| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaurav Patki, Naimesh Solanki, Fatin Atrooz, Farida Allam, Samina Sali. Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress. Brain research. vol 1539. 2014-06-20. PMID:24096214. |
furthermore, brain extracellular signal-regulated kinase-1/2 (erk1/2), and an inflammatory marker, interleukin (il)-6 were activated (p<0.05), while the protein levels of glyoxalase (glo)-1, glutathione reductase (gsr)-1, calcium/calmodulin-dependent protein kinase type (camk)-iv, camp-response-element-binding protein (creb) and brain-derived neurotrophic factor (bdnf) were significantly less (p<0.05) in the hippocampus, but not in the prefrontal cortex and amygdala of socially defeated rats, when compared to control rats. |
2014-06-20 |
2023-08-12 |
rat |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
brain-derived neurotrophic factor (bdnf) signaling through its receptor, tropomyosin receptor kinase b (trkb), plays a critical role in neural plasticity and its dysregulation in striatum and prefrontal cortex (pfc) has been implicated in the etiology of mental health disorders such schizophrenia and drug addiction. |
2014-06-09 |
2023-08-12 |
rat |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
in the present study, we characterized age-dependent differences in bdnf signaling and trkb expression within the nucleus accumbens (nac), caudate putamen (cp) and pfc in rats and determined the effects of administration of the dopamine agonist, skf 83959, which activates the gq-coupled dopamine receptors, the dopamine d5 receptor and the d1-d2 receptor heteromer. |
2014-06-09 |
2023-08-12 |
rat |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
conversely, in pfc the basal expression of bdnf in juvenile rats was significantly lower than in adult rats with an elevated relative expression of trkbfull. |
2014-06-09 |
2023-08-12 |
rat |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
acute administration of skf 83959 to juvenile rats abolished the age-dependent differences in bdnf expression in nac and pfc, and in the relative expression of trkbfull in nac and cp. |
2014-06-09 |
2023-08-12 |
rat |
| Melissa L Perreault, Theresa Fan, Brian F O'Dowd, Susan R Georg. Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Developmental neuroscience. vol 35. issue 5. 2014-06-09. PMID:24021607. |
together these findings indicate that the expression and/or signaling of bdnf and trkb in striatum and pfc of juvenile rats is fundamentally different from that of adult rats, a finding that may have implications in neuropsychiatric disorders that exhibit age-dependent susceptibility such as schizophrenia and drug addiction. |
2014-06-09 |
2023-08-12 |
rat |
| Walaiporn Tongjaroenbuangam, Nootchanart Ruksee, Thanutchaporn Mahanam, Piyarat Govitrapon. Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain. Neurochemistry international. vol 63. issue 5. 2014-06-02. PMID:24036059. |
furthermore, dex reduced brain-derived neurotrophic factor (bdnf), n-methyl-d-aspartate (nmda) receptor subunit (nr2a/b), calcium/calmodulin-dependent protein kinase ii (camkii) in both the prefrontal cortex and hippocampus and synaptophysin in the prefrontal cortex. |
2014-06-02 |
2023-08-12 |
mouse |
| Jérémie Charbord, Pauline Poydenot, Caroline Bonnefond, Maxime Feyeux, Fabrice Casagrande, Benjamin Brinon, Laetitia Francelle, Gwenaelle Aurégan, Martine Guillermier, Michel Cailleret, Pedro Viegas, Camille Nicoleau, Cécile Martinat, Emmanuel Brouillet, Elena Cattaneo, Marc Peschanski, Marc Lechuga, Anselme L Perrie. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem cells (Dayton, Ohio). vol 31. issue 9. 2014-05-07. PMID:23712629. |
acute intraventricular delivery of x5050 increased the expressions of bdnf and several other rest-regulated genes in the prefrontal cortex of mice with quinolinate-induced striatal lesions. |
2014-05-07 |
2023-08-12 |
mouse |
| Junshi Wang, Sanya Fanous, Ernest F Terwilliger, Caroline E Bass, Ronald P Hammer, Ella M Nikulin. BDNF overexpression in the ventral tegmental area prolongs social defeat stress-induced cross-sensitization to amphetamine and increases ΔFosB expression in mesocorticolimbic regions of rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23689674. |
additionally, overexpression of bdnf in the vta alone increased Δfosb in the nucleus accumbens (nac) and prefrontal cortex. |
2014-05-05 |
2023-08-12 |
rat |
| Francesca Calabrese, Gianluigi Guidotti, Giorgio Racagni, Marco A Riv. Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23870838. |
on this basis, the purpose of this study was to provide a detailed investigation of the bdnf system, at transcriptional and translational levels, in the ventral and dorsal hippocampus and in the prefrontal cortex of middle-aged and old rats, compared with in adult animals. |
2014-04-02 |
2023-08-12 |
human |
| Cheryl A Frye, Carolyn J Koonce, Alicia A Wal. Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex. Neuroscience letters. vol 551. 2014-03-21. PMID:23872095. |
levels of brain-derived neurotrophic factor (bdnf) in the prefrontal cortex and hippocampus were lowest among mice administered mpa. |
2014-03-21 |
2023-08-12 |
mouse |
| Jennifer Blaze, Lisa Scheuing, Tania L Rot. Differential methylation of genes in the medial prefrontal cortex of developing and adult rats following exposure to maltreatment or nurturing care during infancy. Developmental neuroscience. vol 35. issue 4. 2014-03-19. PMID:23751776. |
the current study was designed to determine whether exposure to maltreatment or nurturing care is associated with differential methylation of candidate gene loci (bdnf and reelin) within the medial pfc (mpfc) of developing and adult rats. |
2014-03-19 |
2023-08-12 |
rat |
| P V Agostino, R-K Cheng, C L Williams, A E West, W H Mec. Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. Genes, brain, and behavior. vol 12. issue 6. 2014-02-25. PMID:23848551. |
additionally, control mice given microinjections of bdnf antisense oligodeoxynucleotide to inhibit protein expression in the prefrontal cortex showed timing impairments during acquisition similar to carf mice. |
2014-02-25 |
2023-08-12 |
mouse |
| Alja Videtič Paska, Tomaž Zupanc, Peter Pregel. The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior. Psychiatria Danubina. vol 25 Suppl 2. 2014-02-25. PMID:23995205. |
it was also found that the mrna and protein level of bdnf was significantly lower in both the prefrontal cortex and the hippocampus of suicide subjects. |
2014-02-25 |
2023-08-12 |
human |
| Clarissa M Comim, Bruna P Mendonça, Diogo Dominguini, Andreza L Cipriano, Amanda V Steckert, Giselli Scaini, Mariz Vainzof, Emílio L Streck, Felipe Dal-Pizzol, João Queved. Central nervous system involvement in the animal model of myodystrophy. Molecular neurobiology. vol 48. issue 1. 2014-02-12. PMID:23508358. |
in summary, it was observed that homozygous mice presented impairment to the habituation and avoidance memory tasks; low levels of brain-derived neurotrophic factor (bdnf) in the prefrontal cortex, hippocampus, cortex and cerebellum; increased lipid peroxidation in the prefrontal cortex, hippocampus, striatum, and cerebellum; an increase of protein peroxidation in the prefrontal cortex, hippocampus, striatum, cerebellum, and cortex; a decrease of complex i activity in the prefrontal cortex and cerebellum; a decrease of complex ii activity in the prefrontal cortex and cerebellum; a decrease of complex iv activity in the prefrontal cortex and cerebellum; an increase in the cortex; and an increase of creatine kinase activity in the striatum and cerebellum. |
2014-02-12 |
2023-08-12 |
mouse |
| Susan L Andersen, Kai C Sonnta. Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood. Frontiers in synaptic neuroscience. vol 6. 2014-01-30. PMID:24478696. |
juvenile methylphenidate reduces prefrontal cortex plasticity via d3 receptor and bdnf in adulthood. |
2014-01-30 |
2023-08-12 |
rat |
| Laura Psotta, Volkmar Lessmann, Thomas Endre. Impaired fear extinction learning in adult heterozygous BDNF knock-out mice. Neurobiology of learning and memory. vol 103. 2014-01-24. PMID:23578839. |
this deficit in extinction learning is accompanied by a reduction of bdnf protein in the hippocampus, amygdala and the prefrontal cortex. |
2014-01-24 |
2023-08-12 |
mouse |
| Min Meng, Xinhan Zhao, Yonghui Dang, Jingyuan Ma, Lixu Li, Shanzhi G. Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice. Brain research. vol 1519. 2014-01-23. PMID:23623815. |
however, after reinstatement induced by exposure to 6 min of forced swimming (fs), expression of bdnf splice variants ii, iv and vi was increased in the hippocampus, cpu, nacc and prefrontal cortex (pfc). |
2014-01-23 |
2023-08-12 |
mouse |
| Min Meng, Xinhan Zhao, Yonghui Dang, Jingyuan Ma, Lixu Li, Shanzhi G. Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice. Brain research. vol 1519. 2014-01-23. PMID:23623815. |
after reinstatement induced by 40 min of restraint, expression of bdnf splice variants was increased in pfc. |
2014-01-23 |
2023-08-12 |
mouse |
| Yi-Yung Hung, Tiao-Lai Huan. Lower serum tropomyosin receptor kinase B levels in patients with schizophrenia. Biomedical journal. vol 36. issue 3. 2014-01-21. PMID:23806883. |
brain-derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. |
2014-01-21 |
2023-08-12 |
Not clear |