| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Wu, Yan Sun, Zhangjie Wu, Ruiyi Liu, Ying Yin, Nga-Lee Wong, Wenzheng Ju, Hailou Zhan. A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 182. 2024-12-15. PMID:39675136. |
furthermore, mh could increase long-term potential (ltp) in the hippocampal dentate gyrus (dg) and activation of hippocampal caspase4 blocked mh's enhancement on neuronal activities and synaptic plasticity in the hippocampal dg. |
2024-12-15 |
2024-12-21 |
mouse |
| Jelena Borovac, Jayant Rai, Megan Valencia, Hang Li, John Georgiou, Graham L Collingridge, Keizo Takao, Kenichi Okamot. Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors. Frontiers in molecular neuroscience. vol 17. 2024-12-11. PMID:39660172. |
thus, postsynaptic cgmp elevations, specifically in the dg and specifically during conditions that evoke synaptic plasticity or during experience, are able to rapidly modify synaptic strength and behavioral responses, respectively. |
2024-12-11 |
2024-12-13 |
mouse |
| Isaac Vingan, Shwetha Phatarpekar, Victoria Sook Keng Tung, Alejandro Iván Hernández, Oleg V Evgrafov, Juan Marcos Alarco. Spatially resolved transcriptomic signatures of hippocampal subregions and Frontiers in molecular neuroscience. vol 17. 2024-11-15. PMID:39544521. |
we found that recall induced differentially expressed genes (degs) in the ca1 and ca3 hippocampal subregions were enriched with genes involved in synaptic transmission and synaptic plasticity, while degs in the dentate gyrus (dg) were enriched with genes involved in energy balance and ribosomal function. |
2024-11-15 |
2024-11-17 |
Not clear |
| Zhanghong Zhou, E Tian, Jun Wang, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Xixi Yu, Caijuan Qiao, Yuejin Zhang, Yisheng Lu, Sulin Zhan. Cognitive impairments and neurobiological changes induced by unilateral vestibular dysfunction in mice. Neurobiology of disease. 2024-10-31. PMID:39481811. |
rna sequencing of the dg identified differentially expressed genes (degs) and altered pathways related to cognitive function, synaptic plasticity, and neuronal activation. |
2024-10-31 |
2024-11-03 |
mouse |
| James Melros. Dystroglycan-HSPG interactions provide synaptic plasticity and specificity. Glycobiology. vol 34. issue 10. 2024-09-03. PMID:39223703. |
specific functional attributes of hs-proteoglycans (hspgs) are conveyed through interactions with dg and provide synaptic specificity through diverse interactions with an extensive range of cell attachment and adaptor proteins which convey synaptic plasticity. |
2024-09-03 |
2024-09-05 |
human |
| Kuldeep Tripathi, Somoday Hazra, Joyeeta Dutta Hazra, Silvia Mandel, Ruchi Anunu, Martin Kriebel, Hansjurgen Volkmer, Gal Richter-Levi. Selective knockdown of GABAA-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity. The European journal of neuroscience. 2024-06-10. PMID:38858171. |
given the high expression of gabaa α2 in the dentate gyrus (dg) sub-field of the hippocampus, we sought to examine whether manipulation of the α2 subunit in this area will evoke changes in emotional behaviour, memory and learning as well as in synaptic plasticity. |
2024-06-10 |
2024-06-14 |
rat |
| Kuldeep Tripathi, Somoday Hazra, Joyeeta Dutta Hazra, Silvia Mandel, Ruchi Anunu, Martin Kriebel, Hansjurgen Volkmer, Gal Richter-Levi. Selective knockdown of GABAA-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity. The European journal of neuroscience. 2024-06-10. PMID:38858171. |
spatial memory and learning in the morris water maze were also impaired in gabaaα2 receptor knocked down rats, an effect accompanied by alterations in synaptic plasticity, as assessed by long-term potentiation in the dg. |
2024-06-10 |
2024-06-14 |
rat |
| Noah L Steiner, Dvijen C Purohit, Casey M Tiefenthaler, Chitra D Mandya. Abstinence and Fear Experienced during This Period Produce Distinct Cortical and Hippocampal Adaptations in Alcohol-Dependent Rats. Brain sciences. vol 14. issue 5. 2024-05-25. PMID:38790410. |
the current study evaluated the effects of forced abstinence for 1 day (d), 7 d, 21 d, and 42 d following seven weeks of cie on synaptic plasticity proteins in the mpfc and dg. |
2024-05-25 |
2024-05-27 |
rat |
| Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yan. Influenza A Virus PB1-F2 Induces Affective Disorder by Interfering Synaptic Plasticity in Hippocampal Dentate Gyrus. Molecular neurobiology. 2024-03-15. PMID:38488981. |
morphological and western blot studies revealed that pb1-f2 inhibited cell proliferation and oligodendrocyte development, impaired myelin formation, and interfered with synaptic plasticity in dg. |
2024-03-15 |
2024-03-18 |
mouse |
| Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yan. Influenza A Virus PB1-F2 Induces Affective Disorder by Interfering Synaptic Plasticity in Hippocampal Dentate Gyrus. Molecular neurobiology. 2024-03-15. PMID:38488981. |
taken together, our results demonstrated that pb1-f2 induces affective disorders by inhibiting oligodendrocyte development and regulating synaptic plasticity in the dg after iav infection, which lays the foundation for developing future cures of affective disorders after iav infection. |
2024-03-15 |
2024-03-18 |
mouse |
| Qian Tang, Ryota Ojiro, Shunsuke Ozawa, Xinyu Zou, Junta Nakahara, Tomohiro Nakao, Mihoko Koyanagi, Meilan Jin, Toshinori Yoshida, Makoto Shibutan. DNA methylation-altered genes in the rat hippocampal neurogenic niche after continuous exposure to amorphous curcumin. Journal of chemical neuroanatomy. 2024-03-15. PMID:38490283. |
rat offspring who are exposed to an amorphous formula of curcumin (cur) from the embryonic stage have anti-anxiety-like behaviors, enhanced fear extinction learning, and increased synaptic plasticity in the hippocampal dentate gyrus (dg). |
2024-03-15 |
2024-03-18 |
rat |
| Isaac Vingan, Victoria Sook Keng Tung, Shwetha Phatarpekar, A Iván Hernández, Oleg V Evgrafov, Juan Marcos Alarco. Spatially Resolved Transcriptomic Signatures of Hippocampal Subregions and bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260257. |
we found that training induced differentially expressed genes (degs) in the ca1 and ca3 hippocampal subregions were enriched with genes involved in synaptic transmission and synaptic plasticity, while degs in the dentate gyrus (dg) were enriched with genes involved in energy balance and ribosomal function. |
2024-01-23 |
2024-01-25 |
Not clear |
| He Huang, Ning Wang, Jia-Tao Lin, Yong-Kang Qiu, Wei-Feng Wu, Qiang Liu, Chen Chen, Hai-Bi Wang, Yan-Ping Liu, Wei Dong, Jie Wan, Hui Zheng, Cheng-Hua Zhou, Yu-Qing W. Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells. Molecular neurobiology. 2024-01-10. PMID:38200350. |
preconditioning with lv-mfn2 improved long-term cognitive dysfunction after repeated neonatal ketamine exposure by reversing the inhibitory effect of ketamine on synaptic plasticity in the hippocampal dg. |
2024-01-10 |
2024-01-13 |
rat |
| Shahab Ghaderi, Parsa Gholipour, Alireza Komaki, Siamak Shahidi, Faezeh Seif, Mohammad Bahrami-Tapehebur, Iraj Salehi, Mohammad Zarei, Abdolrahman Sarihi, Masome Rashn. Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes-associated cognitive decline: An in vivo study in a rat model. Phytotherapy research : PTR. 2024-01-08. PMID:38185917. |
long-term potentiation (ltp) was induced at hippocampal dentate gyrus (dg) synapses in response to high-frequency stimulation (hfs) applied to the perforant pathway (pp) to evaluate synaptic plasticity. |
2024-01-08 |
2024-01-10 |
rat |
| Virendra Tiwari, Akanksha Mishra, Sonu Singh, Shubha Shukl. Crosstalk between Adult Hippocampal Neurogenesis and Its Role in Alzheimer's Disease. ACS chemical neuroscience. 2023-06-01. PMID:37261380. |
neurogenesis in adult brain is associated with synaptic plasticity, learning, and memory in dentate gyrus (dg) of hippocampus and olfactory bulb. |
2023-06-01 |
2023-08-14 |
Not clear |
| Carmen Vivar, Ben Peterson, Alejandro Pinto, Emma Janke, Henriette van Praa. Running throughout middle-age keeps eNeuro. 2023-05-15. PMID:37188520. |
in rodents, running increases the number of adult-born neurons in the dentate gyrus (dg) of the hippocampus, in association with improved synaptic plasticity and memory function. |
2023-05-15 |
2023-08-14 |
mouse |
| Lei Ye, Shu Shu, Junqiu Jia, Min Sun, Siyi Xu, Xinyu Bao, Huijie Bian, Yi Liu, Meijuan Zhang, Xiaolei Zhu, Feng Bai, Yun X. Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis. Aging cell. 2023-05-13. PMID:37177836. |
our study revealed that aim2 regulates microglial activation during synaptic pruning in the dg region via the complement pathway, leading to impaired synaptic plasticity and ps function in aging mice. |
2023-05-13 |
2023-08-14 |
mouse |
| Farheen Farzana, Malcolm McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J Hannan, Danny M Hatters, Berin A Boughto. Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice. Neurobiology of disease. 2022-11-27. PMID:36436748. |
hippocampal subfields (ca1, ca3 and dg), which formed the highest density of inclusion formation in the mouse brain showed a reduction in the relative abundance of neuron-enriched lipids that have roles in neurotransmission, synaptic plasticity, neurogenesis, and er-stress protection. |
2022-11-27 |
2023-08-14 |
mouse |
| Hualing Peng, Jie Jia, Yisheng Lu, Hua Zhen. Isoflurane Rescue Schizophrenia-Related Deficits through Parvalbumin-Positive Neurons in the Dentate Gyrus. Biomedicines. vol 10. issue 11. 2022-11-11. PMID:36359279. |
isoflurane also helped recovering adult neurogenesis and synaptic plasticity impairments in the dentate gyrus (dg) induced by mk801. |
2022-11-11 |
2023-08-14 |
Not clear |
| Eri Segi-Nishida, Kanzo Suzuk. Regulation of adult-born and mature neurons in stress response and antidepressant action in the dentate gyrus of the hippocampus. Neuroscience research. 2022-08-28. PMID:36030966. |
in mature granule neurons, the predominant cells in the dg, synaptic plasticity is suppressed by chronic stress. |
2022-08-28 |
2023-08-14 |
Not clear |