All Relations between acetylcholinesterase and acetylcholine

Publication Sentence Publish Date Extraction Date Species
Alexey Ivanov, Rezeda Shamagsumova, Marina Larina, Gennady Evtugy. Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer's Disease Drug Determination. Biosensors. vol 14. issue 2. 2024-02-23. PMID:38392012. these consequences can be compensated by the inhibition of acetylcholinesterase (ache) followed by a decrease in the rate of acetylcholine hydrolysis. 2024-02-23 2024-02-25 Not clear
Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. 2024-02-22 2024-02-24 zebrafish
Hitesh Kumar, Ashok Kumar Datusalia, Gopal L Khati. Virtual screening of acetylcholinesterase inhibitors through pharmacophore-based 3D-QSAR modeling, ADMET, molecular docking, and MD simulation studies. In silico pharmacology. vol 12. issue 1. 2024-02-19. PMID:38370859. many studies showed that targeting acetylcholinesterase enzyme (ache) to improve acetylcholine can be an effective option to treat ad. 2024-02-19 2024-02-21 Not clear
Yazhong Ma, Xiaotong Wang, Xin Li, Xi Chen, Zhifeng Teng, Xuekun Wang, Jie Yang, Guoyun Li. COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. Molecular neurobiology. 2024-02-12. PMID:38347285. for brain protection, cop-22 could resist d-gal-induced oxidative stress by increasing the activity of antioxidative defense enzymes and enhancing antioxidant capacity in the brain tissue; cop-22 could improve the dysfunction of the cholinergic system by decreasing the increased activity of acetylcholinesterase and increasing the reduced content of acetylcholine induced by d-gal; and cop-22 could protect nerve cells of the brain. 2024-02-12 2024-02-15 mouse
Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). 2024-02-10 2024-02-12 Not clear
F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. 2024-02-09 2024-02-11 human
Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. alzheimer's disease (ad) is characterized by cognitive decline, often attributed to the deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (ache) within the biological milieu. 2024-02-07 2024-02-09 Not clear
Keisuke Obara, Haruka Mori, Suzune Ihara, Kento Yoshioka, Yoshio Tanak. Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity. Biological & pharmaceutical bulletin. vol 47. issue 1. 2024-02-06. PMID:38296462. if these drugs also inhibit acetylcholinesterase (ache) activity, they may contribute to the suppression of ad progression by increasing brain acetylcholine concentrations. 2024-02-06 2024-02-09 human
Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. the neurotransmitters gamma amino-butyric acid (gaba), acetylcholine (ach), and acetylcholinesterase (ache) in addition to, the gene expressions of brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), and methyl-cpg-binding protein 2 (mecp2) and the dna damage comet analysis at different time intervals of the study, were assessed. 2024-01-17 2024-01-19 rat
Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. 2024-01-16 2024-01-19 Not clear
Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. 2023-12-23 2023-12-25 Not clear
Hussian Maanaki, Terry Xu, Guibing Chen, Xiuxia Du, Jun Wan. Development of integrated smartphone/resistive biosensor for on-site rapid environmental monitoring of organophosphate pesticides in food and water. Biosensors & bioelectronics: X. vol 15. 2023-12-21. PMID:38124900. the biosensor leverages the hydrolytic activity of acetylcholinesterase (ache) to its substrate, acetylcholine (ach), and unique transport properties of polyaniline nanofibers (pannfs) of chitosan/ache/pannf/carbon nanotube (cnt) nanocomposite film on a gold interdigitated electrode. 2023-12-21 2023-12-23 Not clear
Bing Zhang, Yu Wang, Donghui Wu, Qilin Zhao, Yaoyao Chen, Yushu Li, Jian Sun, Xiurong Yan. Fluorescent assay for acetylcholinesterase activity and inhibitor screening based on lanthanide organic/inorganic hybrid materials. Analytical methods : advancing methods and applications. 2023-12-20. PMID:38116865. it is of great significance for the clinical diagnosis of alzheimer's disease (ad) to achieve the on-site activity evaluation of acetylcholinesterase (ache), the hydrolase of acetylcholine (ach). 2023-12-20 2023-12-23 Not clear
Heba-Tallah Abd Elrahim Abd Elkader, Marium Marzoq Hussein, Nema A Mohammed, Heba M Abdo. The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-15. PMID:38099937. our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in tmx-treated rats. 2023-12-15 2023-12-17 rat
João P C Veras, Victor L B França, Hernandes F Carvalho, Valder N Freir. Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description. Chemico-biological interactions. 2023-12-15. PMID:38101596. this pesticide is a potent inhibitor of acetylcholinesterase (ache), which acts by preventing the hydrolysis of acetylcholine (ach). 2023-12-15 2023-12-18 human
Maciej Noga, Agata Michalska, Kamil Jurowsk. The prediction of acute toxicity (LD Archives of toxicology. 2023-12-05. PMID:38051368. the prediction of acute toxicity (ld nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. 2023-12-05 2023-12-10 Not clear
Jarrod A Gott, Sina Stücker, Philipp Kanske, Jan Haaker, Martin Dresle. Acetylcholine and metacognition during sleep. Consciousness and cognition. vol 117. 2023-12-02. PMID:38042119. while recent studies using acetylcholinesterase inhibitors suggest a potential role of acetylcholine in the occurrence of lucid dreaming, the underlying mechanisms by which this effect is produced remains un-modelled and unknown; with the causal link between cholinergic mechanisms and upstream psychological states being complex and elusive. 2023-12-02 2023-12-10 Not clear
Tess L Blom, Thijs T Wingelaa. Current Perspectives on the Management of Patients Poisoned With Novichok: A Scoping Review. Military medicine. 2023-11-30. PMID:38035754. nerve agents have emerged as a global threat since their discovery in the 1930s, posing severe risks due to their inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine in nerve synapses. 2023-11-30 2023-12-10 Not clear
Xiao Shi, Peng Liu, Yanyan Ma, Mingyuan Li, Zhenyu Zhang, Xinyue Zhang, Dahua Shi, Xinxin S. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chemical biology & drug design. 2023-11-27. PMID:38009562. acetylcholinesterase (ache) is a serine hydrolase with classical function to degrade acetylcholine and terminate neurotransmission. 2023-11-27 2023-11-29 Not clear
Göksun Demirel, Sonia Sanajou, Anil Yirün, Deniz Arca Çakir, Aysel Berkkan, Terken Baydar, Pinar Erkekoğl. Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum-induced neurotoxicity in an in vitro Alzheimer's disease model. Journal of applied toxicology : JAT. 2023-11-21. PMID:37989595. in addition, oxidative stress parameters (total antioxidant capacity, lipid peroxidase, protein carbonyl, and reactive oxygen species) and neurotransmitter-related parameters (dopamine, dopamine transporter acetylcholine, and synuclein alpha levels, acetylcholinesterase activity) were measured comparatively in the study groups. 2023-11-21 2023-11-29 cattle