| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Xu, Wanggao Li, Xiaosong Hu, Jiachao Zhan. Arecoline Alleviates Depression via Gut-Brain Axis Modulation, Neurotransmitter Balance, Neuroplasticity Enhancement, and Inflammation Reduction in CUMS Mice. Journal of agricultural and food chemistry. 2025-04-21. PMID:40257350. |
mechanistically, arecoline restored serotonin and norepinephrine levels in the brain and serum, reduced pro-inflammatory markers such as il-1β and lps in both serum and colon, and enhanced hippocampal neuroplasticity through increased bdnf and psd-95 expression. |
2025-04-21 |
2025-04-23 |
mouse |
| Jiaxin Zhou, Yiqiao Zhao, Yilong Li, Jie Li, Jianan Huang, Lin Liu, Zhonghua Liu, Mingzhi Zh. Jasmine tea extract prevents CUMS-induced depression-like behaviors through the modulation of microbiota-gut-brain axis. Food research international (Ottawa, Ont.). vol 209. 2025-04-19. PMID:40253129. |
behavioral assessments, inflammatory marker analysis, hippocampal histology, and brain-derived neurotrophic factor (bdnf) expression assays demonstrated that jt alleviated depressive behaviors, reduced brain tissue damage, and restored cognitive function in cums-exposed rats. |
2025-04-19 |
2025-04-22 |
rat |
| Dool-Ri Oh, Yujin Kim, Bo Yeong Mun, Haeju Ko, Yonguk Kim, Moon Jong Kim, Kyo-Nyeo Oh, Ji-Ae Hong, Donghyuck Ba. Rumex acetosa L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo. Metabolic brain disease. vol 40. issue 5. 2025-04-17. PMID:40244509. |
furthermore, ra significantly increased nr2a, nr2b, psd-95, and glua1 the following downstream signaling extracellular signal-regulated kinase 1/2 (erk1/2), calcium/calmodulin-dependent protein kinase ii (camkii) phosphorylation, and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2025-04-17 |
2025-04-19 |
rat |
| b' Lenka Seillier, Barbora \\xc4\\x8cechov\\xc3\\xa1, Alexandre Seillier, Romana \\xc5\\xa0lamberov\\xc3\\xa. Psilocybin has a narrow therapeutic window as an antidepressant treatment. Progress in neuro-psychopharmacology & biological psychiatry. 2025-04-17. PMID:40246053.' |
furthermore, we explored whether the brain-derived neurotrophic factor (bdnf) levels in the hippocampus and prefrontal cortex (pfc) paralleled the behavioral changes observed after psilocybin. |
2025-04-17 |
2025-04-20 |
rat |
| b' Lenka Seillier, Barbora \\xc4\\x8cechov\\xc3\\xa1, Alexandre Seillier, Romana \\xc5\\xa0lamberov\\xc3\\xa. Psilocybin has a narrow therapeutic window as an antidepressant treatment. Progress in neuro-psychopharmacology & biological psychiatry. 2025-04-17. PMID:40246053.' |
bdnf levels in the hippocampus and pfc increased dose-dependently after psilocybin, but linearly suggesting a dissociation between high bdnf levels and the observed antidepressant-like behaviors. |
2025-04-17 |
2025-04-20 |
rat |
| Wenyuan Wang, Tingting Yang, Na Liu, Lin Yang, Cong Liu, Xiaoxiao Qi, Ning Wang, Mingwei Wang, Yanyong Wan. MiR-223-3p inhibits hippocampal neurons injury and exerts anti- anxiety/depression-like behaviors by directly targeting NLRP3. Psychopharmacology. 2025-04-16. PMID:40237808. |
the overexpression of mir-223-3p resulted in significant reductions in tnf-α, il-1β, and sod levels, an increase in mda activity, as well as upregulation of cyclic adenosine monophosphate (camp), phosphorylated camp response element-binding protein (p-creb), and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2025-04-16 |
2025-04-19 |
rat |
| Paria Hashemi, Mohammad Raman Moloudi, Helia Rahmani, Katayoun Hassanzadeh, Zakaria Vahabzadeh, Esmael Izadpana. Alpha-Pinene Ameliorates Memory Deficits in 3-Nitropropionic Acid-Induced Rat Model of Huntington's Disease. Neurochemical research. vol 50. issue 3. 2025-04-16. PMID:40237934. |
in addition, apn treatment elevated the gene expression levels of bdnf, trka, trkb, and creb, while significantly decreasing p75 ntr showing a dose-dependent effect in the brain cortex and hippocampus, compared to the 3-np group. |
2025-04-16 |
2025-04-19 |
rat |
| Haitham S Mohammed, Dalia H Ahmed, Yasser A Khadrawy, Noha G Madia. Neuroprotection in pentylenetetrazol kindling rat model: A synergistic approach with eugenol and photobiomodulation. Brain research. 2025-04-14. PMID:40228569. |
the study also evaluated cortical and hippocampal levels of brain-derived neurotrophic factor (bdnf), oxidative stress markers (mda, no, and gsh), activities of acetylcholinesterase (ache) and na + k + -atpase, and monoamine neurotransmitters (da, 5-ht, and ne). |
2025-04-14 |
2025-04-17 |
rat |
| Masoumeh Asle-Rousta, Mojdeh Abdollahi, Hossein Moghadam Aghajari, Yasaman Peirov. Eucalyptol Attenuates Lead-Induced Anxiety-like Behaviors by Suppressing Oxidative Stress and Neuroinflammation, Modulating SIRT1/NF-κB Signaling, and Upregulating BDNF Expression. Biological trace element research. 2025-04-09. PMID:40205256. |
it enhanced the expression of brain-derived neurotrophic factor (bdnf) at the level of mrna and protein and reduced neuronal death in different subfields of the hippocampus. |
2025-04-09 |
2025-04-12 |
rat |
| Aysu Kilic, Betul Esra Ipek, Suzin Tatonyan, Kubra Kilic, Huri Demirci, Fatmahan Atalar, Savas Ustunova, Nuran Dariyerl. Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex. Scientific reports. vol 15. issue 1. 2025-04-09. PMID:40204820. |
alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering bdnf levels in the hippocampus and prefrontal cortex. |
2025-04-09 |
2025-04-12 |
rat |
| Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Theresa C Umeji, Kpobari W Nkpaa, Ifeoma Okereke, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakw. Rice bran extract ameliorate heavy metal mixture induced hippocampal toxicity via inhibiting oxido-inflammatory damages and modulating Hmox-1/BDNF/Occludin/Aβ40/Aβ42 in rats. Toxicology research. vol 14. issue 2. 2025-04-09. PMID:40201631. |
subsequently, oxidative stress, inflammation (cyclooxygenase-2) and caspase-3, amyloid precursor proteins (aβ40 and aβ42), hmox-1, occludin and bdnf and transcription factor nrf-2 in the hippocampus were investigated. |
2025-04-09 |
2025-04-11 |
rat |
| Baridoo Donatus Dooka, Chinna N Orish, Anthonet N Ezejiofor, Theresa C Umeji, Kpobari W Nkpaa, Ifeoma Okereke, Ana Cirovic, Aleksandar Cirovic, Orish E Orisakw. Rice bran extract ameliorate heavy metal mixture induced hippocampal toxicity via inhibiting oxido-inflammatory damages and modulating Hmox-1/BDNF/Occludin/Aβ40/Aβ42 in rats. Toxicology research. vol 14. issue 2. 2025-04-09. PMID:40201631. |
collectively, rbe ameliorated mm - induced oxidative stress, neuro-inflammation and hippocampal apoptosis via attenuation of oxidative damages of cellular constituents, neuronal inflammation and subsequent down regulation of amyloid precursor proteins aβ40, aβ42 and up regulation of occludin, bdnf, hmox-1 protein expression via nrf-2 dependent pathways to abrogate hippocampal toxicity associated with spatial learning and memory deficits. |
2025-04-09 |
2025-04-11 |
rat |
| Sina Fatehfar, Parsa Sameei, Naseh Abdollahzade, Leila Chodari, Ehsan Saboory, Shiva Roshan-Milan. Maternal Treadmill Exercise and Zinc Supplementation Alleviate Prenatal Stress-Induced Cognitive Deficits and Restore Neurological Biomarkers in Offspring: A Study on Male Rats Aged 30 and 90 Days. Developmental neurobiology. vol 85. issue 2. 2025-04-08. PMID:40195087. |
at postnatal days 30 and 90, the cognitive function of male offspring was evaluated using the morris water maze (mwm) test, and the hippocampal gene expression levels of caspase-3, brain-derived neurotrophic factor (bdnf), and glial fibrillary acidic protein (gfap) were measured using reverse transcription-polymerase chain reaction (rt-pcr). |
2025-04-08 |
2025-04-10 |
rat |
| Onur Karaca, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Mustafa İleritürk, Özge Kandemir, Sefa Küçükler, Şeyda Öte Karaca, Fatih Mehmet Kandemi. Potent Ameliorative Effects of Rosmarinic Acid on Tramadol-Induced Neurotoxicity in the Brain and Hippocampus; by Suppressing Oxidative stress, Apoptosis, ER stress, and Regulating Cognitive Functions. Molecular neurobiology. 2025-04-07. PMID:40193018. |
oxidative stress, inflammation, endoplasmic reticulum (er) stress, apoptosis damage pathways, glial fibrillary acidic protein (gfap), and brain-derived neurotrophic factor (bdnf) activities were determined in brain and hippocampus tissues. |
2025-04-07 |
2025-04-09 |
rat |
| Natasha Chitakwa, Na Chen, Chuan Chen, Yaqi Li, Di W. Prenatal sleep restriction altered learning ability and memory behaviour by decreasing hippocampal synaptic plasticity in offspring mice. Sleep medicine. vol 131. 2025-04-06. PMID:40188801. |
changes in adult offspring and fetal hippocampal synapse structures were observed and synapse-synthesis-related protein (bdnf and syt7) levels were measured to establish changes indicative of neurodevelopmental impairment. |
2025-04-06 |
2025-04-09 |
mouse |
| Natasha Chitakwa, Na Chen, Chuan Chen, Yaqi Li, Di W. Prenatal sleep restriction altered learning ability and memory behaviour by decreasing hippocampal synaptic plasticity in offspring mice. Sleep medicine. vol 131. 2025-04-06. PMID:40188801. |
synapse-synthesis-related proteins, including brain-derived neurotrophic factor (bdnf) and synaptotagmin-7 (syt7), showed decreased expression in the hippocampus of offspring mice in all sr groups, with bdnf expression also reduced in fetal hippocampi. |
2025-04-06 |
2025-04-09 |
mouse |
| Somayeh Nazari, Saba Niknamfar, Hamed Ghazvini, Raheleh Rafaiee, Armin Allahverdy, Habibolah Khazaie, Seyedeh Masoumeh Seyedhosseini Tamijan. Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine-Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus. Addiction biology. vol 30. issue 4. 2025-04-04. PMID:40183201. |
transcutaneous auricular vagus nerve stimulation restores cognitive impairment in morphine-withdrawn rats: role of bdnf and glial cells in the hippocampus. |
2025-04-04 |
2025-04-06 |
rat |
| Somayeh Nazari, Saba Niknamfar, Hamed Ghazvini, Raheleh Rafaiee, Armin Allahverdy, Habibolah Khazaie, Seyedeh Masoumeh Seyedhosseini Tamijan. Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine-Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus. Addiction biology. vol 30. issue 4. 2025-04-04. PMID:40183201. |
gfap, iba1 and bdnf expression levels in the hippocampus were determined via quantitative polymerase chain reaction (qpcr). |
2025-04-04 |
2025-04-06 |
rat |
| Jingjing Han, Rui Hong, Cong Cao, Lina Zhang, Ao Sun, Yufei Li, Yinxiu Chi, Linlin Zhang, Ya Yang, Xuebin Q. Suppression of KDM5C mitigates the symptoms of Alzheimer's disease by up-regulating BDNF expression. Neurochemistry international. 2025-04-03. PMID:40180246. |
mechanistically, suppression of kdm5c could promote the expression of brain-derived neurotrophic factor (bdnf) to partially protect hippocampal neurons from beta-amyloid damage. |
2025-04-03 |
2025-04-06 |
mouse |
| Tahir Ali, Yanhua Luo, Chengyou Zheng, Shafiq Ur Rahman, Iram Murtaza, Jinxing Feng, Shupeng L. Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 20. issue 1. 2025-04-02. PMID:40175765. |
lps administration increased proinflammatory cytokine production (il-1, il6, and tnf-α), microglial activation (iba-1/gfap), and dysregulation of key synaptic proteins, including bdnf and trkb, in the hippocampus of mice. |
2025-04-02 |
2025-04-04 |
mouse |