| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Zhao, Ting Yang, Jiayan Zhou, Yanli Chen, Qian Shen, Jiankang Zhang, Qianqian Qi. Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption. Current research in pharmacology and drug discovery. vol 5. 2023-07-07. PMID:37416532. |
in this study, fucoidan significantly lowered serum activities of alanine aminotransferase (alt) and aspartate aminotransferase (ast), decreased serum levels of uric acid, creatinine and uric nitrogen, restored the deregulation of the renal urate transporter 1 (urat1), organic anion transporter 1 (oat1), and organic cation/carnitine transporter 1/2 (octn1/2), consistence with alleviation bdl-induced liver and kidney dysfunction, inflammation and fibrosis in mice. |
2023-07-07 |
2023-08-14 |
mouse |
| Heba M Mahmoud, Deiaa E Elsayed Abouzed, Amira M Abo-Youssef, Ramadan A M Hemeid. Zafirlukast protects against hepatic ischemia-reperfusion injury in rats via modulating Bcl-2/Bax and NF-κB/SMAD-4 pathways. International immunopharmacology. vol 122. 2023-07-07. PMID:37418987. |
serum alanine aminotransferase (alt), aspartate aminotransferase (ast), total bilirubin (tbl) levels, and gamma glutamyl transferase (ggt) activity were estimated. |
2023-07-07 |
2023-08-14 |
rat |
| Melva Silitonga, Erlintan Sinaga, Meida Nugrahalia, Pasar M Silitong. Hepatoprotective activity of ethanolic extract of Plectranthus amboinicus (lour.) spreng leaf in DMBA induced rats. Toxicon : official journal of the International Society on Toxinology. 2023-07-07. PMID:37419284. |
at the end of the treatment, blood samples were collected to investigate the levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), bilirubin, total protein, albumin and globulin as well as the hematological parameter, such as neutrophils, monocyte, mean corpuscular hemoglobin (mch), mean corpuscular volume (mcv), mean corpuscular hemoglobin concentration (mchc), and red cell distribution width (rdw) were monitored. |
2023-07-07 |
2023-08-14 |
rat |
| Hang Yuan, Minghua Xie, Naijie Hu, Yudong Zheng, Cuihong Hou, Beiping Tan, Lili Shi, Shuang Zhan. Growth, immunity and transcriptome response to different stocking densities in Litopenaeus vannamei. Fish & shellfish immunology. 2023-07-05. PMID:37406891. |
increasing stocking density significantly increased the activities of aspartate aminotransferase (ast), alanine aminotransferase (alt) and lysozyme (lys) while significantly decreased the activities of catalase (cat) and phenol oxidase (po) in the serum of l. vannamei. |
2023-07-05 |
2023-08-14 |
cat |
| Jian Su, Haoyu Guan, Xikang Fan, Hao Yu, Yu Qin, Jie Yang, Zheng Zhu, Chong Shen, Enchun Pan, Yan Lu, Jin-Yi Zhou, Ming W. Associations of serum aminotransferase and the risk of all-cause and cause-specific mortality in Chinese type 2 diabetes: a community-based cohort study. BMJ open. vol 13. issue 7. 2023-07-05. PMID:37407041. |
investigating the associations of alanine aminotransferase (alt) and aspartate aminotransferase (ast) with all-cause, cardiovascular disease (cvd) and cancer mortality in a large cohort of community-dwelling patients with type 2 diabetes mellitus (t2dm). |
2023-07-05 |
2023-08-14 |
Not clear |
| Mayuko Hori, Kaoru Yasuda, Hiroshi Takahashi, Tomonori Aoi, Yoshiko Mori, Makoto Tsujita, Yuichi Shirasawa, Chika Kondo, Takashi Hashimoto, Hiroichi Koyama, Kunio Morozumi, Shoichi Maruyam. The Impact of Liver Chemistries on Respiratory Failure among Hemodialysis Patients with COVID-19 During the Omicron Wave. Internal medicine (Tokyo, Japan). 2023-07-05. PMID:37407459. |
information on the symptoms and clinical characteristics, including liver chemistries [aspartate aminotransferase (ast) and alanine aminotransferase (alt)], at admission was collected. |
2023-07-05 |
2023-08-14 |
Not clear |
| Jonathon H Hines, Sujesh Pilla. Gallstone Pancreatitis Post Laparoscopic Cholecystectomy: A Case Report. Cureus. vol 15. issue 5. 2023-07-03. PMID:37398787. |
the patient had elevated total bilirubin, aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), and lipase. |
2023-07-03 |
2023-08-14 |
Not clear |
| Boya Zhang, Ying Zhou, Junyu Gu. Association of volatile methylsiloxanes exposure with non-alcoholic fatty liver disease among Chinese adults. Environmental pollution (Barking, Essex : 1987). 2023-07-03. PMID:37399934. |
with per doubling increase in the total cvmss, we observed a 1.40 (95%ci: 0.31, 2.48) increase in alanine aminotransferase (alt), a 1.56 (95%ci: 0.52, 2.61) increase in aspartate aminotransferase (ast) and a 0.04 (0.00, 0.09) increase in nafld index. |
2023-07-03 |
2023-08-14 |
human |
| Jae-Ho Choi, Jun-Hwan Ki. Toxic effects of sub-acute microplastic (polyamide) exposure on the accumulation, hematological, and antioxidant responses in crucian carp, Carassius carassius. Environmental toxicology and pharmacology. 2023-06-30. PMID:37391052. |
plasma components such as calcium, magnesium, glucose, cholesterol, total protein, aspartate aminotransferase (ast), alanine aminotransferase (alt), and alkaline phosphatase (alp) were significantly altered by pa exposure. |
2023-06-30 |
2023-08-14 |
cat |
| Suleyman Koc, Ahmet Aktas, Bilal Sahin, Hatice Ozer, Gozde Erturk Zararsi. Protective effect of ursodeoxycholic acid and resveratrol against tacrolimus induced hepatotoxicity. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023-06-29. PMID:37381715. |
in group b, serum alanine aminotransferase (alt), aspartate aminotransferase (ast), tumor necrosis factor-alpha (tnf), interleukin-1 (il-1), interleukin-6 (il-6), total oxidative status (tos) and malondialdehyde (mda) levels were higher compared to group a, and catalase (cat), superoxide dismutase (sod) levels and total antioxidant status (tas) were lower compared to group a. |
2023-06-29 |
2023-08-14 |
rat |
| Janet Olayemi Olugbodi, Bashir Lawal, Godiya Bako, Amos Sunday Onikanni, Sulama M Abolenin, Soliman S Mohammud, Farid S Ataya, Gaber El-Saber Batih. Effect of sub-dermal exposure of silver nanoparticles on hepatic, renal and cardiac functions accompanying oxidative damage in male Wistar rats. Scientific reports. vol 13. issue 1. 2023-06-29. PMID:37386048. |
our results revealed that the subdermal administration of agnps induced significant increased (p < 0.05) activities of aspartate aminotransferase (ast), alanine transferase (alt), alkaline phosphatase (alp), urea, creatinine, and malondialdehyde (mda) while decreasing the levels of glutathione (gsh), catalase (cat), superoxide dismutase (sod), and total thiol groups in the rat tissues. |
2023-06-29 |
2023-08-14 |
human |
| Franccesco P Boeno, Jay Patel, Ryan N Montalvo, Stephanie S Lapierre-Nguyen, Claire M Schreiber, Ashley J Smude. Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373368. |
while there is currently no standard of care to treat dox hepatic- and nephrotoxicity, endurance exercise preconditioning may be an effective intervention to prevent elevations in liver alanine transaminase (alt) and aspartate aminotransferase (ast) and to improve kidney creatinine clearance. |
2023-06-28 |
2023-08-14 |
rat |
| Raja Chinnappan, Tanveer Ahmad Mir, Sulaiman Alsalameh, Tariq Makhzoum, Salma Adeeb, Khaled Al-Kattan, Ahmed Yaqinuddi. Aptasensors Are Conjectured as Promising ALT and AST Diagnostic Tools for the Early Diagnosis of Acute Liver Injury. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374056. |
abnormal levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast) in human serum are the most sensitive indicator of hepatocellular damage. |
2023-06-28 |
2023-08-14 |
human |
| Arduino A Mangoni, Angelo Zinell. An Updated Systematic Review and Meta-Analysis of the Association between the De Ritis Ratio and Disease Severity and Mortality in Patients with COVID-19. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374107. |
patients with coronavirus disease 2019 (covid-19) often have elevations in markers of liver injury, particularly serum aspartate transaminase (ast) and alanine transaminase (alt). |
2023-06-28 |
2023-08-14 |
Not clear |
| S Rahimnejad, E Leclercq, O Malinovskyi, T Pěnka, J Kolářová, T Polica. Effects of yeast hydrolysate supplementation in low-fish meal diets for pikeperch. Animal : an international journal of animal bioscience. vol 17. issue 7. 2023-06-28. PMID:37379608. |
the highest alanine aminotransferase, aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) activities were detected in the sm60 group, and yh addition significantly decreased the ast and ldh activities. |
2023-06-28 |
2023-08-14 |
Not clear |
| Adem Kara, Seckin Ozkanla. Blockade of P2X7 receptor-mediated purinergic signaling with A438079 protects against LPS-induced liver injury in rats. Journal of biochemical and molecular toxicology. 2023-06-27. PMID:37365769. |
in the biochemical analysis, serum aspartate transaminase (ast) and alanine transaminase (alt) concentrations, the tissue glutathione (gsh) level, and superoxide dismutase (sod) activity dramatically decreased and malondialdehyde (mda) level increased in the lps and lps + dmso groups compared to the lps + a438079 group. |
2023-06-27 |
2023-08-14 |
rat |
| Taseer Ahmad, Taous Khan, Annet Kirabo, Abdul Jabbar Sha. Antioxidant Flavonoid Diosmetin Is Cardioprotective in a Rat Model of Myocardial Infarction Induced by Beta 1-Adrenergic Receptors Activation. Current issues in molecular biology. vol 45. issue 6. 2023-06-27. PMID:37367046. |
to test this hypothesis, we evaluated the cardioprotective potential of diosmetin on isoproterenol-induced mi in rats by performing lead ii electrocardiography (ecg), cardiac biomarkers including troponin i (ctni) and creatinine phosphokinase (cpk), ck-myocardial band, (ck-mb), lactate dehydrogenase (ldh), alanine aminotransferase (alt), and aspartate aminotranferase (ast) by using biolyzer 100, as well as histopathological analysis. |
2023-06-27 |
2023-08-14 |
rat |
| Jiangxue Han, Shunwang Li, Weizhi Wang, Xinhai Jiang, Chao Liu, Lijuan Lei, Yining Li, Ren Sheng, Yuyan Zhang, Yexiang Wu, Jing Zhang, Yuhao Zhang, Yanni Xu, Shuyi S. SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism. Current issues in molecular biology. vol 45. issue 6. 2023-06-27. PMID:37367070. |
liver-related plasma biochemistry parameter tests, oil red o staining, and hematoxylin-eosin staining results showed that e1231 treatment ameliorated plasma dyslipidemia, plasma marker levels of liver damage (alanine aminotransferase (alt) and aspartate aminotransferase (ast)), liver total cholesterol (tc) and triglycerides (tg) contents, and obviously decreased hepatic steatosis score and nafld activity score (nas) in the nafld mouse model. |
2023-06-27 |
2023-08-14 |
mouse |
| Ayaka Kasai, Mitsuo Motobayashi, Makoto Nishioka, Tetsuhiro Fukuyama, Yuji Inab. A serial analysis of serum aspartate aminotransferase levels in patients with acute encephalopathy with biphasic seizures and late reduced diffusion and prolonged febrile seizure. Brain & development. 2023-06-25. PMID:37357027. |
based on our clinical experience, we hypothesized that serial examinations of blood levels of aspartate aminotransferase (ast) in children with febrile convulsive status epilepticus (fcse) revealed higher levels in patients with aesd in the 1st seizure phase than in those with prolonged febrile seizures (pfs). |
2023-06-25 |
2023-08-14 |
Not clear |
| Shengpeng Zhang, Peng Zhu, Jianan Yuan, Kunming Cheng, Qixiang Xu, Wei Chen, Zui Pan, Yongqiu Zhen. Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats. Frontiers in pharmacology. vol 14. 2023-06-22. PMID:37346294. |
the development of nafld was further evaluated by measuring serum concentrations of triglyceride (tg), total cholesterol (t-cho), alanine aminotransferase (alt), aspartate aminotransferase (ast), and lipopolysaccharide (lps). |
2023-06-22 |
2023-08-14 |
rat |