| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myoung-Jun Na, Won-Young Lee, Hyun-Jung Par. Difenoconazole Induced Damage of Bovine Mammary Epithelial Cells via ER Stress and Inflammatory Response. Cells. vol 13. issue 20. 2024-10-25. PMID:39451231. |
dif also induced endoplasmic reticulum (er) stress by increasing the expression of genes or proteins of bip/grp78, protein disulfide isomerase (pdi), activating transcription factor 4 (atf4), c/ebp homologous protein (chop), and endoplasmic reticulum oxidoreductase 1 alpha (ero1-lα). |
2024-10-25 |
2024-10-28 |
human |
| Xunqi Zhang, Yanxiao Han, Chenliu Fan, Yang Jiang, Wen Jiang, Chengyun Zhen. Epigallocatechin gallate induces apoptosis in multiple myeloma cells through endoplasmic reticulum stress induction and cytoskeletal disruption. International immunopharmacology. vol 141. 2024-08-19. PMID:39159563. |
subsequently, mrna sequencing of egcg-treated mm.1s cells revealed a significant upregulation of genes associated with endoplasmic reticulum stress (ers), including p-eif2α (phosphorylation-eukaryotic translation initiation factor 2 alpha), atf4 (activating transcription factor 4), chop (c/ebp homologous protein, ddit3), and puma (p53 upregulated modulator of apoptosis, bbc3), which were confirmed at the protein level by western blotting. |
2024-08-19 |
2024-08-22 |
mouse |
| Ju Zheng, Yixin Li, Ting Zhang, Yanlin Fu, Peiyan Long, Xiao Gao, Zhengwei Wang, Zhizhong Guan, Xiaolan Qi, Wei Hong, Yan Xia. Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury: PERK as a potential target for intervention. Neural regeneration research. vol 20. issue 5. 2024-07-30. PMID:39075912. |
we found that prolongation of oxygen-glucose deprivation activated the er stress pathway protein kinase-like endoplasmic reticulum kinase (perk)/eukaryotic translation initiation factor 2 subunit alpha (eif2α)-activating transcription factor 4 (atf4)-c/ebp homologous protein (chop), increased neuronal apoptosis, and induced autophagy. |
2024-07-30 |
2024-08-02 |
Not clear |
| Chengmei Xiao, Yipu Li, Yushuang Liu, Ruifang Dong, Xiaoyu He, Qing Lin, Xin Zang, Kaibo Wang, Yuanzheng Xia, Lingyi Kon. Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-12. PMID:38994891. |
the formation of this stable complex disrupts the interaction between transcription factor ap-2 alpha (tfap2a) and atf4-g4, resulting in a substantial reduction in intracellular atf4 levels and the eventual death of cancer cells. |
2024-07-12 |
2024-07-14 |
Not clear |
| André A Weber, Xiaojing Yang, Elvira Mennillo, Samantha Wong, Sabrina Le, Jia Ying Ashley Teo, Max Chang, Christopher W Benner, Jeffrey Ding, Mohit Jain, Shujuan Chen, Michael Karin, Robert H Tuke. Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4. The Journal of biological chemistry. vol 300. issue 6. 2024-05-25. PMID:38705390. |
lactational and oral treatment by gavage with tcs leads to the activation of hepatic nuclear receptors constitutive androstane receptor (car), peroxisome proliferator-activated receptor alpha (pparα), and stress sensor, activating transcription factor 4 (atf4). |
2024-05-25 |
2024-05-27 |
mouse |
| Marisa Miljkovic, Alexandra Seguin, Xuan Jia, James E Cox, Jonathan Leon Catrow, Hector Bergonia, John D Phillips, W Zac Stephens, Diane M War. Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. The Journal of biological chemistry. 2023-06-03. PMID:37269954. |
abcb10 null cells showed increased phosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eif2a), increased expression of nutrient sensing transcription factor atf4 and downstream targets dna damage inducible transcript 3 (chop), chac glutathione specific gamma-glutamylcyclotransferase 1 (chac1) and arginyl-trna synthetase 1 (rars). |
2023-06-03 |
2023-08-14 |
mouse |
| Ashish Tyagi, Balaji Chandrasekaran, Ajit K Navin, Vaibhav Shukla, Becaa V Baby, Murali K Ankem, Chendil Damodara. Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. Free radical biology & medicine. 2023-02-10. PMID:36764624. |
upregulation of nox1 complex proteins and generation of ros activates unfolded protein response (upr) via phosphorylation of protein kinase rna-like endoplasmic reticulum kinase (perk), eukaryotic initiation factor 2 alpha (eif2α), and selective translation of activating transcription factor 4 (atf4). |
2023-02-10 |
2023-08-14 |
mouse |
| Yu-Juan Li, Pei-Pei Hu, Zhiqiang Zhang, Zhi-Hang Yuan, Kun Yang, Zhi-Liang Su. Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells. Toxicology. 2022-05-19. PMID:35588915. |
furthermore, the protein kinase ribose nucleic acid (rna)-like endoplasmic reticulum kinase (perk)/eukaryotic initiation factor 2 alpha (eif2α)/activating transcription factor 4 (atf4) signaling pathway was involved in the induction of protective autophagy in neuro-2a cells. |
2022-05-19 |
2023-08-13 |
Not clear |
| Ying Yu, Bing Liu, Xuexiang Li, Dingheng Lu, Likun Yang, Liang Chen, Yunxue Li, Lulin Cheng, Fang Lv, Pu Zhang, Yarong Song, Yifei Xin. ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells. Cell death & disease. vol 13. issue 1. 2022-01-11. PMID:35013120. |
additional investigation revealed that acting transcription factor 4 (atf4) triggered cemip transcription and enhanced protein kinase c alpha (pkcα) membrane translocation, which regulated the serine70 phosphorylation of bcl-2, while the subsequent dissociation of the bcl-2/beclin1 complex led to autophagy. |
2022-01-11 |
2023-08-13 |
Not clear |
| Zhen-Zhen Feng, Ning Luo, Ying Liu, Jian-Nan Hu, Tao Ma, Yong-Ming Ya. ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells. Biochemical and biophysical research communications. vol 563. 2021-11-11. PMID:34058476. |
here we reported that tg stimulation induced the up-regulation of the endoplasmic reticulum (er)-stress chaperon glucose-regulated protein 78 (grp78), which is a master regulator of the upr, the phosphorylation of eukaryotic initiation factor 2 alpha (elf2α) and the induction of activating transcription factor 4 (atf4), which are both protein kinase r (pkr)-like er kinase (perk) downstream targets in tregs. |
2021-11-11 |
2023-08-13 |
Not clear |
| Lijie Dong, Tingting Lin, Wenbo Li, Yaru Hong, Xinjun Ren, YiFeng Ke, Xiaomin Zhang, Xiaorong L. Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function. Journal of molecular medicine (Berlin, Germany). vol 99. issue 7. 2021-10-11. PMID:33770188. |
psf also attenuated er stress via regulation of the protein kinase r (pkr)-like endoplasmic reticulum kinase perk/eukaryotic translation factor 2 alpha (eif2α)/activating transcription factor 4 (atf4) pathway in 4-hne-treated hrmecs. |
2021-10-11 |
2023-08-13 |
mouse |
| Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Ito. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLoS genetics. vol 16. issue 4. 2020-08-03. PMID:32324833. |
gcn2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elf2α) restores homeostasis in response to amino acid starvation (aas) through the inhibition of the general translation and upregulation of amino acid biosynthetic enzymes and transporters by activating the translation of gcn4 and atf4 in yeast and mammals, respectively. |
2020-08-03 |
2023-08-13 |
mouse |
| Jing Wang, Siqi Huang, Ruicheng Tian, Jing Chen, Hongxiang Gao, Chenjie Xie, Yuhua Shan, Zhen Zhang, Song Gu, Min X. The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK. Oncotarget. vol 9. issue 18. 2019-11-20. PMID:29581853. |
upon activation of perk, there is an increase in phosphorylation of the eukaryotic initiation factor-2 alpha (eif2α), which in turn, activates the transcription factor-4 (atf4), responsible for an increased expression of lc3, a common autophagy marker. |
2019-11-20 |
2023-08-13 |
Not clear |
| Juyi Zhang, Peng Zhang, Chengjie Meng, Baoqi Dang, Haiying Li, Haitao Shen, Zhong Wang, Xiang Li, Gang Che. The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage. Acta neurochirurgica. Supplement. vol 127. 2019-10-28. PMID:31407071. |
we found that levels of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (p-eif2α) and activating transcription factor 4 (atf4) increased significantly and peaked at 12 h during the early phase of the ich. |
2019-10-28 |
2023-08-13 |
rat |
| Hyo Jeong Kim, Yeonsoo Joe, Seul-Ki Kim, Se-Ung Park, Jeongmin Park, Yingqing Chen, Jin Kim, Jinhyun Ryu, Gyeong Jae Cho, Young-Joon Surh, Stefan W Ryter, Uh-Hyun Kim, Hun-Taeg Chun. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway. Free radical biology & medicine. vol 110. 2018-04-12. PMID:28578014. |
sesn2 expression was increased by co or co-releasing molecule (corm2), in a manner dependent on signaling through the protein kinase r-like endoplasmic reticulum kinase (perk), eukaryotic initiation factor-2 alpha (eif2α)/ activating transcription factor-4 (atf4)-dependent pathway. |
2018-04-12 |
2023-08-13 |
mouse |
| Yeonwoo Park, Andrea Reyna-Neyra, Lucas Philippe, Carson C Thoree. mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4. Cell reports. vol 19. issue 6. 2018-02-22. PMID:28494858. |
atf4 translation is normally induced by the phosphorylation of eukaryotic initiation factor 2 alpha (eif2α) through a mechanism that requires upstream open reading frames (uorfs) in the atf4 5' utr. |
2018-02-22 |
2023-08-13 |
human |
| Liming Yu, Buying Li, Meng Zhang, Zhenxiao Jin, Weixun Duan, Guolong Zhao, Yang Yang, Zhenhua Liu, Wensheng Chen, Siwang Wang, Jian Yang, Dinghua Yi, Jincheng Liu, Shiqiang Y. Melatonin reduces PERK-eIF2α-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction. Apoptosis : an international journal on programmed cell death. vol 21. issue 7. 2018-02-05. PMID:27170343. |
recently, we demonstrated that melatonin reduced protein kinase rna (pkr)-like er kinase (perk)-eukaryotic initiation factor 2 alpha (eif2α)-activating transcription factor-4 (atf4)-mediated myocardial endoplasmic reticulum (er) stress and apoptosis during myocardial ischemia-reperfusion (mi/r) injury. |
2018-02-05 |
2023-08-13 |
mouse |
| W Rozpedek, D Pytel, B Mucha, H Leszczynska, J A Diehl, I Majstere. The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress. Current molecular medicine. vol 16. issue 6. 2017-10-02. PMID:27211800. |
as a result, the level of phosphorylated eukaryotic initiation factor 2 alpha (eif2α) is markedly elevated, resulting in the promotion of a pro-adaptive signaling pathway by the inhibition of global protein synthesis and selective translation of activating transcription factor 4 (atf4). |
2017-10-02 |
2023-08-13 |
Not clear |
| Karolina Pakos-Zebrucka, Izabela Koryga, Katarzyna Mnich, Mila Ljujic, Afshin Samali, Adrienne M Gorma. The integrated stress response. EMBO reports. vol 17. issue 10. 2017-07-24. PMID:27629041. |
the core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eif2α) by one of four members of the eif2α kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor atf4, that together promote cellular recovery. |
2017-07-24 |
2023-08-13 |
Not clear |
| Ze-Qun Jiang, Yan-Xia Ma, Mu-Han Li, Xiu-Qin Zhan, Xu Zhang, Ming-Yan Wan. 5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway. Chinese journal of natural medicines. vol 13. issue 12. 2016-10-11. PMID:26721708. |
based on immunofluorescence and western blot assays, we found that galn/tnf-α induced er stress in the cells, as indicated by the disturbance of intracellular ca(2+) concentration, the activation of protein kinase rna (pkr)-like er kinase (perk), phosphorylation of eukaryotic initiation factor 2 alpha (eif2α), and expression of atf4 and chop proteins, which was reversed by 5-hmf pre-treatment in a dose-dependent manner. |
2016-10-11 |
2023-08-13 |
human |