| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Stice, S Spoor, C Bohon, D M Smal. Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science (New York, N.Y.). vol 322. issue 5900. 2008-11-03. PMID:18927395. |
the dorsal striatum plays a role in consummatory food reward, and striatal dopamine receptors are reduced in obese individuals, relative to lean individuals, which suggests that the striatum and dopaminergic signaling in the striatum may contribute to the development of obesity. |
2008-11-03 |
2023-08-12 |
Not clear |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
in animals, a substantial body of data indicates that dopamine activity in the midbrain is tightly associated with reward processing. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
here, by using 6-[(18)f]fluorodopa (fdopa) positron emission tomography (pet) and event-related 3t functional magnetic resonance imaging (fmri) in the same subjects, we directly demonstrate a link between midbrain dopamine synthesis and reward-related prefrontal activity in humans, show that healthy aging induces functional alterations in the reward system, and identify an age-related change in the direction of the relationship (from a positive to a negative correlation) between midbrain dopamine synthesis and prefrontal activity. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
taken together, our findings provide an important characterization of the interactions between midbrain dopamine function and the reward system in healthy young humans and older subjects, and identify the changes in this regulatory circuit that accompany aging. |
2008-10-24 |
2023-08-12 |
human |
| Steven W Clay, Jason Allen, Theorore Parra. A review of addiction. Postgraduate medicine. vol 120. issue 2. 2008-10-21. PMID:18654058. |
first, the mesolimbic dopamine reward pathway, which is essential for survival, can be physically altered by drug abuse to result in uncontrolled cravings. |
2008-10-21 |
2023-08-12 |
Not clear |
| Can Ozan Tan, Daniel Bulloc. A local circuit model of learned striatal and dopamine cell responses under probabilistic schedules of reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 40. 2008-10-17. PMID:18829964. |
a local circuit model of learned striatal and dopamine cell responses under probabilistic schedules of reward. |
2008-10-17 |
2023-08-12 |
Not clear |
| Can Ozan Tan, Daniel Bulloc. A local circuit model of learned striatal and dopamine cell responses under probabilistic schedules of reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 40. 2008-10-17. PMID:18829964. |
recently, dopamine (da) neurons of the substantia nigra pars compacta (snc) were found to exhibit sustained responses related to reward uncertainty, in addition to the phasic responses related to reward-prediction errors (rpes). |
2008-10-17 |
2023-08-12 |
Not clear |
| Birgit Abler, Ian Greenhouse, Dost Ongur, Henrik Walter, Stephan Hecker. Abnormal reward system activation in mania. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 9. 2008-10-08. PMID:17987058. |
transmission of reward signals is a function of dopamine, a neurotransmitter known to be involved in the mechanism of psychosis. |
2008-10-08 |
2023-08-12 |
human |
| Garret D Stuber, Marianne Klanker, Bram de Ridder, M Scott Bowers, Ruud N Joosten, Matthijs G Feenstra, Antonello Bonc. Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science (New York, N.Y.). vol 321. issue 5896. 2008-10-02. PMID:18802002. |
we used in vivo voltammetry and in vitro patch-clamp electrophysiology to show that both dopamine release to reward predictive cues and enhanced synaptic strength onto dopamine neurons develop over the course of cue-reward learning. |
2008-10-02 |
2023-08-12 |
Not clear |
| Amine Bahi, Alexander W Kusnecov, Jean-Luc Dreye. Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference. Behavioural brain research. vol 191. issue 1. 2008-09-24. PMID:18436315. |
in this study, the role of mesolimbic dopamine (da) pathways in the development of cocaine reward was examined by conditioned-place preference in rats with bilateral intra-accumbens injections of upa-expressing lentiviral vectors. |
2008-09-24 |
2023-08-12 |
rat |
| Brandon J Aragona, Nathan A Cleaveland, Garret D Stuber, Jeremy J Day, Regina M Carelli, R Mark Wightma. Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753384. |
preferential enhancement of dopamine transmission within the nucleus accumbens (nac) shell is a fundamental aspect of the neural regulation of cocaine reward. |
2008-09-18 |
2023-08-12 |
Not clear |
| David B Carr, Peter W Kaliva. Confused about NMDA and addiction? Targeted knockouts provide answers and new questions. Neuron. vol 59. issue 3. 2008-09-17. PMID:18701061. |
nmda-dependent plasticity in vta dopamine neurons has been hypothesized to be an important first step in the development of long-term changes in the brain reward circuitry that underlie addiction. |
2008-09-17 |
2023-08-12 |
Not clear |
| Nathan Herrmann, Lana S Rothenburg, Sandra E Black, Michelle Ryan, Barbara A Liu, Usoa E Busto, Krista L Lanctô. Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. Journal of clinical psychopharmacology. vol 28. issue 3. 2008-09-11. PMID:18480686. |
all patients participated in a dextroamphetamine challenge test (one 10-mg oral dose) before treatment with methylphenidate to gauge the functional integrity of the dopamine brain reward system. |
2008-09-11 |
2023-08-12 |
Not clear |
| Robert G Kender, Steven E Harte, Elizabeth M Munn, George S Borszc. Affective analgesia following muscarinic activation of the ventral tegmental area in rats. The journal of pain. vol 9. issue 7. 2008-09-10. PMID:18387853. |
cholinergic stimulation of dopamine neurons in the ventral tegmental area (vta) underlies activation of the brain reward circuitry. |
2008-09-10 |
2023-08-12 |
rat |
| Brenda M Geiger, Gerald G Behr, Lauren E Frank, Angela D Caldera-Siu, Margery C Beinfeld, Efi G Kokkotou, Emmanuel N Potho. Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 8. 2008-09-03. PMID:18477764. |
this phenotype was associated with a 50% reduction in basal extracellular dopamine, as measured by a microdialysis probe in the nucleus accumbens, a projection site of the mesolimbic dopamine system that has been implicated in food reward. |
2008-09-03 |
2023-08-12 |
rat |
| Taku Nagai, Kiyofumi Yamad. [Role of tissue plasminogen activator in the rewarding effect of nicotine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 43. issue 3. 2008-09-03. PMID:18646640. |
here we show that the tpa-plasmin system regulates nicotine-induced reward and dopamine release. |
2008-09-03 |
2023-08-12 |
mouse |
| Mary-Anne Enoc. The role of GABA(A) receptors in the development of alcoholism. Pharmacology, biochemistry, and behavior. vol 90. issue 1. 2008-08-28. PMID:18440057. |
the dopamine (da) mesolimbic reward pathway originating in the ventral tegmental area (vta), and interacting stress circuitry play an important role in the development of addiction. |
2008-08-28 |
2023-08-12 |
Not clear |
| Shunsuke Kobayashi, Wolfram Schult. Influence of reward delays on responses of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 31. 2008-08-28. PMID:18667616. |
influence of reward delays on responses of dopamine neurons. |
2008-08-28 |
2023-08-12 |
Not clear |
| Shunsuke Kobayashi, Wolfram Schult. Influence of reward delays on responses of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 31. 2008-08-28. PMID:18667616. |
to address this issue, we investigated the temporal discounting behavior in a choice situation and studied the effects of reward delay on the value signals of dopamine neurons. |
2008-08-28 |
2023-08-12 |
Not clear |
| Shunsuke Kobayashi, Wolfram Schult. Influence of reward delays on responses of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 31. 2008-08-28. PMID:18667616. |
reward delay reduced the responses of dopamine neurons to pavlovian conditioned stimuli according to a hyperbolic decay function similar to that observed in choice behavior. |
2008-08-28 |
2023-08-12 |
Not clear |