| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weijia Chen, Pengli Guo, Lili Su, Xiangjuan Guo, Meiling Shi, Jianan Geng, Ying Zong, Yan Zhao, Rui Du, Zhongmei H. Combining Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Total Ginsenoside Ginseng Root and Its Impact on Antidepressant Effects. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684318. |
the results showed that tggr improved depression-like behavior in mice and increased the decrease in serum 5-hydroxytryptamine (5-ht) and brain-derived neurotrophic factor (bdnf) levels caused by cums. |
2024-12-17 |
2024-12-21 |
mouse |
| Johann Emilio Gonzales Embang, Ying Hui Valerie Tan, Yu Xuan Ng, Gerard Jude Ponce Loyola, Lik-Wei Wong, Yuqing Guo, Yanhong Don. Role of sleep and neurochemical biomarkers in synaptic plasticity related to neurological and psychiatric disorders: A scoping review. Journal of neurochemistry. vol 169. issue 1. 2024-12-15. PMID:39676063. |
slow-wave and rapid-eye movement sleep, sleep spindles, sleep cycle disruption, k-complex(kc) density, hippocampal seeg, bdnf, il-6, inos mrna expression, plasma serotonin, csf aβ-42, t-tau and p-tau proteins, and serum cortisol revealed associations with cognitive dysfunction. |
2024-12-15 |
2024-12-21 |
Not clear |
| Wenbao Jia, Qianting Ma, Ruixue Xing, Xiaolu Yang, Dongmin Liu, Hongliang Zeng, Zhen Liu, Shujuan Liu, Wei Xu, Zhonghua Liu, Wenliang W. Jianghua Kucha black tea containing theacrine attenuates depression-like behavior in CUMS mice by regulating gut microbiota-brain neurochemicals and cytokines. Food research international (Ottawa, Ont.). vol 198. 2024-12-06. PMID:39643357. |
furthermore, jh upregulated levels of monoamine neurotransmitters (5-ht and da) and brain-derived neurotrophic factor (bdnf), while downregulating pro-inflammatory cytokines il-6 and tnf-α in brain tissue. |
2024-12-06 |
2024-12-10 |
mouse |
| Ning Ma, Hong Wang, Qing Lu, Jinren Liu, Xiaolin Fan, Liang Li, Qi Wang, Xiao Li, Boya Yu, Yuhao Zhang, Junhong Ga. Temporal changes of neurobehavior in rats following varied blast magnitudes and screening of serum biomarkers in early stage of brain injury. Scientific reports. vol 14. issue 1. 2024-12-03. PMID:39627295. |
serum dopamine (da), 5-hydroxytryptamine (5-ht), brain-derived neurotrophic factor (bdnf) and gamma-aminobutyric acid (gaba) were measured at the same time points. |
2024-12-03 |
2024-12-06 |
rat |
| Ning Ma, Hong Wang, Qing Lu, Jinren Liu, Xiaolin Fan, Liang Li, Qi Wang, Xiao Li, Boya Yu, Yuhao Zhang, Junhong Ga. Temporal changes of neurobehavior in rats following varied blast magnitudes and screening of serum biomarkers in early stage of brain injury. Scientific reports. vol 14. issue 1. 2024-12-03. PMID:39627295. |
(3) the serum da levels decreased significantly at 1 d post-exposure in the medium and high overpressure groups; the 5-ht levels decreased significantly at 1 d and 90 d in the high overpressure groups; the bdnf levels decreased significantly at 90 d in the high overpressure groups. |
2024-12-03 |
2024-12-06 |
rat |
| Viviana Ciraci, Letizia Santoni, Enrico Tongiorg. Selective Noradrenergic Activation of BDNF Translation by Mirtazapine. Molecular neurobiology. 2024-11-18. PMID:39557799. |
in this study, we used the human neuroblastoma sh-sy5y cell line to investigate whether mirtazapine could enhance bdnf translation by modulating serotonin and/or norepinephrine and their receptors. |
2024-11-18 |
2024-11-22 |
human |
| Koilmani Emmanuvel Rajan, Baskaran Nishanthini, Swamynathan Sowndhary. AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins. Neurochemical research. vol 50. issue 1. 2024-11-18. PMID:39556261. |
further analysis showed reduction of 5-aminoimidazole-4-carboxamide ribonucleoside (aicar, a metabolite involved in purine metabolism) an amp kinase activator, influenced the hypoxanthine-guanine phosphoribosyltransferase (hprt), serotonin transporter (sert), postsynaptic density protein (psd) -95, its phosphorylation and brain-derived neurotrophic factor (bdnf) in crs animals, which displayed deficit in memory. |
2024-11-18 |
2024-11-22 |
rat |
| Priyanka Agrawal, Pallavi Singh, K P Sing. Vilazodone exposure during pregnancy: Effects on embryo-fetal development, pregnancy outcomes and fetal neurotoxicity by BDNF/Bax-Bcl2/5-HT mediated mechanisms. Neurotoxicology. 2024-11-12. PMID:39532268. |
these effects were associated with developmental neurotoxicity, which manifested as decreased fetal brain size and weight, a substantial reduction in neocortical layer thickness, brain-derived neurotrophic factor (bdnf) expression, serotonin, dopamine, and norepinephrine neurotransmitter levels (5-ht, da, and ne), and increased apoptotic activity (bax and bcl-2 ratio) and acetylcholinesterase levels in the developing brain. |
2024-11-12 |
2024-11-17 |
rat |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
background mood disorders like major depressive disorder (mdd) and bipolar disorder (bd) involve complex interactions between brain-derived neurotrophic factor (bdnf) and serotonin. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
this study uniquely addresses this gap by examining how bdnf and serotonin interact and relate to mood disorder severity, providing new insights into their joint role in mdd and bd. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
objectives the objective of this study was to examine the correlation between serum bdnf and plasma serotonin levels and to assess how these correlations relate to the severity of symptoms and overall disease severity in mdd and bd. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
methodology this cross-sectional study, conducted at the khyber medical university, peshawar, from january to september 2023, examined the correlation between bdnf and serotonin in individuals with mdd and bd. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
serum bdnf and serotonin levels were analyzed using enzyme-linked immunosorbent assay (elisa) kits. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
in the mdd group, significant negative correlations were observed between bdnf levels and mood disorder severity (r = -0.32, p = 0.045), whereas serotonin levels did not show significant correlations (r = -0.21, p = 0.23). |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
in the bd group, bdnf levels also showed a significant negative correlation with manic symptoms (r = -0.28, p = 0.048), but serotonin levels showed no significant correlation. |
2024-11-04 |
2024-11-06 |
human |
| Mian Rohail Hayat, Muhammad Umair, Hina Ikhtiar, Shandana Wazir, Ameena Palwasha, Maheen Sha. The Relationship Between Brain-Derived Neurotrophic Factor and Serotonin in Major Depressive and Bipolar Disorders: A Cross-Sectional Analysis. Cureus. vol 16. issue 10. 2024-11-04. PMID:39493096. |
those without comorbidities also had higher bdnf levels (23.8 ± 5.9 ng/ml) than those with comorbidities (18.2 ± 4.5 ng/ml), while serotonin levels varied similarly across these subgroups. |
2024-11-04 |
2024-11-06 |
human |
| Osmar Henrique Dos Santos Junior, Severina Cassia de Andrade Silva, Maria Daniele Teixeira Beltrão de Lemos, Thyago de Oliveira Rodrigues, Aline Isabel da Silva, Claudia J Lagranh. Effects of serotonergic manipulation in the brainstem and hypothalamus of overnourished rats during lactation. Life sciences. 2024-11-03. PMID:39490520. |
the fluoxetine treatment was performed from postnatal day 3 (pnd3) to postnatal day 21 (pnd21) to evaluate mitochondrial function, oxidative balance, and the mrna levels of monoaminergic molecules such as serotonin and dopamine, pro-inflammatory cytokines, and bdnf. |
2024-11-03 |
2024-11-06 |
rat |
| Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-Na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-En Deng, Yuanyuan Zhang, Yimeng Feng, Junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Gen. Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. European journal of pharmacology. 2024-10-19. PMID:39426465. |
it also decreased serum adrenal cortical hormone (acth) and corticosterone (cort) levels while increasing 5-ht and brain-derived neurotrophic factor (bdnf) levels in the cums rats, as measured by the enzyme-linked immunosorbent assay (elisa). |
2024-10-19 |
2024-10-22 |
rat |
| b' Dominika Jar\\xc4\\x8du\\xc5\\xa1kov\\xc3\\xa1, Ivan Tk\\xc3\\xa1\\xc4\\x8d, Nata\\xc5\\xa1a Hlav\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa1, Alena Stan\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1 Yaluri, Miriam Koz\\xc3\\xa1rov\\xc3\\xa1, Viera Habalov\\xc3\\xa1, Lucia Klim\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1, Jozef \\xc5\\xbdidzik, Martin Javorsk\\xc3\\xbd, Aneta Bedn\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder. BMC psychiatry. vol 24. issue 1. 2024-10-16. PMID:39407134.' |
this study investigated the association between genetic variants involved in serotonin signaling and brain-derived neurotrophic factor (bdnf) with the response to escitalopram treatment in patients with mdd. |
2024-10-16 |
2024-10-18 |
Not clear |
| Nevine Fathy, Merna A Labib, Reham M Essam, Noha A El-Boghdad. The Interplay between MiR-134/BDNF and LKB1/AMPK/SIRT1 Accentuates the Antidepressant Efficacy of Empagliflozin in Ovariectomized Rats. ACS chemical neuroscience. 2024-10-01. PMID:39350330. |
moreover, empa curtailed ovx-induced alterations of serum estradiol, hippocampal serotonin, mir-134 expression, as well as bdnf. |
2024-10-01 |
2024-10-03 |
rat |