| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerhard Cvirn, Siegfried Gallistl, Martin Koestenberger, Joerg Kutschera, Bettina Leschnik, Wolfgang Muntea. Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma. Thrombosis research. vol 105. issue 5. 2003-08-12. PMID:12062545. |
we investigated the effects of different ps concentrations on prothrombin activation and thrombin generation in cord and adult plasma containing apc and different amounts of alpha 2-macroglobulin (a2-m). |
2003-08-12 |
2023-08-12 |
Not clear |
| Mehtap Yuksel, Kenji Okajima, Mitsuhiro Uchiba, Seikoh Horiuchi, Hiroaki Okab. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Thrombosis and haemostasis. vol 88. issue 2. 2003-07-11. PMID:12195699. |
apc inhibited both the binding of nuclear factor-kappa b (nf-kappa b) to target sites and the degradation of i kappa b alpha. |
2003-07-11 |
2023-08-12 |
human |
| David T Berg, Bruce Gerlitz, Jing Shang, Tommy Smith, Paula Santa, Mark A Richardson, Ken D Kurz, Brian W Grinnell, Ken Mace, Bryan E Jone. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 8. 2003-06-17. PMID:12671072. |
similar to other serine proteases, functional apc levels are regulated by the serine protease inhibitor family of proteins including alpha(1)-antitrypsin and protein c inhibitor. |
2003-06-17 |
2023-08-12 |
human |
| David T Berg, Bruce Gerlitz, Jing Shang, Tommy Smith, Paula Santa, Mark A Richardson, Ken D Kurz, Brian W Grinnell, Ken Mace, Bryan E Jone. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 8. 2003-06-17. PMID:12671072. |
using apc-substrate modeling, we designed and produced a number of derivatives with the goal of altering the proteolytic specificity of apc such that the variants exhibited resistance to inactivation by protein c inhibitor and alpha(1)-antitrypsin yet maintained their primary anticoagulant activity. |
2003-06-17 |
2023-08-12 |
human |
| Alireza R Rezai. Exosite-dependent regulation of the protein C anticoagulant pathway. Trends in cardiovascular medicine. vol 13. issue 1. 2003-06-16. PMID:12554095. |
the proteolytic activity of apc in plasma is slowly inhibited by three serpins: protein c inhibitor, plasminogen activator inhibitor-1, and alpha(1)-antitrypsin. |
2003-06-16 |
2023-08-12 |
Not clear |
| Rachel Sterne-Marr, John J G Tesmer, Peter W Day, RoseAnn P Stracquatanio, Jill-Ann E Cilente, Katharine E O'Connor, Alexey N Pronin, Jeffrey L Benovic, Philip B Wedegaertne. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. The Journal of biological chemistry. vol 278. issue 8. 2003-04-22. PMID:12427730. |
the adenomatous polyposis coli (apc) binding site of axin involves residues on alpha helices 3, 4, and 5 (the "b" site) of its rh domain. |
2003-04-22 |
2023-08-12 |
Not clear |
| Sabine Roth, Nicholas Willcox, Rita Rzepka, Matthias P Mayer, Inga Melcher. Major differences in antigen-processing correlate with a single Arg71<-->Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 6. 2002-10-23. PMID:12218116. |
we explored the much stronger processing/presentation of full-length recombinant human acetylcholine receptor alpha subunit to a specific t cell clone by apc from drb1*0401+ than *0408+ donors. |
2002-10-23 |
2023-08-12 |
human |
| B R Lauwerys, J Van Snick, F A Houssia. Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity. Lupus. vol 11. issue 6. 2002-08-20. PMID:12139377. |
biologically active il-12 is a 70 kda heterodimeric cytokine (il-12 p70) mainly produced by antigen-presenting cells (apc) and made of disulfide-linked alpha (p35) and beta (p40) chains. |
2002-08-20 |
2023-08-12 |
human |
| Francesca Fallarino, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Roberta Bianchi, Brendan Marshall, Derin B Keskin, Andrew L Mellor, Maria C Fioretti, Ursula Grohmann, Paolo Puccett. Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. International immunology. vol 14. issue 1. 2002-05-23. PMID:11751753. |
therefore, in the mouse, cd8 alpha(+) dc may be unique apc capable of fully expressing the ido mechanism functionally. |
2002-05-23 |
2023-08-12 |
mouse |
| b' Ada Kolman, Natalia Kotova, Jan Graw\\xc3\\xa. Aphidicolin induces 6-thioguanine resistant mutants in human diploid fibroblasts. Mutation research. vol 499. issue 2. 2002-03-21. PMID:11827715.' |
cytotoxic and mutagenic effects of aphidicolin (apc), an inhibitor of dna polymerases alpha and delta, were studied in human diploid vh-10 fibroblasts. |
2002-03-21 |
2023-08-12 |
human |
| M A Galea, A Eleftheriou, B R Henderso. ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11585828. |
b56 alpha is a regulatory subunit of protein phosphatase 2a; however, its ability to shift apc to the nucleus was independent of phosphatase activity. |
2002-01-10 |
2023-08-12 |
Not clear |
| M A Galea, A Eleftheriou, B R Henderso. ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11585828. |
we conclude that apc nuclear import is regulated by the arm domain through its interaction with b56 alpha and postulate that apc/b56 alpha complexes target the dephosphorylation of specific proteins within the nucleus. |
2002-01-10 |
2023-08-12 |
Not clear |
| P C Hopkins, R N Pike, S R Ston. Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C. Journal of molecular evolution. vol 51. issue 5. 2001-05-31. PMID:11080374. |
we substituted residues of the reactive-site loop of antithrombin into alpha(1)-antitrypsin and tested the chimeras against thrombin, factor xa, and apc. |
2001-05-31 |
2023-08-12 |
Not clear |
| Y F Yang, M Tomura, S Ono, T Hamaoka, H Fujiwar. Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. International immunology. vol 12. issue 12. 2001-01-25. PMID:11099306. |
in addition to il-4 production of v(alpha)14(+) nkt cells, they have recently been demonstrated to have the capacity to stimulate il-12 production by antigen-presenting cells (apc). |
2001-01-25 |
2023-08-12 |
mouse |
| Y F Yang, M Tomura, S Ono, T Hamaoka, H Fujiwar. Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. International immunology. vol 12. issue 12. 2001-01-25. PMID:11099306. |
while il-12 production induced during culture of v(alpha)14(+) nkt cells and apc depended on the interaction between cd40 ligand on nkt cells and cd40 on apc, the expression levels of these key molecules were comparable in cells from wild-type and ifn-gamma(-/-) mice. |
2001-01-25 |
2023-08-12 |
mouse |
| Y F Yang, M Tomura, S Ono, T Hamaoka, H Fujiwar. Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. International immunology. vol 12. issue 12. 2001-01-25. PMID:11099306. |
these results illustrate a mandatory role for ifn-gamma in v(alpha)14(+) nkt cell-stimulated il-12 production by apc. |
2001-01-25 |
2023-08-12 |
mouse |
| P Pellegrini, I Contasta, A M Berghella, T Del Beato, C U Casciani, D Adorn. The TH1 and TH2 cytokine network in healthy subjects: suggestions for experimental studies to create prognostic and diagnostic indices for biotherapeutic treatments. Cancer biotherapy & radiopharmaceuticals. vol 15. issue 3. 2000-12-06. PMID:10941534. |
the influence of apc was evaluated by adding: serum levels of tnf alpha and il1 beta to the environment network model, and production levels of ifn gamma, il10 and il6, after stimulus with lps, to the cellular network model. |
2000-12-06 |
2023-08-12 |
human |
| C A Eads, R V Lord, S K Kurumboor, K Wickramasinghe, M L Skinner, T I Long, J H Peters, T R DeMeester, K D Danenberg, P V Danenberg, P W Laird, K A Skinne. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer research. vol 60. issue 18. 2000-10-13. PMID:11016622. |
in this study, we extend the methylation analysis of eac to include three other genes, apc, cdh1 (e-cadherin), and esr1 (er, estrogen receptor alpha), in addition to cdkn2a. |
2000-10-13 |
2023-08-12 |
human |
| L Tuosto, A Costanzo, F Guido, B Marinari, S Vossio, F Moretti, M Levrero, E Piccolell. Mitogen-activated kinase kinase kinase 1 regulates T cell receptor- and CD28-mediated signaling events which lead to NF-kappaB activation. European journal of immunology. vol 30. issue 9. 2000-10-12. PMID:11009075. |
using jurkat t cells stimulated with superantigen presented on b7-positive apc, we showed that cd28- and tcr-stimulated nf-kappab-dependent transcription is associated to the activation of ikappab kinase beta (ikkbeta) and, to a lesser extent, of ikappab kinase alpha (ikkalpha). |
2000-10-12 |
2023-08-12 |
Not clear |
| B White, M Schmidt, C Murphy, W Livingstone, D O'Toole, M Lawler, L O'Neill, D Kelleher, H P Schwarz, O P Smit. Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line. British journal of haematology. vol 110. issue 1. 2000-09-13. PMID:10930989. |
we assessed the effect of apc on lps-induced tumour necrosis factor alpha (tnf-alpha) production and on the activation of the central proinflammatory transcription factor nuclear factor-kappab (nf-kappab) in a thp-1 cell line. |
2000-09-13 |
2023-08-12 |
Not clear |