| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kwok-On Lai, Yali Zhao, Toh Hean Ch'ng, Kelsey C Marti. Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 44. 2008-12-22. PMID:18957537. |
here, we show that cyclic amp response element binding protein 2 (creb2)/activating transcription factor 4 (atf4), a transcriptional repressor that modulates long-term synaptic plasticity and memory, localizes to distal dendrites of rodent hippocampal neurons and neurites of aplysia sensory neurons (sns) and binds to specific importin alpha isoforms. |
2008-12-22 |
2023-08-12 |
aplysia |
| Gang Chen, Cuiling Ma, Kimberly A Bower, Xianglin Shi, Zunji Ke, Jia Lu. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. Journal of neuroscience research. vol 86. issue 4. 2008-07-08. PMID:17941056. |
using sh-sy5y neuroblastoma cells and primary cerebellar granule neurons as in vitro models, we demonstrated that exposure to ethanol alone had little effect on the expression of markers for er stress; however, ethanol drastically enhanced the expression of grp78, chop, atf4, atf6, and phosphorylated perk and eif2 alpha when induced by tunicamycin and thapsigargin. |
2008-07-08 |
2023-08-12 |
Not clear |
| P Christopher LaRosa, Jean-Jack M Riethoven, Han Chen, Yuannan Xia, You Zhou, Mei Chen, Jess Miner, Michael E From. Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. Physiological genomics. vol 31. issue 3. 2008-01-16. PMID:17878318. |
western blot analysis found increased phosphorylation of eif2 alpha and increased production of atf4 confirming at least part of the response to t10c12 cla is mediated through the isr pathway. |
2008-01-16 |
2023-08-12 |
mouse |
| Claudio Hetz, Joaquín Castilla, Claudio Sot. Perturbation of endoplasmic reticulum homeostasis facilitates prion replication. The Journal of biological chemistry. vol 282. issue 17. 2007-06-14. PMID:17329244. |
expression of a dominant negative form of ire1 alpha or xbp-1 significantly increased prp aggregation, whereas overexpression of atf4 or an active mutant form of xbp-1 and atf6 had the opposite affect. |
2007-06-14 |
2023-08-12 |
Not clear |
| Fang Liu, Kiyoshi Inageda, Gen Nishitai, Masato Matsuok. Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells. Environmental health perspectives. vol 114. issue 6. 2006-07-11. PMID:16759985. |
after exposure to 10 microm cdcl2, the levels of activating transcription factor 4 (atf4) were increased at 2 hr, with a further enhancement after that ; this accumulation followed the transient but marked phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eif2(alpha)) on serine 51. |
2006-07-11 |
2023-08-12 |
Not clear |
| Fang Liu, Kiyoshi Inageda, Gen Nishitai, Masato Matsuok. Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells. Environmental health perspectives. vol 114. issue 6. 2006-07-11. PMID:16759985. |
compared with other heavy-metal compounds such as manganese chloride, zinc chloride, mercuric chloride, and lead chloride, cdcl2 could increase the levels of grp78, atf4, and the phosphorylated form of eif2(alpha) more markedly without definite cellular damage. |
2006-07-11 |
2023-08-12 |
Not clear |
| Fang Liu, Kiyoshi Inageda, Gen Nishitai, Masato Matsuok. Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells. Environmental health perspectives. vol 114. issue 6. 2006-07-11. PMID:16759985. |
these results show that cadmium induces the expression of grp78 probably via phosphorylation of eif2(alpha) and resultant translation of atf4, and this er stress response plays a role in protection against cadmium cytotoxicity in this renal epithelial cell. |
2006-07-11 |
2023-08-12 |
Not clear |
| Phoebe D Lu, Heather P Harding, David Ro. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. The Journal of cell biology. vol 167. issue 1. 2004-11-22. PMID:15479734. |
stress-induced eukaryotic translation initiation factor 2 (eif2) alpha phosphorylation paradoxically increases translation of the metazoan activating transcription factor 4 (atf4), activating the integrated stress response (isr), a pro-survival gene expression program. |
2004-11-22 |
2023-08-12 |
Not clear |
| I Novoa, H Zeng, H P Harding, D Ro. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. The Journal of cell biology. vol 153. issue 5. 2001-06-28. PMID:11381086. |
phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eif2alpha) on serine 51 integrates general translation repression with activation of stress-inducible genes such as atf4, chop, and bip in the unfolded protein response. |
2001-06-28 |
2023-08-12 |
Not clear |
| V V Levenson, I A Davidovich, I B Roninso. Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer research. vol 60. issue 18. 2000-10-13. PMID:11016623. |
these include genes involved in dna replication and repair (e.g., pcna, xrcc1, b-myb, and gadd45), transcriptional regulators associated with stress response, and cell cycle checkpoint control (e.g., yb-1, dbpa, and atf4), and genes for signal transduction proteins (e.g., protein tyrosine phosphatase 1b and regulatory subunits alpha and beta of camp-dependent protein kinase). |
2000-10-13 |
2023-08-12 |
Not clear |