| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanhai Kang, Li Sheng, Jia L. HINT1 promotes neuronal apoptosis and triggers schizophrenia-like behavior in rats. Behavioural brain research. 2024-10-19. PMID:39426527. |
hint1 expression in the hippocampus was analyzed via rt-pcr and western blot. |
2024-10-19 |
2024-10-22 |
rat |
| Xiaopeng Sun, Shugang Xu, Jingjing Wang, Xiaohong Li, Hongtao Sun, Wanyong Zha. Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats. Neuroreport. 2024-10-18. PMID:39423323. |
the motor function of the rats in each group was evaluated by beam walking test and inclined-grid climbing test, brain water content was calculated by the wet-dry weight method, evan's blue staining was used to measure the blood-brain barrier (bbb) permeability, the change of hippocampal neurons was observed by nissl staining, the expressions of brdu, neun, and cd86 positive cells were detected by immunofluorescence staining, and the expressions of bcl-2, bax, inos, il-10, and arg-1 were detected by western blot. |
2024-10-18 |
2024-10-21 |
rat |
| Ning Zhang, Yongjie Ma, Yuqing Li, Yiqi Wang, Lisheng Zhang, Mincheng Zheng, Yu Tian, Ruiying Zhang, Kanlin Yang, Jieyuan Li, Fuman Yan, Haimei Liu, Yaxing Zhang, Jinwen Xu, Cong Yu, Jiean X. Paeonol prevents sepsis-associated encephalopathy via regulating the HIF1A pathway in microglia. International immunopharmacology. vol 143. issue Pt 1. 2024-10-03. PMID:39362015. |
to assess the therapeutic potential of paeonol in mice treated with lps, behavioral assessments were conducted using the open-field test (oft), tail suspension test (tst), and forced swimming test (fst), and quantitative pcr (qpcr), western blot, and immunofluorescent staining were utilized to determine the expression levels of inflammatory molecules in the hippocampus in vivo and microglial cells in vitro. |
2024-10-03 |
2024-10-07 |
mouse |
| Jing Peng, Sha Yang, Chaomin Zhou, Chenguang Qin, Kaiyun Fang, Ying Tan, Jingjing Da, Jiqing Zhang, Yan Zh. Identification of common biomarkers in diabetic kidney disease and cognitive dysfunction using machine learning algorithms. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333211. |
the results demonstrated the up-regulation of sh3rf1 in the cortex, hippocampus and kidney of mice, which was further confirmed by immunofluorescence and western blot validation. |
2024-09-27 |
2024-10-01 |
mouse |
| Li Zhang, Dandan Li, Yurong Liu, Xiaona Zhang, Kaixin Wei, Xiaorong Zhao, Huijing Ma, Bo Niu, Rui Cao, Xiuwei Wan. Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation. Neurochemistry international. 2024-09-22. PMID:39307459. |
the effect of cl on ntd occurrence was assessed by 5-ethynyl-2'-deoxyuridine (edu) staining, immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel), quantitative real-time reverse transcription polymerase chain reaction (qrt-pcr), and western blot in ntd embryonic brain tissues and immortalized hippocampal neuron cells (ht-22). |
2024-09-22 |
2024-09-26 |
mouse |
| Jian Liu, Hui Yang, Hong-Qing Zhao, Wei Li, Zhuo Liu, Yu-Hong Wan. [Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 17. 2024-09-22. PMID:39307798. |
the protein expressions of cd300f, tlr4, synaptophysin(syn), and postsynaptic density protein 95(psd-95) in microglial cells of the hippocampus were detected by immunofluorescence and western blot. |
2024-09-22 |
2024-09-26 |
rat |
| Juan-Juan Jiao, Yang Hu, Yu-Jia Cui, Chun-Mei Tuo, Yi-Xuan Wang, Xin-Yi Li, Yi Zhang, Mei-Na W. Anisomycin alleviates cognitive impairments and pathological features in 3xTg-AD mice. Neuropharmacology. 2024-09-20. PMID:39303856. |
in the present study, anisomycin was intragastrically administrated to female triple-transgenic ad (3xtg-ad) model mice, then morris water maze test was used to observe the long-term spatial memory of mice, the in vivo hippocampal field potential recording was performed to evaluate the synaptic plasticity, the western blot and immunofluorescence were employed to detect pathological changes, and the bioinformatics analysis was used to predict the potential target of anisomycin exerting effects in ad. |
2024-09-20 |
2024-09-23 |
mouse |
| Ting Chen, Juan Yang, Yongsu Zheng, Xuejiao Zhou, Hao Huang, Haiqing Zhang, Zucai X. ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic. Synapse (New York, N.Y.). vol 78. issue 5. 2024-09-17. PMID:39285628. |
the analysis of western blot was also used to measure the phosphorylated and total erk1/2 and drp1 protein expression levels in the rat hippocampus. |
2024-09-17 |
2024-09-19 |
rat |
| Zan Zhou, Wen-Jun Jiang, Yan-Ping Wang, Jun-Qiang Si, Xian-Si Zeng, Li L. CD36-mediated ROS/PI3K/AKT signaling pathway exacerbates cognitive impairment in APP/PS1 mice after noise exposure. The Science of the total environment. 2024-09-05. PMID:39233068. |
meanwhile, western blot results from the hippocampus and entorhinal cortex indicated that cd36 protein levels increased by approximately 1.5-fold (p < 0.001) and 1.3-fold (p < 0.05) respectively, after noise exposure in app/ps1 mice. |
2024-09-05 |
2024-09-08 |
mouse |
| Junying Wang, Yu Wang, Yu Chen, Jinling Zhang, Yue Zhang, Shaoyuan Li, Haohan Zhu, Xingke Song, Liwei Hou, Lei Wang, Yifei Wang, Zixuan Zhang, Peijing Ron. Transcutaneous Auricular Vagus Stimulation Attenuates LPS-Induced Depression-Like Behavior by Regulating Central α7nAChR/JAK2 Signaling. Molecular neurobiology. 2024-08-30. PMID:39212875. |
the expressions of tumor necrosis factor alpha (tnf-ɑ) and phosphorylated-janus kinase2 (p-jak2), phosphorylated-signal transducer and activator of transcription3(p-stat3) in the hypothalamus, amygdala, and hippocampus were detected by western blot. |
2024-08-30 |
2024-09-04 |
rat |
| Lixia Luo, Shitong Lin, Guoli Hu, Jiahui Wu, Yulin Hu, Fengjing Nong, Cheng Lu, Rongbin Chen, Jin Li. Molecular mechanism of Rolupram reducing neuroinflammation in noise induced tinnitus mice through TLR4/NF kB/NLRP3 protein/caspase-1/IL-1 β signaling pathway. International journal of biological macromolecules. 2024-08-24. PMID:39181359. |
finally, qpcr and western blot were used to detect the expression of tlr4, nf kb, nlrp3, caspase-1, and il-1 β in the hippocampus of each group of mice. |
2024-08-24 |
2024-08-28 |
mouse |
| Fu Zhou, Rong Hu, Yuzhu Wang, Xiaohui Wu, Xuan Chen, Zhiqin Xi, Kebin Zen. Calsyntenin-1 expression and function in brain tissue of lithium-pilocarpine rat seizure models. Synapse (New York, N.Y.). vol 78. issue 5. 2024-08-22. PMID:39171546. |
seven days after se, western blot analysis was performed to evaluate the expression of clstn1 in the hippocampus and temporal lobe. |
2024-08-22 |
2024-08-24 |
rat |
| Yun Fan, Yun Ling, Jiulve Hu, Zijun Hou, Runpeng Dou, Chunxiang Zho. Linggui Zhugan decoction as a potential medicine for neuroprotection in Alzheimer's Disease via AMPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 7. 2024-08-04. PMID:39097880. |
western blot results showed that lgzg could affect neun, ampk, p53, slc7a11 and gpx4 levels in the hippocampus of ad model, which was all proteins related to ampk pathway. |
2024-08-04 |
2024-08-06 |
mouse |
| Sonia Melgar-Locatelli, M Carmen Mañas-Padilla, Adriana Castro-Zavala, Patricia Rivera, María Del Carmen Razola-Díaz, Francisco J Monje, Celia Rodríguez-Pérez, Estela Castilla-Orteg. Diet enriched with high-phenolic cocoa potentiates hippocampal brain-derived neurotrophic factor expression and neurogenesis in healthy adult micewith subtle effects on memory. Food & function. 2024-07-29. PMID:39069830. |
adult hippocampal neurogenesis and brain-derived neurotrophic factor (bdnf) expression in the hippocampus and prefrontal cortex were evaluated using immunohistochemistry and western blot. |
2024-07-29 |
2024-08-02 |
mouse |
| Hyeong-Min Kim, Hyun-Seok Jo, Eun-Jong Kim, Ji-Min Na, Hyeng-Kyu Park, Jae-Young Han, Ki-Hong Kim, Insung Choi, Min-Keun Son. The Effect of Repetitive Transcranial Magnetic Stimulation on Cognition in Diffuse Axonal Injury in a Rat Model. Neurology international. vol 16. issue 4. 2024-07-25. PMID:39051213. |
after post-mwm tests, all rats were euthanized, and their brain tissues, particularly from the hippocampus, were collected for immunohistochemistry and western blot analyses. |
2024-07-25 |
2024-07-28 |
rat |
| Hyeong-Min Kim, Hyun-Seok Jo, Eun-Jong Kim, Ji-Min Na, Hyeng-Kyu Park, Jae-Young Han, Ki-Hong Kim, Insung Choi, Min-Keun Son. The Effect of Repetitive Transcranial Magnetic Stimulation on Cognition in Diffuse Axonal Injury in a Rat Model. Neurology international. vol 16. issue 4. 2024-07-25. PMID:39051213. |
immunohistochemistry and western blot analyses indicated increased expression of bdnf, vegf, and map2 in the hippocampal brain tissue of the dai-t group. |
2024-07-25 |
2024-07-28 |
rat |
| Zhonghua Xiong, Jiahui Deng, Pandeng Xie, Chongyang Tang, Jing Wang, Qinqin Deng, Yujiao Yang, Jing Zhang, Mengyi Guo, Xiongfei Wang, Yuguang Guan, Guoming Luan, Jian Zhou, Tianfu L. Deep Brain Stimulation Inhibits Epileptic Seizures via Increase of Adenosine Release and Inhibition of ENT1, CD39, and CD73 Expression. Molecular neurobiology. 2024-07-23. PMID:39042219. |
in the present study, video electroencephalogram monitoring, morris water maze assays, in vivo measurements of adenosine using fiber photometry, histochemistry, and western blot were performed on the hippocampus. |
2024-07-23 |
2024-07-25 |
rat |
| P Panczyszyn-Trzewik, P Misztak, G Nowak, M Sowa-Kucm. Association of Α-Klotho with regulation of Keap1/Nrf2/Interleukin-1 pathway and AMPA receptor trafficking in the brain of suicide victims. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 75. issue 3. 2024-07-23. PMID:39042386. |
commercially available enzyme-linked immunoassay (elisa) and western blot analysis were performed in the hippocampus (hp) and frontal cortex (fcx) of suicide victims and matched controls. |
2024-07-23 |
2024-07-25 |
Not clear |
| Jeferson Jantsch, Fernanda da Silva Rodrigues, Victor Silva Dias, Gabriel de Farias Fraga, Sarah Eller, Márcia Giovenardi, Renata Padilha Guede. Calorie Restriction Attenuates Memory Impairment and Reduces Neuroinflammation in Obese Aged Rats. Molecular neurobiology. 2024-07-22. PMID:39037530. |
western blot data indicate that the obesogenic diet may disrupt the blood-brain barrier and lead to an increase in toll-like receptor 4 in the hippocampus, events that could contribute to the cognitive deficits observed. |
2024-07-22 |
2024-07-24 |
rat |
| Yuanyuan Wang, Xin Men, Xiaodong Huang, Xiaoxiao Qiu, Weilong Wang, Jin Zhou, Zhenfeng Zho. Unraveling the signaling network between dysregulated microRNA and mRNA expression in sevoflurane-induced developmental neurotoxicity in rat. Heliyon. vol 10. issue 13. 2024-07-19. PMID:39027541. |
rats were exposed to sevoflurane for 4 h on their seventh day after birth, and the hippocampus was collected for analysis of neuroapoptosis by western blot and immunohistochemistry. |
2024-07-19 |
2024-07-21 |
rat |