| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James Melros. CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity. Journal of neuroscience research. vol 102. issue 7. 2024-07-22. PMID:39034899. |
diverse cs, ks, and hspgs stabilize the blood-brain barrier and neurovascular unit, provide smart gel neurotransmitter neuron vesicle storage and delivery, organize the neuromuscular junction basement membrane, and provide motor neuron synaptic plasticity, and photoreceptor and neuron synaptic functions. |
2024-07-22 |
2024-07-24 |
Not clear |
| Ningning Guo, Xin Wang, Muran Xu, Jie Bai, Hao Yu, Le Zhan. PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression. Pharmacological research. 2024-07-11. PMID:38992850. |
numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction. |
2024-07-11 |
2024-07-14 |
Not clear |
| Majid Zaki-Dizaji, Mohammad Foad Abazari, Hossein Razzaghi, Irene Shkolnikov, Brian R Christi. GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients. Brain, behavior, & immunity - health. vol 39. 2024-07-10. PMID:38983774. |
the metabotropic glutamate receptor 7 (mglur7) is a presynaptic g-protein-coupled glutamate receptor that modulates neurotransmitter release and synaptic plasticity at presynaptic terminals. |
2024-07-10 |
2024-07-12 |
Not clear |
| Mahdiyeh Hedayati-Moghadam, Fateme Razazpour, Mohammad Pourfridoni, Faezeh Mirzaee, Yousef Baghchegh. Ethanol's impact on the brain: a neurobiological perspective on the mechanisms of memory impairment. Molecular biology reports. vol 51. issue 1. 2024-06-25. PMID:38918289. |
key findings from the included studies shed light on the impact of ethanol on neurotransmitter systems, synaptic plasticity, and neuroinflammation in relation to memory impairment. |
2024-06-25 |
2024-06-29 |
Not clear |
| Sandilya Garemilla, Richa Kumari, Rahul Kuma. CDK5 as a therapeutic tool for the treatment of Alzheimer's Disease: A Review. European journal of pharmacology. 2024-06-20. PMID:38901526. |
we begin by elucidating the physiological functions of cdk5 in normal brain development and neuronal maintenance, highlighting its involvement in synaptic plasticity, neurotransmitter release, and cytoskeletal dynamics. |
2024-06-20 |
2024-06-23 |
Not clear |
| Sijing Li, Zijian Xia. Recent Research Progress on the Use of Transcranial Magnetic Stimulation in the Treatment of Vascular Cognitive Impairment. Neuropsychiatric disease and treatment. vol 20. 2024-06-17. PMID:38883416. |
next, the article explained the potential physiological mechanisms of tms in treating vci, particularly its role in promoting synaptic plasticity, regulating neurotransmitter balance, and improving the function of the default mode network. |
2024-06-17 |
2024-06-19 |
Not clear |
| Liangye Ji, ZiJun Meng, Xiangjun Dong, Qunxian Wang, Yanshuang Jiang, Jie Zhang, Dongjie Hu, Shipeng Guo, Weihui Zhou, Weihong Son. ICA1 affects APP processing through the PICK1-PKCα signaling pathway. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-17. PMID:38884369. |
islet cell autoantigen 1 (ica1) is involved in autoimmune diseases and may affect synaptic plasticity as a neurotransmitter. |
2024-06-17 |
2024-06-19 |
mouse |
| Felipe Araujo Gouhie, Karina Oliveira Barbosa, Amanda Borges Rufino Cruz, Milena Mariana Wellichan, Tainá Montini Zampoll. Cognitive effects of piracetam in adults with memory impairment: A systematic review and meta-analysis. Clinical neurology and neurosurgery. vol 243. 2024-06-15. PMID:38878641. |
piracetam, a widely recognized nootropic drug, is hypothesized to enhance memory function through its influence on synaptic plasticity and neurotransmitter levels. |
2024-06-15 |
2024-06-18 |
Not clear |
| Marzieh Abdollahi, Jesus D Castaño, Jennifer Ben Salem, Francis Beaudr. Anandamide Modulates Thermal Avoidance in Caenorhabditis elegans Through Vanilloid and Cannabinoid Receptor Interplay. Neurochemical research. 2024-06-07. PMID:38847909. |
enrichment analysis unveiled significant involvement of ion homeostasis pathways, which are crucial for maintaining neuronal function and synaptic transmission, suggesting aea's impact on neurotransmitter release and synaptic plasticity. |
2024-06-07 |
2024-06-10 |
human |
| Pawan Faris, Doris Pischedda, Fulvia Palesi, Egidio D'Angel. New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment. Frontiers in cellular neuroscience. vol 18. 2024-05-27. PMID:38799988. |
we initially consider the major forebrain alterations in cias, addressing impairments in neurotransmitter systems, synaptic plasticity, and connectivity. |
2024-05-27 |
2024-05-31 |
Not clear |
| Fu-Li Zhang, Xiao-Ke Yang, Yu-Ting Qi, Si-Yu Tian, Wei-Hua Huan. Nanoelectrochemistry reveals how presynaptic neurons regulate vesicle release to sustain synaptic plasticity under repetitive stimuli. Chemical science. vol 15. issue 20. 2024-05-24. PMID:38784745. |
although there is a considerable body of knowledge on protein expression and receptor migration in different categories of synaptic plasticity, the contribution and impact of presynaptic vesicle release and neurotransmitter levels towards plasticity remain largely unclear. |
2024-05-24 |
2024-05-27 |
Not clear |
| Nengyin Xia, Lingyun Xu, Mengyuan Huang, Dengrui Xu, Yang Li, Haoming Wu, Zhinan Mei, Zejun Y. Neuroprotection of macamide in a mouse model of Alzheimer's disease involves Nrf2 signaling pathway and gut microbiota. European journal of pharmacology. vol 975. 2024-05-12. PMID:38734297. |
the animal experiments showed that m 18:2 prevented the scopolamine (scp)-induced cognitive impairment and neurotransmitter disorders, increased the positive rates of nrf2 and ho-1 in hippocampal ca1, improved the synaptic plasticity by maintaining synaptic morphology and increasing the synapse density. |
2024-05-12 |
2024-05-27 |
mouse |
| Lei Wang, Xiaoming Liu, Chenlu Zhu, Shouyi Wu, Zhilei Li, Lipeng Jing, Zhenchang Zhang, Yuhong Jing, Yonggang Wan. Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice. The journal of headache and pain. vol 25. issue 1. 2024-05-10. PMID:38724948. |
central sensitization refers to the enhanced response to sensory stimulation, which involves changes in neuronal excitability, synaptic plasticity, and neurotransmitter release. |
2024-05-10 |
2024-05-27 |
mouse |
| Arpna Srivastava, Priya Rajput, Manjari Tripathi, Poodipedi Sarat Chandra, Ramesh Doddamani, Mehar Chand Sharma, Sanjeev Lalwani, Jyotirmoy Banerjee, Aparna Banerjee Dixi. Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy. Molecular neurobiology. 2024-04-30. PMID:38687446. |
our findings reveal a molecular blueprint of altered protein networks in mtle brain and highlight dysregulated pathways and processes including altered cargo transport, neurotransmitter release from synaptic vesicles, synaptic plasticity, proteostasis, rna homeostasis, ion transport and transmembrane transport, cytoskeleton disorganization, metabolic and mitochondrial dysfunction, blood micro-particle function, extracellular matrix organization, immune response, neuroinflammation, and cell signaling. |
2024-04-30 |
2024-05-03 |
human |
| Junyu Wu, Xue Xu, Shifeng Zhang, Minping Li, Yuemin Qiu, Gengxin Lu, Zhihui Zheng, Haiwei Huan. Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation. Molecular neurobiology. 2024-04-30. PMID:38689145. |
notable molecular candidates implicated in this process include variations in ion channels and neurotransmitter profiles, as well as neuronal and synaptic plasticity, metabolic processes, and electrophysiological modifications. |
2024-04-30 |
2024-05-03 |
Not clear |
| Xiang Gu, Ling Li. Spatiotemporal expression of AP-2/myosin Ⅵ in mouse cochlear IHCs and correlation with auditory function. Acta oto-laryngologica. 2024-04-25. PMID:38662892. |
recycling of synaptic vesicles plays an important role in vesicle pool replenishment, neurotransmitter release and synaptic plasticity. |
2024-04-25 |
2024-04-28 |
mouse |
| J Wren Kim, Adeline J H Yong, Erin E Aisenberg, Joseph H Lobel, Wei Wang, Ted M Dawson, Valina L Dawson, Ruixuan Gao, Yuh Nung Jan, Helen S Bateup, Nicholas T Ingoli. Molecular recording of calcium signals via calcium-dependent proximity labeling. Nature chemical biology. 2024-04-24. PMID:38658655. |
in neurons, calcium transients play a central role in regulating neurotransmitter release and synaptic plasticity. |
2024-04-24 |
2024-04-28 |
Not clear |
| Maria P Mogavero, Michele Salemi, Giuseppe Lanza, Antonio Rinaldi, Giovanna Marchese, Maria Ravo, Maria Grazia Salluzzo, Amedeo Antoci, Lourdes M DelRosso, Oliviero Bruni, Luigi Ferini-Strambi, Raffaele Ferr. Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis. iScience. vol 27. issue 4. 2024-04-15. PMID:38617564. |
genetic predisposition plays a key role in rls and evidence indicates its inflammatory nature; the high involvement of mainly neurotropic viruses and the torch complex might trigger inflammatory/immune reactions in genetically predisposed subjects and activate a series of biological pathways-especially il-17, receptor potential channels, nuclear factor kappa-light-chain-enhancer of activated b cells, nod-like receptor, mitogen-activated protein kinase, p53, mitophagy, and ferroptosis-involved in neurotransmitter mechanisms, synaptic plasticity, axon guidance, neurodegeneration, carcinogenesis, and metabolism. |
2024-04-15 |
2024-04-17 |
human |
| Shubhrajit Roy, Svetlana Lutsenk. Mechanism of Cu entry into the brain: many unanswered questions. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526278. |
brain tissue requires high amounts of copper (cu) for its key physiological processes, such as energy production, neurotransmitter synthesis, maturation of neuropeptides, myelination, synaptic plasticity, and radical scavenging. |
2024-03-25 |
2024-03-27 |
Not clear |
| Hayder M Al-Kuraishy, Esraa H Fahad, Salah Al-Windy, Suzy A El-Sherbeni, Walaa A Negm, Gaber El-Saber Batih. The effects of cholesterol and statins on Parkinson's neuropathology: a narrative review. Inflammopharmacology. 2024-03-19. PMID:38499742. |
different studies highlighted that statins, via inhibition of brain hmg-coa, can affect neuronal integrity through suppression of neuronal cholesterol, which regulates synaptic plasticity and neurotransmitter release. |
2024-03-19 |
2024-03-21 |
Not clear |