| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P C Hopkins, D C Crowther, R W Carrell, S R Ston. Development of a novel recombinant serpin with potential antithrombotic properties. The Journal of biological chemistry. vol 270. issue 20. 1995-06-12. PMID:7744836. |
recombinant alpha 1-antitrypsin with a p1 arginine residue (arg-alpha 1-antitrypsin) is a rapid inhibitor of both thrombin and activated protein c (apc). |
1995-06-12 |
2023-08-12 |
Not clear |
| M Oshima, M Z Atass. Effect of amino acid substitutions within the region 62-76 of I-A beta b on binding with and antigen presentation of Torpedo acetylcholine receptor alpha-chain peptide 146-162. Journal of immunology (Baltimore, Md. : 1950). vol 154. issue 10. 1995-05-31. PMID:7537303. |
however, apc of b6 also presented peptide alpha 146-162 much less efficiently to peptide-specific t cells of bm12. |
1995-05-31 |
2023-08-12 |
mouse |
| M R Jacquier-Sarlin, F M Gabert, M B Villiers, M G Colom. Modulation of antigen processing and presentation by covalently linked complement C3b fragment. Immunology. vol 84. issue 1. 1995-04-18. PMID:7890301. |
ligands such as complement fragments (c3, c4), igg or alpha 2-macroglobulin, which bind antigen (ag) before their uptake by antigen-presenting cells (apc), are likely to modulate the different steps of ag processing and presentation. |
1995-04-18 |
2023-08-12 |
human |
| L R Coia, E R Saute. Esophageal cancer. Current problems in cancer. vol 18. issue 4. 1995-04-06. PMID:7533069. |
a variety of tumor-suppressor genes (including p53, apc, dcc and rb) and proto-oncogenes (including prad1, egfr, c-erb-2 and tgf alpha) may be involved in the development and progression of esophageal cancer. |
1995-04-06 |
2023-08-12 |
Not clear |
| S T Cooper, F C Churc. Reactive site mutants of recombinant protein C inhibitor. Biochimica et biophysica acta. vol 1246. issue 1. 1995-02-07. PMID:7811727. |
changing the reactive site p1 and p2 residues to those of either proteinase nexin-1, alpha 1-proteinase inhibitor or heparin cofactor ii resulted in a decrease in inhibitory activity towards thrombin and apc. |
1995-02-07 |
2023-08-12 |
Not clear |
| C A Rey-Millet, C L Villiers, F M Gabert, S Chesne, M G Colom. C3b covalently associated to tetanus toxin modulates TT processing and presentation by U937 cells. Molecular immunology. vol 31. issue 17. 1995-01-13. PMID:7997244. |
complement protein c3, like c4 and alpha 2-macroglobulin (alpha 2m), is a potentially bivalent ligand: (1) its proteolytic fragment, c3b, is able to interact covalently with antigens, and (2) this bound fragment is able to interact non-covalently with specific complement receptors of antigen presenting cells (apc). |
1995-01-13 |
2023-08-12 |
Not clear |
| A Estellés, J Gilabert, F España, J Vila, M Martinez, S Hendl, J Azna. Alterations in fibrinolytic and protein C pathways in gynaecological surgery: low molecular weight heparin prophylaxis. Haemostasis. vol 24. issue 4. 1995-01-12. PMID:7988953. |
a significant increase in activated protein c:alpha 1 antitrypsin (apc:alpha 1at) complex levels was observed in the hr group in comparison with the lr group, and a strong decrease in protein c inhibitor in the early postoperative period was detected in all the groups. |
1995-01-12 |
2023-08-12 |
Not clear |
| A Estellés, J Gilabert, F España, J Vila, M Martinez, S Hendl, J Azna. Alterations in fibrinolytic and protein C pathways in gynaecological surgery: low molecular weight heparin prophylaxis. Haemostasis. vol 24. issue 4. 1995-01-12. PMID:7988953. |
both patients showed pre-operative levels of pai-1 antigen or activity and apc:alpha 1at complexes above the mean + 1 sd of the pre-operative levels in the hr group. |
1995-01-12 |
2023-08-12 |
Not clear |
| T Nakase, H Wada, K Minamikawa, Y Wakita, M Shimura, K Hiyoyama, S Tamaki, S Shirakawa, K Deguchi, J Nisiok. Increased activated protein C-protein C inhibitor complex level in patients positive for lupus anticoagulant. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. vol 5. issue 2. 1994-09-12. PMID:8054449. |
activated protein c (apc)-protein c inhibitor (pci) complex and apc-alpha 1antitrypsin (alpha 1at) complex levels were measured in 29 patients positive for lupus anticoagulant (la). |
1994-09-12 |
2023-08-12 |
human |
| J E Phillips, S T Cooper, E E Potter, F C Churc. Mutagenesis of recombinant protein C inhibitor reactive site residues alters target proteinase specificity. The Journal of biological chemistry. vol 269. issue 24. 1994-07-14. PMID:8206990. |
changing the p1 residue arg354-->met generated a reactive site similar to alpha 1-proteinase inhibitor which was a much poorer inhibitor of thrombin, apc, trypsin, and urokinase. |
1994-07-14 |
2023-08-12 |
Not clear |
| J S Spencer, J H Freed, R T Kub. Expression and function of mixed isotype MHC class II molecules in normal mice. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 12. 1994-01-14. PMID:8258692. |
although a20 expresses very low levels of mixed isotype, 10 to 100 nmol of the peptide produced a detectable response, illustrating the remarkable efficiency in presenting this peptide through e alpha da beta d. the ability of normal mouse apc to use this restriction element despite its extremely low expression has important implications for the activation of t cells by low levels of peptide-mhc complexes. |
1994-01-14 |
2023-08-12 |
mouse |
| S E Macatonia, C S Hsieh, K M Murphy, A O'Garr. Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. International immunology. vol 5. issue 9. 1994-01-06. PMID:7902129. |
we have examined the antigen presenting cell (apc) requirements for primary t cell activation and t helper (th) cell phenotype differentiation using naive cd4+ t cells from alpha beta tcr transgenic mice. |
1994-01-06 |
2023-08-12 |
mouse |
| H Luo, H Chen, P Daloze, G St-Louis, J W. Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin. Clinical and experimental immunology. vol 94. issue 2. 1993-12-14. PMID:8222329. |
the proliferation of t cells stimulated via an alternative pathway using phorbol myristate acetate (pma) and anti-cd28 antibody (alpha cd28) in the absence of antigen-presenting cells (apc) was strongly inhibited by rapa. |
1993-12-14 |
2023-08-12 |
human |
| H Luo, H Chen, P Daloze, G St-Louis, J W. Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin. Clinical and experimental immunology. vol 94. issue 2. 1993-12-14. PMID:8222329. |
t cell proliferation provoked via a combination of cd3/tcr and cd28 pathways using anti-cd3 antibody (alpha cd3) plus alpha cd28 was also inhibited by rapa in the presence of apc. |
1993-12-14 |
2023-08-12 |
human |
| H Luo, H Chen, P Daloze, G St-Louis, J W. Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin. Clinical and experimental immunology. vol 94. issue 2. 1993-12-14. PMID:8222329. |
we have further demonstrated in a two-stage culture system that rapa strongly inhibited il-4-stimulated proliferation of t cells, the latter being either pretreated with alpha cd3 in the presence of apc, or with pma plus alpha cd28 in the absence of apc. |
1993-12-14 |
2023-08-12 |
human |
| R M Mesters, M J Heeb, J H Griffi. Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C. Protein science : a publication of the Protein Society. vol 2. issue 9. 1993-11-23. PMID:8401232. |
however, peptide-(311-325) had no effect on apc amidolytic activity or on the reaction of apc with the serpin, recombinant [arg358]alpha 1-antitrypsin. |
1993-11-23 |
2023-08-12 |
Not clear |
| L C Burkly, S Degermann, J Longley, J Hagman, R L Brinster, D Lo, R A Flavel. Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 8. 1993-11-09. PMID:8409379. |
we employed the ig kappa gene enhancer and promoter to target the class ii e alpha gene, and thereby i-e, exclusively to b cells to address their apc function in vivo. |
1993-11-09 |
2023-08-12 |
mouse |
| A Mori, P Thomas, Y Tagaya, H Iijima, H Grey, K Ishizak. Epitope specificity of bee venom phospholipase A2-specific suppressor T cells which produce antigen-binding glycosylation inhibiting factor. International immunology. vol 5. issue 8. 1993-10-28. PMID:7691164. |
from the spleen cells of balb/c mice primed with bee venom phospholipase a2 (pla2), we established seven t cell hybridomas which constitutively secreted glycosylation inhibiting factor (gif), expressed both cd3 and tcr alpha beta, and responded to antigen-pulsed antigen presenting cells (apc) for the formation of ige-binding factor. |
1993-10-28 |
2023-08-12 |
mouse |
| A R Rezaie, C T Esmo. Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. The Journal of biological chemistry. vol 268. issue 27. 1993-10-20. PMID:8104182. |
further characterization revealed that apc e192q is inhibited 280 times faster than apc by alpha 1-antitrypsin (k2 = 2.8 x 10(3) m-1s-1 versus 10 m-1 s-1), and unlike apc, apc e192q is inhibited by antithrombin iii in the presence of heparin (k2 = 1.17 x 10(3) m-1 s-1) m-1 s-1) and absence of heparin (k2 = 57 m-1 s-1). |
1993-10-20 |
2023-08-12 |
Not clear |
| A R Rezaie, C T Esmo. Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors. The Journal of biological chemistry. vol 268. issue 27. 1993-10-20. PMID:8104182. |
like factor xa, apc e192q rapidly processed factor ix to factor ix alpha. |
1993-10-20 |
2023-08-12 |
Not clear |