| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D B Drachman, K R McIntosh, B Yan. Factors that determine the severity of experimental myasthenia gravis. Annals of the New York Academy of Sciences. vol 841. 1998-08-04. PMID:9668247. |
(3) the alpha 146-162-specific t cells of b6 mice, in turn, interact strongly with achr-specific b cells of b6 mice. |
1998-08-04 |
2023-08-12 |
mouse |
| M Z Atassi, M Oshim. Autoimmune responses against acetylcholine receptor: T and B cell collaboration and manipulation by synthetic peptides. Critical reviews in immunology. vol 17. issue 5-6. 1998-02-25. PMID:9419435. |
we have mapped the t and b cell epitopes on achr alpha subunit in human mg and in eamg-susceptible (c57bl/6, b6) and nonsusceptible mouse strains. |
1998-02-25 |
2023-08-12 |
mouse |
| B Yang, K R McIntosh, D B Drachma. How subtle differences in MHC class II affect the severity of experimental myasthenia gravis. Clinical immunology and immunopathology. vol 86. issue 1. 1998-02-05. PMID:9434796. |
we prepared large numbers of achr-specific t cell hybridomas from each strain and characterized their epitope specificities and t cell receptor (tcr) gene usage: half the b6 hybridomas responded to a single achr peptide (alpha 146-162), and their tcr genes encoded restricted v alpha and v beta chains and cdr3 motifs. |
1998-02-05 |
2023-08-12 |
mouse |
| T Ishimoto, K Yamamoto, Y Fukui, Y Fukuda, K Dohi, T Sasazuk. In vitro and in vivo evidence for high frequency of I-Ab-reactive CD4+ T cells in HLA-DQ or HLA-DRA transgenic mice lacking endogenous MHC class I and/or class II expression. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 8. 1997-11-07. PMID:9378957. |
to distinguish these two possibilities, we estimated the frequency of i-ab-reactive cd4+ t cells selected by hla-dq or dr alpha e beta b molecules, using hla-dq6 and hla-dra transgenic c57bl/6 (b6) mice lacking endogenous mhc class i and/or class ii molecules (dq6a0/0 and dr alpha 30a0/0 beta 20/0). |
1997-11-07 |
2023-08-12 |
mouse |
| K Nakagaw. [Defective generation of NK1.1+ T cells in aly/aly mice associated with thymic architecture]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 72. issue 3. 1997-09-15. PMID:9226468. |
when deoxy-guanosine (dguo)-treated fetal thymi from (b6 x b10.g) f1 mice were transplanted to aly/aly mice which had been thymectomized and reconstituted with bm cells of aly/aly mice, normal proportions of the nk1.1+ tcr alpha beta+ thymocytes were observed in the thymus grafts. |
1997-09-15 |
2023-08-12 |
mouse |
| K Hiromatsu, J Usami, Y Aoki, M Makino, Y Yoshika. Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice. Microbiology and immunology. vol 41. issue 3. 1997-07-02. PMID:9130234. |
b220+ tcr alpha beta t cells, unique to lupus prone mice, also increased in the b6 lpr/lpr mice after infection. |
1997-07-02 |
2023-08-12 |
mouse |
| K Hiromatsu, J Usami, Y Aoki, M Makino, Y Yoshika. Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice. Microbiology and immunology. vol 41. issue 3. 1997-07-02. PMID:9130234. |
cd4+ b220+ tcr alpha beta t cells increased profoundly among the b220+ tcr alpha beta t cells from lp-bm5 mulv-infected b6 lpr/lpr mice, while the b220+ tcr alpha beta t cells observed in non-infected b6 lpr/lpr mice were largely of the cd4-cd8- phenotype. |
1997-07-02 |
2023-08-12 |
mouse |
| K Toyooka, S Maruo, T Iwahori, N Yamamoto, X G Tai, R Abe, Y Takahama, M Murakami, T Uede, T Hamaoka, H Fujiwar. CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism. International immunology. vol 8. issue 2. 1996-12-10. PMID:8671600. |
further, whereas il-2 receptor (il-2r) alpha chain expression was significantly induced on b6 t cells stimulated with bm12 apc; stimulation with bm12 b cells did not induce il-2r expression over background levels. |
1996-12-10 |
2023-08-12 |
mouse |
| J S Rosenberg, M Oshima, M Z Atass. B-cell activation in vitro by helper T cells specific to region alpha 146-162 of Torpedo californica nicotinic acetylcholine receptor. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 7. 1996-11-25. PMID:8816433. |
an exclusive t cell epitope within residues alpha 146-162 of torpedo californica (t), tachr, plays an important role in experimental autoimmune mg pathogenesis in b6 mice. |
1996-11-25 |
2023-08-12 |
mouse |
| J S Rosenberg, M Oshima, M Z Atass. B-cell activation in vitro by helper T cells specific to region alpha 146-162 of Torpedo californica nicotinic acetylcholine receptor. Journal of immunology (Baltimore, Md. : 1950). vol 157. issue 7. 1996-11-25. PMID:8816433. |
to study its function, we established, from tachr-primed b6 mice, two t alpha 146-162-specific t cell lines (p14th) which comprised th2-type cells because they secreted il-4 but not il-2. |
1996-11-25 |
2023-08-12 |
mouse |
| K Heiskanen, M A Siimes, L Salmenperä, J Perheentup. Low vitamin B6 status associated with slow growth in healthy breast-fed infants. Pediatric research. vol 38. issue 5. 1996-02-22. PMID:8552443. |
to evaluate the effect of vitamin b6 status on infant growth, we studied longitudinally anthropometry and the erythrocyte parameters that reflect long-term vitamin b6 status [erythrocyte pyridoxal 5'-phosphate concentration (eplp), erythrocyte aspartate transaminase basal activity (east0), and its activation co-efficient (alpha east)] in 44 infants. |
1996-02-22 |
2023-08-12 |
Not clear |
| K Heiskanen, M A Siimes, L Salmenperä, J Perheentup. Low vitamin B6 status associated with slow growth in healthy breast-fed infants. Pediatric research. vol 38. issue 5. 1996-02-22. PMID:8552443. |
in seven of these infants, a low vitamin b6 status (eplp < 10th, and east0 > 10th or alpha east > 90th percentile for these values in reference infants) was observed between 4 and 6 mo of age. |
1996-02-22 |
2023-08-12 |
Not clear |
| P I Karachunski, N Ostlie, M Bellone, A J Infante, B M Conti-Fin. Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scandinavian journal of immunology. vol 42. issue 2. 1995-09-07. PMID:7631155. |
cd4+ cells from bm12 mice immunized with tachr do not recognize three sequence regions of the tachr alpha subunit which dominate the cd4+ cell sensitization in b6 mice. |
1995-09-07 |
2023-08-12 |
mouse |
| P I Karachunski, N Ostlie, M Bellone, A J Infante, B M Conti-Fin. Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scandinavian journal of immunology. vol 42. issue 2. 1995-09-07. PMID:7631155. |
cd4+ cells from tachr-sensitized f1 mice were challenged with tachr and alpha subunit epitope peptides, using f1, b6 or bm12 apc. |
1995-09-07 |
2023-08-12 |
mouse |
| P I Karachunski, N Ostlie, M Bellone, A J Infante, B M Conti-Fin. Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scandinavian journal of immunology. vol 42. issue 2. 1995-09-07. PMID:7631155. |
b6 and f1 apc presented all these ag efficiently, while bm12 apc presented tachr and peptide t alpha 150-169 poorly and erratically. |
1995-09-07 |
2023-08-12 |
mouse |
| P I Karachunski, N Ostlie, M Bellone, A J Infante, B M Conti-Fin. Mechanisms by which the I-ABM12 mutation influences susceptibility to experimental myasthenia gravis: a study in homozygous and heterozygous mice. Scandinavian journal of immunology. vol 42. issue 2. 1995-09-07. PMID:7631155. |
anti-t alpha 150-169 lines from both b6 and f1 mice had a strong preferential usage of v beta 6. |
1995-09-07 |
2023-08-12 |
mouse |
| H Y Lei, C Y Shun, J Y Wang, T R Hsiue, S H Lei. Involvement of histamine or tumor necrosis factor in early-type hypersensitivity. Immunopharmacology. vol 29. issue 2. 1995-07-12. PMID:7775159. |
meanwhile, gat-induced eth in b6 mice was inhibited by anti-tnf alpha antibody suggesting that tnf alpha is involved. |
1995-07-12 |
2023-08-12 |
mouse |
| H Y Lei, C Y Shun, J Y Wang, T R Hsiue, S H Lei. Involvement of histamine or tumor necrosis factor in early-type hypersensitivity. Immunopharmacology. vol 29. issue 2. 1995-07-12. PMID:7775159. |
a/j and cba strains as well as balb/c mice were classified as histamine type while a. tl, b10.br, and c3h/he in addition to b6 mice were tnf alpha type. |
1995-07-12 |
2023-08-12 |
mouse |
| H Y Lei, C Y Shun, J Y Wang, T R Hsiue, S H Lei. Involvement of histamine or tumor necrosis factor in early-type hypersensitivity. Immunopharmacology. vol 29. issue 2. 1995-07-12. PMID:7775159. |
the observation that gat-induced eth in (balb/c x b6)f1 mice was inhibited by both diphenhydramine and anti-tnf alpha suggests that the mediation of the actions of histamine or tnf alpha by gat was genetically controlled and inherited as the dominant trait in (balb/c x b6)f1 mice. |
1995-07-12 |
2023-08-12 |
mouse |
| M Oshima, M Z Atass. Effect of amino acid substitutions within the region 62-76 of I-A beta b on binding with and antigen presentation of Torpedo acetylcholine receptor alpha-chain peptide 146-162. Journal of immunology (Baltimore, Md. : 1950). vol 154. issue 10. 1995-05-31. PMID:7537303. |
previous study has shown that reduced t cell response to peptide alpha 146-162 of torpedo californica acetylcholine receptor (tachr) in b6.c-h-2bm12 (bm12) mice, a mutant of c57bl/6 (b6) mice, correlated with its nonsusceptiblity to experimental autoimmune myasthenia gravis. |
1995-05-31 |
2023-08-12 |
mouse |