| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Hoogendoorn, M E Nesheim, A R Gile. A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model. Blood. vol 75. issue 11. 1990-07-09. PMID:2346780. |
complexes of apc with both pci and alpha 1at were observed on immunoblots, and further identified and quantified using a sandwich elisa employing antibodies to both pc and these inhibitors. |
1990-07-09 |
2023-08-11 |
Not clear |
| H Hoogendoorn, M E Nesheim, A R Gile. A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model. Blood. vol 75. issue 11. 1990-07-09. PMID:2346780. |
additional experiments with lower doses of f.xa/pcps suggest that pci is the preferred inhibitor of apc, but as the availability of this inhibitor becomes limiting, alpha 1at plays an increasingly crucial role as a secondary inhibitor of endogenously generated apc. |
1990-07-09 |
2023-08-11 |
Not clear |
| H Hoogendoorn, M E Nesheim, A R Gile. A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model. Blood. vol 75. issue 11. 1990-07-09. PMID:2346780. |
moreover, evidence is presented suggesting the existence of additional inhibitor(s) of apc that may have a role similar to alpha 1at. |
1990-07-09 |
2023-08-11 |
Not clear |
| J Moreno, L Adorini, G J Hämmerlin. Co-dominant restriction by a mixed-haplotype I-A molecule (alpha k beta b) for the lysozyme peptide 52-61 in H-2k x H-2b F1 mice. Journal of immunology (Baltimore, Md. : 1950). vol 144. issue 9. 1990-05-25. PMID:1970351. |
their responsiveness to hel and synthetic hel peptides was analyzed with the use of l cells transfected with either i-a alpha k beta b or i-a alpha b beta k as apc. |
1990-05-25 |
2023-08-11 |
mouse |
| E M Eugui, S J Almquis. Antibodies against membrane interleukin 1 alpha activate accessory cells to stimulate proliferation of T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 4. 1990-03-22. PMID:2304900. |
some monoclonal antibodies (mabs) against interleukin (il) 1 alpha have been found to activate antigen-presenting cells (apc, human peripheral blood monocytes and b lymphocytes), so that unstimulated t lymphocytes cultured with them are induced to proliferate and secrete il-2. |
1990-03-22 |
2023-08-11 |
human |
| E M Eugui, S J Almquis. Antibodies against membrane interleukin 1 alpha activate accessory cells to stimulate proliferation of T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 4. 1990-03-22. PMID:2304900. |
in the absence of apc, mabs against il-1 alpha do not induce proliferation of t lymphocytes. |
1990-03-22 |
2023-08-11 |
human |
| E M Eugui, S J Almquis. Antibodies against membrane interleukin 1 alpha activate accessory cells to stimulate proliferation of T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 4. 1990-03-22. PMID:2304900. |
proliferation of t lymphocytes cannot be induced by culture supernatants and requires contact with apc activated by mabs against il-1 alpha. |
1990-03-22 |
2023-08-11 |
human |
| E M Eugui, S J Almquis. Antibodies against membrane interleukin 1 alpha activate accessory cells to stimulate proliferation of T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 4. 1990-03-22. PMID:2304900. |
the observations imply that surface membrane il-1 alpha can function as a triggering molecule on apc, which could play an important role in the initiation of immune responses by t lymphocytes. |
1990-03-22 |
2023-08-11 |
human |
| E Mellins, L Smith, B Arp, T Cotner, E Celis, D Piou. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature. vol 343. issue 6253. 1990-02-21. PMID:1967485. |
the complex of peptide and mhc molecule on the apc surface provides the stimulatory ligand for the alpha beta t cell receptor. |
1990-02-21 |
2023-08-11 |
Not clear |
| F J van der Meer, N H van Tilburg, A van Wijngaarden, I K van der Linden, E Briët, R M Bertin. A second plasma inhibitor of activated protein C: alpha 1-antitrypsin. Thrombosis and haemostasis. vol 62. issue 2. 1989-12-18. PMID:2554521. |
the second order rate constant for the reaction between purified alpha 1-at and apc was found to be 269 m-1 min-1 in the absence of calcium and 602 m-1 min-1 in the presence of calcium. |
1989-12-18 |
2023-08-11 |
human |
| H Bhayani, Y Paterso. Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations. The Journal of experimental medicine. vol 170. issue 5. 1989-12-11. PMID:2553848. |
epitopes, i.e., residues that interact with the tcr, and agretopes, i.e., residues in the mhc-binding site, were assigned for the two peptide antigens in the presence of apc bearing e beta kek alpha, eb beta ek alpha, or eb beta ek alpha using t cell hybridomas of the phenotypes i, iiia, and iv. |
1989-12-11 |
2023-08-11 |
mouse |
| J Houmard, V Capuano, T Coursin, N Tandeau de Marsa. Genes encoding core components of the phycobilisome in the cyanobacterium Calothrix sp. strain PCC 7601: occurrence of a multigene family. Journal of bacteriology. vol 170. issue 12. 1989-01-05. PMID:2461358. |
nucleotide sequence determination has allowed the identification of five apc genes: apca1 (alpha ap1), apca2 (alpha ap2), apcb1 (beta ap1), apcc (l7.8c), and apce (l92cm). |
1989-01-05 |
2023-08-11 |
Not clear |
| S Saito, T Tadakuma, H Inoko, K Sait. Mode of antigen presentation required for triggering of T cell response: analysis by use of azobenzenearsonate-tyrosine derivatives as antigens and L cells transfected with I-Ak genes as antigen presenting cells. Molecular immunology. vol 25. issue 6. 1988-11-21. PMID:3139994. |
the present study was undertaken to confirm that the macromolecules on apc are ia molecules, by using l cells transfected with a beta k and a alpha k genes as apc. |
1988-11-21 |
2023-08-11 |
Not clear |
| S Saito, T Tadakuma, H Inoko, K Sait. Mode of antigen presentation required for triggering of T cell response: analysis by use of azobenzenearsonate-tyrosine derivatives as antigens and L cells transfected with I-Ak genes as antigen presenting cells. Molecular immunology. vol 25. issue 6. 1988-11-21. PMID:3139994. |
these results indicate strongly that the macromolecules on apc which associate with aba-l-tyr are a beta k a alpha k gene products, i.e., i-ak molecules. |
1988-11-21 |
2023-08-11 |
Not clear |
| M J Heeb, J H Griffi. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. The Journal of biological chemistry. vol 263. issue 24. 1988-09-20. PMID:3261294. |
to identify the second major plasma inhibitor of apc, immunoblot studies of enzyme-inhibitor complexes were made to compare apc addition to normal plasma and to plasma deficient in protein c inhibitor or alpha 1-antitrypsin. |
1988-09-20 |
2023-08-11 |
human |
| M J Heeb, J H Griffi. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. The Journal of biological chemistry. vol 263. issue 24. 1988-09-20. PMID:3261294. |
the results showed that alpha 1-antitrypsin is the second major plasma apc inhibitor. |
1988-09-20 |
2023-08-11 |
human |
| M J Heeb, J H Griffi. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. The Journal of biological chemistry. vol 263. issue 24. 1988-09-20. PMID:3261294. |
given the association rate constant of alpha 1-antitrypsin for apc of 10 m-1 s-1 and its plasma concentration of approximately 40 microm, it accounts for approximately half of the heparin-independent apc inhibitory activity of plasma. |
1988-09-20 |
2023-08-11 |
human |
| M J Heeb, J H Griffi. Physiologic inhibition of human activated protein C by alpha 1-antitrypsin. The Journal of biological chemistry. vol 263. issue 24. 1988-09-20. PMID:3261294. |
thus, alpha 1-antitrypsin is a major physiologic inhibitor of apc. |
1988-09-20 |
2023-08-11 |
human |
| H Bhayani, F R Carbone, Y Paterso. The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant. Journal of immunology (Baltimore, Md. : 1950). vol 141. issue 2. 1988-08-03. PMID:2454990. |
the leader sequences do not differentially influence the ability of the peptides to be presented by apc displaying ia molecules of related haplotype, i.e., e alpha ke beta k, e alpha ke beta b, and e alpha ke beta s, to t cells which recognize the pigeon cytochrome c determinant on such presenting cells. |
1988-08-03 |
2023-08-11 |
pigeon |
| H Quill, R H Schwart. Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. Journal of immunology (Baltimore, Md. : 1950). vol 138. issue 11. 1987-07-02. PMID:3035012. |
rather, recognition of only ek beta:ek alpha and antigen resulted in the specific induction of a long-lived state of proliferative nonresponsiveness to subsequent stimulation by conventional apc and antigen. |
1987-07-02 |
2023-08-11 |
Not clear |