| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael D Roth, Gayle C Baldwin, Donald P Tashki. Effects of delta-9-tetrahydrocannabinol on human immune function and host defense. Chemistry and physics of lipids. vol 121. issue 1-2. 2003-08-22. PMID:12505703. |
leukocytes express both cannabinoid receptor type 1 (cb1) and cannabinoid receptor type 2 (cb2), and levels of mrna encoding for them are increased in peripheral blood leukocytes obtained from marijuana smokers, suggesting cannabinoid receptor activation in vivo. |
2003-08-22 |
2023-08-12 |
human |
| Demetris P Papahatjis, Spyros P Nikas, Thanos Andreou, Alexandros Makriyanni. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443781. |
1',1'-cyclopropyl side chain substituents enhance the affinities of delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the cb1 and cb2 cannabinoid receptors. |
2003-07-16 |
2023-08-12 |
Not clear |
| Demetris P Papahatjis, Spyros P Nikas, Thanos Andreou, Alexandros Makriyanni. Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & medicinal chemistry letters. vol 12. issue 24. 2003-07-16. PMID:12443781. |
the results support the hypothesis for a subsite within cb1 and cb2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. |
2003-07-16 |
2023-08-12 |
Not clear |
| Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Paula Vissio, Javier Fernández Solari, Adriana Seilicovich, Samuel M McCann, Valeria Rettor. The effect of anandamide on prolactin secretion is modulated by estrogen. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 4. 2003-04-01. PMID:12578974. |
recent research has revealed that endogenous cannabinoid receptors (cb1 and cb2) react with the active ingredient of marijuana, delta(9)-tetrahydrocannabinol. |
2003-04-01 |
2023-08-12 |
rat |
| Lisa Walter, Allyn Franklin, Anke Witting, Christian Wade, Yiheng Xie, George Kunos, Ken Mackie, Nephi Stell. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 4. 2003-03-24. PMID:12598628. |
it is important to note that cannabinol and cannabidiol, two nonpsychotropic ingredients present in the marijuana plant, prevent the 2-ag-induced cell migration by antagonizing the cb2 and abnormal-cannabidiol-sensitive receptors, respectively. |
2003-03-24 |
2023-08-12 |
Not clear |
| Liang Nong, Catherine Newton, Qingwen Cheng, Herman Friedman, Michael D Roth, Thomas W Klei. Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. Journal of neuroimmunology. vol 127. issue 1-2. 2002-07-11. PMID:12044989. |
these studies suggest that marijuana smoking and immune activation can alter the basal levels of cb1 and cb2 in pbmcs. |
2002-07-11 |
2023-08-12 |
Not clear |
| L Nong, C Newton, H Friedman, T W Klei. CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. Advances in experimental medicine and biology. vol 493. 2002-05-20. PMID:11727770. |
marijuana cannabinoid receptors (cbr), cb1 and cb2, are g protein-coupled receptors reported to be expressed in brain as well as cells of the periphery. |
2002-05-20 |
2023-08-12 |
human |
| Z Járai, J A Wagner, K Varga, K D Lake, D R Compton, B R Martin, A M Zimmer, T I Bonner, N E Buckley, E Mezey, R K Razdan, A Zimmer, G Kuno. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 24. 2000-01-06. PMID:10570211. |
here we show that "abnormal cannabidiol" (abn-cbd) is a neurobehaviorally inactive cannabinoid that does not bind to cb1 receptors, yet causes sr141716a-sensitive hypotension and mesenteric vasodilation in wild-type mice and in mice lacking cb1 receptors or both cb1 and cb2 receptors. |
2000-01-06 |
2023-08-12 |
mouse |
| C S Breivogel, S R Childer. The functional neuroanatomy of brain cannabinoid receptors. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974175. |
the effects of the primary psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol, are mediated by cannabinoid receptors, cb1 and cb2. |
1999-05-06 |
2023-08-12 |
Not clear |