| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stacey L Lehman, Sandra Ryeom, Constantinos Koumeni. Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. Scientific reports. vol 5. 2016-07-06. PMID:26123823. |
gcn2 phosphorylates the alpha subunit of the eukaryotic translation initiation factor eif2, leading to global downregulation of translation to conserve amino acids and initiation of a transcriptional program through atf4 to promote recovery from nutrient deprivation. |
2016-07-06 |
2023-08-13 |
mouse |
| Fangyi Chen, Rongbo Wu, Zhu Zhu, Wangping Yin, Min Xiong, Jianwei Sun, Miaozhong Ni, Guoping Cai, Xinchao Zhan. Wogonin protects rat dorsal root ganglion neurons against tunicamycin-induced ER stress through the PERK-eIF2α-ATF4 signaling pathway. Journal of molecular neuroscience : MN. vol 55. issue 4. 2015-11-27. PMID:25417142. |
furthermore, wogonin downregulated expression level of er stress genes coding for glucose-regulated protein 78 (grp78), c/ebp homologous protein (chop), active caspase 12, transcription factor 4 (atf4), and phosphorylation of pancreatic er stress kinase (perk) and eukaryotic initiation factor 2 alpha (eif2α). |
2015-11-27 |
2023-08-13 |
rat |
| Hongmin Luo, Jinko Sawashita, Geng Tian, Yingye Liu, Lin Li, Xin Ding, Zhe Xu, Mu Yang, Hiroki Miyahara, Masayuki Mori, Jinze Qian, Yaoyong Wang, Keiichi Higuch. Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart. Laboratory investigation; a journal of technical methods and pathology. vol 95. issue 3. 2015-05-01. PMID:25545477. |
furthermore, gene transcription of several endoplasmic reticulum (er) stress-related proteins increased, including eukaryotic translation initiation factor 2 alpha kinase 3 (eif2ak3), activating transcription factor 6 (atf6), activating transcription factor 4 (atf4), x-box-binding protein 1 splicing (xbp1s), dna-damage inducible transcript 3 (ddit3), and autophagy protein 5 (atg5). |
2015-05-01 |
2023-08-13 |
mouse |
| Mary Ní Fhlathartaigh, Jill McMahon, Richard Reynolds, David Connolly, Eibhlín Higgins, Timothy Counihan, Una Fitzgeral. Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252779. |
our and other studies have demonstrated upregulation of er stress markers chop, bip, atf4, xbp1 and phosphorylated e-if2 alpha (p-eif2 alpha) in biopsy and post-mortem human multiple sclerosis (ms) samples. |
2015-03-31 |
2023-08-12 |
human |
| Chunhong Feng, Kai He, Chunyan Zhang, Song Su, Bo Li, Yuxiao Li, Chun-Yan Duan, Shaokun Chen, Run Chen, Youping Liu, Hong Li, Mei Wei, Xianming Xia, Rongyang Da. JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587347. |
in human cca cells, the phosphorylation of eukaryotic initiation factor alpha (eif2α) results in the accumulation of activating transcription factor 4 (atf4) and grp78 independent of unfolded protein response (upr). |
2014-10-28 |
2023-08-12 |
human |
| Yuta Komoike, Masato Matsuok. Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). vol 142-143. 2014-03-20. PMID:24055755. |
exposure of the brf41 cells to tbt caused phosphorylation of the zebrafish homolog of protein kinase rna-activated-like er kinase (perk), eukaryotic translation initiation factor 2 alpha (eif2α), and inositol-requiring enzyme 1 (ire1), characteristic splicing of x-box binding protein 1 (xbp1) mrna, and enhanced expression of activating transcription factor 4 (atf4) protein. |
2014-03-20 |
2023-08-12 |
zebrafish |
| Tavane D Cambiaghi, Catia M Pereira, Renuka Shanmugam, Michael Bolech, Ronald C Wek, Evelyn Sattlegger, Beatriz A Castilh. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochemical and biophysical research communications. vol 443. issue 2. 2014-03-10. PMID:24333428. |
in response to a range of environmental stresses, phosphorylation of the alpha subunit of the translation initiation factor 2 (eif2α) represses general protein synthesis coincident with increased translation of specific mrnas, such as those encoding the transcription activators gcn4 and atf4. |
2014-03-10 |
2023-08-12 |
Not clear |
| Fusako Usuki, Masatake Fujimura, Akio Yamashit. Endoplasmic reticulum stress preconditioning attenuates methylmercury-induced cellular damage by inducing favorable stress responses. Scientific reports. vol 3. 2014-02-14. PMID:23907635. |
we demonstrate that methylmercury (mehg)-susceptible cells preconditioned with an inhibitor of endoplasmic reticulum (er) ca(2+)-atpase, thapsigargin, showed resistance to mehg cytotoxicity through favorable stress responses, which included phosphorylation of eukaryotic initiation factor 2 alpha (eif2α), accumulation of activating transcription factor 4 (atf4), upregulation of stress-related proteins, and activation of extracellular signal regulated kinase pathway. |
2014-02-14 |
2023-08-12 |
Not clear |
| René St-Arnaud, Bahareh Hekmatneja. Combinatorial control of ATF4-dependent gene transcription in osteoblasts. Annals of the New York Academy of Sciences. vol 1237. 2012-01-05. PMID:22082360. |
we discuss the results supporting the relevance of these interactions and present the first evidence of a functional interaction between atf4, fiat (factor-inhibiting atf4-mediated transcription), and αnac (nascent polypeptide-associated complex and coactivator alpha), three proteins that have been previously shown to associate using various protein-protein interaction assays. |
2012-01-05 |
2023-08-12 |
Not clear |
| Harmeet Malhi, Randal J Kaufma. Endoplasmic reticulum stress in liver disease. Journal of hepatology. vol 54. issue 4. 2011-07-15. PMID:21145844. |
perk phosphorylates eukaryotic initiation factor 2 alpha (eif2α) resulting in global mrna translation attenuation, and concurrently selectively increases the translation of several mrnas, including the transcription factor atf4, and its downstream target chop. |
2011-07-15 |
2023-08-12 |
Not clear |
| S M Kim, S Y Yoon, J E Choi, J S Park, J M Choi, T Nguyen, D H Ki. Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600673. |
activating transcription factor (atf4) which induces apoptosis in response to eif2 alpha phosphorylation was increased and translocated to nuclei in oa-treated neurons. |
2011-04-18 |
2023-08-12 |
rat |
| S M Kim, S Y Yoon, J E Choi, J S Park, J M Choi, T Nguyen, D H Ki. Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600673. |
these results suggest that the successive events of activation of eif2 alpha kinases and eif2 alpha phosphorylation leading to atf4 nuclear translocation may contribute to neuronal death. |
2011-04-18 |
2023-08-12 |
rat |
| Ailiang Zhang, Jie Zhang, Peng Sun, Changjiang Yao, Changhui Su, Tao Sui, Hua Huang, Xiaojian Cao, Yingbin G. EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes. Neuroscience letters. vol 478. issue 1. 2010-08-26. PMID:20444431. |
immunocytochemical analysis and western blotting for some related molecules, including pancreatic er stress kinase (perk), p-perk, eukaryotic initiation factor 2 alpha (eif2 alpha), p-eif2 alpha, activating transcription factor 4 (atf4), caspase-12, were examined. |
2010-08-26 |
2023-08-12 |
rat |
| José Edgar Nicoletti-Carvalho, Tatiane C Araújo Nogueira, Renata Gorjão, Carla Rodrigues Bromati, Tatiana S Yamanaka, Antonio Carlos Boschero, Licio Augusto Velloso, Rui Curi, Gabriel Forato Anhê, Silvana Bordi. UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells. The Journal of endocrinology. vol 206. issue 2. 2010-07-30. PMID:20488947. |
in addition, we have demonstrated that il6 is unable to overcome pa-stimulated upr, as assessed by activating transcription factor 4 (atf4) and c/ebp homologous protein (chop) expression, x-box binding protein-1 gene mrna splicing, and pancreatic eukaryotic initiation factor-2 alpha kinase phosphorylation, whereas no significant induction of upr by pro-inflammatory cytokines was detected. |
2010-07-30 |
2023-08-12 |
Not clear |
| Ju-Young Kim, Ji-Hwan Hwang, Mi-Ran Cha, Mi-Young Yoon, Eun-Soon Son, Akihiro Tomida, Bosung Ko, Si-Whan Song, Kazuo Shin-ya, Yong-il Hwang, Hae-Ryong Par. Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. Journal of cellular physiology. vol 224. issue 1. 2010-05-24. PMID:20232300. |
indeed, arc-g blocked expression of upr target genes such as phosphorylated-perk, atf4, chop, and grp78, which was accompanied by enhanced phosphorylation of eif2 alpha during glucose deprivation. |
2010-05-24 |
2023-08-12 |
Not clear |
| Micah J Drummond, Erin L Glynn, Christopher S Fry, Kyle L Timmerman, Elena Volpi, Blake B Rasmusse. An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. American journal of physiology. Endocrinology and metabolism. vol 298. issue 5. 2010-05-03. PMID:20304764. |
although there were no changes in gcn2 expression and eif2 alpha phosphorylation, atf4 protein expression reached significance by 2 h post-eaa (p < 0.05). |
2010-05-03 |
2023-08-12 |
human |
| Rinki Minakshi, Kartika Padhan, Manjusha Rani, Nabab Khan, Faizan Ahmad, Shahid Jamee. The SARS Coronavirus 3a protein causes endoplasmic reticulum stress and induces ligand-independent downregulation of the type 1 interferon receptor. PloS one. vol 4. issue 12. 2010-03-17. PMID:20020050. |
only the perk pathway was found to be activated in 3a-expressing cells based on (1) increased phosphorylation of eukaryotic initiation factor 2 alpha (eif2alpha) and inhibitory effects of a dominant-negative form of eif2alpha on grp78 promoter activity, (2) increased translation of activating transcription factor 4 (atf4) mrna, and (3) atf4-dependent activation of the c/ebp homologous protein (chop) gene promoter. |
2010-03-17 |
2023-08-12 |
Not clear |
| Charlie C Huang, Calin-Bogdan Chiribau, Mithu Majumder, Cheng-Ming Chiang, Ronald C Wek, Robert J Kelm, Kamel Khalili, Martin D Snider, Maria Hatzoglo. A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). The Journal of biological chemistry. vol 284. issue 47. 2009-12-14. PMID:19720825. |
during endoplasmic reticulum stress, binding of pur alpha to the ine decreased; the element acted as a positive regulator in early stress by binding of the transcription factor atf4 and as a negative regulator in prolonged stress by binding the stress-induced c/ebp family member, chop. |
2009-12-14 |
2023-08-12 |
Not clear |
| Eleftheria Diakogiannaki, Hannah J Welters, Noel G Morga. Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. The Journal of endocrinology. vol 197. issue 3. 2009-07-07. PMID:18492819. |
palmitate (0.025-0.25 mm) induced the expression of various markers of the rna-dependent protein kinase-like er eukaryotic initiation factor 2 alpha (eif2 alpha) kinase (perk)-dependent pathway of er stress (phospho-eif2 alpha; atf4, activating transcription factor 4 and c/ebp homologous protein (chop-10)) although it failed to promote the expression of the er chaperone grp78. |
2009-07-07 |
2023-08-12 |
Not clear |
| Baoqin Xuan, Zhikang Qian, Emi Torigoi, Dong Y. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. Journal of virology. vol 83. issue 8. 2009-04-10. PMID:19193809. |
in infection, pul38 allowed hcmv to upregulate phosphorylation of pkr-like er kinase (perk) and the alpha subunit of eukaryotic initiation factor 2 (eif-2alpha), as well as induce robust accumulation of activating transcriptional factor 4 (atf4), key components of the perk pathway. |
2009-04-10 |
2023-08-12 |
human |