| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hua Yuan, Hua Long, Jing Liu, Lili Qu, Jingzao Chen, Xiang Mo. Effects of infrasound on hippocampus-dependent learning and memory in rats and some underlying mechanisms. Environmental toxicology and pharmacology. vol 28. issue 2. 2011-09-08. PMID:21784010. |
it was found that mrna and protein expression levels of hippocampal bdnf and trkb were significantly decreased in real-time pcr and western blot, and the number of brdu-labeled cells in hippocampus was also reduced when compared to control. |
2011-09-08 |
2023-08-12 |
rat |
| Thierry Deltheil, Kenji Tanaka, Christelle Reperant, René Hen, Denis J David, Alain M Gardie. Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19236729. |
the present study examined neurochemical and behavioural consequences of an acute intrahippocampal injection of bdnf combined with an antidepressant by using in-vivo intracerebral microdialysis in the ventral hippocampus (vhi) in conscious mice and behavioural paradigms predictive of antidepressant and anxiolytic-like effects [the mouse forced swim test (fst), the open-field (of) paradigm and the elevated plus maze (epm)]. |
2011-09-06 |
2023-08-12 |
mouse |
| Thierry Deltheil, Kenji Tanaka, Christelle Reperant, René Hen, Denis J David, Alain M Gardie. Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19236729. |
finally, the neurochemical and behavioural effects of bdnf on the serotonergic system might occur at both pre- and post-synaptic levels since by using in-situ hybridization, we showed that trkb-r mrna was expressed in the hippocampus and the dorsal raphe nucleus in adult mice. |
2011-09-06 |
2023-08-12 |
mouse |
| Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Ana K Ferraro, Marcelo F Vitto, Patrícia Cesconetto, Claúdio T Souza, João Queved. Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21397634. |
the camp response element bindig (creb) and brain-derived neurotrophic factor (bdnf) protein levels and protein kinase c (pkc) and protein kinase a (pka) phosphorylation were assessed in the prefrontal cortex, hippocampus and amygdala by imunoblot. |
2011-09-06 |
2023-08-12 |
rat |
| Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Ana K Ferraro, Marcelo F Vitto, Patrícia Cesconetto, Claúdio T Souza, João Queved. Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behavioural brain research. vol 221. issue 1. 2011-09-06. PMID:21397634. |
combined treatment with ketamine and imipramine produced stronger increases of creb and bdnf protein levels in the prefrontal cortex, hippocampus and amygdala, and pka phosphorylation in the hippocampus and amygdala and pkc phosphorylation in prefrontal cortex. |
2011-09-06 |
2023-08-12 |
rat |
| Liqin Liu, Yan Luo, Ruirui Zhang, Jianyou Gu. [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 36. issue 10. 2011-09-06. PMID:21837980. |
whereas serum corticosterone level was significantly increased in rats exposed to cums, expressions of gr mrna in hippocampus, and bdnf mrna in hippocampus and frontal cortex, were decreased in cums-treated rats. |
2011-09-06 |
2023-08-12 |
mouse |
| Maria Giuseppina Pisu, Riccardo Dore, Maria Cristina Mostallino, Manila Loi, Francesca Pibiri, Roberta Mameli, Roberto Cadeddu, Pietro Paolo Secci, Mariangela Serr. Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21420441. |
down-regulation of hippocampal bdnf and arc associated with improvement in aversive spatial memory performance in socially isolated rats. |
2011-09-02 |
2023-08-12 |
rat |
| Maria Giuseppina Pisu, Riccardo Dore, Maria Cristina Mostallino, Manila Loi, Francesca Pibiri, Roberta Mameli, Roberto Cadeddu, Pietro Paolo Secci, Mariangela Serr. Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21420441. |
we now show that isolation of rats at weaning reduced immobility time in the forced swim test, decreased sucrose intake and preference, and down-regulated both brain-derived neurotrophic factor (bdnf) and activity-regulated cytoskeletal associated protein (arc) in the hippocampus. |
2011-09-02 |
2023-08-12 |
rat |
| Maria Giuseppina Pisu, Riccardo Dore, Maria Cristina Mostallino, Manila Loi, Francesca Pibiri, Roberta Mameli, Roberto Cadeddu, Pietro Paolo Secci, Mariangela Serr. Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21420441. |
isolated rats also showed an increase in the plasma level of corticosterone on the 5th day of training and increased expression of bdnf and arc in the hippocampus on both days 1 and 5. |
2011-09-02 |
2023-08-12 |
rat |
| Claudia A Grillo, Gerardo G Piroli, Kris F Kaigler, Steven P Wilson, Marlene A Wilson, Lawrence P Reaga. Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21458499. |
plasma, hippocampal and amygdalar brain-derived neurotrophic factor (bdnf) levels were reduced in hypo-iras rats, suggesting that the obesity/hyperleptinemic phenotype may elicit this behavioral phenotype through modulation of neurotrophic factor expression. |
2011-09-02 |
2023-08-12 |
rat |
| Claudia A Grillo, Gerardo G Piroli, Kris F Kaigler, Steven P Wilson, Marlene A Wilson, Lawrence P Reaga. Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats. Behavioural brain research. vol 222. issue 1. 2011-09-02. PMID:21458499. |
collectively, these data support the hypothesis for an increased risk for mood disorders in obesity, which may be related to decreased expression of hippocampal and amygdalar bdnf. |
2011-09-02 |
2023-08-12 |
rat |
| Zhen Huang, Xiao-Ming Zhong, Zhao-Yi Li, Chun-Rong Feng, Ai-Juan Pan, Qing-Qiu Ma. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neuroscience letters. vol 493. issue 3. 2011-09-01. PMID:21334417. |
repeated cort injections also significantly decreased brain-derived neurotrophic factor (bdnf) protein levels in the hippocampus and frontal cortex of the rats. |
2011-09-01 |
2023-08-12 |
rat |
| Zhen Huang, Xiao-Ming Zhong, Zhao-Yi Li, Chun-Rong Feng, Ai-Juan Pan, Qing-Qiu Ma. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neuroscience letters. vol 493. issue 3. 2011-09-01. PMID:21334417. |
the results suggest that curcumin produces an antidepressant-like effect in cort-treated rats, which is possibly mediated by increasing bdnf expression in the hippocampus and frontal cortex. |
2011-09-01 |
2023-08-12 |
rat |
| Tania L Roth, Phillip R Zoladz, J David Sweatt, David M Diamon. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of psychiatric research. vol 45. issue 7. 2011-08-30. PMID:21306736. |
epigenetic modification of hippocampal bdnf dna in adult rats in an animal model of post-traumatic stress disorder. |
2011-08-30 |
2023-08-12 |
rat |
| Tania L Roth, Phillip R Zoladz, J David Sweatt, David M Diamon. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of psychiatric research. vol 45. issue 7. 2011-08-30. PMID:21306736. |
we have found here that the psychosocial stress regimen significantly increased bdnf dna methylation in the dorsal hippocampus, with the most robust hypermethylation detected in the dorsal ca1 subregion. |
2011-08-30 |
2023-08-12 |
rat |
| Tania L Roth, Phillip R Zoladz, J David Sweatt, David M Diamon. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of psychiatric research. vol 45. issue 7. 2011-08-30. PMID:21306736. |
these results provide evidence that traumatic stress occurring in adulthood can induce cns gene methylation, and specifically, support the hypothesis that epigenetic marking of the bdnf gene may underlie hippocampal dysfunction in response to traumatic stress. |
2011-08-30 |
2023-08-12 |
rat |
| Tania L Roth, Phillip R Zoladz, J David Sweatt, David M Diamon. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. Journal of psychiatric research. vol 45. issue 7. 2011-08-30. PMID:21306736. |
furthermore, this work provides support for the speculative notion that altered hippocampal bdnf dna methylation is a cellular mechanism underlying the persistent cognitive deficits which are prominent features of the pathophysiology of ptsd. |
2011-08-30 |
2023-08-12 |
rat |
| Volkmar Lessmann, Sigrid Stroh-Kaffei, Violetta Steinbrecher, Elke Edelmann, Tanja Brigadski, Werner Kilb, Heiko J Luhman. The expression mechanism of the residual LTP in the CA1 region of BDNF k.o. mice is insensitive to NO synthase inhibition. Brain research. vol 1391. 2011-08-30. PMID:21458431. |
here we addressed the question whether the residual ltp in the ca1 region of hippocampal slices from heterozygous bdnf knockout mice (bdnf⁺/⁻) is dependent on nitric oxide (no) signaling. |
2011-08-30 |
2023-08-12 |
mouse |
| H F Zhao, Q Li, Y L. Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus. Neuroscience. vol 183. 2011-08-26. PMID:21463662. |
in the present study, we found that long-term ginsenoside treatment prevented age-related reductions of psd-95, pkcγ, and bdnf in the hippocampus. |
2011-08-26 |
2023-08-12 |
mouse |
| Akinobu Suzuki, Hotaka Fukushima, Takuya Mukawa, Hiroki Toyoda, Long-Jun Wu, Ming-Gao Zhao, Hui Xu, Yuze Shang, Kengo Endoh, Taku Iwamoto, Nori Mamiya, Emiko Okano, Shunsuke Hasegawa, Valentina Mercaldo, Yue Zhang, Ryouta Maeda, Miho Ohta, Sheena A Josselyn, Min Zhuo, Satoshi Kid. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677163. |
the importance of bdnf in stm was verified by microinfusing bdnf or bdnf inhibitors into the hippocampus of wild-type or transgenic mice. |
2011-08-22 |
2023-08-12 |
mouse |