| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Long-Fei Li, Ying Gao, Yuan Xu, Dan-Jie Su, Qi Yang, An Liu, Sai-Ying Wang, Xiu-Ling Tang, Jun Zhao, Li Luo, Tao Yan, Yu-Mei Wu, Shui-Bing Liu, Ming-Gao Zhao, Le Yan. Praeruptorin C alleviates cognitive impairment in type 2 diabetic mice through restoring PI3K/AKT/GSK3β pathway. Phytotherapy research : PTR. 2023-07-17. PMID:37458182. |
electrophysiological recordings were made to monitor synaptic plasticity in the hippocampus. |
2023-07-17 |
2023-08-14 |
mouse |
| Brigitte M González Olmo, Menaz N Bettes, James W DeMarsh, Fangli Zhao, Candice Askwith, Ruth M Barriento. Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling. NPJ science of food. vol 7. issue 1. 2023-07-17. PMID:37460765. |
short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via il-1 signaling. |
2023-07-17 |
2023-08-14 |
rat |
| Brigitte M González Olmo, Menaz N Bettes, James W DeMarsh, Fangli Zhao, Candice Askwith, Ruth M Barriento. Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling. NPJ science of food. vol 7. issue 1. 2023-07-17. PMID:37460765. |
here, we explored the extent to which short-term hfd consumption disrupts hippocampal synaptic plasticity, as measured by long-term potentiation (ltp), in young adult and aged rats. |
2023-07-17 |
2023-08-14 |
rat |
| Brigitte M González Olmo, Menaz N Bettes, James W DeMarsh, Fangli Zhao, Candice Askwith, Ruth M Barriento. Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling. NPJ science of food. vol 7. issue 1. 2023-07-17. PMID:37460765. |
these findings suggest that hippocampal memory impairments in aged rats following hfd consumption occur through the deterioration of synaptic plasticity and that il-1β is a critical driver of that deterioration. |
2023-07-17 |
2023-08-14 |
rat |
| Jane K Schröder, Laila Abdel-Hafiz, Amira A H Ali, Teresa C Cousin, Johanna Hallenberger, Filipe Rodrigues Almeida, Max Anstötz, Maximilian Lenz, Andreas Vlachos, Charlotte von Gall, Federica Tundo-Lavall. Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus. Cells. vol 12. issue 13. 2023-07-14. PMID:37443792. |
our results indicate that the light/dark cycle drives diurnal differences in synaptic plasticity in hippocampus. |
2023-07-14 |
2023-08-14 |
mouse |
| Jane K Schröder, Laila Abdel-Hafiz, Amira A H Ali, Teresa C Cousin, Johanna Hallenberger, Filipe Rodrigues Almeida, Max Anstötz, Maximilian Lenz, Andreas Vlachos, Charlotte von Gall, Federica Tundo-Lavall. Effects of the Light/Dark Phase and Constant Light on Spatial Working Memory and Spine Plasticity in the Mouse Hippocampus. Cells. vol 12. issue 13. 2023-07-14. PMID:37443792. |
this indicates that acute constant light affects hippocampal function and synaptic plasticity. |
2023-07-14 |
2023-08-14 |
mouse |
| Eric T Winzenried, Anna C Everett, Erin R Saito, Roxanne M Miller, Taylor Johnson, Eliza Neal, Zachary Boyce, Calvin Smith, Chloe Jensen, Spencer Kimball, Adam Brantley, Gabriel Melendez, Devin Moffat, Erin Davis, Lyndsey Aponik, Tyler Crofts, Bryson Dabney, Jeffrey G Edward. Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446371. |
effects of a true prophylactic treatment on hippocampal and amygdala synaptic plasticity and gene expression in a rodent chronic stress model of social defeat. |
2023-07-14 |
2023-08-14 |
rat |
| Sung Rae Kim, Yunkyung Eom, Sung Hoon Le. Comprehensive analysis of sex differences in the function and ultrastructure of hippocampal presynaptic terminals. Neurochemistry international. 2023-07-14. PMID:37451344. |
while previous research has explored sex differences in postsynaptic structures, synaptic plasticity, and hippocampus-dependent functions, the hippocampal presynaptic terminals remain largely uninvestigated. |
2023-07-14 |
2023-08-14 |
mouse |
| Rui Zheng, Fang-Xiao Xu, Lin Zhou, Junyu Xu, Ying Shen, Ke Hao, Xin-Tai Wang, Junjie Den. Ablation of KIF2C in Purkinje cells impairs metabotropic glutamate receptor trafficking and motor coordination in male mice. The Journal of physiology. 2023-07-11. PMID:37431690. |
key points: kif2c is localized in synaptic spines of hippocampus neurons, and regulates excitatory transmission, synaptic plasticity and cognitive behaviour. |
2023-07-11 |
2023-08-14 |
mouse |
| Weiwei Yu, Ziyi Wu, Xingyue Li, Mengmeng Ding, Ying Xu, Ping Zha. Ketamine counteracts sevoflurane-induced depressive-like behavior and synaptic plasticity impairments through the adenosine A2A receptor/ERK pathway in rats. Molecular neurobiology. 2023-07-10. PMID:37428405. |
our results suggest that ketamine mediates erk1/2 phosphorylation by downregulating a2ar expression and that p-erk1/2 increases the production of synaptic-associated proteins, enhancing synaptic plasticity in the hippocampus and thereby ameliorating the depressive-like behavior induced by sevoflurane inhalation in rats. |
2023-07-10 |
2023-08-14 |
rat |
| Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olm. SCHEDULE-INDUCED ALCOHOL INTAKE DURING ADOLESCENCE SEX DEPENDENTLY IMPAIRS HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY. Behavioural brain research. 2023-07-09. PMID:37423317. |
schedule-induced alcohol intake during adolescence sex dependently impairs hippocampal synaptic plasticity and spatial memory. |
2023-07-09 |
2023-08-14 |
rat |
| Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olm. SCHEDULE-INDUCED ALCOHOL INTAKE DURING ADOLESCENCE SEX DEPENDENTLY IMPAIRS HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY. Behavioural brain research. 2023-07-09. PMID:37423317. |
however, only male rats that consumed alcohol showed spatial memory deficits which correlated with inhibition of hippocampal synaptic plasticity as long-term potentiation. |
2023-07-09 |
2023-08-14 |
rat |
| Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olm. SCHEDULE-INDUCED ALCOHOL INTAKE DURING ADOLESCENCE SEX DEPENDENTLY IMPAIRS HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY. Behavioural brain research. 2023-07-09. PMID:37423317. |
in contrast, alcohol did not modify hippocampal gene expression of ampa and nmda glutamate receptor subunits, although there are differences in the expression levels of several genes relevant to synaptic plasticity mechanisms underlying learning and memory processes, related to alcohol consumption as ephb2, sex differences as pi3k or the interaction of both factors such as pten. |
2023-07-09 |
2023-08-14 |
rat |
| Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olm. SCHEDULE-INDUCED ALCOHOL INTAKE DURING ADOLESCENCE SEX DEPENDENTLY IMPAIRS HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY. Behavioural brain research. 2023-07-09. PMID:37423317. |
in conclusion, elevated alcohol intake during adolescence seems to have a negative impact on spatial memory and hippocampal synaptic plasticity in a sex dependent manner, even both sexes exhibit similar blood alcohol concentrations and drinking patterns. |
2023-07-09 |
2023-08-14 |
rat |
| Fankun Zhou, Lu Ouyang, Qi Li, Shuo Yang, Sisi Liu, Han Yu, Qiyue Jia, Shaoqi Rao, Jie Xie, Guihua Du, Chang Feng, Guangqin Fa. Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture. Molecular neurobiology. 2023-07-05. PMID:37407880. |
hippocampal limk1-mediated structural synaptic plasticity in neurobehavioral deficits induced by a low-dose heavy metal mixture. |
2023-07-05 |
2023-08-14 |
human |
| Fankun Zhou, Lu Ouyang, Qi Li, Shuo Yang, Sisi Liu, Han Yu, Qiyue Jia, Shaoqi Rao, Jie Xie, Guihua Du, Chang Feng, Guangqin Fa. Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture. Molecular neurobiology. 2023-07-05. PMID:37407880. |
our results showed that heavy metal mixture exposure altered rat fear responses and spatial learning at general population exposure levels and that these alterations were accompanied by downregulation of limk1 phosphorylation and structural synaptic plasticity dysfunction in rat hippocampal tissues and cultured hippocampal neurons. |
2023-07-05 |
2023-08-14 |
human |
| Zijun Wang, Brian K Kennedy, Lik-Wei Wong, Sreedharan Sajikuma. Aging inverts the effects of p75 FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 8. 2023-07-04. PMID:37401900. |
aging inverts the effects of p75 age-induced impairments in learning and memory are in part caused by changes to hippocampal synaptic plasticity during aging. |
2023-07-04 |
2023-08-14 |
Not clear |
| Arantzazu Belloso-Iguerategui, Marta Zamarbide, Leyre Merino-Galan, Tatiana Rodríguez-Chinchilla, Belén Gago, Enrique Santamaria, Joaquín Fernández-Irigoyen, Carl W Cotman, G Aleph Prieto, Ana Quiroga-Varela, María Cruz Rodríguez-Oro. Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit. Brain : a journal of neurology. 2023-07-04. PMID:37403195. |
overall, we found impaired synaptic plasticity and proteome dysregulation at hippocampal terminals to be the first events that contribute to the development of cognitive deficits in experimental parkinsonism. |
2023-07-04 |
2023-08-14 |
human |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
prebiotics inhibit neuroinflammation, neuronal apoptosis, and reactive gliosis in the hippocampus but restore synaptic plasticity, neuronal proliferation, and neurogenesis. |
2023-06-29 |
2023-08-14 |
mouse |
| Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D Martínez, Álvaro O Ardiles, Marco Fuenzalid. Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity. Biomolecules. vol 13. issue 6. 2023-06-28. PMID:37371467. |
pannexin-1 modulates inhibitory transmission and hippocampal synaptic plasticity. |
2023-06-28 |
2023-08-14 |
mouse |