| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kim Nuytens, Ilse Gantois, Pieter Stijnen, Emilia Iscru, Annelies Laeremans, Lutgarde Serneels, Lien Van Eylen, Stephen A Liebhaber, Koen Devriendt, Detlef Balschun, Lutgarde Arckens, John W M Creemers, Rudi D'Hoog. Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice. Neurobiology of disease. vol 51. 2013-07-24. PMID:23153818. |
the observed alterations in learning and memory and hippocampal ltp are concomitant with decreased expression of the immediate early gene zif268 in dorsomedial striatum and hippocampal ca1 region, increased creb phosphorylation, and increased hippocampal bdnf expression. |
2013-07-24 |
2023-08-12 |
mouse |
| Yang Yang, Xiao-Peng Jing, Shou-Peng Zhang, Run-Xia Gu, Fang-Xu Tang, Xiu-Lian Wang, Yan Xiong, Mei Qiu, Xu-Ying Sun, Dan Ke, Jian-Zhi Wang, Rong Li. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PloS one. vol 8. issue 1. 2013-07-22. PMID:23383172. |
high dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of bdnf signaling. |
2013-07-22 |
2023-08-12 |
mouse |
| Yang Yang, Xiao-Peng Jing, Shou-Peng Zhang, Run-Xia Gu, Fang-Xu Tang, Xiu-Lian Wang, Yan Xiong, Mei Qiu, Xu-Ying Sun, Dan Ke, Jian-Zhi Wang, Rong Li. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PloS one. vol 8. issue 1. 2013-07-22. PMID:23383172. |
in keeping with these findings, high dose intake of zinc resulted in decreased hippocampal bdnf level and trkb neurotrophic signaling. |
2013-07-22 |
2023-08-12 |
mouse |
| Yang Yang, Xiao-Peng Jing, Shou-Peng Zhang, Run-Xia Gu, Fang-Xu Tang, Xiu-Lian Wang, Yan Xiong, Mei Qiu, Xu-Ying Sun, Dan Ke, Jian-Zhi Wang, Rong Li. High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling. PloS one. vol 8. issue 1. 2013-07-22. PMID:23383172. |
these results indicate that zinc plays an important role in hippocampus-dependent learning and memory and bdnf expression, high dose supplementation of zinc induces specific zinc deficiency in hippocampus, which further impair learning and memory due to decreased availability of synaptic zinc and bdnf deficit. |
2013-07-22 |
2023-08-12 |
mouse |
| Pierangelo Cifelli, Eleonora Palma, Cristina Roseti, Gianluca Verlengia, Michele Simonat. Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. Frontiers in cellular neuroscience. vol 7. 2013-07-22. PMID:23874269. |
in the pilocarpine model, bdnf displayed a paramount effect, decreasing rundown in the hippocampus at the time of the first seizure, as well as in the hippocampus and cortex in the chronic period. |
2013-07-22 |
2023-08-12 |
human |
| Carlos V Melo, Miranda Mele, Michele Curcio, Diogo Comprido, Carla G Silva, Carlos B Duart. BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PloS one. vol 8. issue 1. 2013-07-19. PMID:23326507. |
bdnf regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. |
2013-07-19 |
2023-08-12 |
rat |
| Carlos V Melo, Miranda Mele, Michele Curcio, Diogo Comprido, Carla G Silva, Carlos B Duart. BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PloS one. vol 8. issue 1. 2013-07-19. PMID:23326507. |
cultured rat hippocampal neurons were incubated with 100 ng/ml bdnf, for different periods of time, and vglut gene and protein expression were assessed by real-time pcr and immunoblotting, respectively. |
2013-07-19 |
2023-08-12 |
rat |
| Carlos V Melo, Miranda Mele, Michele Curcio, Diogo Comprido, Carla G Silva, Carlos B Duart. BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PloS one. vol 8. issue 1. 2013-07-19. PMID:23326507. |
fluorescence microscopy imaging showed that bdnf stimulation upregulates the number, integrated density and intensity of vglut1 and vglut2 puncta in neurites of cultured hippocampal neurons (div7), indicating that the neurotrophin also affects the subcellular distribution of the transporter in developing neurons. |
2013-07-19 |
2023-08-12 |
rat |
| Zhengwei Li, Chengdong Sun, Tao Zhang, Jianbing Mo, Qiong Shi, Xianfeng Zhang, Maochun Yuan, Long Chen, Xueqiang Mao, Rutong Yu, Xiuping Zho. Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis. Journal of neurochemistry. vol 125. issue 5. 2013-07-19. PMID:23534605. |
we have previously demonstrated that ggt promotes the basal and neuronal activity and brain-derived neurotrophic factor (bdnf)-induced dendritic morphogenesis of cultured hippocampal neurons and cerebellar slices. |
2013-07-19 |
2023-08-12 |
rat |
| Zhengwei Li, Chengdong Sun, Tao Zhang, Jianbing Mo, Qiong Shi, Xianfeng Zhang, Maochun Yuan, Long Chen, Xueqiang Mao, Rutong Yu, Xiuping Zho. Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis. Journal of neurochemistry. vol 125. issue 5. 2013-07-19. PMID:23534605. |
in addition, ggt and its known substrate rac was activated by bdnf, which promotes synaptogenesis in cultured hippocampal neurons. |
2013-07-19 |
2023-08-12 |
rat |
| Megan Allen, Clark Bird, Wei Feng, Guanglu Liu, Wenqi Li, Nora I Perrone-Bizzozero, Yue Fen. HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383270. |
moreover, in a hud transgenic mouse model, the bdnf long 3'utr mrna is increased in the hippocampal dentate granule cells (dgcs), leading to elevated expression of bdnf protein that is transported and stored in the mossy fiber (mf) terminals. |
2013-07-17 |
2023-08-12 |
mouse |
| Bai Lu, Guhan Nagappan, Xiaoming Guan, Pradeep J Nathan, Paul Wre. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature reviews. Neuroscience. vol 14. issue 6. 2013-07-16. PMID:23674053. |
understanding the role of brain-derived neurotrophic factor (bdnf) in synaptic plasticity and synaptogenesis, the impact of the bdnf val66met polymorphism in alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. |
2013-07-16 |
2023-08-12 |
Not clear |
| Jianxin Zhao, Huazhou Xu, Yuanxiang Tian, Manxiang Hu, Hongling Xia. Effect of electroacupuncture on brain-derived neurotrophic factor mRNA expression in mouse hippocampus following cerebral ischemia-reperfusion injury. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 33. issue 2. 2013-07-16. PMID:23789227. |
this work aims to observe the effects of electroacupuncture on brain-derived neurotrophic factor (bdnf) mrna expression in mouse hippocampus following cerebral ischemia-reperfusion injury. |
2013-07-16 |
2023-08-12 |
mouse |
| Sung-Eun Kim, Il-Gyu Ko, Mal-Soon Shin, Chang-Ju Kim, Byung-Kwan Jin, Hoon-Pyo Hong, Yong-Seok Je. Treadmill exercise and wheel exercise enhance expressions of neutrophic factors in the hippocampus of lipopolysaccharide-injected rats. Neuroscience letters. vol 538. 2013-07-11. PMID:23403101. |
we found that brain inflammation impaired spatial learning ability and suppressed the induction of ltp in the hippocampus, as well as weakening expressions of brain-derived neurotrophic factor (bdnf) and its receptor tyrosine kinase b (trk-b) with the phosphorylated cyclic amp response element binding protein (p-creb). |
2013-07-11 |
2023-08-12 |
rat |
| Dongyu Min, Feng Guo, Shu Zhu, Xiaoxue Xu, Xiaoyuan Mao, Yonggang Cao, Xintong Lv, Qinghua Gao, Lei Wang, Tianbao Chen, Chris Shaw, Liying Hao, Jiqun Ca. The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia. Neuroscience letters. vol 538. 2013-07-11. PMID:23403102. |
here we have demonstrated changes in the levels of cav1.2, calmodulin, p-camkii, p-creb and bdnf proteins by western blot analysis and the co-localization of p-camkii/cav1.2 by double-labeling immunofluorescence in the hippocampus of app/ps1 mice and vd gerbils. |
2013-07-11 |
2023-08-12 |
mouse |
| Min Chul Lee, Koshiro Inoue, Masahiro Okamoto, Yu Fan Liu, Takashi Matsui, Jang Soo Yook, Hideaki Soy. Voluntary resistance running induces increased hippocampal neurogenesis in rats comparable to load-free running. Neuroscience letters. vol 537. 2013-07-09. PMID:23352660. |
recently, we reported that voluntary resistance wheel running with a resistance of 30% of body weight (rwr), which produces shorter distances but higher work levels, enhances spatial memory associated with hippocampal brain-derived neurotrophic factor (bdnf) signaling compared to wheel running without a load (wr) [17]. |
2013-07-09 |
2023-08-12 |
rat |
| A Ferrés-Coy, F Pilar-Cuellar, R Vidal, V Paz, M Masana, R Cortés, M C Carmona, L Campa, A Pazos, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis. Translational psychiatry. vol 3. 2013-07-04. PMID:23321808. |
moreover, short-term sert-sirna treatment modified mouse brain variables considered to be key markers of antidepressant action: reduced expression and function of 5-ht(1a)-autoreceptors, elevated extracellular serotonin in forebrain and increased neurogenesis and expression of plasticity-related genes (bdnf, vegf, arc) in hippocampus. |
2013-07-04 |
2023-08-12 |
mouse |
| Jing Li, Ying Zhou, Bin-Bin Liu, Qing Liu, Di Geng, Lian-Jin Weng, Li-Tao Y. Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-04. PMID:23573124. |
nobiletin ameliorates the deficits in hippocampal bdnf, trkb, and synapsin i induced by chronic unpredictable mild stress. |
2013-07-04 |
2023-08-12 |
mouse |
| Jing Li, Ying Zhou, Bin-Bin Liu, Qing Liu, Di Geng, Lian-Jin Weng, Li-Tao Y. Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-04. PMID:23573124. |
depressive-like anhedonia (assessed by sucrose preference) and serum corticosterone secretion were evaluated in the cums, followed by brain-derived neurotrophic factor (bdnf), its tropomyosin-related kinase receptor b (trkb), and the downstream target synapsin i expressions in the hippocampus. |
2013-07-04 |
2023-08-12 |
mouse |
| Jing Li, Ying Zhou, Bin-Bin Liu, Qing Liu, Di Geng, Lian-Jin Weng, Li-Tao Y. Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-04. PMID:23573124. |
furthermore, we also found that cums-induced deficits of hippocampal bdnf, trkb, and synapsin i were ameliorated by nobiletin. |
2013-07-04 |
2023-08-12 |
mouse |