| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven R Laviolette, Karim Nader, Derek van der Koo. Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes. Behavioural brain research. vol 129. issue 1-2. 2002-04-11. PMID:11809491. |
in the present study, we report that bilateral microinjections of a da receptor antagonist, alpha-flupenthixol (0.3-3 microg/0.5 microl) into the nucleus accumbens (nac), blocks morphine reward (10 mg/kg, i.p.) |
2002-04-11 |
2023-08-12 |
Not clear |
| S Genedani, S Saltini, A Benelli, M Filaferro, A Bertolin. Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742215. |
these results may suggest (i) a role for brain polyamines in depression and in reward processes, and (ii) that the antidepressant effect of same may be due, at least in part, to a normalization of putrescine levels in the nucleus accumbens septi. |
2002-03-18 |
2023-08-12 |
rat |
| C A Dackis, C P O'Brie. Cocaine dependence: a disease of the brain's reward centers. Journal of substance abuse treatment. vol 21. issue 3. 2002-01-16. PMID:11728784. |
da signal-receiving neurons in the nucleus accumbens synthesize endogenous opioids and project to numerous reward regions. |
2002-01-16 |
2023-08-12 |
Not clear |
| P D Marti. Locomotion towards a goal alters the synchronous firing of neurons recorded simultaneously in the subiculum and nucleus accumbens of rats. Behavioural brain research. vol 124. issue 1. 2002-01-03. PMID:11423162. |
thus, synchronous interactions between subiculum and nucleus accumbens occur preferentially when the animal is required to locate a fixed goal in space, i.e., the functional connectivity is altered by the navigational demands of the spatial reward task. |
2002-01-03 |
2023-08-12 |
rat |
| I Aharon, N Etcoff, D Ariely, C F Chabris, E O'Connor, H C Breite. Beautiful faces have variable reward value: fMRI and behavioral evidence. Neuron. vol 32. issue 3. 2001-12-20. PMID:11709163. |
functional magnetic resonance imaging at 3 t shows that passive viewing of beautiful female faces activates reward circuitry, in particular the nucleus accumbens. |
2001-12-20 |
2023-08-12 |
human |
| R A Chambers, J H Krystal, D W Sel. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological psychiatry. vol 50. issue 2. 2001-12-10. PMID:11526998. |
in this model, disturbances in drug reward are mediated, in part, by dysregulated neural integration of dopamine and glutamate signaling in the nucleus accumbens resulting form frontal cortical and hippocampal dysfunction. |
2001-12-10 |
2023-08-12 |
Not clear |
| L J Young, M M Lim, B Gingrich, T R Inse. Cellular mechanisms of social attachment. Hormones and behavior. vol 40. issue 2. 2001-12-04. PMID:11534973. |
both the nucleus accumbens and ventral pallidum are key relay nuclei in the brain circuits implicated in reward, such as the mesolimbic dopamine and opioid systems. |
2001-12-04 |
2023-08-12 |
Not clear |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
the present study was undertaken to test the hypothesis that infusion of rolipram into the nucleus accumbens would decrease cocaine-induced enhancement of the sensitivity of brain stimulation reward (bsr) pathways. |
2001-10-25 |
2023-08-12 |
rat |
| C M Knapp, K Lee, M Foye, D A Ciraulo, C Kornetsk. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life sciences. vol 69. issue 14. 2001-10-25. PMID:11589507. |
these results suggest that infusion into the nucleus accumbens of rolipram, an agent that putatively elevates camp levels in this structure, can enhance the sensitivity of reward pathways to bsr and can augment cocaine's actions on these pathways. |
2001-10-25 |
2023-08-12 |
rat |
| C L Wyvell, K C Berridg. Incentive sensitization by previous amphetamine exposure: increased cue-triggered "wanting" for sucrose reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 19. 2001-10-11. PMID:11567074. |
we reported previously that an amphetamine microinjection into the nucleus accumbens enables pavlovian reward cues in a conditioned incentive paradigm to trigger excessive instrumental pursuit. |
2001-10-11 |
2023-08-12 |
rat |
| B Knutson, C M Adams, G W Fong, D Homme. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 16. 2001-08-30. PMID:11459880. |
anticipation of increasing monetary reward selectively recruits nucleus accumbens. |
2001-08-30 |
2023-08-12 |
human |
| H L Alderson, J A Parkinson, T W Robbins, B J Everit. The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats. Psychopharmacology. vol 153. issue 4. 2001-05-17. PMID:11243493. |
it has been suggested that the nucleus accumbens (nacc) may be involved in heroin reward, and the core and shell regions respond differently following administration of a number of drugs of abuse. |
2001-05-17 |
2023-08-12 |
rat |
| K Blum, E R Braverman, J M Holder, J F Lubar, V J Monastra, D Miller, J O Lubar, T J Chen, D E Coming. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of psychoactive drugs. vol 32 Suppl. 2001-04-26. PMID:11280926. |
the net effect of neurotransmitter interaction at the mesolimbic brain region induces "reward" when dopamine (da) is released from the neuron at the nucleus accumbens and interacts with a dopamine d2 receptor. |
2001-04-26 |
2023-08-12 |
Not clear |
| K Blum, E R Braverman, J M Holder, J F Lubar, V J Monastra, D Miller, J O Lubar, T J Chen, D E Coming. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of psychoactive drugs. vol 32 Suppl. 2001-04-26. PMID:11280926. |
"the reward cascade" involves the release of serotonin, which in turn at the hypothalmus stimulates enkephalin, which in turn inhibits gaba at the substania nigra, which in turn fine tunes the amount of da released at the nucleus accumbens or "reward site." |
2001-04-26 |
2023-08-12 |
Not clear |
| E T Tabuchi, A B Mulder, S I Wiene. Position and behavioral modulation of synchronization of hippocampal and accumbens neuronal discharges in freely moving rats. Hippocampus. vol 10. issue 6. 2001-03-08. PMID:11153717. |
in addition, behavior dependence of the synchrony between these nucleus accumbens and hippocampus neurons was examined by studying data in relation to three different synchronization points: reward box arrival, box departure, and arrival at the center of the maze. |
2001-03-08 |
2023-08-12 |
rat |
| C L Wyvell, K C Berridg. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward "wanting" without enhanced "liking" or response reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 21. 2001-02-22. PMID:11050134. |
we conclude that nucleus accumbens dopamine specifically mediates the ability of reward cues to trigger "wanting" (incentive salience) for their associated rewards, independent of both hedonic impact and response reinforcement. |
2001-02-22 |
2023-08-12 |
rat |
| M Koch, A Schmid, H U Schnitzle. Role of muscles accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward. Psychopharmacology. vol 152. issue 1. 2001-02-15. PMID:11041317. |
this study investigated the role of nucleus accumbens dopamine d1 and d2 receptors in two different paradigms of conditioned reward. |
2001-02-15 |
2023-08-12 |
Not clear |
| K D Carr, G Y Kim, S Cabeza de Vac. Chronic food restriction in rats augments the central rewarding effect of cocaine and the delta1 opioid agonist, DPDPE, but not the delta2 agonist, deltorphin-II. Psychopharmacology. vol 152. issue 2. 2001-02-08. PMID:11057524. |
the increased expression of c-fos in nucleus accumbens (nac) shell, in particular, suggests that food restriction may augment drug reward by modulating dopamine (da) synaptic function in this area. |
2001-02-08 |
2023-08-12 |
rat |
| S V Albertin, A B Mulder, E Tabuchi, M B Zugaro, S I Wiene. Lesions of the medial shell of the nucleus accumbens impair rats in finding larger rewards, but spare reward-seeking behavior. Behavioural brain research. vol 117. issue 1-2. 2001-02-08. PMID:11099771. |
the goal of this study was to help better understand the importance of the nucleus accumbens (nacc) in the processing of position and reward value information for goal-directed orientation behaviors. |
2001-02-08 |
2023-08-12 |
rat |
| T M Tzschentk. The medial prefrontal cortex as a part of the brain reward system. Amino acids. vol 19. issue 1. 2001-02-01. PMID:11026491. |
in turn it projects back to the vta and the nucleus accumbens septi (nas), which are generally considered as main components of the brain reward system. |
2001-02-01 |
2023-08-12 |
rat |