| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng-Xiong Xi, Eliot L Gardne. Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. Current drug abuse reviews. vol 1. issue 3. 2009-08-13. PMID:19430578. |
these compounds target brain neurotransmitter or neuromodulator systems, including dopamine (da), gamma-aminobutyric acid (gaba), endocannabinoid, glutamate, opioid and serotonin, which have been shown to be critically involved in drug reward and addiction. |
2009-08-13 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riege. Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. Neuropharmacology. vol 48. issue 8. 2009-07-17. PMID:15878779. |
substantial evidence suggests that all commonly abused drugs act upon the brain reward circuitry to ultimately increase extracellular concentrations of the neurotransmitter dopamine in the nucleus accumbens and other forebrain areas. |
2009-07-17 |
2023-08-12 |
Not clear |
| Petra Schweinhardt, David A Seminowicz, Erik Jaeger, Gary H Duncan, M Catherine Bushnel. The anatomy of the mesolimbic reward system: a link between personality and the placebo analgesic response. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 15. 2009-05-12. PMID:19369556. |
since reward processing is closely linked to the ventral striatum and the neurotransmitter dopamine, we examined the relationships between brain gray matter, placebo analgesic response, and personality traits associated with dopaminergic neurotransmission. |
2009-05-12 |
2023-08-12 |
human |
| V Paez Espinosa, Y Liu, M Ferrini, A Anghel, Y Nie, P V Tripathi, R Porche, E Jansen, R C Stuart, E A Nillni, K Lutfy, T C Friedma. Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction. Neuroscience. vol 156. issue 3. 2009-04-14. PMID:18771713. |
drug addiction is a state of altered brain reward and self-regulation mediated by both neurotransmitter and hormonal systems. |
2009-04-14 |
2023-08-12 |
rat |
| Raffaella Isola, Hailin Zhang, Gopi A Tejwani, Norton H Neff, Maria Hadjiconstantino. Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum. Psychopharmacology. vol 201. issue 4. 2009-04-01. PMID:18807250. |
nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. |
2009-04-01 |
2023-08-12 |
Not clear |
| Jose A Crespo, Petra Stöckl, Katja Zorn, Alois Saria, Gerald Zerni. Nucleus accumbens core acetylcholine is preferentially activated during acquisition of drug- vs food-reinforced behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 13. 2009-02-19. PMID:18418362. |
acquisition of drug-reinforced behavior is accompanied by a systematic increase of release of the neurotransmitter acetylcholine (ach) rather than dopamine, the expected prime reward neurotransmitter candidate, in the nucleus accumbens core (acbc), with activation of both muscarinic and nicotinic ach receptors in the acbc by ach volume transmission being necessary for the drug conditioning. |
2009-02-19 |
2023-08-12 |
Not clear |
| Dianne P Figlewicz, Stephen C Benoi. Insulin, leptin, and food reward: update 2008. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:18945945. |
specifically, insulin and leptin can decrease food reward behaviors and modulate the function of neurotransmitter systems and neural circuitry that mediate food reward, i.e., midbrain dopamine and opioidergic pathways. |
2009-02-06 |
2023-08-12 |
Not clear |
| M Christopher Newland, Elliott M Paletz, Miranda N Ree. Methylmercury and nutrition: adult effects of fetal exposure in experimental models. Neurotoxicology. vol 29. issue 5. 2009-01-23. PMID:18652843. |
it is hypothesized that altered reward processing, dopamine and gabaergic neurotransmitter systems, and cortical regions associated with choice and perseveration are especially sensitive to developmental mehg at low exposure levels. |
2009-01-23 |
2023-08-12 |
human |
| A Nessa, S A Latif, N I Siddiqui, M A Hussain, M A Hossai. Drug abuse and addiction. Mymensingh medical journal : MMJ. vol 17. issue 2. 2008-12-05. PMID:18626465. |
almost all addictive drugs over stimulate the reward system of the brain, flooding it with the neurotransmitter dopamine. |
2008-12-05 |
2023-08-12 |
Not clear |
| Wayne C Drevets, Jonathan Savitz, Michael Trimbl. The subgenual anterior cingulate cortex in mood disorders. CNS spectrums. vol 13. issue 8. 2008-10-16. PMID:18704022. |
in experimental animals, this region participates in an extended "visceromotor network" of structures that modulates autonomic/neuroendocrine responses and neurotransmitter transmission during the neural processing of reward, fear, and stress. |
2008-10-16 |
2023-08-12 |
human |
| Birgit Abler, Ian Greenhouse, Dost Ongur, Henrik Walter, Stephan Hecker. Abnormal reward system activation in mania. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 9. 2008-10-08. PMID:17987058. |
transmission of reward signals is a function of dopamine, a neurotransmitter known to be involved in the mechanism of psychosis. |
2008-10-08 |
2023-08-12 |
human |
| Michael A Walke. Treatment of autism spectrum disorders: neurotransmitter signaling pathways involved in motivation and reward as therapeutic targets. Expert opinion on therapeutic targets. vol 12. issue 8. 2008-09-16. PMID:18620518. |
treatment of autism spectrum disorders: neurotransmitter signaling pathways involved in motivation and reward as therapeutic targets. |
2008-09-16 |
2023-08-12 |
Not clear |
| E Shearman, S Fallon, H Sershen, A Lajth. Nicotine-induced monoamine neurotransmitter changes in the brain of young rats. Brain research bulletin. vol 76. issue 6. 2008-08-19. PMID:18598854. |
to examine possible mechanisms for this difference in our continuing study of reward mechanisms, we compared nicotine-induced neurotransmitter changes in the brain regions of adult and young sprague-dawley rats, assaying the transmitters via microdialysis in conscious freely moving animals. |
2008-08-19 |
2023-08-12 |
rat |
| Kae Nakamura, Masayuki Matsumoto, Okihide Hikosak. Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 20. 2008-06-19. PMID:18480289. |
recent pharmacological studies suggest that another monoamine neurotransmitter, serotonin, is also involved in reward processing. |
2008-06-19 |
2023-08-12 |
monkey |
| Abel Lajth. Interrelated mechanisms in reward and learning. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17935832. |
the primary aim of our studies is to examine the role of neurotransmitter changes in reward and learning processes. |
2008-05-05 |
2023-08-12 |
Not clear |
| Abel Lajth. Interrelated mechanisms in reward and learning. Neurochemistry international. vol 52. issue 1-2. 2008-05-05. PMID:17935832. |
here, we discuss reward processes, which we define as changes examined after administration of nicotine, cocaine or food, each of which induces changes in neurotransmitter levels and functions in cognitive areas as well as in reward areas. |
2008-05-05 |
2023-08-12 |
Not clear |
| Christopher W She. From the neurobiologic basis of alcohol dependency to pharmacologic treatment strategies: bridging the knowledge gap. Southern medical journal. vol 101. issue 2. 2008-03-31. PMID:18364621. |
increasing evidence shows that the development of ad involves changes in neurotransmitter function in the areas of the brain associated with alcohol craving and reward. |
2008-03-31 |
2023-08-12 |
Not clear |
| Thomas S Hnasko, Bethany N Sotak, Richard D Palmite. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 46. 2007-12-19. PMID:18003826. |
these findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated sert blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in dd mice. |
2007-12-19 |
2023-08-12 |
mouse |
| Shaun Fallon, Erin Shearman, Henry Sershen, Abel Lajth. Food reward-induced neurotransmitter changes in cognitive brain regions. Neurochemical research. vol 32. issue 10. 2007-11-20. PMID:17721820. |
although food reward elements overlap with other reward systems sharing some neurotransmitter compounds, it significantly differs indicating a specific reward to process for food consumption. |
2007-11-20 |
2023-08-12 |
Not clear |
| Linda P Dwoskin, B Matthew Joyce, Guangrong Zheng, Nichole M Neugebauer, Vamshi K Manda, Paul Lockman, Roger L Papke, Michael T Bardo, Peter A Crook. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17727820. |
one strategy is to develop subtype-selective nicotinic receptor (nachr) antagonists that inhibit nicotine-evoked dopamine (da) release, the primary neurotransmitter involved in nicotine reward. |
2007-11-06 |
2023-08-12 |
rat |