| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noriaki Hidaka, Katsuya Suemaru, Kenshi Takechi, Bingjin Li, Hiroaki Arak. Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains. Acta medica Okayama. vol 65. issue 4. 2012-01-05. PMID:21860534. |
to clarify the precise mechanism(s), we investigated the effect of valproate on such impairment and examined the levels of brain-derived neurotrophic factor (bdnf) and c-fos protein in the prefrontal cortex and the hippocampus 24h after the last administration of ecs. |
2012-01-05 |
2023-08-12 |
rat |
| Noriaki Hidaka, Katsuya Suemaru, Kenshi Takechi, Bingjin Li, Hiroaki Arak. Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains. Acta medica Okayama. vol 65. issue 4. 2012-01-05. PMID:21860534. |
repeated ecs increased the bdnf protein levels in the hippocampus and prefrontal cortex in the presence or absence of valproate, indicating that the increase in bdnf protein levels resulted from electrical stimulation. |
2012-01-05 |
2023-08-12 |
rat |
| Nashat Abumaria, Bin Yin, Ling Zhang, Xiang-Yao Li, Tao Chen, Giannina Descalzi, Liangfang Zhao, Matae Ahn, Lin Luo, Chen Ran, Min Zhuo, Guosong Li. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 42. 2011-12-08. PMID:22016520. |
in intact animals, elevation of brain magnesium increased nmda receptors (nmdars) signaling, bdnf expression, density of presynaptic puncta, and synaptic plasticity in the pfc but, interestingly, not in the basolateral amygdala. |
2011-12-08 |
2023-08-12 |
rat |
| Kai-Ren Luo, Chen-Jee Hong, Ying-Jay Liou, Sheue-Jane Hou, Yn-Ho Huang, Shih-Jen Tsa. Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 8. 2011-11-14. PMID:20728493. |
we measured bdnf and s100b protein levels in the serum, prefrontal cortex, striatum and hippocampus of rats in models of depression, i.e., olfactory bulbectomy (obx) and chronic unpredictable stress (cus) models. |
2011-11-14 |
2023-08-12 |
rat |
| Caroline M Coppens, Taweeporn Siripornmongcolchai, Karin Wibrand, Maria Nordheim Alme, Bauke Buwalda, Sietse F de Boer, Jaap M Koolhaas, Clive R Bramha. Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes. Frontiers in behavioral neuroscience. vol 5. 2011-11-10. PMID:22065953. |
we show that social defeat during adolescence and adulthood differentially regulates expression of the immediate early genes bdnf, arc, carp, and tieg1, as measured by qpcr in tissue lysates from prefrontal cortex, nucleus accumbens, and hippocampus. |
2011-11-10 |
2023-08-12 |
human |
| Hoau-Yan Wang, Domenica Crupi, Jingjing Liu, Andres Stucky, Giuseppe Cruciata, Alessandro Di Rocco, Eitan Friedman, Angelo Quartarone, M Felice Ghilard. Repetitive transcranial magnetic stimulation enhances BDNF-TrkB signaling in both brain and lymphocyte. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795553. |
here we show that daily 5 hz rtms for 5 d improves bdnf-trkb signaling in rats by increasing the affinity of bdnf for trkb, which results in higher tyrosine-phosphorylated trkb, increased recruitment of plc-γ1 and shc/n-shc to trkb, and heightened downstream erk2 and pi-3k activities in prefrontal cortex and in lymphocytes. |
2011-10-07 |
2023-08-12 |
human |
| Elizabeth S Chen, Carl Ernst, Gustavo Tureck. The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:21134314. |
the epigenetic effects of antidepressant treatment on human prefrontal cortex bdnf expression. |
2011-09-19 |
2023-08-12 |
human |
| A A Braun, N R Herring, T L Schaefer, A M Hemmerle, J W Dickerson, K B Seroogy, C V Vorhees, M T William. Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions. Neuroscience. vol 184. 2011-09-13. PMID:21453757. |
increases in bdnf mrna were also seen in the hippocampal ca1, prefrontal cortex (pfc), piriform cortex, and locus coeruleus but only at specific times. |
2011-09-13 |
2023-08-12 |
rat |
| B Ray, D L Gaskins, T J Sajdyk, J P Spence, S D Fitz, A Shekhar, D K Lahir. Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats. Neuroscience. vol 184. 2011-09-13. PMID:21477639. |
protein studies were then conducted to quantify levels of app, aβ, bdnf and presynaptic proteins in the prefrontal cortex (pfc). |
2011-09-13 |
2023-08-12 |
rat |
| Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Ana K Ferraro, Marcelo F Vitto, Patrícia Cesconetto, Claúdio T Souza, João Queved. Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21397634. |
the camp response element bindig (creb) and brain-derived neurotrophic factor (bdnf) protein levels and protein kinase c (pkc) and protein kinase a (pka) phosphorylation were assessed in the prefrontal cortex, hippocampus and amygdala by imunoblot. |
2011-09-06 |
2023-08-12 |
rat |
| Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Ana K Ferraro, Marcelo F Vitto, Patrícia Cesconetto, Claúdio T Souza, João Queved. Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21397634. |
combined treatment with ketamine and imipramine produced stronger increases of creb and bdnf protein levels in the prefrontal cortex, hippocampus and amygdala, and pka phosphorylation in the hippocampus and amygdala and pkc phosphorylation in prefrontal cortex. |
2011-09-06 |
2023-08-12 |
rat |
| Mia Thompson Ray, Cynthia Shannon Weickert, Eugene Wyatt, Maree J Webste. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. Journal of psychiatry & neuroscience : JPN. vol 36. issue 3. 2011-08-15. PMID:21223646. |
brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor (trkb-tk+) and glutamic acid decarboxylase (gad67) mrna levels have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. |
2011-08-15 |
2023-08-12 |
Not clear |
| Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Andreza L Cipriano, Bruna S Panizzutti, Laura Stertz, Camila Lersch, Flávio Kapczinski, João Queved. Maternal deprivation induces depressive-like behaviour and alters neurotrophin levels in the rat brain. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21161589. |
in addition adrenocorticotrophin hormone (acth) levels was assessed in serum and brain-derived-neurotrophic factor (bdnf), neurotrophin-3 (nt-3) and nerve growth factor (ngf) protein levels were assessed in prefrontal cortex, hippocampus and amygdala. |
2011-05-19 |
2023-08-12 |
rat |
| Hui Yu, Zhe-yu Che. The role of BDNF in depression on the basis of its location in the neural circuitry. Acta pharmacologica Sinica. vol 32. issue 1. 2011-04-25. PMID:21131999. |
here, we present an overview of the current knowledge concerning bdnf actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (nac) and amygdala as their relation to depression. |
2011-04-25 |
2023-08-12 |
Not clear |
| Ling Ma, Dong-Dong Wang, Tian-Yi Zhang, Hui Yu, Yue Wang, Shu-Hong Huang, Francis S Lee, Zhe-Yu Che. Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 6. 2011-03-25. PMID:21307245. |
cta conditioning induced increased bdnf levels in the central nuclei of amygdala (cea) and insular cortex, but not in the basolateral amygdala (bla) and ventromedial prefrontal cortex. |
2011-03-25 |
2023-08-12 |
Not clear |
| Fabio Fumagalli, Annamaria Cattaneo, Lucia Caffino, Marcello Ibba, Giorgio Racagni, Ezio Carboni, Massimo Gennarelli, Marco Andrea Riv. Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats: comparison with methylphenidate. Pharmacological research. vol 62. issue 6. 2011-03-11. PMID:20691787. |
opposite effects were seen in the prefrontal cortex, a critical region in attention disorders, where atx increased while mph reduced total and exon iv bdnf mrna levels. |
2011-03-11 |
2023-08-12 |
rat |
| Fabio Fumagalli, Annamaria Cattaneo, Lucia Caffino, Marcello Ibba, Giorgio Racagni, Ezio Carboni, Massimo Gennarelli, Marco Andrea Riv. Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats: comparison with methylphenidate. Pharmacological research. vol 62. issue 6. 2011-03-11. PMID:20691787. |
analysis of bdnf-mediated signalling in the prefrontal cortex revealed that atx enhanced akt and gsk3β phosphorylation whereas mph reduced the synaptic levels of trkb, the high-affinity bdnf receptor, and erk1/2 activation. |
2011-03-11 |
2023-08-12 |
rat |
| Fabio Fumagalli, Annamaria Cattaneo, Lucia Caffino, Marcello Ibba, Giorgio Racagni, Ezio Carboni, Massimo Gennarelli, Marco Andrea Riv. Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats: comparison with methylphenidate. Pharmacological research. vol 62. issue 6. 2011-03-11. PMID:20691787. |
our findings show that atx and mph exert an opposite modulation of the bdnf system, primarily in prefrontal cortex that, independently from the behavioral control exerted by the two drugs, may be important for long-term consequences on cognitive function. |
2011-03-11 |
2023-08-12 |
rat |
| Timothy W Whitfield, Xiangdang Shi, Wei-Lun Sun, Jacqueline F McGint. The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 3. 2011-02-23. PMID:21248106. |
we have previously demonstrated that infusion of bdnf into the dorsomedial prefrontal cortex (dmpfc) immediately after the last of 10 cocaine sa sessions attenuates contextual, cue- and cocaine prime-induced reinstatement of cocaine-seeking (berglind et al., 2007) and normalizes cocaine-induced disruption of glutamatergic transmission in the nucleus accumbens (berglind et al., 2009). |
2011-02-23 |
2023-08-12 |
rat |
| Frank Krueger, Matteo Pardini, Edward D Huey, Vanessa Raymont, Jeffrey Solomon, Robert H Lipsky, Colin A Hodgkinson, David Goldman, Jordan Grafma. The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 2. 2011-02-22. PMID:21228168. |
the human prefrontal cortex (pfc) shows lifelong neuroplastic adaption implicating the val66met bdnf polymorphism in the recovery of higher-order executive functions after traumatic brain injury (tbi). |
2011-02-22 |
2023-08-12 |
human |