| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chi-Ching Yang, Jong-Yi Fang, Tuan-Liang Hong, Tzu-Ching Wang, Ya-En Zhou, Ta-Chen Li. Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats. International immunopharmacology. vol 15. issue 1. 2013-06-24. PMID:23142091. |
the animal experiments showed that the ccl(4) treatment increased serum alanine aminotransferase (alt) and aspartate aminotransferase (ast) activities, but decreased triglyceride (tg) and glutathione (gsh) levels as well as glutathione peroxidase (gpx), superoxide dismutase (sod) and catalase (cat) activities. |
2013-06-24 |
2023-08-12 |
rat |
| Yuzhen Wang, Yunxu Li, Jiming Xie, Yong Zhang, Jinling Wang, Xiaolin Sun, Heping Zhan. Protective effects of probiotic Lactobacillus casei Zhang against endotoxin- and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities. International immunopharmacology. vol 15. issue 1. 2013-06-24. PMID:23146349. |
in addition, pretreatment with lcz significantly decreased alanine transaminase (alt) and aspartate aminotransferase (ast) levels in lps/d-galn-challenged rats, which were accompanied by diminished liver injuries, reduced malondialdehyde (mda) content and increased superoxide dismutase (sod) activity in liver homogenates. |
2013-06-24 |
2023-08-12 |
rat |
| Kostas I Sombolos, Stelios K Fragidis, Gerasimos I Bamichas, Victoria N Hatsiou, Christos K Bantis, Hellada S Tsantekidou, Taisir A Natse, Christina I Fytil. Dogma disputed: postdialysis increase of aminotransferase values cannot be attributed to an inhibitor removal by hemodialysis. ASAIO journal (American Society for Artificial Internal Organs : 1992). vol 58. issue 6. 2013-06-21. PMID:23013841. |
the objective of this study was to assess changes of aspartate aminotransferase (ast [serum glutamic oxalacetic transaminase]) and alanine aminotransferase (alt [serum glutamic pyruvic transaminase]) values after a hemodialysis (hd) session. |
2013-06-21 |
2023-08-12 |
Not clear |
| Mohammed Shakil Akhtar, Fuad Qaw, J Francis Borgio, Waleed Albuali, Ahmed Suliman, Zaki Nasserullah, Sana Al-Jarrash, Amein Al-Al. Spectrum of α-thalassemia mutations in transfusion-dependent β-thalassemia patients from the Eastern Province of Saudi Arabia. Hemoglobin. vol 37. issue 1. 2013-06-20. PMID:23297837. |
comparison of the clinical phenotype of β-thal patients, with and without an α-thal mutation, showed that patients with β-thal alone had a significantly elevated level of alanine transaminase (alt) (mean 72.5 iu/l) and aspartate transaminase (ast) (mean 71.8 iu/l) (p <0.005). |
2013-06-20 |
2023-08-12 |
Not clear |
| Chunjing Zhang, Chunchao Han, Baosheng Zhao, Haitao Y. The protective effects of aqueous extracts of wild-growing and fermented Royal Sun mushroom, Agaricus brasiliensis S. Wasser et al. (higher basidiomycetes), in CCl4-induced oxidative damage in rats. International journal of medicinal mushrooms. vol 14. issue 6. 2013-06-20. PMID:23510249. |
an in vivo study of carbon tetrachloride (ccl4)-induced antioxidant activity in 2-month-old rats was conducted by examining the levels of activities of alanine aminotransaminase (alt) and aspartate aminotransaminase (ast) and the antioxidant enzymes, including glutathione peroxidase (gshpx) and catalase (cat). |
2013-06-20 |
2023-08-12 |
rat |
| Aleksandra Topic, Mirjana Djuki. Diagnostic characteristics and application of alcohol biomarkers. Clinical laboratory. vol 59. issue 3-4. 2013-06-19. PMID:23724610. |
alcohol biomarkers traditionally used in clinical practice [blood alcohol concentration (bac), gamma-glutamyl transferase (ggt), carbohydrate-deficient transferrin (cdt), the ratio ggt/cdt, alanine aminotransferase (alt), aspartate aminotransferase (ast), the rati. |
2013-06-19 |
2023-08-12 |
human |
| O Atakisi, E Atakisi, A Ozcan, M Karapehlivan, A Kar. Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats. European review for medical and pharmacological sciences. vol 17. issue 4. 2013-06-18. PMID:23467944. |
in this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 fa) on diethylnitrosamine (den) toxicity with respect to alterations including nitric oxide (no) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (ast), alanine aminotransferase (alt) and alkaline phosphatase (alp) activities in rats. |
2013-06-18 |
2023-08-12 |
rat |
| E V Vinnitskaia, V N Drozdov, Iu M Iunusova, G G Varvanina, N A Shaposhnikova, A V Petrakov, E V Tkachenko, L B Lazebni. [Diagnostic value of serum markers of fibrosis in chronic liver diseases]. Terapevticheskii arkhiv. vol 85. issue 2. 2013-06-18. PMID:23653935. |
to estimate the diagnostic value (dv) of direct markers of liver fibrosis, such as type iv collagen (c-iv), hyaluronic acid (ha), tissue inhibitor of metalloproteinases-1 (timp-1) in combination with indirect markers of fibrosis, such as alanine aminotransferase (alt), aspartate aminotransferase (ast), and gamma-glutamyl transpeptidase (gamma-gtp), alkaline phosphatase (alp), platelets, tumor necrosis factor-alpha (tnf-alpha) in evaluating liver fibrosis. |
2013-06-18 |
2023-08-12 |
Not clear |
| Heibatullah Kalantari, Hamid Galehdari, Zahra Zaree, Rudolf Gesztelyi, Balazs Varga, David Haines, Mariann Bombicz, Arpad Tosaki, Bela Juhas. Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 51. 2013-06-17. PMID:23010670. |
the in vivo liver toxicity of artemisia dracunculus was assessed in the blood of mice treated orally with the extract of the herb, using alanine aminotransferase (alt) and aspartate aminotransferase (ast) as liver function indicators. |
2013-06-17 |
2023-08-12 |
mouse |
| Sebastian G Bernardo, Marina Moskalenko, Michael Pan, Shaily Shah, Harleen K Sidhu, Serge Sicular, Sara Harcharik, Rui Chang, Philip Friedlander, Yvonne M Saenge. Elevated rates of transaminitis during ipilimumab therapy for metastatic melanoma. Melanoma research. vol 23. issue 1. 2013-06-17. PMID:23262440. |
aspartate aminotransferase (ast) and alanine aminotransferase (alt) elevation, as defined by the national cancer institute's common terminology criteria for adverse events, each occurred in six of 11 cases (≥grade 1), a notably higher frequency than could be expected on the basis of the fda licensing study where elevations were reported in 0.8 and 1.5% of patients for ast and alt, respectively. |
2013-06-17 |
2023-08-12 |
Not clear |
| Adelheid Weidinger, Peter Dungel, Martin Perlinger, Katharina Singer, Corina Ghebes, J Catharina Duvigneau, Andrea Müllebner, Ute Schäfer, Heinz Redl, Andrey V Kozlo. Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators. Frontiers in physiology. vol 4. 2013-06-14. PMID:23760194. |
the leakage of aspartate aminotransferase (ast) was observed only during the hypoxic phase in the hox/rox model. |
2013-06-14 |
2023-08-12 |
rat |
| Thomas M Herndon, Suzanne G Demko, Xiaoping Jiang, Kun He, Joseph E Gootenberg, Martin H Cohen, Patricia Keegan, Richard Pazdu. U.S. Food and Drug Administration Approval: peginterferon-alfa-2b for the adjuvant treatment of patients with melanoma. The oncologist. vol 17. issue 10. 2013-06-13. PMID:23002124. |
the most common (>60%) grade 1-4 adverse reactions were fatigue, increased alanine aminotransferase (alt) and aspartate aminotransferase (ast), pyrexia, headache, anorexia, myalgia, nausea, chills, and injection site reactions. |
2013-06-13 |
2023-08-12 |
Not clear |
| Saber A Sakr, Samah M Abo-El-Yazi. Effect of fenugreek seed extract on adriamycin-induced hepatotoxicity and oxidative stress in albino rats. Toxicology and industrial health. vol 28. issue 10. 2013-06-12. PMID:22082829. |
the liver enzymes, aspartate aminotransferase (alt) and alanine aminotransferase (ast) were increased in the sera of treated rats. |
2013-06-12 |
2023-08-12 |
rat |
| Andrey A Toropov, Alla P Toropova, Bakhtiyor F Rasulev, Emilio Benfenati, Giuseppina Gini, Danuta Leszczynska, Jerzy Leszczynsk. CORAL: binary classifications (active/inactive) for Liver-Related Adverse Effects of Drugs. Current drug safety. vol 7. issue 4. 2013-06-10. PMID:23062237. |
two datasets which contain compounds with two serum enzyme markers of liver toxicity: alanine aminotransferase (alt, n=187) and aspartate aminotransferase (ast, n=209) are analyzed. |
2013-06-10 |
2023-08-12 |
Not clear |
| Rowaida Refaat, Mona Salama, Elham Abdel Meguid, Ashgan El Sarha, Mennatallah Gowaye. Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23117086. |
serum was analyzed for measurement of albumin, c-reactive protein (crp), nitrite/nitrate concentrations, interleukin 1β (il-1β), tumor necrosis factor-α (tnf-α), vascular endothelial growth factor (vegf), aspartate transaminase (ast) and alanine transaminase (alt). |
2013-06-10 |
2023-08-12 |
rat |
| Concha de la Fuente, Carmen Hinojosa, Isabel Gilabert, Maria Ángeles Jiménez Sousa, Jose Manuel González, Raúl Ortiz de Lejarazu, Ana Loma, Concepción Nieto, Rosa Arnaiz, Jesús F Bermejo-Marti. Interleukin 28B rs12979860 (CT/TT) genotype is associated with milder hepatic damage in the natural evolution of HCV/HIV coinfection. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 33. issue 1. 2013-06-05. PMID:23030669. |
logistic regression analysis adjusting by [age], [sex], [hcv viral genotype], [hcv viral load], [hiv viral load], and [cd4 t cells levels] revealed the il-28b rs12979860 (ct/tt) genotype as a protective factor against alanine aminotransferase (alt) levels (>100 iu/l), aspartate aminotransferase (ast) levels (>75 iu/l), and ast-to-platelet ratio index (apri) score for liver fibrosis (>1.5) [or, (95% ci), p]: alt [0.026 (0.001-0.576) 0.021]; ast [0.001 (0.000-0.297) 0.019]; apri [0.031 (0.002-0.41) 0.008]. |
2013-06-05 |
2023-08-12 |
Not clear |
| K K Sharma, Bhuvnesh Shrivastava, Preeti Nandal, Neeta Sehgal, V R B Sastry, A Kalra, R C Kuha. Nutritional and toxicological assessment of white-rot fermented animal feed. Indian journal of microbiology. vol 52. issue 2. 2013-06-05. PMID:23729880. |
the aflatoxin b1, b2, g1 and g2 were either absent or present in permissive levels in t3 and t4 diets and exhibited normal stress enzyme activity in case of alanine aminotransferase (alt), aspartate aminotransferase (ast) and lactate dehydrogenase (ldh) enzymes whereas, rats fed on t2 diet showed elevated levels of stress enzymes (alt, ast and ldh activity), 100% high morbidity and 8.3% mortality. |
2013-06-05 |
2023-08-12 |
rat |
| Youdan Shi, Li Zhang, Rong Jiang, Weiying Chen, Weiping Zheng, Li Chen, Li Tang, Longhui Li, Longjiang Li, Weixue Tang, Yaping Wang, Yu Y. Protective effects of nicotinamide against acetaminophen-induced acute liver injury. International immunopharmacology. vol 14. issue 4. 2013-06-04. PMID:23059795. |
pretreatment with nam for 30 min significantly decreased plasma levels of alanine aminotransferase (alt), aspartate aminotransferase (ast) and malondialdehyde (mda), and diminished histopathologic evidence of hepatic toxicity in mice following apap administration. |
2013-06-04 |
2023-08-12 |
mouse |
| Seok-Jin Kang, Sang-Hee Jeong, Eun-Joo Kim, Joon-Hyoung Cho, Young-Il Park, Sung-Won Park, Hyo-Sook Shin, Seong-Wan Son, Hwan-Goo Kan. Evaluation of hepatotoxicity of chemicals using hepatic progenitor and hepatocyte-like cells derived from mouse embryonic stem cells: effect of chemicals on ESC-derived hepatocyte differentiation. Cell biology and toxicology. vol 29. issue 1. 2013-06-04. PMID:23108452. |
the toxic effects of carbon tetrachloride (ccl(4)), 5-fluorouracil (5-fu), and arsanilic acid (ars) were evaluated by measuring the expressions of cytokeratin (ck18) and gata binding protein 4 (gata-4) and the activities of aspartate transaminase (ast), lactate dehydrogenase (ldh), and alkaline phosphatase (alp) during the hepatic differentiation process. |
2013-06-04 |
2023-08-12 |
mouse |
| Valerie T Politano, Aurelia A Lapczynski, Gretchen Ritacco, Anne Marie Ap. Ninety-day toxicity study of alpha-iso-methylionone in rats. International journal of toxicology. vol 31. issue 6. 2013-06-04. PMID:23283689. |
statistically significant changes in blood chemistry parameters (reduced aspartate aminotransferase [ast], and increased cholesterol, creatinine, and total protein) were observed in both sexes at 500 mg/kg/d. |
2013-06-04 |
2023-08-12 |
rat |