| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Da Eun Kim, Bo Yoon Chang, Byeong Min Jeon, Jong In Baek, Sun Chang Kim, Sung Yeon Ki. SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway. International journal of molecular sciences. vol 21. issue 12. 2021-03-09. PMID:32630596. |
in nafld mice, sgl 121 significantly improved body fat mass; levels of hepatic triglyceride (tg), hepatic malondialdehyde (mda), serum total cholesterol (tc), high-density lipoprotein (hdl), and low-density lipoprotein (ldl); and activities of alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2021-03-09 |
2023-08-13 |
mouse |
| Hang Qu, Xin Gao, Zhen-Yu Wang, Juan-Juan Y. Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo. International journal of biological macromolecules. vol 155. 2021-03-08. PMID:31712149. |
the results showed that pnp80b-2 prevented elevation of biomarkers for liver injury in each model, including alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp) and total bilirubin (tbil). |
2021-03-08 |
2023-08-13 |
cat |
| Xi Jin, Jianguo Gao, Ruoheng Zheng, Mosang Yu, Yue Ren, Tianlian Yan, Yue Huang, Youming L. Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. Cell death & disease. vol 11. issue 2. 2021-03-08. PMID:32054840. |
circrna_002581 knockdown markedly attenuated lipid droplet accumulation, reduced the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), pro-inflammatory cytokines, apoptosis, h |
2021-03-08 |
2023-08-13 |
mouse |
| Hinako Nanri, Ikuko Kashino, Takeshi Kochi, Masafumi Eguchi, Shamima Akter, Akiko Nanri, Isamu Kabe, Tetsuya Mizou. Cross-Sectional Study on the Association between Dietary Non-Enzymatic Antioxidant Capacity and Serum Liver Enzymes: The Furukawa Nutrition and Health Study. Nutrients. vol 12. issue 7. 2021-03-08. PMID:32664291. |
a multiple-regression analysis was performed to explore the association between dietary neac intake and the serum levels of liver enzymes (aspartate aminotransferase (ast), alanine aminotransferase (alt), and gamma-glutamyltransferase (ggt)), after adjustment for confounding factors. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chi Zhang, Jiechang Zhao, Erhunmwunsee Famous, Shenyuan Pan, Xue Peng, Jun Tia. Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil. Food chemistry. vol 346. 2021-03-08. PMID:33387832. |
in a ccl4-induced liver injury mice model, the bpeo treated groups showed increases in the catalase (cat), glutathione (gsh) and total superoxide dismutase (t-sod) activities present in the liver and kidney, and reverses the ccl4-elevated total bilirubin (tbil), glutamate pyruvate transaminase (alt), aspartate aminotransferase (ast), alkaline phosphatase (akp) and malondialdehyde (mda) level, which were confirmed in further analyses of kidney tissue sections. |
2021-03-08 |
2023-08-13 |
mouse |
| Arjunlokesh Netaji, Vandana Jain, Arun Kumar Gupta, Udit Kumar, Manisha Jan. Utility of MR proton density fat fraction and its correlation with ultrasonography and biochemical markers in nonalcoholic fatty liver disease in overweight adolescents. Journal of pediatric endocrinology & metabolism : JPEM. vol 33. issue 4. 2021-03-05. PMID:32146441. |
results mr fat fraction had a moderate positive correlation with serum alanine transaminase (alt) and aspartate transaminase (ast) (ρ = 0.634, p < 0.001, ρ = 0.516, p = 0.002, respectively) and had a negligible or weak correlation with body mass index (bmi), bmi standard deviation score (sds), waist circumference (wc), fasting insulin, homeostatic model assessment of insulin resistance (homa-ir), serum triglyceride, low-density lipoprotein (ldl), high-density lipoprotein (hdl) and total cholesterol levels. |
2021-03-05 |
2023-08-13 |
Not clear |
| Erli Zhang, Jingbo Huang, Kun Wang, Qinlei Yu, Chao Zhu, Hua Re. Pterostilbene Protects Against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF- Journal of medicinal food. vol 23. issue 9. 2021-03-05. PMID:32701014. |
aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels in serum and malondialdehyde (mda), myeloperoxidase (mpo), glutathione (gsh), and superoxide dismutase (sod) contents in liver were examined using detection kits. |
2021-03-05 |
2023-08-13 |
mouse |
| Deise Jaqueline Ströher, Micaela Federizzi de Oliveira, Patrícia Martinez-Oliveira, Bruna Cocco Pilar, Márcia Denise Pavanelo Cattelan, Eliseu Rodrigues, Kalyne Bertolin, Paulo Bayard Dias Gonçalves, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredin. Virgin Coconut Oil Associated with High-Fat Diet Induces Metabolic Dysfunctions, Adipose Inflammation, and Hepatic Lipid Accumulation. Journal of medicinal food. vol 23. issue 7. 2021-03-04. PMID:31800339. |
hfd+vco group increased in diet intake, weight gain, low-density lipoprotein cholesterol level, and aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels. |
2021-03-04 |
2023-08-13 |
rat |
| Oluwatosin Adebisi Dosumu, Solomon Oladapo Rotimi, Oluwagbemiga Olanrewaju Adeleye, Adio Jamiu Akamo, Kehinde Temitope Osinuga, Odunayo Anthonia Taiwo, Oluwatosin Oyebola Omotosho, Latifah Oyefoluke San. Vitamin K protects against 7,12-dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats. Environmental toxicology. vol 36. issue 3. 2021-03-04. PMID:33063951. |
aspartate aminotransaminase (ast), alanine aminotransaminase (alt), γ-glutamyltransferase (ggt), alkaline phosphatase (alp), and lactate dehydrogenase (ldh) activities were significantly (p < .05) elevated in the serum but reduced in the liver of dmba-administered group. |
2021-03-04 |
2023-08-13 |
rat |
| Tristan Ruhwedel, Julian M M Rogasch, Kai Huang, Henning Jann, Imke Schatka, Christian Furth, Holger Amthauer, Christoph Wet. The Prognostic Value of the De Ritis Ratio for Progression-Free Survival in Patients with NET Undergoing [ Cancers. vol 13. issue 4. 2021-03-03. PMID:33562643. |
the prognostic value of the de ritis ratio for progression-free survival in patients with net undergoing [ the de ritis ratio (aspartate aminotransferase [ast]/alanine aminotransferase [alt]) has demonstrated prognostic value in various cancer entities. |
2021-03-03 |
2023-08-13 |
Not clear |
| Robert J Wong, Mamta K Jain, George Therapondos, Mitchell L Shiffman, Onkar Kshirsagar, Christopher Clark, Mae Thame. Sustained Improvements in Markers of Liver Disease Severity After Hepatitis C Treatment. Journal of clinical and experimental hepatology. vol 10. issue 2. 2021-03-02. PMID:32189926. |
we aim to evaluate longitudinal changes in aspartate (ast), alanine (alt) aminotransferase, platelet count (plt), and fibrosis-4 (fib-4) after hcv treatment. |
2021-03-02 |
2023-08-13 |
Not clear |
| Lei Qiao, Xina Dou, Shuqi Yan, Baohua Zhang, Chunlan X. Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity. Food & function. vol 11. issue 4. 2021-03-02. PMID:32243488. |
our results showed that oral administration of senps significantly inhibited the increase of the serum alanine aminotransferase (alt), aspartate aminotransferase (ast), diamine oxidase (dao) and d-lactic acid (d-la) levels induced by diquat, and increased the total superoxide dismutase (t-sod), thioredoxin reductase (trxr) and glutathione peroxidase (gsh-px) activities in serum and jejunum. |
2021-03-02 |
2023-08-13 |
mouse |
| Hao-Nan Wang, Shi-Bing Liang, Xiao-Ling Yao, Bao-Yong Lai, Tian-Yuan Wen, Ning S. [Systematic review and Meta-analysis of efficacy and safety of Compound Glycyrrhizin Injection in improving chronic hepatitis B liver damage]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 3. 2021-03-02. PMID:33645037. |
in the comparison between cgi+other commonly used drugs(including energy mixture, glutathione, vitamins, potassium magnesium aspartate) and diammonium glycyrrhizinate+other commonly used drugs, the results showed that cgi combined with other commonly used drugs was better than the control group in reducing alt and ast level and improving the clinical total effective rate, and there was no statistical difference between the two groups in increasing the rate of alt normalization. |
2021-03-02 |
2023-08-13 |
human |
| Yu-Zhong DU, Jie Su, Mei-Qiu Yan, Su-Hong Chen, Gui-Yuan Lyu, Jing-Jing Y. [Improvement effect and mechanism of ethanol extract from Citri Reticulatae Pericarpium on triglyceride in hyperlipidemia model rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 1. 2021-03-02. PMID:33645070. |
triglyceride(tg), alanine aminotransferase(alt), aspartate aminotransferase(ast), alkaline phosphatase(alp) in serum, tg in liver tissue and tg in fecal were detected. |
2021-03-02 |
2023-08-13 |
rat |
| Yun Ling, Zheng Shi, Xingliang Yang, Zhaowei Cai, Lixia Wang, Xuming Wu, Aiqin Ye, Jianping Jian. Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism. Experimental gerontology. vol 130. 2021-03-01. PMID:31760082. |
we found that ptfc significantly reduced levels of serum cholesterol (tc), triglyceride (tg) and low-density lipoprotein cholesterol (ldl-c) and improved levels of alanine transaminase (alt), aspartate transaminase (ast) and alkaline phosphatase (alp) which associated with liver function in golden hamsters. |
2021-03-01 |
2023-08-13 |
Not clear |
| Xiaohong Pang, Qian Qiao, Sayyaphone Vonglorkham, Zhongwen Feng, Lijun Pang, Siyun Chen, Dandan Wang, Lingling Lao, Xing Lin, Jinbin We. Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32540645. |
the results showed that aapc significantly ameliorated lps/d-galn-induced ali in mice, as evidenced by the improvement of liver pathology and the decrease in serum alanine aminotransferase (alt) and aspartate transaminase (ast) activities. |
2021-03-01 |
2023-08-13 |
mouse |
| Jie Lin, Han-Fei Huang, Shi-Kun Yang, Jian Duan, Si-Ming Qu, Bo Yuan, Zhong Zen. The effect of Ginsenoside Rg1 in hepatic ischemia reperfusion (I/R) injury ameliorates ischemia-reperfusion-induced liver injury by inhibiting apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32603889. |
the results showed that rg1 reduced the levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2021-03-01 |
2023-08-13 |
rat |
| Shufang Li, Meng Zhang, Bei Zhan. MTMR14 protects against hepatic ischemia-reperfusion injury through interacting with AKT signaling in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 129. 2021-03-01. PMID:32768948. |
mtmr14-tg mice following hepatic ir operation had obviously ameliorated liver pathological changes, along with improved hepatic dysfunction, which was proved by the decreased serum alanine amino transferase (alt) and aspartate amino transferase (ast) levels. |
2021-03-01 |
2023-08-13 |
mouse |
| Julia C Drees, Soora Wi, Joanna B Ready, Richard S Dlott, Barbara J Fetterman, Suk I Seo, Mary Pat Pauly, Matthew S Petrie, Thomas S Lore. Serum Fibrosis Marker Panels FIB-4 Index and Aspartate Aminotransferase (AST)-to-Platelet Ratio Index (APRI) Are Equivalent to AST Alone at Predicting Liver Fibrosis in a Cohort of 1731 Patients Infected with Hepatitis C Virus. The journal of applied laboratory medicine. vol 2. issue 1. 2021-03-01. PMID:33636957. |
serum fibrosis marker panels fib-4 index and aspartate aminotransferase (ast)-to-platelet ratio index (apri) are equivalent to ast alone at predicting liver fibrosis in a cohort of 1731 patients infected with hepatitis c virus. |
2021-03-01 |
2023-08-13 |
Not clear |
| Julia C Drees, Soora Wi, Joanna B Ready, Richard S Dlott, Barbara J Fetterman, Suk I Seo, Mary Pat Pauly, Matthew S Petrie, Thomas S Lore. Serum Fibrosis Marker Panels FIB-4 Index and Aspartate Aminotransferase (AST)-to-Platelet Ratio Index (APRI) Are Equivalent to AST Alone at Predicting Liver Fibrosis in a Cohort of 1731 Patients Infected with Hepatitis C Virus. The journal of applied laboratory medicine. vol 2. issue 1. 2021-03-01. PMID:33636957. |
compared to biopsy, several studies demonstrated favorable performance of noninvasive multianalyte serum fibrosis marker panels [fibrosis-4 (fib-4) index] and aspartate aminotransferase (ast)-to-platelet ratio index (apri), but suggested cutoffs vary widely. |
2021-03-01 |
2023-08-13 |
Not clear |