| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Flavio Ronchetto, Domenico Barone, Marcella Cintorino, Michele Berardelli, Silvana Lissolo, Renzo Orlassino, Piero Ossola, Santi Tofan. Extremely low frequency-modulated static magnetic fields to treat cancer: A pilot study on patients with advanced neoplasm to assess safety and acute toxicity. Bioelectromagnetics. vol 25. issue 8. 2005-03-31. PMID:15515038. |
aspartate aminotransferase (ast) and alanine aminotransferase (alt) elevation (grade 2 toxicity) in 1 patient and microscopic urinary abnormalities in 5 patients were the only negative effects observed. |
2005-03-31 |
2023-08-12 |
human |
| V G Barskova, V A Nasonova, T N Tsapina, A E Karateev, I A Iakunina, M S Eliseev, E V Il'inykh, E L Nasono. [The effectiveness and safety of nimesulide (nimesile) in patients with gouty arthritis]. Klinicheskaia meditsina. vol 82. issue 12. 2005-03-29. PMID:15732721. |
the tolerability of the drug was evaluated by its effect on renal (the levels of creatinine and urea, creatinine clearance) and hepatic (alanine transferase (alt), aspartate transferase (ast), gamma-glutamyltranspeptidase (gamma-gtp)) functions, and blood pressure (bp) [24-hour bp monitoring (24-h bpm) before and after treatment. |
2005-03-29 |
2023-08-12 |
Not clear |
| N Kimura, I Yoshimura, T Sako, A Inoue, K Tadami, T Ara. Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of fattening steers. Veterinary research communications. vol 29. issue 1. 2005-03-23. PMID:15727288. |
activities of hexokinase (hk), glucose-6-phosphate dehydrogenase (g6pd), aspartate aminotransferase (ast), and malate dehydrogenase (mdh) in cytosolic fractions, and glutamate dehydrogenase (gldh), mdh and ast in mitochondrial fractions in peripheral leukocytes of steers at 24 months of age were significantly higher than those at 8 months. |
2005-03-23 |
2023-08-12 |
Not clear |
| Ahmet Atessahin, Izzet Karahan, Ibrahim Pirincc. Effects of therapeutic and toxic doses of levamisole on thyroid hormones and some biochemical parameters in sheep. Cell biochemistry and function. vol 22. issue 5. 2005-03-18. PMID:15338466. |
while serum alkaline phosphatase (alp) activities were decreased, aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh) and creatinine kinase (ck) activities were increased significantly by levamisole. |
2005-03-18 |
2023-08-12 |
Not clear |
| Masaaki Miyata, Aki Tozawa, Hijiri Otsuka, Toshifumi Nakamura, Kiyoshi Nagata, Frank J Gonzalez, Yasushi Yamazo. Role of farnesoid X receptor in the enhancement of canalicular bile acid output and excretion of unconjugated bile acids: a mechanism for protection against cholic acid-induced liver toxicity. The Journal of pharmacology and experimental therapeutics. vol 312. issue 2. 2005-03-18. PMID:15466244. |
serum aspartate aminotransferase (ast) activity was elevated 15.7-fold after feeding a 0.25% cholic acid diet, whereas only slight increases in serum ast (1.7- and 2.5-fold) were observed in wild-type mice fed 0.25 and 1% cholic acid diet, respectively. |
2005-03-18 |
2023-08-12 |
mouse |
| Hen I Lin, David Wang, Fur-Jiang Leu, Chao-Fuh Chen, Hsing I Che. Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor. The Chinese journal of physiology. vol 47. issue 3. 2005-03-15. PMID:15612529. |
immunohistochemistry was used to examine the protein expression of endothelial and inducible nitric oxide synthases (enos, inos) and nitrotyrosine after i/r challenges to the liver, and blood levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), lactic dehydrogenase (ldh), hydroxyl radical and no were measured before ischemia and after reperfusion. |
2005-03-15 |
2023-08-12 |
rat |
| Gönül Simsek, Hafize Uzun, Seval Aydin, Yesari Karter, Ali Benian, Nuran Dariyerli, Safiye Kaya, Günnur Yigi. The role of nitric oxide on bone metabolism in ovariectomized rats following chronic ethanol intake. Life sciences. vol 76. issue 17. 2005-03-15. PMID:15707879. |
serum interleukin (il)-1beta, il-6, tumor necrosis factor (tnf)-alpha, no, calcium (ca), phosphorous (p), parathyroid hormone (pth), 25 hydroxyvitamind3 [25(oh)d3], alkaline phosphatase (alp), bone alkaline phosphatase (b-alp), alanine amino transferase (alt), aspartate amino transferase (ast), gamma-glutamyltransferase (ggt) levels were measured in different stages of the experiment. |
2005-03-15 |
2023-08-12 |
rat |
| Helen Tremlett, Joel Oge. Hepatic injury, liver monitoring and the beta-interferons for multiple sclerosis. Journal of neurology. vol 251. issue 11. 2005-03-14. PMID:15592724. |
of the commonly used biochemical liver tests, alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (ap) and bilirubin appear the most useful for routine monitoring of ifnb treatment. |
2005-03-14 |
2023-08-12 |
Not clear |
| X Ye, H C Meeker, P B Kozlowski, J Wegiel, K C Wang, H Imaki, R I Car. Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8): a mouse model for the study of liver diseases. Histology and histopathology. vol 19. issue 4. 2005-03-11. PMID:15375757. |
samp8 mice also show abnormal liver function tests: significantly increased levels of alanine amino-transferase (alt) and aspartate aminotransferase (ast). |
2005-03-11 |
2023-08-12 |
mouse |
| Ilyas Ozardali, Muharrem Bitiren, Ali Ziya Karakilçik, Mustafa Zerin, Nurten Aksoy, Davut Mus. Effects of selenium on histopathological and enzymatic changes in experimental liver injury of rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 56. issue 1-2. 2005-03-10. PMID:15581276. |
while the activities of aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (alp) were significantly increased (p < 0.05, p < 0.05 and p < 0.01, respectively), gamma-glutamyle transferase (ggt) activity was not statistically affected (p < 0.05) with carbon tetrachloride-injection. |
2005-03-10 |
2023-08-12 |
rat |
| Masato Abe. [Aspartate aminotransferase (AST), alanine aminotransferase (ALT)]. Nihon rinsho. Japanese journal of clinical medicine. vol 62 Suppl 11. 2005-03-10. PMID:15628414. |
[aspartate aminotransferase (ast), alanine aminotransferase (alt)]. |
2005-03-10 |
2023-08-12 |
Not clear |
| Rahul A Nathwani, Shireen Pais, Telfer B Reynolds, Neil Kaplowit. Serum alanine aminotransferase in skeletal muscle diseases. Hepatology (Baltimore, Md.). vol 41. issue 2. 2005-03-10. PMID:15660433. |
in acute cases, aspartate aminotransferase (ast) and alt were both elevated, and the ast/alt ratio was greater than 3, but this ratio approached 1 after a few days because of a faster decline in ast. |
2005-03-10 |
2023-08-12 |
Not clear |
| Jing Gao, Xinhui Tang, Huan Dou, Yimei Fan, Xiaoning Zhao, Qiang X. Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. The Journal of pharmacy and pharmacology. vol 56. issue 11. 2005-03-07. PMID:15525453. |
in the acute hepatic damage test, remarkable rises in the activity of serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) (5.7- and 2.0-fold) induced by ccl(4) were reversed and significant morphological changes were lessened with pre-treatment with 50 and 100 mg kg(-1) tcce. |
2005-03-07 |
2023-08-12 |
Not clear |
| Göksel Sener, Ozer Sehirli, Yeşim Ipçi, Feriha Ercan, Serap Sirvanci, Nursal Gedik, Berrak C Yeğe. Aqueous garlic extract alleviates ischaemia-reperfusion-induced oxidative hepatic injury in rats. The Journal of pharmacy and pharmacology. vol 57. issue 1. 2005-03-07. PMID:15639002. |
serum aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels were determined to assess liver functions. |
2005-03-07 |
2023-08-12 |
rat |
| Saura C Sahu, Philip P Sapienza, Robert L Sprando, Thomas F X Collins, Ivan A Ross, Thomas J Flynn, Paddy L Wiesenfeld, Michael W O'Donnell, Chung S Ki. Hepatotoxicity of androstenedione in pregnant rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 43. issue 2. 2005-03-03. PMID:15621347. |
on gestation day 20, blood and livers were collected from the pregnant rats for analysis of hepatotoxicity endpoints: serum alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), glutathione (gsh) and glutathione s-transferase (gst), total microsomal p450, nuclear dna damage and lipid peroxidation. |
2005-03-03 |
2023-08-12 |
rat |
| Rahul A Nathwani, S Ram Kumar, Telfer B Reynolds, Neil Kaplowit. Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. The American journal of gastroenterology. vol 100. issue 2. 2005-03-01. PMID:15667485. |
choledocholithiasis causes elevations in levels of alkaline phosphatase out of proportion to aspartate aminotransferase (ast) and alanine aminotransferase (alt). |
2005-03-01 |
2023-08-12 |
Not clear |
| Laura Dugo, Marika Collin, Salvatore Cuzzocrea, Christoph Thiemerman. 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. European journal of pharmacology. vol 498. issue 1-3. 2005-02-28. PMID:15364008. |
g+/g- shock for 6 h resulted in an increase in serum levels of creatinine (indicator of renal dysfunction), alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma-glutamyl transferase (gamma-gt), bilirubin (markers for hepatic injury and dysfunction) and creatine kinase (ck, an indicator of neuromuscular, skeletal muscle or cardiac injury). |
2005-02-28 |
2023-08-12 |
rat |
| Hanefi Ozbek, Gülçin Saltan Citoğlu, Haluk Dülger, Serdar Uğraş, Betül Seve. Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. Journal of ethnopharmacology. vol 95. issue 2-3. 2005-02-22. PMID:15507327. |
biochemical parameters of hepatic damage such as serum aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp) and bilirubin concentrations were determined. |
2005-02-22 |
2023-08-12 |
rat |
| María J Tutor-Crespo, Jesús Hermida, J Carlos Tuto. Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs. Clinical biochemistry. vol 37. issue 8. 2005-02-18. PMID:15302618. |
this would be expected to lead to a decrease in the sensitivity of aspartate aminotransferase (ast) and alanine aminotransferase (alt) for the detection of hepatocellular damage in these patients if optimized methods with coenzyme supplementation are not used. |
2005-02-18 |
2023-08-12 |
Not clear |
| Aruna Kode, Rukkumani Rajagopalan, Suresh Varma Penumathsa, Venugopal P Meno. Influence of a thiazole derivative on ethanol and thermally oxidized sunflower oil-induced oxidative stress. Fundamental & clinical pharmacology. vol 18. issue 5. 2005-02-17. PMID:15482378. |
hepatotoxicity was assessed by measuring the activity of plasma aspartate transaminase (ast), alkaline phosphatase (alp) and gamma-glutamyl transferase (ggt), which were elevated in thermally oxidized oil, and ethanol fed rats when compared with normal control rats. |
2005-02-17 |
2023-08-12 |
rat |