| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Heidbreder, M Gewiss, S Lallemand, B P Roques, P De Witt. Inhibition of enkephalin metabolism and activation of mu- or delta-opioid receptors elicit opposite effects on reward and motility in the ventral mesencephalon. Neuropharmacology. vol 31. issue 3. 1992-08-20. PMID:1321359. |
nevertheless, the identification of the specific opioid receptors associated with modulation of tegmental dopamine activity and its behavioural concomitants on motility and reward is far from clear, considering the mixed nature of the ligands usually employed. |
1992-08-20 |
2023-08-11 |
rat |
| A M Young, M H Joseph, J A Gra. Increased dopamine release in vivo in nucleus accumbens and caudate nucleus of the rat during drinking: a microdialysis study. Neuroscience. vol 48. issue 4. 1992-08-14. PMID:1378576. |
the support that the results provide for the hypothesized connection between reward and limbic dopamine is discussed. |
1992-08-14 |
2023-08-11 |
rat |
| P P Rompré, P Bauco, A Gratto. Facilitation of brain stimulation reward by mesencephalic injections of neurotensin-(1-13). European journal of pharmacology. vol 211. issue 3. 1992-08-06. PMID:1319909. |
the effects on brain stimulation reward of neurotensin-(1-13) microinjected at different concentrations (2.5, 5, 10 and 20 micrograms/0.5 microliters) into the ventral mesencephalic region containing mesocorticolimbic dopamine neurons were tested in 12 male rats. |
1992-08-06 |
2023-08-11 |
rat |
| P P Rompré, P Bauco, A Gratto. Facilitation of brain stimulation reward by mesencephalic injections of neurotensin-(1-13). European journal of pharmacology. vol 211. issue 3. 1992-08-06. PMID:1319909. |
neurotensin lowered the stimulation frequency required to sustain threshold levels of responding for brain stimulation reward, suggesting that this neuropeptide is involved in modulating the activity of dopamine neurons that mediate behaviors motivated by positive reinforces. |
1992-08-06 |
2023-08-11 |
rat |
| P P Rompré, P Bauco, A Gratto. Facilitation of brain stimulation reward by mesencephalic injections of neurotensin-(1-13). European journal of pharmacology. vol 211. issue 3. 1992-08-06. PMID:1319909. |
subsequent injection of morphine (2.5-5 micrograms/0.5 microliter) into the same site produced a weaker facilitation of brain stimulation reward than expected, suggesting that local damage after multiple central injections or prior injections of neurotensin itself reduced the responsiveness of dopamine neurons to opiates. |
1992-08-06 |
2023-08-11 |
rat |
| J D Salamon. Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes. Psychopharmacology. vol 107. issue 2-3. 1992-07-30. PMID:1615120. |
the suggestions that dopamine (da) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. |
1992-07-30 |
2023-08-11 |
Not clear |
| G F Koo. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends in pharmacological sciences. vol 13. issue 5. 1992-07-14. PMID:1604710. |
three major brain systems appear to be involved in drug reward--dopamine, opioid and gaba. |
1992-07-14 |
2023-08-11 |
Not clear |
| G F Koo. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends in pharmacological sciences. vol 13. issue 5. 1992-07-14. PMID:1604710. |
data implicating dopamine and opioid systems in indirect sympathomimetic and opiate reward include critical elements in both the nucleus accumbens and ventral tegmental areas. |
1992-07-14 |
2023-08-11 |
Not clear |
| G F Koo. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends in pharmacological sciences. vol 13. issue 5. 1992-07-14. PMID:1604710. |
ethanol reward appears to depend on an interaction with the gabaa receptor complex but may also involve common elements such as dopamine and opioid peptides in this midbrain-forebrain-extrapyramidal circuit. |
1992-07-14 |
2023-08-11 |
Not clear |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
chronic cocaine produces increases in brain reward thresholds that may reflect the "dysphoria" and anhedonia associated with cocaine dependence and suggests a dysregulation of brain reward systems possibly involving dopamine. |
1992-06-22 |
2023-08-11 |
rat |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
the most pervasive commonality amongst noncannabinoid drugs of abuse is that they enhance electrical brain stimulation reward and act as direct or indirect dopamine agonists in the reward relevant dopaminergic projections of the medial forebrain bundle (mfb). |
1992-05-14 |
2023-08-11 |
Not clear |
| E L Gardner, J H Lowinso. Marijuana's interaction with brain reward systems: update 1991. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1806947. |
specifically, delta 9-thc enhances mfb electrical brain stimulation reward, and enhances both basal and stimulated dopamine release in reward relevant mfb projection loci. |
1992-05-14 |
2023-08-11 |
Not clear |
| T Ljungberg, P Apicella, W Schult. Responses of monkey dopamine neurons during learning of behavioral reactions. Journal of neurophysiology. vol 67. issue 1. 1992-04-24. PMID:1552316. |
previous studies have shown that dopamine (da) neurons respond to stimuli of behavioral significance, such as primary reward and conditioned stimuli predicting reward and eliciting behavioral reactions. |
1992-04-24 |
2023-08-11 |
monkey |
| J A Stamford, R Muscat, J J O'Connor, J Patel, S J Trout, W J Wieczorek, Z L Kruk, P Willne. Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1796133. |
voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine. |
1992-04-07 |
2023-08-11 |
rat |
| G Phillips, P Willner, R Musca. Suppression or facilitation of operant behaviour by raclopride dependent on concentration of sucrose reward. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1839065. |
under both food deprived and non-deprived conditions, the dopamine d-2 antagonist raclopride dose-dependently decreased responding for 1% or 10% sucrose, but increased responding for, and consumption of, 95% sucrose reward. |
1992-04-07 |
2023-08-11 |
rat |
| E Miliaressis, C Emond, Z Meral. Re-evaluation of the role of dopamine in intracranial self-stimulation using in vivo microdialysis. Behavioural brain research. vol 46. issue 1. 1992-03-26. PMID:1664727. |
rats were implanted with an electrode-microdialysis assembly in order to test the hypothesis that the reward signal elicited by medial forebrain bundle stimulation is relayed by the meso-accumbens dopamine cells. |
1992-03-26 |
2023-08-11 |
rat |
| E Miliaressis, C Emond, Z Meral. Re-evaluation of the role of dopamine in intracranial self-stimulation using in vivo microdialysis. Behavioural brain research. vol 46. issue 1. 1992-03-26. PMID:1664727. |
our reasoning was that if the reward signal travels along the meso-accumbens dopaminergic neurons, the release of dopamine should not depend on the stimulus parameters because behaviorally equivalent stimuli should produce a constant output in all neural stages carrying the reward signal. |
1992-03-26 |
2023-08-11 |
rat |
| M Doherty, A Gratto. Behavioral evidence of depolarization block of mesencephalic dopamine neurons by acute haloperidol in partially 6-hydroxydopamine-lesioned rats. Behavioral neuroscience. vol 105. issue 4. 1991-12-26. PMID:1657033. |
the effects of acute haloperidol (hal) and apomorphine (apo) administration were tested on the responsiveness of rats to medial forebrain bundle (mfb) brain stimulation reward (bsr) before and 28 days after partial dopamine (da) depletion. |
1991-12-26 |
2023-08-11 |
rat |
| R Sandyk, S R Ka. Tobacco addiction as a marker of age at onset of schizophrenia. The International journal of neuroscience. vol 57. issue 3-4. 1991-12-03. PMID:1938168. |
since addictive behaviour may be related to decreased dopamine activity in the mesolimbic reward circuitry, we predict a higher prevalence of tobacco addiction in patients with an earlier age at onset of schizophrenia. |
1991-12-03 |
2023-08-11 |
Not clear |
| G P Mark, D S Blander, B G Hoebe. A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion. Brain research. vol 551. issue 1-2. 1991-11-01. PMID:1913157. |
the conditioned taste aversion (cta) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. |
1991-11-01 |
2023-08-11 |
human |