| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuichi Chiba, Tadahiro Numakawa, Midori Ninomiya, Misty C Richards, Chisato Wakabayashi, Hiroshi Kunug. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22664354. |
we investigated the effects of chronic restraint stress (crs: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (gr) expression as well as brain-derived neurotrophic factor (bdnf)-dependent neural function in the prefrontal cortex (pfc). |
2013-01-21 |
2023-08-12 |
human |
| Shuichi Chiba, Tadahiro Numakawa, Midori Ninomiya, Misty C Richards, Chisato Wakabayashi, Hiroshi Kunug. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22664354. |
when the pfc was removed after crs and subject to western blot analysis, the gr expression reduced compared with control, while the levels of bdnf and its receptors remained unchanged. |
2013-01-21 |
2023-08-12 |
human |
| Wei-Sheng Wang, Shuo Kang, Wen-Tao Liu, Mu Li, Yao Liu, Chuan Yu, Jie Chen, Zhi-Qiang Chi, Ling He, Jing-Gen Li. Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 40. 2013-01-17. PMID:23035088. |
we found that cpa extinction training induced an increase in recruiting camp response element-binding protein (creb) to and acetylation of histone h3 at the promoters of bdnf exon i transcript and increased bdnf mrna and protein expression in the ventromedial prefrontal cortex (vmpfc) of acute morphine-dependent rats and that such epigenetic regulation of bdnf gene transcription could be facilitated or diminished by intra-vmpfc infusion of hdac inhibitor trichostatin a or extracellular signal-regulated kinase (erk) inhibitor u0126 (1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene) before extinction training. |
2013-01-17 |
2023-08-12 |
rat |
| Jos Prickaerts, Jochen De Vry, Janneke Boere, Gunter Kenis, Maria S Quinton, Sharon Engel, Larry Melnick, Rudy Schreibe. Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. Journal of molecular neuroscience : MN. vol 48. issue 1. 2013-01-09. PMID:22581450. |
differential bdnf responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. |
2013-01-09 |
2023-08-12 |
rat |
| Jos Prickaerts, Jochen De Vry, Janneke Boere, Gunter Kenis, Maria S Quinton, Sharon Engel, Larry Melnick, Rudy Schreibe. Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. Journal of molecular neuroscience : MN. vol 48. issue 1. 2013-01-09. PMID:22581450. |
the prefrontal cortex contained increased bdnf levels only after dov 216,303 treatment. |
2013-01-09 |
2023-08-12 |
rat |
| Yoko Furukawa-Hibi, Atsumi Nitta, Hidefumi Fukumitsu, Hitomi Somiya, Kazuya Toriumi, Shoei Furukawa, Toshitaka Nabeshima, Kiyofumi Yamad. Absence of SHATI/Nat8l reduces social interaction in mice. Neuroscience letters. vol 526. issue 2. 2012-12-19. PMID:22940080. |
lack of the shati gene increased brain-derived neurotrophic factor (bdnf) mrna in the prefrontal cortex and hippocampus, and decreased glial cell line-derived neurotrophic factor (gdnf) mrna in the striatum and hippocampus, and lipopolysaccharides-induced tnf-α factor (litaf) mrna in the striatum. |
2012-12-19 |
2023-08-12 |
mouse |
| Franciela P Della, Helena M Abelaira, Gislaine Z Réus, Karine F Ribeiro, Altamir R Antunes, Giselli Scaini, Isabela C Jeremias, Lis Mairá M dos Santos, Gabriela C Jeremias, Emilio L Streck, João Queved. Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats. Behavioural brain research. vol 233. issue 2. 2012-12-10. PMID:22659397. |
the bdnf levels were increased in the prefrontal cortex with tianeptine and decreased in the nucleus accumbens after acute treatment; in chronic treatment, bdnf levels were increased in the prefrontal and hippocampus with tianeptine. |
2012-12-10 |
2023-08-12 |
rat |
| Gislaine Z Réus, Helena M Abelaira, Fabiano R Agostinho, Karine F Ribeiro, Marcelo F Vitto, Thais F Luciano, Claúdio T de Souza, João Queved. The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. Journal of psychiatric research. vol 46. issue 8. 2012-12-04. PMID:22575330. |
adult wistar rats received an acute injection of olz (3 or 6 mg/kg) and/or flx (12.5 or 25 mg/kg), and were evaluated for akt, bdnf, creb, bcl-2 and bad protein levels in the prefrontal cortex, hippocampus and striatum. |
2012-12-04 |
2023-08-12 |
rat |
| Gislaine Z Réus, Helena M Abelaira, Fabiano R Agostinho, Karine F Ribeiro, Marcelo F Vitto, Thais F Luciano, Claúdio T de Souza, João Queved. The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. Journal of psychiatric research. vol 46. issue 8. 2012-12-04. PMID:22575330. |
our results showed that treatment with flx and olz alone or in combination increased the akt, creb, bdnf, bcl-2 and bad levels in the prefrontal cortex, hippocampus and striatum. |
2012-12-04 |
2023-08-12 |
rat |
| Nataly Ladurelle, Cecilia Gabriel, Adela Viggiano, Elisabeth Mocaër, Etienne E Baulieu, Massimiliano Bianch. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology. vol 221. issue 3. 2012-11-26. PMID:22160164. |
agomelatine (s20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and bdnf in the rat hippocampus, amygdala and pfc. |
2012-11-26 |
2023-08-12 |
rat |
| R Andero, K J Ressle. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior. vol 11. issue 5. 2012-11-20. PMID:22530815. |
specifically, bdnf gene expression and activation of its high-affinity tropomyosin-related kinase b (trkb) receptor are necessary in the amygdala, hippocampus and prefrontal cortex for the formation of emotional memories, including fear memories. |
2012-11-20 |
2023-08-12 |
Not clear |
| Hyemee Park, Doyoung Yoo, Sunoh Kwon, Tae-Won Yoo, Hi-Joon Park, Dae-Hyun Hahm, Hyejung Lee, Seung-Tae Ki. Acupuncture stimulation at HT7 alleviates depression-induced behavioral changes via regulation of the serotonin system in the prefrontal cortex of maternally-separated rat pups. The journal of physiological sciences : JPS. vol 62. issue 4. 2012-10-29. PMID:22627707. |
the immobility time of maternally-separated rat pups was increased, and increased 5-htt expression and reduced bdnf level were observed in the pfc. |
2012-10-29 |
2023-08-12 |
rat |
| Rong-Jian Liu, Francis S Lee, Xiao-Yuan Li, Francis Bambico, Ronald S Duman, George K Aghajania. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological psychiatry. vol 71. issue 11. 2012-10-04. PMID:22036038. |
it was hypothesized, given evidence that local synapse formation is dependent on dendritic translation of bdnf messenger rna, that loss-of-function met allele mice would show synaptic deficits both at baseline and in response to ketamine, an n-methyl-d-aspartate antagonist that stimulates synaptogenesis in prefrontal cortex (pfc). |
2012-10-04 |
2023-08-12 |
mouse |
| André Veloso Lima Rueda, Ana Maria Aristimunho Teixeira, Mauricio Yonamine, Rosana Camarin. Environmental enrichment blocks ethanol-induced locomotor sensitization and decreases BDNF levels in the prefrontal cortex in mice. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22126132. |
environmental enrichment blocks ethanol-induced locomotor sensitization and decreases bdnf levels in the prefrontal cortex in mice. |
2012-10-01 |
2023-08-12 |
mouse |
| André Veloso Lima Rueda, Ana Maria Aristimunho Teixeira, Mauricio Yonamine, Rosana Camarin. Environmental enrichment blocks ethanol-induced locomotor sensitization and decreases BDNF levels in the prefrontal cortex in mice. Addiction biology. vol 17. issue 4. 2012-10-01. PMID:22126132. |
both repeated ethanol and ee decreased bdnf levels in the prefrontal cortex but not in the hippocampus. |
2012-10-01 |
2023-08-12 |
mouse |
| Ann M Hemmerle, Jonathan W Dickerson, Nicole R Herring, Tori L Schaefer, Charles V Vorhees, Michael T Williams, Kim B Seroog. (±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. The Journal of comparative neurology. vol 520. issue 11. 2012-09-28. PMID:22237931. |
the prefrontal cortex was particularly vulnerable to mdma-induced alterations in that bdnf, nt-3, trkb, and trkc mrnas were all upregulated at multiple time points. |
2012-09-28 |
2023-08-12 |
rat |
| Fabio Fumagalli, Francesca Calabrese, Alessia Luoni, Francesca Bolis, Giorgio Racagni, Marco A Riv. Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress. The international journal of neuropsychopharmacology. vol 15. issue 2. 2012-09-27. PMID:21349227. |
the aim of this study was to investigate the ability of chronic treatment with the novel antipsychotic lurasidone to modulate bdnf expression in hippocampus and prefrontal cortex, under basal conditions or in response to an acute stress, a major precipitating element in psychiatric disorders. |
2012-09-27 |
2023-08-12 |
rat |
| Fabio Fumagalli, Francesca Calabrese, Alessia Luoni, Francesca Bolis, Giorgio Racagni, Marco A Riv. Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress. The international journal of neuropsychopharmacology. vol 15. issue 2. 2012-09-27. PMID:21349227. |
by means of real-time pcr, we found that (1) chronic lurasidone treatment increases total bdnf mrna levels in rat prefrontal cortex and, to less extent, in hippocampus; (2) the modulation of bdnf mrna levels in response to acute swim stress in lurasidone-treated rats was markedly potentiated in hippocampus, and to less extent in prefrontal cortex, through the selective regulation of different neurotrophin isoforms. |
2012-09-27 |
2023-08-12 |
rat |
| Fabio Fumagalli, Francesca Calabrese, Alessia Luoni, Francesca Bolis, Giorgio Racagni, Marco A Riv. Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress. The international journal of neuropsychopharmacology. vol 15. issue 2. 2012-09-27. PMID:21349227. |
the increase of bdnf mrna levels in prefrontal cortex was paralleled by an enhancement of mature bdnf protein levels. |
2012-09-27 |
2023-08-12 |
rat |
| Gislaine Z Réus, Helena M Abelaira, Roberto B Stringari, Gabriel R Fries, Flávio Kapczinski, João Queved. Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22327556. |
memantine treatment reverses anhedonia, normalizes corticosterone levels and increases bdnf levels in the prefrontal cortex induced by chronic mild stress in rats. |
2012-09-07 |
2023-08-12 |
rat |