| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lingchang Shi, Ying He, Yujun Lian, Jie Luo, Xuan Zhu, Hongqing Zha. Melanin-concentrating hormone: A promising target for antidepressant treatment. Pharmacology, biochemistry, and behavior. 2025-03-13. PMID:40081601. |
this review systematically analyzes the mechanistic interplay between mch signaling and depression pathophenotypes, including its relationship with the hypothalamic-pituitary-adrenal (hpa) axis, neurotransmitter systems, synaptic plasticity, and the regulation of sleep-wakefulness. |
2025-03-13 |
2025-03-16 |
Not clear |
| Zhenyu Huang, Haibo Tan, Yuanfei Fu, Huanxin Xie, Huangsheng Tan, Kun Gao, Hongkan Lo. Neurotransmitter Imbalance and Amygdala Synaptic Plasticity in Lumbar Disc Herniation-induced Chronic Pain and Related Emotional Disturbances:A multi-omics analysis. Neuropharmacology. 2025-03-08. PMID:40057176. |
neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional disturbances:a multi-omics analysis. |
2025-03-08 |
2025-03-12 |
rat |
| Zhenyu Huang, Haibo Tan, Yuanfei Fu, Huanxin Xie, Huangsheng Tan, Kun Gao, Hongkan Lo. Neurotransmitter Imbalance and Amygdala Synaptic Plasticity in Lumbar Disc Herniation-induced Chronic Pain and Related Emotional Disturbances:A multi-omics analysis. Neuropharmacology. 2025-03-08. PMID:40057176. |
this study investigates the role of neurotransmitter imbalances and key regulatory molecules in ldh-induced chronic pain and related emotional disturbances, with a focus on synaptic plasticity in the amygdala. |
2025-03-08 |
2025-03-12 |
rat |
| Zhenyu Huang, Haibo Tan, Yuanfei Fu, Huanxin Xie, Huangsheng Tan, Kun Gao, Hongkan Lo. Neurotransmitter Imbalance and Amygdala Synaptic Plasticity in Lumbar Disc Herniation-induced Chronic Pain and Related Emotional Disturbances:A multi-omics analysis. Neuropharmacology. 2025-03-08. PMID:40057176. |
this study provides evidence that neurotransmitter imbalances and alterations in synaptic plasticity within the amygdala may contribute to the persistence of chronic pain and associated emotional disturbances in ldh. |
2025-03-08 |
2025-03-12 |
rat |
| Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo, Veronica Ghiglieri, Paolo Calabres. Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease. Current neuropharmacology. 2025-02-24. PMID:39988779. |
in this review, we will discuss the mechanisms underlying the actions of agonists and antagonists of 5-ht and da receptors on striatal synaptic plasticity in physiological conditions and parkinson's disease (pd), a movement disorder in which an imbalance of these two neurotransmitter systems has been hypothesized. |
2025-02-24 |
2025-02-26 |
Not clear |
| Sanarya Al-Jaf, Alaa Y Soliman, Ahmed F El-Yazbi, Khaled S Abd-Elrahma. Unveiling the Interplay: Neurovascular Coupling, Astrocytes and G Protein-Coupled Receptors in Alzheimer's Disease. ACS pharmacology & translational science. vol 8. issue 2. 2025-02-20. PMID:39974631. |
astrocytes are a type of glial cell that are involved in actively modulating synaptic plasticity, neurotransmitter homeostasis, and neuroinflammatory responses. |
2025-02-20 |
2025-02-23 |
Not clear |
| Boyd R Rorabaugh, Daniel J Morga. CB1 receptor coupling to extracellular regulated kinase via multiple Gαi/o isoforms. Neuroreport. 2025-02-20. PMID:39975996. |
cannabinoid type 1 receptors (cb1rs) play important roles in regulating neurotransmitter release, synaptic plasticity, cell differentiation, and survival. |
2025-02-20 |
2025-02-23 |
mouse |
| Borna Puljko, Marija Štracak, Svjetlana Kalanj-Bognar, Ivana Todorić Laidlaw, Kristina Mlinac-Jerkovi. Gangliosides and Cholesterol: Dual Regulators of Neuronal Membrane Framework in Autism Spectrum Disorder. International journal of molecular sciences. vol 26. issue 3. 2025-02-13. PMID:39941090. |
in addition to maintaining membrane integrity, neuronal signaling, and synaptic plasticity, these lipids play a role in neurotransmitter release and calcium signaling. |
2025-02-13 |
2025-02-15 |
Not clear |
| Fahad Imtiaz Rahman, Thomas M Webster, Corey R Hopkin. Update on mGlu4 modulator patents: 2017 to present. Expert opinion on therapeutic patents. 2025-02-13. PMID:39948693. |
metabotropic glutamate receptor 4 (mglur4) regulates disease by modulating neurotransmitter release and synaptic plasticity and has been implicated in various diseases, including neurodegenerative disorders and psychiatric conditions, where its dysregulation can impact synaptic function and neuronal signaling. |
2025-02-13 |
2025-02-16 |
Not clear |
| Zhining Chen, Gabrielle I Coste, Evan Li, Richard L Huganir, Austin R Graves, Adam S Charle. Automatic detection of fluorescently labeled synapses in volumetric in vivo imaging data. bioRxiv : the preprint server for biology. 2025-02-03. PMID:39896629. |
many forms of learning are thought to be encoded by synaptic plasticity, wherein the strength of specific synapses is regulated by modulating expression of neurotransmitter receptors. |
2025-02-03 |
2025-02-05 |
mouse |
| Sami Awda Algaid. Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging. Brain research. 2025-01-26. PMID:39864644. |
these structural changes are accompanied by disruptions in neurotransmitter systems, most notably glutamatergic and gabaergic signaling, and alterations in synaptic plasticity mechanisms. |
2025-01-26 |
2025-01-29 |
Not clear |
| Yuncan Chen, Jiayi Hu, Ying Zhang, Lulu Peng, Xiaoyu Li, Cong Li, Xunyi Wu, Cong Wan. Epilepsy therapy beyond neurons: unveiling astrocytes as cellular targets. Neural regeneration research. 2025-01-17. PMID:39819836. |
astrocytes, the largest group of nonneuronal cells in the central nervous system, play several crucial roles in maintaining ionic and energy metabolic homeostasis in neurons, regulating neurotransmitter levels, and modulating synaptic plasticity. |
2025-01-17 |
2025-01-20 |
Not clear |
| Ahmad Golkar, Mohammad Dalfardi, Mahdiyeh Hedayati-Moghadam, Hedyeh Askarpour, Mahmoud Hosseini, Yousef Baghchegh. Understanding the neurobiological mechanisms of LPS‑induced memory impairment. Acta neurobiologiae experimentalis. vol 84. issue 4. 2025-01-15. PMID:39812528. |
several potential mechanisms have been proposed to explain lps‑induced memory deficits, including neuroinflammation, alterations in synaptic plasticity, disruption of neurotransmitter systems, and dysfunction of the blood‑brain barrier. |
2025-01-15 |
2025-01-17 |
Not clear |
| Adedamola Saidi Soladogun, Li Zhan. The Neural Palette of Heme: Altered Heme Homeostasis Underlies Defective Neurotransmission, Increased Oxidative Stress, and Disease Pathogenesis. Antioxidants (Basel, Switzerland). vol 13. issue 12. 2025-01-08. PMID:39765770. |
we discuss the molecular mechanisms by which heme modulates neuronal activity and synaptic plasticity, emphasizing its influence on ion channels and neurotransmitter receptors. |
2025-01-08 |
2025-01-13 |
Not clear |
| Yu Shi, Wen W. Advances in transcranial focused ultrasound neuromodulation for mental disorders. Progress in neuro-psychopharmacology & biological psychiatry. 2025-01-05. PMID:39756638. |
animal studies have demonstrated the efficacy of tfus in improving psychiatric symptoms and modulating neural circuits through various mechanisms, such as enhancing neuronal activity, synaptic plasticity, and neurotransmitter release. |
2025-01-05 |
2025-01-08 |
human |
| Huan Yang, Jie Gao, Hai-Yan Wang, Xin-Mei Ma, Bing-Yao Liu, Qian-Zhong Song, Hui Cheng, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. The effects and possible mechanisms of whole-body vibration on cognitive function: A narrative review. Brain research. 2024-12-11. PMID:39662790. |
based on the analysis of literatures, we came to the conclusion that the impact of wbv on cognitive function depends mainly on the frequency and duration of vibration, short-term low-frequency wbv may have a positive impact on cognitive function, while long term exposure to wbv may lead to cognitive decline, and the mechanisms may be involved in neuroinflammation, oxidative stress, synaptic plasticity, and neurotransmitter changes. |
2024-12-11 |
2024-12-14 |
Not clear |
| Mayur B Kale, Nitu L Wankhede, Ashok Kumar Bishoyi, Suhas Ballal, Rishiv Kalia, Renu Arya, Sachin Kumar, Mohammad Khalid, Monica Gulati, Mohit Umare, Brijesh G Taksande, Aman B Upaganlawar, Milind J Umekar, Spandana Rajendra Kopalli, Mohammad Fareed, Sushruta Koppul. Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders. Neuroscience. 2024-11-28. PMID:39608699. |
by investigating synaptic plasticity and alterations in neurotransmitter release dynamics, researchers can uncover valuable information about disease progression and potential therapeutic targets. |
2024-11-28 |
2024-12-01 |
Not clear |
| Jung-Mi Choi, Rakshya Acharya, Hye Lim Cha, Kwang-Wook Lee, Jewoo Seo, Esther Yang, Hyun Kim, Jong Hyuk Yoon, Da-Young Chang, Sung-Soo Kim, Sang Jeong Kim, Lutz Birnbaumer, Haeyoung Suh-Ki. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 49. 2024-11-27. PMID:39602265. |
cb1r activates the epilepsy-associated protein go to regulate neurotransmitter release and synaptic plasticity in the cerebellum. |
2024-11-27 |
2024-11-30 |
Not clear |
| Joanna Agata Motyl, Grażyna Gromadzka, Grzegorz Arkadiusz Czapski, Agata Adamczy. SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596147. |
it plays a crucial role in maintaining cellular structures and organelle functions, particularly in supporting synaptic plasticity and regulating neurotransmitter turnover. |
2024-11-27 |
2024-11-29 |
Not clear |
| Wudu Lado, Ahrom Ham, Hongyu Li, Hong Zhang, Audrey Yuen Chang, Sergio Pablo Sardi, Roy N Alcalay, Ottavio Arancio, Serge Przedborsky, Guomei Tan. Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation. Brain : a journal of neurology. 2024-11-19. PMID:39562000. |
the mutation disrupts hippocampal synaptic plasticity and basal synaptic transmission by reducing the density of hippocampal ca3-ca1 synapses, a mechanism that is dissociated from αsyn-mediated presynaptic neurotransmitter release. |
2024-11-19 |
2024-11-23 |
mouse |