cr, and co) (hmc) in some cosmetics (kohl eye, compact powder, and lipsticks) from najaf markets using cr39 detectors and spectrophotometry, respectively. |
2021-05-28 |
2023-08-13 |
Not clear |
| Aleksandra Furtak, Anna Maria Wedrychowicz, Malgorzata Sladek, Andrzej Wedrychowicz, Krzysztof Fyderek, Jerzy Starzy. Infliximab Therapy Could Decrease the Risk of the Development of Thyroid Disorders in Pediatric Patients With Crohn's Disease. Frontiers in endocrinology. vol 11. 2021-05-26. PMID:33042019. |
taking into consideration the role of tumor necrosis factor alpha (tnf-alpha) in the immune-mediated inflammation that underlies both diseases, we evaluated an ultrasound of thyroid gland in pediatric cd patients, naïve, and treated with infliximab (ifx), an anti-tnf-alpha antibody, to assess the risk for aitd and evaluated the usefulness of ultrasonography to diagnose aitd in patients with cd. |
2021-05-26 |
2023-08-13 |
Not clear |
| Ulf Helwig, Michael Mross, Stefan Schubert, Heinz Hartmann, Alina Brandes, Dara Stein, Christian Kempf, Jana Knop, Sarah Campbell-Hill, Robert Ehehal. Real-world clinical effectiveness and safety of vedolizumab and anti-tumor necrosis factor alpha treatment in ulcerative colitis and Crohn's disease patients: a German retrospective chart review. BMC gastroenterology. vol 20. issue 1. 2021-05-14. PMID:32640990. |
we sought to evaluate the real-world effectiveness of vedolizumab (vdz) and anti-tumor necrosis factor alpha (anti-tnfα) in uc and cd patients in germany. |
2021-05-14 |
2023-08-13 |
Not clear |
| Tao Wang, Li Wang, Yi Zhang, Jian Sun, Yilin Xie, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zo. Puerarin Restores Autophagosome-Lysosome Fusion to Alleviate Cadmium-Induced Autophagy Blockade via Restoring the Expression of Rab7 in Hepatocytes. Frontiers in pharmacology. vol 12. 2021-05-04. PMID:33935722. |
in the present study, to investigate the detailed mechanisms by which pue targets autophagy to alleviate cd hepatotoxicity, alpha mouse liver 12 (aml12) cells were used to construct a model of cd-induced hepatocyte injury |
2021-05-04 |
2023-08-13 |
mouse |
| Ting Lian, Xudong Zhang, Xiye Wang, Rong Wang, Huan Gao, Fadao Tai, Qi Y. Neonatal exposure to chlordecone alters female social behaviors and central estrogen alpha receptor expression in socially monogamous mandarin voles. Toxicology research. vol 9. issue 3. 2021-04-29. PMID:32670549. |
using socially monogamous mandarin voles as an experimental animal model, the present study aimed to evaluate the impact of neonatal exposure to cd on female social behaviors and central estrogen receptor alpha (erα) expression in adulthood. |
2021-04-29 |
2023-08-13 |
Not clear |
| Andrew Leber, Raquel Hontecillas, Victoria Zoccoli-Rodriguez, Jean-Frederic Colombel, Jyoti Chauhan, Marion Ehrich, Nicholas Farinola, Josep Bassaganya-Rier. The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial. Inflammatory bowel diseases. vol 26. issue 4. 2021-04-05. PMID:31077582. |
bt-11 significantly decreases interferon gamma positive (ifnγ+) and tumor necrosis factor alpha positive (tnfα+) cluster of differentiation 4 positive (cd4+) t cells and increases forkhead box p3 positive (foxp3+) cd4+ t cells in colonic lamina propria mononuclear cells from patients with cd and patients with uc at concentrations of 0.01 µm when treated ex vivo. |
2021-04-05 |
2023-08-13 |
human |
| Mikayla Shanafelt, Taylor Rabara, Danielle MacArt, Caroline Williams, Ryan Hekman, Hyun Joo, Jerry Tsai, Craig Vierr. Structural Characterization of Black Widow Spider Dragline Silk Proteins CRP1 and CRP4. Molecules (Basel, Switzerland). vol 25. issue 14. 2021-03-02. PMID:32674428. |
we demonstrate by far-uv cd spectroscopy that these proteins contain similar secondary structure, having substantial amounts of random coil conformation, followed by lower levels of beta sheet, alpha helical and beta turn structures. |
2021-03-02 |
2023-08-13 |
spider |
| Susan Ghazi, Soline Bourgeois, Alvaro Gomariz, Milica Bugarski, Dominik Haenni, Joana R Martins, César Nombela-Arrieta, Robert J Unwin, Carsten A Wagner, Andrew M Hall, Eilidh Craigi. Multiparametric imaging reveals that mitochondria-rich intercalated cells in the kidney collecting duct have a very high glycolytic capacity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 6. 2021-01-15. PMID:32367531. |
alpha intercalated cells (αics) in the kidney collecting duct (cd) belong to a family of mitochondria rich cells (mrcs) and have a crucial role in acidifying the urine via apical v-atpase pumps. |
2021-01-15 |
2023-08-13 |
mouse |
| Nicole Power Guerra, Luisa Müller, Kristin Pilz, Annika Glatzel, Daniel Jenderny, Deborah Janowitz, Brigitte Vollmar, Angela Kuhl. Dietary-Induced Low-Grade Inflammation in the Liver. Biomedicines. vol 8. issue 12. 2020-12-29. PMID:33317065. |
histologic analysis of the cellular immune response in the liver showed no difference between hfd and cd and expression analysis of immunologic mediators like interleukin (il)-1β, il-6, il-10 and tumor necrosis factor alpha also point towards a pro-inflammatory response to cd, comparable to lgi in hfd. |
2020-12-29 |
2023-08-13 |
mouse |
| Javier Pemán, Alba Ruiz-Gaitán, Carolina García-Vidal, Miguel Salavert, Paula Ramírez, Francesc Puchades, Marta García-Hita, Ana Alastruey-Izquierdo, Guillermo Quindó. Fungal co-infection in COVID-19 patients: Should we be concerned? Revista iberoamericana de micologia. vol 37. issue 2. 2020-11-11. PMID:33041191. |
critically ill covid-19 patients have higher pro-inflammatory (il-1, il-2, il-6, tumor necrosis alpha) and anti-inflammatory (il-4, il-10) cytokine levels, less cd |
2020-11-11 |
2023-08-13 |
Not clear |
| Kinga Kowalska-Duplaga, Tomasz Gosiewski, Przemysław Kapusta, Agnieszka Sroka-Oleksiak, Andrzej Wędrychowicz, Stanisław Pieczarkowski, Agnieszka H Ludwig-Słomczyńska, Paweł P Wołkow, Krzysztof Fydere. Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn's disease. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31827191. |
moreover, differences in alpha and beta diversities in respect to calprotectin and pcdai were observed: patients with calprotectin <100 µg/g and with pcdai below 10 points vs those with calprotectin >100 µg/g and mild (10-27.7 points), moderate (27.5-40 points) or severe (>40 points) cd disease activity had higher richness and diversity of gut microbiota. |
2020-11-06 |
2023-08-13 |
Not clear |
| b' Viktor Domislovi\\xc4\\x87, Darija Vrane\\xc5\\xa1i\\xc4\\x87 Bender, Ana Bari\\xc5\\xa1i\\xc4\\x87, Marko Brinar, Dina Ljubas Kele\\xc4\\x8di\\xc4\\x87, Cecilija Rotim, Martin Novosel, Marija Mata\\xc5\\xa1in, \\xc5\\xbdeljko Krznari\\xc4\\x8. HIGH PREVALENCE OF UNTREATED AND UNDERTREATED VITAMIN D DEFICIENCY AND INSUFFICIENCY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. Acta clinica Croatica. vol 59. issue 1. 2020-10-29. PMID:32724281.' |
tumor necrosis factor alpha inhibitors were associated with higher serum vitamin d levels in cd and uc, and ileal involvement, ileal and ileocolonic resection with lower levels. |
2020-10-29 |
2023-08-13 |
Not clear |
| Vaibhav Sharma, Alagiri Srinivasan, Ajoy Roychoudhury, Komal Rani, Mitali Tyagi, Kapil Dev, Fredrik Nikolajeff, Saroj Kuma. Characterization of protein extracts from different types of human teeth and insight in biomineralization. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31249316. |
detailed structural characterization of these protein extracts was done by fourier transform infrared spectroscopy (ftir) and circular dichroism (cd) which showed that a major fraction of the proteins present are unstructured in nature including primarily random coils in addition to the other structures like extended beta (β) structure, poly-l-proline-type ii (ppii) helix, turns, with only a small fraction constituting of ordered structures like alpha (α) helix and β sheets. |
2020-10-26 |
2023-08-13 |
human |
| Ahana Das, Pijush Basak, Arnab Pramanik, Rajib Majumder, Avishek Ghosh, Saugata Hazra, Manas Guria, Maitree Bhattacharyya, Samudra Prosad Bani. Ribosylation induced structural changes in Bovine Serum Albumin: understanding high dietary sugar induced protein aggregation and amyloid formation. Heliyon. vol 6. issue 9. 2020-10-06. PMID:33015393. |
parallely, there was a significant decrease of alpha helicity as revealed by circular dichroism (cd) and fourier transformed-infra red (ft-ir) spectra. |
2020-10-06 |
2023-08-13 |
cattle |