| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincenzo Micale, Vincenzo Di Marzo, Alexandra Sulcova, Carsten T Wotjak, Filippo Drag. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacology & therapeutics. vol 138. issue 1. 2013-08-26. PMID:23261685. |
the endocannabinoid system (ecs), comprising two g protein-coupled receptors (the cannabinoid receptors 1 and 2 [cb1 and cb2] for marijuana's psychoactive principle ∆(9)-tetrahydrocannabinol [∆(9)-thc]), their endogenous small lipid ligands (namely anandamide [aea] and 2-arachidonoylglycerol [2-ag], also known as endocannabinoids), and the proteins for endocannabinoid biosynthesis and degradation, has been suggested as a pro-homeostatic and pleiotropic signaling system activated in a time- and tissue-specific way during physiopathological conditions. |
2013-08-26 |
2023-08-12 |
Not clear |
| M Waldman, E Hochhauser, M Fishbein, D Aravot, A Shainberg, Y Sarn. An ultra-low dose of tetrahydrocannabinol provides cardioprotection. Biochemical pharmacology. vol 85. issue 11. 2013-07-16. PMID:23537701. |
tetrahydrocannabinol (thc), the major psychoactive component of marijuana, is a cannabinoid agonist that exerts its effects by activating at least two specific receptors (cb1 and cb2) that belong to the seven transmembrane g-protein coupled receptor (gpcr) family. |
2013-07-16 |
2023-08-12 |
mouse |
| John C Ashto. The atypical cannabinoid O-1602: targets, actions, and the central nervous system. Central nervous system agents in medicinal chemistry. vol 12. issue 3. 2013-06-13. PMID:22831390. |
o-1602 is a cannabidiol analogue that does not bind with high affinity to either the cannabinoid cb1 receptor or cb2 receptor. |
2013-06-13 |
2023-08-12 |
Not clear |
| Raphael Mechoulam, Linda A Parke. The endocannabinoid system and the brain. Annual review of psychology. vol 64. 2013-06-10. PMID:22804774. |
the psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (thc), was isolated in the mid-1960s, but the cannabinoid receptors, cb1 and cb2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. |
2013-06-10 |
2023-08-12 |
Not clear |
| Andrea Rotter, Kristina Bayerlein, Max Hansbauer, Judith Weiland, Wolfgang Sperling, Johannes Kornhuber, Teresa Bierman. CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence. European addiction research. vol 19. issue 1. 2013-05-17. PMID:22948261. |
cb1 and cb2 receptor expression and promoter methylation in patients with cannabis dependence. |
2013-05-17 |
2023-08-12 |
human |
| Vincenzo Di Marzo, Luciano De Petrocelli. Why do cannabinoid receptors have more than one endogenous ligand? Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1607. 2013-04-08. PMID:23108541. |
the endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle, Δ(9)-tetrahydrocannabinol, and includes two g-protein-coupled receptors (gpcrs; the cannabinoid cb1 and cb2 receptors), their endogenous ligands (the endocannabinoids, the best studied of which are anandamide and 2-arachidonoylglycerol (2-ag)), and the proteins that regulate the levels and activity of these receptors and ligands. |
2013-04-08 |
2023-08-12 |
human |
| Monika Styrczewska, Anna Kulma, Katarzyna Ratajczak, Ryszard Amarowicz, Jan Szop. Cannabinoid-like anti-inflammatory compounds from flax fiber. Cellular & molecular biology letters. vol 17. issue 3. 2012-12-31. PMID:22706678. |
it was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the cbd from cannabis sativa activates the specific peripheral cannabinoid receptor 2 (cb2) gene expression. |
2012-12-31 |
2023-08-12 |
mouse |
| Sandeep Singla, Rajesh Sachdeva, Jawahar L Meht. Cannabinoids and atherosclerotic coronary heart disease. Clinical cardiology. vol 35. issue 6. 2012-10-11. PMID:22278660. |
the pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors cb1 and cb2, which are widely distributed in the cardiovascular system, have been well described. |
2012-10-11 |
2023-08-12 |
human |
| Benjamin S Harvey, Katharina S Ohlsson, Jesper L V Mååg, Ian F Musgrave, Scott D Smi. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22233683. |
in this study we compared the effects of cb1 and cb2 receptor-selective ligands, the endocannabinoid anandamide and the phytocannabinoid cannabidiol, against oxidative stress and the toxic hallmark alzheimer's protein, β-amyloid (aβ) in neuronal cell lines. |
2012-06-04 |
2023-08-12 |
Not clear |
| Benjamin S Harvey, Katharina S Ohlsson, Jesper L V Mååg, Ian F Musgrave, Scott D Smi. Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22233683. |
pc12 or sh-sy5y cells were selectively exposed to either hydrogen peroxide, tert-butyl hydroperoxide or aβ, alone or in the presence of the cb1 specific agonist arachidonyl-2'-chloroethylamide (acea), cb2 specific agonist jwh-015, anandamide or cannabidiol. |
2012-06-04 |
2023-08-12 |
Not clear |
| Sharon Anavi-Goffer, Gemma Baillie, Andrew J Irving, Jürg Gertsch, Iain R Greig, Roger G Pertwee, Ruth A Ros. Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22027819. |
in this study, we investigated the gpr55 pharmacology of various cannabinoids, including analogues of the cb1 receptor antagonist rimonabant®, cb2 receptor agonists, and cannabis sativa constituents. |
2012-05-08 |
2023-08-12 |
Not clear |
| J Michael Bostwic. Blurred boundaries: the therapeutics and politics of medical marijuana. Mayo Clinic proceedings. vol 87. issue 2. 2012-03-26. PMID:22305029. |
pubmed searches were conducted using the following keywords: medical marijuana, medical cannabis, endocannabinoid system, cb1 receptors, cb2 receptors, thc, cannabidiol, nabilone, dronabinol, nabiximols, rimonabant, marijuana legislation, marijuana abuse, marijuana dependence, and marijuana and schizophrenia. |
2012-03-26 |
2023-08-12 |
human |
| R Maldonado, F Berrendero, A Ozaita, P Robled. Neurochemical basis of cannabis addiction. Neuroscience. vol 181. 2012-03-16. PMID:21334423. |
the psychoactive compounds contained in cannabis induce their pharmacological effects by the activation of at least two different receptors, cb1 and cb2 cannabinoid receptors. |
2012-03-16 |
2023-08-12 |
Not clear |
| Bogna Ignatowska-Jankowska, Maciej M Jankowski, Artur H Swiergie. Cannabidiol decreases body weight gain in rats: involvement of CB2 receptors. Neuroscience letters. vol 490. issue 1. 2011-05-04. PMID:21172406. |
cannabidiol decreases body weight gain in rats: involvement of cb2 receptors. |
2011-05-04 |
2023-08-12 |
rat |
| Sieglinde Marquart, Pawel Zerr, Alfiya Akhmetshina, Katrin Palumbo, Nicole Reich, Michal Tomcik, Angelika Horn, Clara Dees, Matthias Engel, Jochen Zwerina, Oliver Distler, Georg Schett, Jörg H W Distle. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis and rheumatism. vol 62. issue 11. 2010-11-30. PMID:20617520. |
cannabinoids are derivates of the marijuana component Δ(9) -tetrahydrocannabinol that exert their effects on mesenchymal cells and immune cells via cb1 and cb2 receptors. |
2010-11-30 |
2023-08-12 |
Not clear |
| Douglas McHugh, Sherry S J Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradsha. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC neuroscience. vol 11. 2010-06-29. PMID:20346144. |
the endogenous cannabinoid system regulates microglial migration via cb2 receptors and an as yet unidentified gpcr termed the 'abnormal cannabidiol' (abn-cbd) receptor. |
2010-06-29 |
2023-08-12 |
Not clear |
| Douglas McHugh, Sherry S J Hu, Neta Rimmerman, Ana Juknat, Zvi Vogel, J Michael Walker, Heather B Bradsha. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC neuroscience. vol 11. 2010-06-29. PMID:20346144. |
abn-cbd is a synthetic isomer of the phytocannabinoid cannabidiol (cbd) and is inactive at cb1 or cb2 receptors, but functions as a selective agonist at this gi/o-coupled gpcr. |
2010-06-29 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Vincenzo Di Marz. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 5. issue 1. 2010-05-11. PMID:19847654. |
the molecular mechanism of action of delta(9)-tetrahydrocannabinol (thc), the psychotropic constituent of cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid cb1 and cb2 receptors. |
2010-05-11 |
2023-08-12 |
Not clear |
| Itai Bab, Andreas Zimmer, Eitan Melame. Cannabinoids and the skeleton: from marijuana to reversal of bone loss. Annals of medicine. vol 41. issue 8. 2010-03-09. PMID:19634029. |
the active component of marijuana, delta(9)-tetrahydrocannabinol, activates the cb1 and cb2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. |
2010-03-09 |
2023-08-12 |
mouse |
| Kathryn A Seely, Mark S Levi, Paul L Prathe. The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19359525. |
it is interesting that cannabinoids, derived from the marijuana plant (cannabis sativa), produce similar protective effects via cb1 and cb2 receptors. |
2009-07-27 |
2023-08-12 |
mouse |