| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Vicente, F España, D Tabernero, A Estellés, J Aznar, S Hendl, J H Griffi. Evidence of activation of the protein C pathway during acute vascular damage induced by Mediterranean spotted fever. Blood. vol 78. issue 2. 1991-08-21. PMID:1648982. |
apc:alpha 1at complex levels were increased in patients at day 1 (27 +/- 13 ng/ml) compared with controls (7 +/- 2 ng/ml), and apc:pci and kk:pci complexes, which were not detectable in any of the controls, were present in 57% and 75% of the 28 msf patients, with mean levels of 11 +/- 5 and 46 +/- 16 ng/ml, respectively. |
1991-08-21 |
2023-08-11 |
Not clear |
| K Nakano, H Hayashi, K Okugawa, H Furuichi, M Ido, Y Sohmur. Accelerated recovery of antigen-presenting cell activity by the administration of interleukin 1 alpha in 5-fluorouracil-treated mice. Cellular immunology. vol 136. issue 1. 1991-08-08. PMID:2060021. |
in this study, we investigated the effect of human recombinant interleukin-1 alpha (il-1 alpha) on antigen-presenting cell (apc) activity of spleen cells in mice treated with 5-fluorouracil (5-fu). |
1991-08-08 |
2023-08-11 |
mouse |
| K Nakano, H Hayashi, K Okugawa, H Furuichi, M Ido, Y Sohmur. Accelerated recovery of antigen-presenting cell activity by the administration of interleukin 1 alpha in 5-fluorouracil-treated mice. Cellular immunology. vol 136. issue 1. 1991-08-08. PMID:2060021. |
the injection of 5-fu decreased apc activity of both b cells and non-t non-b cells, but the administration of il-1 alpha accelerated its recovery. |
1991-08-08 |
2023-08-11 |
mouse |
| K Nakano, H Hayashi, K Okugawa, H Furuichi, M Ido, Y Sohmur. Accelerated recovery of antigen-presenting cell activity by the administration of interleukin 1 alpha in 5-fluorouracil-treated mice. Cellular immunology. vol 136. issue 1. 1991-08-08. PMID:2060021. |
thus, the accelerated recovery of apc activity by il-1 alpha was suggested to be due to the recovery in the numbers of apc activity-bearing cell subpopulations and also due to the recovery of the apc activity of each subpopulation. |
1991-08-08 |
2023-08-11 |
mouse |
| A M Zubiaga, E Muñoz, B T Hube. Production of IL-1 alpha by activated Th type 2 cells. Its role as an autocrine growth factor. Journal of immunology (Baltimore, Md. : 1950). vol 146. issue 11. 1991-06-25. PMID:1827818. |
in this report we present evidence that in addition to il-4 th2 cells also produce il-1 alpha in its active form in the absence of apc. |
1991-06-25 |
2023-08-11 |
Not clear |
| F España, A Gruber, M J Heeb, S R Hanson, L A Harker, J H Griffi. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons. Blood. vol 77. issue 8. 1991-05-21. PMID:1849759. |
in vivo complex formation of activated protein c with protein c inhibitor (apc-pci) and with alpha 1-antitrypsin (apc-alpha 1at) following infusion of 0.25 or 1.0 mg apc/kg in 1 hour into baboons was studied using immunoblotting and sandwich enzyme-linked immunosorbent assay (elisa)s. before apc infusion, detectable plasma levels (about 30 ng/ml) of apc-alpha 1at complex were found in the baboon plasma. |
1991-05-21 |
2023-08-11 |
Not clear |
| F España, A Gruber, M J Heeb, S R Hanson, L A Harker, J H Griffi. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons. Blood. vol 77. issue 8. 1991-05-21. PMID:1849759. |
these data show that both pci and alpha 1at are physiologic inhibitors of apc and suggest that when pci is depleted by a high dose of apc, alpha 1at becomes the major inhibitor of apc. |
1991-05-21 |
2023-08-11 |
Not clear |
| D H Sorscher, M Cordeiro-Ston. Gene replication in the presence of aphidicolin. Biochemistry. vol 30. issue 4. 1991-03-05. PMID:1899196. |
we have investigated whether activation of initiation sites, in proximity to genes that are replicated in different portions of the s phase, could be detected when synchronized 10t1/2 cells were maintained in aphidicolin (apc), an inhibitor of dna polymerases alpha and delta. |
1991-03-05 |
2023-08-11 |
Not clear |
| M Laurell, J Stenflo, T H Carlso. Turnover of *I-protein C inhibitor and *I-alpha 1-antitrypsin and their complexes with activated protein C. Blood. vol 76. issue 11. 1991-01-29. PMID:2175221. |
turnover of *i-protein c inhibitor and *i-alpha 1-antitrypsin and their complexes with activated protein c. the rates of clearance and catabolism of human protein c inhibitor (pci) and human alpha 1-antitrypsin (alpha 1-at) and their complexes with human activated protein c (apc) were studied in the rabbit. |
1991-01-29 |
2023-08-11 |
human |
| M Laurell, J Stenflo, T H Carlso. Turnover of *I-protein C inhibitor and *I-alpha 1-antitrypsin and their complexes with activated protein C. Blood. vol 76. issue 11. 1991-01-29. PMID:2175221. |
these results lead to the conclusion that the relative contribution of pci and alpha 1-at to the physiologic inhibition of apc cannot be determined only from the rates of the formation of these complexes in vitro, or from measurement of their levels in plasma. |
1991-01-29 |
2023-08-11 |
human |
| D Cefai, P Debre, M Kaczorek, T Idziorek, B Autran, G Bismut. Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. The Journal of clinical investigation. vol 86. issue 6. 1991-01-22. PMID:1979339. |
both glycoproteins clearly inhibit the t cell proliferation induced in an antigen-presenting cell (apc)-free system by various cross-linked monoclonal antibodies specific for the cd3 molecule or the tcr alpha chain (up to 80% inhibition). |
1991-01-22 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
we developed an elisa to quantitate complexes of activated protein c (apc) with a major plasma apc inhibitor, alpha 1-antitrypsin (alpha 1at) in human plasma based on the sandwich principle using two different antibodies directed towards protein c and alpha 1at, respectively. |
1990-12-20 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
this elisa test was specific for apc:alpha 1at complexes and sensitive to greater than or equal to 150 pg complex. |
1990-12-20 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
fifty-one of 56 healthy donors had apc:alpha 1at complex levels above the detection limit (3 ng/ml) ranging from 4 to 14 ng/ml (mean value +/- sd: 7.6 +/- 2.5 ng/ml). |
1990-12-20 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
patients (n = 10) with disseminated intravascular coagulation (dic) had detectable levels of apc:alpha 1at complex ranging from 21 to 125 ng/ml (median: 69 ng/ml). |
1990-12-20 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
apc:alpha 1at complex was detected in 25 of 26 patients with deep venous thrombosis (dvt), with levels ranging from 5 to 136 ng/ml (median: 23 ng/ml), whereas apc:pci was detected in only 6 dvt patients, with levels between 11 and 105 ng/ml. |
1990-12-20 |
2023-08-11 |
human |
| F España, V Vicente, D Tabernero, I Scharrer, J H Griffi. Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intravascular coagulation and thrombotic disease. Thrombosis research. vol 59. issue 3. 1990-12-20. PMID:2173167. |
moreover, it emphasizes that both pci and alpha 1at are physiologic inhibitors of apc. |
1990-12-20 |
2023-08-11 |
human |
| D Tabernero, F España, V Vicente, A Estellés, J Gilabert, J Azna. Protein C inhibitor and other components of the protein C pathway in patients with acute deep vein thrombosis during heparin treatment. Thrombosis and haemostasis. vol 63. issue 3. 1990-10-19. PMID:2169656. |
activated protein c (apc) complexed to its two major plasma inhibitors, pci and alpha 1-antitrypsin (alpha 1at) were measured by specific elisa's. |
1990-10-19 |
2023-08-11 |
human |
| D Tabernero, F España, V Vicente, A Estellés, J Gilabert, J Azna. Protein C inhibitor and other components of the protein C pathway in patients with acute deep vein thrombosis during heparin treatment. Thrombosis and haemostasis. vol 63. issue 3. 1990-10-19. PMID:2169656. |
before treatment, 18 of the 19 patients studied had increased levels of apc:alpha 1at complexes with a mean value of 27 +/- 22 ng/ml (range, 6-86 ng/ml) compared to normal values (8 +/- 2 ng/ml) and 12 of the patients also had detectable apc:pci complex levels with a mean value of 11 +/- 17 ng/ml (range, 5-68 ng/ml). |
1990-10-19 |
2023-08-11 |
human |
| H Hoogendoorn, M E Nesheim, A R Gile. A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model. Blood. vol 75. issue 11. 1990-07-09. PMID:2346780. |
a model of protein c (pc) activation in vivo was used to investigate the complexing of activated pc (apc) with its plasma inhibitors, pc inhibitor (pci) and alpha 1-antitrypsin (alpha 1at). |
1990-07-09 |
2023-08-11 |
Not clear |