| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kentaro Tanaka, Reiko Saito, Kenya Sanada, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Hiromichi Ueno, Yasuhito Motojima, Takanori Matsuura, Mitsuhiro Yoshimura, Takashi Maruyama, Tatsushi Onaka, Yukiyo Yamamoto, Koichi Kusuhara, Yoichi Uet. Expression of hypothalamic feeding-related peptide genes and neuroendocrine responses in an experimental allergic encephalomyelitis rat model. Peptides. vol 129. 2021-06-07. PMID:32298774. |
the expression of orexigenic peptide genes npy and agrp were significantly increased, whereas the levels of anorectic peptide genes (pomc and cart) were significantly decreased in the hypothalamus of eae rats. |
2021-06-07 |
2023-08-13 |
human |
| Zhengzhi Tian, Shaoqi Xu, Mei Wang, Ya Li, Hu Chen, Ni Tang, Bin Wang, Xin Zhang, Zhiqiong L. Identification, tissue distribution, periprandial expression, and anorexigenic effect of spexin in Siberian sturgeon, Acipenser baeri. Fish physiology and biochemistry. vol 46. issue 6. 2021-05-07. PMID:32794103. |
moreover, compared with the saline group, the mrna expression of anorectic nucb2, cart, ucn3, and pyy in the hypothalamus was significantly upregulated and orectic npy was significantly downregulated at 1 h after spexin injection; in the stomach, the mrna expression of nucb2 and pyy was significantly upregulated. |
2021-05-07 |
2023-08-13 |
Not clear |
| Randriely Merscher Sobreira de Lima, Lucas Victor Dos Santos Bento, Marcelo di Marcello Valladão Lugon, Valerio Garrone Barauna, Athelson Stefanon Bittencourt, Carla Dalmaz, Ana Paula Santana de Vasconcellos Bittencour. Early life stress and the programming of eating behavior and anxiety: Sex-specific relationships with serotonergic activity and hypothalamic neuropeptides. Behavioural brain research. vol 379. 2021-05-03. PMID:31790781. |
also, we evaluated anxiety and the expression of the leptin receptor, neuropeptides pomc, cart, npy in the hypothalamus, as well as the serotoninergic system in the amygdala and hypothalamus as possible modulators of these behaviors. |
2021-05-03 |
2023-08-13 |
rat |
| Noelle Nadermann, Hélène Volkof. Effects of short-term exercise on food intake and the expression of appetite-regulating factors in goldfish. Peptides. vol 123. 2020-12-10. PMID:31678371. |
in this study, we examined the effects of short-term (30 min, at low and high water flow) exercise on food intake, glucose levels and the expressions of appetite regulators in goldfish hypothalamus (irisin, orexin, cart, leptin), intestine (cck, pyy, proglucagon/glp-1), muscle (irisin) and liver (leptin), of brain-derived neurotrophic factor (bdnf) in brain, interleukin-6 (il6) in muscle and hypothalamus, and major metabolic enzymes, the glycolytic enzyme glucokinase (gck) and its regulatory protein (gckr) in liver, the lipolytic enzyme lipoprotein lipase in intestine and muscle, and trypsin in intestine. |
2020-12-10 |
2023-08-13 |
Not clear |
| Jennifer W Hil. Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons. Open neuroendocrinology journal (Online). vol 3. 2020-10-01. PMID:28042349. |
neurons that express pro-opiomelanocortin (pomc) and cocaine- and amphetamine-regulated transcript (cart) in the arcuate nucleus of the hypothalamus suppress feeding and increase energy expenditure in response to circulating adiposity signals such as leptin. |
2020-10-01 |
2023-08-13 |
Not clear |
| b' Aynur M\\xc3\\xbcd\\xc3\\xbcro\\xc4\\x9flu Kirmizibekmez, Murat Mengi, Ertan Yurdako\\xc5\\x9. Interaction of Cocaine- and Amphetamine-regulated Transcript and Neuropeptide Y on Behavior in the Central Nervous System. Noro psikiyatri arsivi. vol 53. issue 2. 2020-09-30. PMID:28360786.' |
in the central nervous system, cocaine- and amphetamine-regulated transcript (cart) 55-102 peptide is localized in areas, such as the ventral tegmental area, amygdala, hypothalamus, and hippocampus, where emotional activity is regulated. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shu-Chen Chu, Pei-Ni Chen, Ching-Han Yu, Yih-Shou Hsieh, Dong-Yih Ku. Double immunofluorescent evidence that oxidative stress-associated activation of JNK/AP-1 signaling participates in neuropeptide-mediated appetite control. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 11. 2020-09-07. PMID:31519469. |
amphetamine (amph), an appetite suppressant, alters expression levels of neuropeptide y (npy) and cocaine- and amphetamine-regulated transcript (cart) in the hypothalamus. |
2020-09-07 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
this study evaluated the effects of adx on icv (lateral ventricle) injection of insulin-induced changes on food intake, mrna expression of hypothalamic neuropeptides (insulin receptor (insr), proopiomelanocortin, cocaine and amphetamine-regulated transcript (cart), agouti-related protein, neuropeptide y (npy) in the arcuate nucleus of the hypothalamus (arc), corticotrophin-releasing factor in the paraventricular nucleus of the hypothalamus) and hypothalamic protein content of insulin signaling-related molecules (insulin receptor substrate (irs) 1, protein kinase b (akt), extracellular-signal-regulated kinase (erk1/2), c-jun n-terminal kinase (jnk), protein tyrosine phosphatase-1b (ptp1b) and t cell protein tyrosine phosphatase (tcptp)) compared with sham animals, adx increased the hypothalamic content of pjnk/jnk, ptp1b and tcptp, as well as decreased mrna expression of insr, and corticosterone (b) treatment reversed these effects. |
2020-04-06 |
2023-08-13 |
rat |
| Ernane Torres Uchoa, Paula Beatriz Marangon, Rodrigo Rorato, Silvia Graciela Ruginsk, Lucas Kniess Debarba, Jose Antunes-Rodrigues, Lucila L K Elia. Adrenalectomy impairs insulin-induced hypophagia and related hypothalamic changes. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31189132. |
these data demonstrate that adx reduces the expression of insr and increases insulin counter-regulators in the hypothalamus, as well as adx abolishes hypophagia, activation of hypothalamic akt pathway and changes in cart and npy mrna expression in the arc induced by insulin. |
2020-04-06 |
2023-08-13 |
rat |
| Ji-Yao Li, Xiaoyin Wu, Allen Lee, Shi-Yi Zhou, Chung Owyan. Altered R-spondin 1/CART neurocircuit in the hypothalamus contributes to hyperphagia in diabetes. Journal of neurophysiology. vol 121. issue 3. 2020-02-25. PMID:30649980. |
new & noteworthy this study reports that cocaine and amphetamine-regulated transcript (cart) neurons in the arcuate nucleus (arc) of hypothalamus acted downstream of r-spondin 1 (rspo1) to inhibit food intake. |
2020-02-25 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
the present study was undertaken to reveal the functional interaction between cocaine- and amphetamine-regulated transcript (cart), a well-known anorexic peptide, and insulin within the framework of hypothalamus in the regulation of feeding behavior and body weight. |
2020-02-25 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. Involvement of neuropeptide CART in the central effects of insulin on feeding and body weight. Pharmacology, biochemistry, and behavior. vol 181. 2020-02-25. PMID:31054945. |
we suggest that increased cart contents in the hypothalamus may be causally linked with anorexia and weight loss induced by insulin. |
2020-02-25 |
2023-08-13 |
rat |
| Jia-Qi Xu, Xiao-Ming Xu, Zhong-Qiang Bi, Lu-Lu Shi, Jing Cao, Zhi-Jun Zha. The less weight loss due to modest food restriction drove more fat accumulation in striped hamsters refed with high-fat diet. Hormones and behavior. vol 110. 2020-01-22. PMID:30790562. |
the fr15%-re group showed considerable decreases in gene expression of arcuate nucleus co-expressing proopiomelanocortin (pomc), cocaine - and amphetamineregulated transcript (cart) and the long isoform of leptin receptor (leprb) in the hypothalamus and of several genes associated with fatty acid transport to mitochondria and β-oxidation in brown adipose tissue and liver. |
2020-01-22 |
2023-08-13 |
Not clear |
| b' Sanja Kova\\xc4\\x8devi\\xc4\\x87, Jelena Nestorov, Gordana Mati\\xc4\\x87, Ivana Elakovi\\xc4\\x8. Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats. Neuroendocrinology. vol 108. issue 4. 2019-12-26. PMID:30572328.' |
in the hypothalamus, a crossroad of stress responses and energy balance, insulin and glucocorticoids regulate the expression of orexigenic neuropeptides, neuropeptide y (npy) and agouti-related protein (agrp), and anorexigenic neuropeptides, proopio-melanocortin (pomc) and cocaine- and amphetamine-regulated transcript (cart). |
2019-12-26 |
2023-08-13 |
rat |
| Hamid Ahmadian-Moghadam, Mitra-Sadat Sadat-Shirazi, Mohammad-Reza Zarrindas. Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide. Peptides. vol 110. 2019-08-09. PMID:30391426. |
cocaine and amphetamine-regulated transcript (cart) was discovered in 1995 in the rat striatum but later was found to be highly expressed in the hypothalamus. |
2019-08-09 |
2023-08-13 |
rat |
| Kartik T Nakhate, Nishikant K Subhedar, Dadasaheb M Kokar. A role of neuropeptide CART in hyperphagia and weight gain induced by olanzapine treatment in rats. Brain research. vol 1695. 2019-07-11. PMID:29775565. |
we suggest that decreased cart contents in the hypothalamus may be causally linked with the hyperphagia and weight gain induced by olanzapine. |
2019-07-11 |
2023-08-13 |
rat |
| Aleksandra Wisłowska-Stanek, Adam Płaźnik, Karolina Kołosowska, Anna Skórzewska, Danuta Turzyńska, Monika Liguz-Lęcznar, Paweł Krząścik, Marek Gryz, Janusz Szyndler, Alicja Sobolewska, Małgorzata Lehne. Differences in the dopaminergic reward system in rats that passively and actively behave in the Porsolt test. Behavioural brain research. vol 359. 2019-04-19. PMID:30366032. |
in the parvocellular region of paraventricular nucleus of the hypothalamus passive animals had a higher expression of cart compared to passive restraint rats and active control rats. |
2019-04-19 |
2023-08-13 |
rat |
| Aitak Farzi, Jackie Lau, Chi Kin Ip, Yue Qi, Yan-Chuan Shi, Lei Zhang, Ramon Tasan, Günther Sperk, Herbert Herzo. Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure. eLife. vol 7. 2019-01-21. PMID:30129922. |
cocaine- and amphetamine-regulated transcript (cart) is widely expressed in the hypothalamus and an important regulator of energy homeostasis; however, the specific contributions of different cart neuronal populations to this process are not known. |
2019-01-21 |
2023-08-13 |
mouse |
| Sheila Leone, Claudio Ferrante, Lucia Recinella, Annalisa Chiavaroli, Adriano Mollica, Csaba Tömböly, Azzurra Stefanucci, Marilisa Pia Dimmito, Szabolcs Dvorácskó, Vittore Verratti, Luciano De Petrocellis, Giustino Orlando, Luigi Brunett. Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats. Neuropeptides. vol 72. 2018-12-11. PMID:30396596. |
finally, rats were sacrificed and agouti-related peptide (agrp), neuropeptide y (npy), pro-opiomelanocortin (pomc) and cocaine- and amphetamine-regulated transcript (cart) and fatty acid amide hydrolase (faah) gene expression in the hypothalamus was measured by real-time reverse transcription polymerase chain reaction. |
2018-12-11 |
2023-08-13 |
rat |
| Jin-Hyoung Kim, Satid Chatchaiphan, Michelle T Crown, Samantha L White, Robert H Devli. Effect of growth hormone overexpression on gastric evacuation rate in coho salmon. Fish physiology and biochemistry. vol 44. issue 1. 2018-08-17. PMID:28894993. |
to further investigate the molecular basis of these responses, we examined the messenger rna (mrna) levels of several genes in appetite- and gastric-regulation pathways (agrp1, bbs, cart, cck, glp, ghrelin, grp, leptin, mc4r, npy, and pomc) by qpcr analyses in the brain (hypothalamus, preoptic area) and pituitary, and in peripheral tissues associated with digestion (liver, stomach, intestine, and adipose tissue). |
2018-08-17 |
2023-08-13 |
Not clear |