| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanad M El-Khatib, Arya R Vagadia, Anh C D Le, Janet E Baulch, Ding Quan Ng, Mingyu Du, Kevin G Johnston, Zhiqun Tan, Xiangmin Xu, Alexandre Chan, Munjal M Achary. BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences. Acta neuropathologica communications. vol 12. issue 1. 2024-12-19. PMID:39696694. |
notably, rt-exposed mice exhibited significantly reduced hippocampal bdnf, accompanied by increased neuroinflammation, loss of neuronal plasticity-related immediate early gene product, cfos, and synaptic density. |
2024-12-19 |
2024-12-21 |
mouse |
| Mohamed Hesham Khali. The BDNF-Interactive Model for Sustainable Hippocampal Neurogenesis in Humans: Synergistic Effects of Environmentally-Mediated Physical Activity, Cognitive Stimulation, and Mindfulness. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684635. |
this paper bridges critical gaps through proposing a novel, environmentally mediated brain-derived neurotrophic factor (bdnf)-interactive model that promises to sustain adult hippocampal neurogenesis in humans. |
2024-12-17 |
2024-12-21 |
human |
| Bruna da Silva Oliveira, Thaís de Mérici Domingues E Paula, Lucas Carvalho Cardoso, João Vitor Lopes Ferreira, Caroline Amaral Machado, Heliana de Barros Fernandes, Brener Cunha Carvalho, Ingrid Dos Santos Freitas, Lorena Taveira Nogueira, Antônio Lúcio Teixeira, Eliana Cristina de Brito Toscano, Aline Silva de Miranda, Fernanda Radicchi Campos Lobato de Almeid. Caffeine intake during gestation and lactation causes long-term behavioral impairments in heterogenic mice offspring in a sex-dependent manner. Pharmacology, biochemistry, and behavior. 2024-12-16. PMID:39681183. |
hippocampal levels of cx3cl1 and bdnf were decreased in female f1tt and f2tt groups; while among males exposed to caffeine, only f1 offspring had reduced hippocampal cx3cl1 levels. |
2024-12-16 |
2024-12-21 |
mouse |
| Johann Emilio Gonzales Embang, Ying Hui Valerie Tan, Yu Xuan Ng, Gerard Jude Ponce Loyola, Lik-Wei Wong, Yuqing Guo, Yanhong Don. Role of sleep and neurochemical biomarkers in synaptic plasticity related to neurological and psychiatric disorders: A scoping review. Journal of neurochemistry. vol 169. issue 1. 2024-12-15. PMID:39676063. |
slow-wave and rapid-eye movement sleep, sleep spindles, sleep cycle disruption, k-complex(kc) density, hippocampal seeg, bdnf, il-6, inos mrna expression, plasma serotonin, csf aβ-42, t-tau and p-tau proteins, and serum cortisol revealed associations with cognitive dysfunction. |
2024-12-15 |
2024-12-21 |
Not clear |
| Keke Cui, Yiying Zhou, Lizhi Zhang, Yudong Ying, Yan Xue, Xiaoqin Zhang, Qinwen Wang, Haowei Shen, Wenhua Zhou, Feng Gao, Zhengchun Wan. Light Treatment Ameliorates Sub-chronic MK-801-Induced Cognitive Deficits in Mice Through Up-regulating BDNF/p-CREB/p-ERK Signaling Pathway. Molecular neurobiology. 2024-12-14. PMID:39673660. |
subsequent investigations revealed elevated levels of brain-derived neurotrophic factor (bdnf) and heightened phosphorylation of camp response element-binding phosphorylation protein (p-creb) in the hippocampus of the lt/cias group compared to the cias group. |
2024-12-14 |
2024-12-21 |
mouse |
| Yuanyu Song, Yinghua Chen, Wei Sun, Changqing Li, Junfeng Li, Haoyu Wang, Ruiqi Qin, Xiaoqing Su, Tong Wu, Hongxu Zhao, Yusheng Ha. [Exploration of electroacupuncture at "Fengchi" (GB 20) and "Sishencong" (EX-HN 1) for attenuating learning and memory impairment in vascular dementia rats based on NMDAR/CREB/BDNF signaling pathway]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 44. issue 12. 2024-12-10. PMID:39658379. |
to explore the mechanism of electroacupuncture (ea) at "fengchi" (gb 20) and "sishencong" (ex-hn 1) on learning and memory impairment in vascular dementia (vd) rats by observing the influences on the n-methyl-d-aspartate receptor (nmdar)/cyclic adenosine monophosphate response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling pathway and the excitotoxicity induced by hippocampal calcium overload. |
2024-12-10 |
2024-12-13 |
rat |
| Elif Türkdönmez Ak, Büşra Okuyucu, Burcu Hatipoğlu, Gökhan Arsla. The effect of acetylcholinesterase inhibitor rivastigmine in pentylenetetrazole-induced kindling model of epilepsy in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-12-06. PMID:39643806. |
in addition, 24 h after the ptz injection, the hippocampus was extracted and mrna expression levels of n-methyl d-aspartate receptor subunit 2b (nr2b) and brain-derived neurotrophic factor (bdnf) were measured by qpcr analysis. |
2024-12-06 |
2024-12-10 |
rat |
| Ya-Qi Yang, Murezati Tiliwaerde, Na-Na Gao, Wei Gu, Ting-Ting Zhang, Zeng-Liang Ji. GW117 induces anxiolytic effects by improving hippocampal functions. Pharmacology, biochemistry, and behavior. 2024-11-29. PMID:39613193. |
mechanistic studies revealed that gw117 notably increased the expression of bdnf, gfap, and bcl-2, while reducing bax and cleaved caspase-3 levels in the hippocampus of cums model rats. |
2024-11-29 |
2024-12-02 |
rat |
| Bo Pang, Ting Ca. Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. Behavioural pharmacology. 2024-11-29. PMID:39611623. |
in addition, hesperidin increased the expression of ampa receptor protein (glur1) and synaptic proteins (bdnf, psd95, synapsin1) in the hippocampus of cums-exposed mice. |
2024-11-29 |
2024-12-01 |
mouse |
| Bo Pang, Ting Ca. Hesperidin produces antidepressant effects by activating AMPA receptor: enhancing synaptic proteins to promote hippocampal neuronal activities. Behavioural pharmacology. 2024-11-29. PMID:39611623. |
furthermore, inhibition of ampa receptor activity by nbqx blocked the effect of hesperidin in reversing the depressive phenotypes, upregulated the expression of synaptic proteins (bdnf, psd95, synapsin1) and cfos-positive cells in the hippocampus, and increased the number of ki67-positive cells in the dentate gyrus of the hippocampus of cums-exposed mice. |
2024-11-29 |
2024-12-01 |
mouse |
| Mousa Shaabani Ghahremanlo, Vida Hojati, Gholamhassan Vaezi, Shahram Sharaf. Transgenerational of Oxidative Damage Induced by Prenatal Ethanol Exposure on Spatial Learning/Memory and BDNF in the of Male Rats. IBRO neuroscience reports. vol 17. 2024-11-25. PMID:39583589. |
this study investigates how prenatal ethanol exposure triggers oxidative stress (os) and affects neurotrophic factors (ntfs), particularly brain-derived growth factor (bdnf) gene expression in the hippocampus, influencing learning and memory decline across two generations of male offspring from ethanol-exposed female rats. |
2024-11-25 |
2024-11-27 |
rat |
| Mousa Shaabani Ghahremanlo, Vida Hojati, Gholamhassan Vaezi, Shahram Sharaf. Transgenerational of Oxidative Damage Induced by Prenatal Ethanol Exposure on Spatial Learning/Memory and BDNF in the of Male Rats. IBRO neuroscience reports. vol 17. 2024-11-25. PMID:39583589. |
analysis of antioxidant enzyme activity including glutathione peroxidase (gpx), superoxide dismutase (sod), and malondialdehyde (mda), and bdnf gene expression in the hippocampus further highlighted the impacts of prenatal ethanol exposure. |
2024-11-25 |
2024-11-27 |
rat |
| Xiaoyu Pan, Anqi Guo, Kaiyu Guan, Congcong Chen, Shengnan Xu, Yali Tang, Xi Li, Zhengwei Huan. Lactobacillus rhamnosus GG attenuates depression-like behaviour and cognitive deficits in chronic ethanol exposure mice by down-regulating systemic inflammatory factors. Addiction biology. vol 29. issue 11. 2024-11-25. PMID:39585236. |
the use of lgg and antibiotics alleviated the depression-like behaviour and cognitive impairment of cee-induced mice, reduced expression of inflammatory factors such as interleukin (il)-6, il-1β and tumour necrosis factor (tnf)-α in the ileum, serum and brain and increased the expression of synaptophysin (syn), postsynaptic density protein-95 (psd-95) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2024-11-25 |
2024-11-27 |
mouse |
| Lilian Leite Fausto, Adriano Alberti, Gabriela Kades, Risoní Pereira Dias de Carvalho, Viviane Freiberger, Leticia Ventura, Paula Dias, Eliton Marcio Zanoni, Ben Hur Soares, Matheus Luchini Dutra, Daniel Fernandes Martins, Clarissa Martinelli Comi. Effects of a Ketogenic Diet on the Assessment of Biochemical and Clinical Parameters in Duchenne Muscular Dystrophy: A Preclinical Investigation. Molecular neurobiology. vol 61. issue 12. 2024-11-22. PMID:38816675. |
the protocol led to an increase in hippocampal bdnf and mitochondrial respiratory complex activity in muscle tissue and the central nervous system (cns), while also decreasing creatine kinase activity only in the striatum. |
2024-11-22 |
2024-11-24 |
mouse |
| Nezha Bouhaddou, Meryem Mabrouk, Farah Atifi, Abdelhakim Bouyahya, Younes Zai. The link between BDNF and platelets in neurological disorders. Heliyon. vol 10. issue 21. 2024-11-21. PMID:39568824. |
among these factors, brain-derived neurotrophic factor (bdnf) - a protein belonging to the neurotrophin family - is widely expressed both in the hippocampus and in platelets. |
2024-11-21 |
2024-11-23 |
Not clear |
| Takayo Odaira-Satoh, Osamu Nakagawasai, Kohei Takahashi, Ryotaro Ono, Miharu Wako, Wataru Nemoto, Koichi Tan-N. Captopril prevents depressive-like behavior in an animal model of depression by enhancing hippocampal neurogenesis via activation of the ACE2/Ang (1-7)/Mas receptor/AMPK/BDNF pathway. Progress in neuro-psychopharmacology & biological psychiatry. 2024-11-19. PMID:39561916. |
we tested the effect of cap on the depressive-like behavior of these mice in the tail-suspension test, quantified ace2, p-amp activated protein kinase (ampk), and brain-derived neurotrophic factor (bdnf) using western blots, and examined the changes in ang (1-7) level, neurogenesis, and in the expression of ace2 and masr on various cell types in the hippocampus using immunohistochemistry. |
2024-11-19 |
2024-11-23 |
mouse |
| Takayo Odaira-Satoh, Osamu Nakagawasai, Kohei Takahashi, Ryotaro Ono, Miharu Wako, Wataru Nemoto, Koichi Tan-N. Captopril prevents depressive-like behavior in an animal model of depression by enhancing hippocampal neurogenesis via activation of the ACE2/Ang (1-7)/Mas receptor/AMPK/BDNF pathway. Progress in neuro-psychopharmacology & biological psychiatry. 2024-11-19. PMID:39561916. |
while obx mice exhibited a depressive-like behavior in the tail-suspension test, as well as a reduction in ace2, ang (1-7), p-ampk, bdnf, and hippocampal neurogenesis, these changes were prevented by cap administration. |
2024-11-19 |
2024-11-23 |
mouse |
| Pallavi Singh, Priyanka Agrawal, K P Sing. Neurocognitive impairments in rat offspring after maternal exposure to Vortioxetine: Involvement of BDNF, apoptosis and cholinergic mediated signaling pathways. Reproductive toxicology (Elmsford, N.Y.). 2024-11-18. PMID:39557222. |
specifically, vox 2mg/kg exposure significantly reduced brain-derived neurotrophic factor (bdnf) expression, increased pro-apoptotic bax expression, decreased anti-apoptotic bcl-2 expression, and elevated acetylcholinesterase (ache) activity in the hippocampus. |
2024-11-18 |
2024-11-22 |
rat |
| Hui Li, Xiaoyu Guo, Pengxiang Li, Xinyu Gao, Xizi Song, Xinrui Chen, Rong Liang, Jiajia Yang, Yu Li, Huaiyong Chen, Yongzhi Huang, Weiran Zhang, Quan Sun, Liqun Che. Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors. Environment international. vol 194. 2024-11-16. PMID:39549365. |
rna-seq results indicated that the depressive like behavior of mice exposed to pm2.5 might be related to pro-inflammatory and anti-inflammatory cytokines, as well as the bdnf pathways in the hippocampus and olfactory bulb. |
2024-11-16 |
2024-11-20 |
mouse |
| Foluso A Atiba, Pilani Nkomozepi, Felix E Mbajiorgu, Amadi O Ihunw. Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut. Metabolic brain disease. vol 40. issue 1. 2024-11-16. PMID:39546053. |
the levels of brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and malondialdehyde (mda) of the matched hippocampal tissues were also checked in the pups. |
2024-11-16 |
2024-11-18 |
rat |