| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Srinivasan Ganesan, Simon P L Travis, Tariq Ahmad, Riadh Jazraw. Role of tumor necrosis factor in Crohn's disease. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 9. 2003-05-27. PMID:12498003. |
tumor necrosis factor-alpha (tnf alpha) is one of several pro-inflammatory cytokines that have been implicated in the pathogenesis of crohn's disease (cd). |
2003-05-27 |
2023-08-12 |
Not clear |
| Srinivasan Ganesan, Simon P L Travis, Tariq Ahmad, Riadh Jazraw. Role of tumor necrosis factor in Crohn's disease. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 9. 2003-05-27. PMID:12498003. |
treatment with antibodies to tnf alpha has been shown to reduce mucosal inflammation in the disease, promote tissue healing, achieve and maintain remission, improve the cd activity index (cdai) and improve the quality of life. |
2003-05-27 |
2023-08-12 |
Not clear |
| Srinivasan Ganesan, Simon P L Travis, Tariq Ahmad, Riadh Jazraw. Role of tumor necrosis factor in Crohn's disease. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 9. 2003-05-27. PMID:12498003. |
the first part of this article reviews the role of tnf alpha in cd. |
2003-05-27 |
2023-08-12 |
Not clear |
| Livia Biancone, Massimo Fantini, Claudio Tosti, Rosamaria Bozzi, Piero Vavassori, Francesco Pallon. Fecal alpha 1-antitrypsin clearance as a marker of clinical relapse in patients with Crohn's disease of the distal ileum. European journal of gastroenterology & hepatology. vol 15. issue 3. 2003-05-19. PMID:12610321. |
we assessed the usefulness of fecal alpha 1-atcl in predicting clinical relapse in patients with inactive ileal cd. |
2003-05-19 |
2023-08-12 |
Not clear |
| Teruyuki Komatsu, Shoichi Hayakawa, Eishun Tsuchida, Hiroyuki Nishid. Meso-tetrakis[o-(N-methyl)pyridinium]porphyrin ensembles with axially coordinated cyclodextrin-penetrating phenethylimidazole: reversible dioxygen-binding in aqueous DMF solution. Chemical communications (Cambridge, England). issue 1. 2003-05-19. PMID:12610960. |
alpha-cyclodextrin (alpha cd)-penetrating 2-methyl-1-phenethylimidazole coordinates to the zinc(ii) and iron(ii) complexes of meso-tetrakis[o-(n-methyl)pyridinium] porphyrinate, giving non-covalently linked alpha cd-porphyrin ensembles; the iron(ii) complex can reversibly bind and release dioxygen in aqueous dmf solution. |
2003-05-19 |
2023-08-12 |
Not clear |
| Ling Fu, Jack J-N Lian. Enhanced stability of alpha B-crystallin in the presence of small heat shock protein Hsp27. Biochemical and biophysical research communications. vol 302. issue 4. 2003-05-13. PMID:12646227. |
size exclusion chromatography, circular dichroism (cd), and light scattering measurements indicated that hsp27 prevented alpha b-crystallin from heat-induced structural changes and high molecular weight (hmw) aggregation. |
2003-05-13 |
2023-08-12 |
Not clear |
| Takashi Ueno, Takahiro Miyanaga, Fumitaka Kawakami, Maiko Okano, Takashi Tanaka, Kenzo Ohtsuk. Further characterization of galloyl pedunculagin as an effective autophosphorylation inhibitor of C-kinase in vitro. Biological & pharmaceutical bulletin. vol 25. issue 11. 2003-05-02. PMID:12419947. |
in addition, the cd analysis suggests that the proline-containing six amino acid residues (pvltpp) including a threonine residue (autophosphorylation site) at the c-terminal region (positions 635-640) of c-kinase alpha may be one of the gp-binding sites. |
2003-05-02 |
2023-08-12 |
human |
| Dario Giardinà, Mauro Crucianelli, Piero Angeli, Michela Buccioni, Ugo Gulini, Gabriella Marucci, Gianni Sagratini, Carlo Melchiorr. Structure--activity relationships among novel phenoxybenzamine-related beta-chloroethylamines. Bioorganic & medicinal chemistry. vol 10. issue 5. 2003-04-29. PMID:11886792. |
a series of beta-chloroethylamines 5--18, structurally related to the irreversible alpha(1)-adrenoceptor antagonist phenoxybenzamine [pb, n-benzyl-n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)amine hydrochloride, 1] and the competitive antagonist wb4101 [n-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-n-[2-(2,6-dimethoxyphenoxy)ethyl]amine hydrochloride, 2], were synthesized and evaluated for their activity at alpha-adrenoceptors of the epididymal and the prostatic portion of young cd rat vas deferens. |
2003-04-29 |
2023-08-12 |
rat |
| Dario Giardinà, Mauro Crucianelli, Piero Angeli, Michela Buccioni, Ugo Gulini, Gabriella Marucci, Gianni Sagratini, Carlo Melchiorr. Structure--activity relationships among novel phenoxybenzamine-related beta-chloroethylamines. Bioorganic & medicinal chemistry. vol 10. issue 5. 2003-04-29. PMID:11886792. |
in conclusion, we found beta-chloroethylamines that demonstrate a multiplicity of alpha(1)-adrenoceptors in the epididymal portion of young cd rat vas deferens and, as a consequence, they are possible useful tools for alpha(1)-adrenoceptor characterization. |
2003-04-29 |
2023-08-12 |
rat |
| Malaichamy Sathiyendiran, Ramaswamy Murugave. Di-tert-butyl phosphate as synthon for metal phosphate materials via single-source coordination polymers [M(dtbp)(2)](n) (M = Mn, Cu) and [Cd(dtbp)(2)(H2O)](n) (dtbp-H = (tBuO)(2)P(O)OH). Inorganic chemistry. vol 41. issue 24. 2003-04-09. PMID:12444784. |
crystal data for 3: c(48)h(114)cd(3)o(27)p(6), triclinic, p1, a = 12.689(3) a, b = 14.364(3) a, c = 22.491(5) a, alpha = 84.54(3) degrees, beta = 79.43(3) degrees, gamma = 70.03(3) degrees, z = 2. |
2003-04-09 |
2023-08-12 |
Not clear |
| D M Brabazon, N G Abdulaev, J P Marino, K D Ridg. Evidence for structural changes in carboxyl-terminal peptides of transducin alpha-subunit upon binding a soluble mimic of light-activated rhodopsin. Biochemistry. vol 42. issue 2. 2003-03-21. PMID:12525157. |
to assess whether these designed mimics could provide a structural insight into the interaction between light-activated rhodopsin and g(t), the ability of an hptrx fusion protein comprised of the second (cd) and third (ef) cytoplasmic loops (hptrx/cdef) to bind g(t) alpha-subunit (g(t)(alpha)) peptides was examined using nuclear magnetic resonance (nmr) spectroscopy. |
2003-03-21 |
2023-08-12 |
cattle |
| H J Ellis, E L Pollock, W Engel, J S Fraser, S Rosen-Bronson, H Wieser, P J Ciclitir. Investigation of the putative immunodominant T cell epitopes in coeliac disease. Gut. vol 52. issue 2. 2003-03-03. PMID:12524402. |
residues 62-75 of alpha(2) gliadin have been proposed as the immunodominant epitope in the majority of cd patients. |
2003-03-03 |
2023-08-12 |
Not clear |
| H Yamini Shrivastava, Mookandi Kanthimathi, Balachandran Unni Nai. Copper II complex of a tridentate ligand: an artificial metalloprotease for bovine serum albumin. Biochimica et biophysica acta. vol 1573. issue 2. 2003-02-25. PMID:12399024. |
the circular dichroism (cd) spectrum of the isolated fragments shows nearly 38% and 32% of alpha helical content in 49 and 45 kda fragments, respectively, which shows that the cleavage leads to no changes in the secondary structure of the protein fragments. |
2003-02-25 |
2023-08-12 |
cattle |
| Gurvinder Kaur, N Sarkar, S Bhatnagar, S Kumar, C C Rapthap, M K Bhan, N K Mehr. Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes. Human immunology. vol 63. issue 8. 2003-01-30. PMID:12121676. |
the hla-dqb1*0201 was observed in all the 35 patients (100%), whereas the dq2 heterodimer alpha(0)beta(0) occurred in 97.1% of cd patients (31.4% in double dose, 65.7% in single dose) and revealed significant deviation from healthy controls (chi(2) = 102.08, p = 7.56e-11). |
2003-01-30 |
2023-08-12 |
human |
| Bahadir M Güllüoğlu, B Serdar Aksoy, Emel Sayin Ozveri, Meral Yüksel, Emel E Demiralp, A Ozdemir Akta. Optimal timing and temperature for hyperthermic preconditioning in an animal model of fecal peritonitis. Journal of investigative surgery : the official journal of the Academy of Surgical Research. vol 15. issue 3. 2003-01-22. PMID:12139784. |
eight hours after the induction of peritonitis, rats were sacrified and samples were taken for measurements of cd4+, cd8+, cd(11b), b cells, nk cells, and tumor necrosis factor alpha (tnfalpha) and thiobarbituric acid-reactive substances (tbars) levels. |
2003-01-22 |
2023-08-12 |
rat |
| José A Garrote, Eduardo Arranz, Juan J Tellería, Jesús Castro, Carmen Calvo, Alfredo Blanco-Quiró. TNF alpha and LT alpha gene polymorphisms as additional markers of celiac disease susceptibility in a DQ2-positive population. Immunogenetics. vol 54. issue 8. 2003-01-09. PMID:12439617. |
we have assessed the role of tnfalpha and linfotoxin alpha (tnfbeta) in cd and their relative value as cd markers in addition to the presence of dq2. |
2003-01-09 |
2023-08-12 |
Not clear |
| Pei Tang, Pravat K Mandal, Yan X. NMR structures of the second transmembrane domain of the human glycine receptor alpha(1) subunit: model of pore architecture and channel gating. Biophysical journal. vol 83. issue 1. 2002-12-27. PMID:12080117. |
using nmr and circular dichroism (cd), we determined the high-resolution structures of the tm2 segment of human alpha(1) glyr and an anesthetic-insensitive mutant (s267y) in dodecyl phosphocholine (dpc) and sodium dodecyl sulfate (sds) micelles. |
2002-12-27 |
2023-08-12 |
human |
| Kirsty J McLean, Myles R Cheesman, Stuart L Rivers, Alison Richmond, David Leys, Stephen K Chapman, Graeme A Reid, Nicholas C Price, Sharon M Kelly, John Clarkson, W Ewen Smith, Andrew W Munr. Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis. Journal of inorganic biochemistry. vol 91. issue 4. 2002-11-19. PMID:12237220. |
cd spectra in the far uv region describe a mainly alpha helical conformation, but the visible cd spectrum shows a band of positive sign in the soret region, distinct from spectra for other p450s recognized thus far. |
2002-11-19 |
2023-08-12 |
Not clear |
| Carsten Strohmann, Daniel Schildbac. Bis[[diphenyl(piperidinomethyl)silyl]methyl]cadmium and -magnesium. Acta crystallographica. Section C, Crystal structure communications. vol 58. issue Pt 8. 2002-11-12. PMID:12154290. |
the si-c and m-c bonds (m is cd or mg) are shortened compared with the corresponding non-metallated compounds, indicating stabilization by the diffuse polarizable si centres (alpha effect). |
2002-11-12 |
2023-08-12 |
Not clear |
| Shigenori Nagatomo, Yayoi Jin, Masako Nagai, Hiroshi Hori, Teizo Kitagaw. Changes in the abnormal alpha-subunit upon CO-binding to the normal beta-subunit of Hb M Boston: resonance Raman, EPR and CD study. Biophysical chemistry. vol 98. issue 1-2. 2002-10-22. PMID:12128200. |
heme-heme interaction in hb m boston (his alpha 58-->tyr) was investigated with visible and uv resonance raman (rr), epr, and cd spectroscopies. |
2002-10-22 |
2023-08-12 |
Not clear |