| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing He, Zhen Wang, Yuchen Wang, Mengjie Zhu, Zhile Liang, Kanghong Zhang, Yuge Xu, Gong Che. Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2. Neural regeneration research. vol 20. issue 6. 2024-08-06. PMID:39104117. |
furthermore, we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers aqp4 (astrocyte endfeet signal), cx43 (gap junction signal), and s100β. |
2024-08-06 |
2024-08-08 |
mouse |
| Ari Misael Martínez-Torres, Julio Morá. Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury. Experimental brain research. 2024-07-23. PMID:39043897. |
aquaporin 4 (aqp4) is a water channel that allows bidirectional water diffusion across the astrocyte membrane and participates in the distinct phases of cerebral edema. |
2024-07-23 |
2024-07-26 |
Not clear |
| Ji-Yun Kang, Jin-Seok Lee, Jing-Hua Wang, Chang-Gue So. Sleep deprivation in adolescent mice impairs long-term memory till early adulthood via suppression of hippocampal astrocytes. Sleep. 2024-06-27. PMID:38934552. |
furthermore, the hippocampal region exhibited significantly diminished protein expressions of astrocyte, characterized by lowered levels of aquaporin 4 (aqp4), a representative molecule involved in brain clearance processes, and reduced protein expressions of brain-derived neurotrophic factor (bdnf). |
2024-06-27 |
2024-06-29 |
mouse |
| Nadia Skauli, Negar Zohoorian, Shervin Banitalebi, Samuel Geiseler, Maher Salameh, Shreyas B Rao, Cecilie Morland, Ole P Ottersen, Mahmood Amiry-Moghadda. Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke. The Journal of physiology. 2024-06-26. PMID:38924526. |
aquaporin-4 (aqp4) is the main water channel in brain and is enriched in perivascular astrocyte processes abutting brain microvessels. |
2024-06-26 |
2024-06-29 |
mouse |
| Nadia Skauli, Negar Zohoorian, Shervin Banitalebi, Samuel Geiseler, Maher Salameh, Shreyas B Rao, Cecilie Morland, Ole P Ottersen, Mahmood Amiry-Moghadda. Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke. The Journal of physiology. 2024-06-26. PMID:38924526. |
these findings provide new insights in the role of aqp4 in ischaemic injury indicating that aqp4 affects both infarct volume and astrocyte reactivity in the peri-infarct zone. |
2024-06-26 |
2024-06-29 |
mouse |
| Nadia Skauli, Negar Zohoorian, Shervin Banitalebi, Samuel Geiseler, Maher Salameh, Shreyas B Rao, Cecilie Morland, Ole P Ottersen, Mahmood Amiry-Moghadda. Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke. The Journal of physiology. 2024-06-26. PMID:38924526. |
key points: aquaporin-4 (aqp4) is the main water channel in brain and is enriched in perivascular astrocyte processes abutting microvessels. |
2024-06-26 |
2024-06-29 |
mouse |
| Nadia Skauli, Negar Zohoorian, Shervin Banitalebi, Samuel Geiseler, Maher Salameh, Shreyas B Rao, Cecilie Morland, Ole P Ottersen, Mahmood Amiry-Moghadda. Aquaporin-4 deletion leads to reduced infarct volume and increased peri-infarct astrocyte reactivity in a mouse model of cortical stroke. The Journal of physiology. 2024-06-26. PMID:38924526. |
these findings provide new insights into the role of aqp4 in stroke, indicating that aqp4 affects both infarct volume and astrocyte reactivity in the peri-infarct zone. |
2024-06-26 |
2024-06-29 |
mouse |
| Zuzana Hermanova, Lukas Valihrach, Jan Kriska, Mansi Maheta, Jana Tureckova, Mikael Kubista, Miroslava Anderov. The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies. Frontiers in cellular neuroscience. vol 18. 2024-06-01. PMID:38818517. |
the deletion of aqp4 and trpv4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies. |
2024-06-01 |
2024-06-02 |
mouse |
| Lina Zhao, Zhen Zhang, Pei Wang, Nannan Zhang, Hao Shen, Hening Wu, Zhiyong Wei, Fei Yang, Yunying Wang, Zhijie Yu, Haibo Li, Zhanfei Hu, Hongyan Zhai, Zhiwei Wang, Fuhong Su, Keliang Xie, Yun L. NHH promotes Sepsis-associated Encephalopathy with the expression of AQP4 in astrocytes through the gut-brain Axis. Journal of neuroinflammation. vol 21. issue 1. 2024-05-28. PMID:38802927. |
the results of the in vitro experiments showed that ammonia up-regulated aqp4 expression in astrocytes, resulting in astrocyte damage. |
2024-05-28 |
2024-06-03 |
mouse |
| Lina Zhao, Zhen Zhang, Pei Wang, Nannan Zhang, Hao Shen, Hening Wu, Zhiyong Wei, Fei Yang, Yunying Wang, Zhijie Yu, Haibo Li, Zhanfei Hu, Hongyan Zhai, Zhiwei Wang, Fuhong Su, Keliang Xie, Yun L. NHH promotes Sepsis-associated Encephalopathy with the expression of AQP4 in astrocytes through the gut-brain Axis. Journal of neuroinflammation. vol 21. issue 1. 2024-05-28. PMID:38802927. |
the results of this study suggest that ammonia up-regulates astrocyte aqp4 expression through the gut-brain axis, which may be a potential mechanism for the occurrence of sae. |
2024-05-28 |
2024-06-03 |
mouse |
| Justin L Bollinger, Shobha Johnsamuel, Lauren L Vollmer, Alexander M Kuhn, Eric S Wohle. Stress-induced dysfunction of neurovascular astrocytes contributes to sex-specific behavioral deficits. bioRxiv : the preprint server for biology. 2024-05-27. PMID:38798398. |
studies showed that knockdown of aqp4 in the pfc in males is sufficient to disrupt astrocyte phenotype and increase behavioral susceptibility to a sub-chronic stressor. |
2024-05-27 |
2024-05-31 |
mouse |
| Yuan Zhang, Jianfeng Xu, Pengcheng Li, Bo Luo, Hui Tan. Activation of Wnt signaling mitigates blood-brain barrier disruption by inhibiting vesicular transcytosis after traumatic brain injury in mice. Experimental neurology. 2024-04-19. PMID:38641126. |
post-tbi observations revealed substantial increases in macromolecule (evans blue and albumin) leakage, cav-1 transport vesicle count, astrocyte end-feet edema, and augmented aquaporin-4 (aqp4) expression, culminating in bbb disruption. |
2024-04-19 |
2024-04-22 |
mouse |
| Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian W. The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease. Aging and disease. 2024-03-19. PMID:38502590. |
our findings revealed the existence of a specific astrocyte subpopulation marked by low levels of gfap and the presence of aqp4 and cd63 expression, which showed functional enrichment in aβ clearance and tau protein binding, and diminished in ad. |
2024-03-19 |
2024-03-23 |
mouse |
| Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Li. Ginkgolide B can alleviate spinal glymphatic system dysfunction and provide neuroprotection in PDN rats by inhibiting matrix metalloproteinase-9. Neuropharmacology. 2024-03-16. PMID:38492884. |
aquaporin-4 (aqp4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. |
2024-03-16 |
2024-03-19 |
rat |
| Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David C Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato, Maria Svelto, Antonio Frigeri, Valentina Benfenati, Grazia Paola Nicchi. Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment. Glia. 2024-02-16. PMID:38362923. |
in the adult brain, the water channel aquaporin-4 (aqp4) is expressed in astrocyte endfoot, in supramolecular assemblies, called "orthogonal arrays of particles" (oaps) together with the transient receptor potential vanilloid 4 (trpv4), finely regulating the cell volume. |
2024-02-16 |
2024-02-18 |
Not clear |
| Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David C Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato, Maria Svelto, Antonio Frigeri, Valentina Benfenati, Grazia Paola Nicchi. Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment. Glia. 2024-02-16. PMID:38362923. |
the present study aimed at investigating the contribution of aqp4 and trpv4 to cns early postnatal development using wt and aqp4 ko brain and retina and neuronal stem cells (nscs), as an in vitro model of astrocyte differentiation. |
2024-02-16 |
2024-02-18 |
Not clear |
| Heng Huang, Lishan Lin, Tengteng Wu, Cheng Wu, Leping Zhou, Ge Li, Fengjuan Su, Fengyin Liang, Wenyuan Guo, Weineng Chen, Qiuhong Jiang, Yalun Guan, Xuejiao Li, Pingyi Xu, Yu Zhang, Wanli Smith, Zhong Pe. Phosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFNγ and aggravates dopaminergic neurodegeneration. NPJ Parkinson's disease. vol 10. issue 1. 2024-01-31. PMID:38296953. |
exogeneous ifnγ significantly increased astrocyte expression of ifnγ receptor, amplified aqp4 depolarization, and exacerbated neuroinflammation in r1441g transgenic mice. |
2024-01-31 |
2024-02-03 |
mouse |
| Yu Song, Tao Xue, Shiwu Guo, Zhen Yu, Chengming Yun, Jie Zhao, Zhiwen Song, Zhiyuan Li. Inhibition of aquaporin-4 and its subcellular localization attenuates below-level central neuropathic pain by regulating astrocyte activation in a rat spinal cord injury model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 21. issue 2. 2024-01-18. PMID:38237380. |
inhibition of aqp4 with tgn020 suppressed astrocyte activation, attenuated the development and maintenance of below-level cnp and promoted motor function recovery in vivo. |
2024-01-18 |
2024-01-21 |
rat |
| Yu Song, Tao Xue, Shiwu Guo, Zhen Yu, Chengming Yun, Jie Zhao, Zhiwen Song, Zhiyuan Li. Inhibition of aquaporin-4 and its subcellular localization attenuates below-level central neuropathic pain by regulating astrocyte activation in a rat spinal cord injury model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 21. issue 2. 2024-01-18. PMID:38237380. |
targeted inhibition of aqp4 subcellular localization with trifluoperazine effectively diminished astrocyte activation in vitro and further ablated astrocyte activation, attenuated the development and maintenance of below-level cnp, and accelerated functional recovery in vivo. |
2024-01-18 |
2024-01-21 |
rat |
| Luka Vlahovic, Jamie McDonald, Jessica Hinman, Anna Tomczak, Christopher Lock, Chella A Palmer, Lawrence J Cook, Michael R Yeaman, Melinda K Burnett, Gayle K Deutsch, Lorene M Nelson, May H Ha. Prevalence, Demographic, and Clinical Factors Associated With Cognitive Dysfunction in Patients With Neuromyelitis Optica Spectrum Disorder. Neurology. vol 102. issue 1. 2024-01-02. PMID:38165361. |
neuromyelitis optica spectrum disorder (nmosd) is a chronic cns demyelinating autoimmune disorder targeting the astrocyte antigen aquaporin-4 (aqp4), typically presenting with optic neuritis, transverse myelitis, and brain syndromes. |
2024-01-02 |
2024-01-05 |
Not clear |