| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masako Isokaw. Time-dependent induction of CREB phosphorylation in the hippocampus by the endogenous cannabinoid. Neuroscience letters. vol 457. issue 1. 2009-07-22. PMID:19429161. |
present findings demonstrate: (1) the hippocampus is vulnerable to the direct chemical effect of anandamide and r(+)-methanandamide in isolation of synaptic influences from the midbrain reward neurons, and (2) the effect of r(+)-methanandamide is cumulative as evidenced by the sustained elevation of creb activities in response to a chronic dosage that is too low and thus fails to exert any acute effect. |
2009-07-22 |
2023-08-12 |
Not clear |
| Carl R Lupica, Arthur C Riege. Endocannabinoid release from midbrain dopamine neurons: a potential substrate for cannabinoid receptor antagonist treatment of addiction. Neuropharmacology. vol 48. issue 8. 2009-07-17. PMID:15878779. |
the data from these studies therefore suggest that the endocannabinoid system and the cb1 receptors located in the ventral mesencephalon may play an important role in regulating drug reward processes, and that this substrate is recruited whenever dopamine neuron activity is increased. |
2009-07-17 |
2023-08-12 |
Not clear |
| M de Rover, F J Meye, G M J Ramaker. Presynaptic metabotropic glutamate receptors regulate glutamatergic input to dopamine neurons in the ventral tegmental area. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18534761. |
the ventral tegmental area is part of the midbrain dopamine system and is crucially involved in reward, motivation and drug abuse. |
2009-06-29 |
2023-08-12 |
mouse |
| b' C Marcangione, P-P Rompr\\xc3\\xa. Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18556137.' |
they suggest that among ventral midbrain projection sites, the bnst and nas-shell constitute important components of the circuitry implicated in reward. |
2009-06-29 |
2023-08-12 |
rat |
| Giovanna Vanni-Mercier, François Mauguière, Jean Isnard, Jean-Claude Drehe. The hippocampus codes the uncertainty of cue-outcome associations: an intracranial electrophysiological study in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 16. 2009-05-22. PMID:19386925. |
in monkeys, midbrain dopaminergic neurons code two statistical properties of reward: a prediction error at the outcome and uncertainty during the delay period between cues and outcomes. |
2009-05-22 |
2023-08-12 |
human |
| Paula L Croxson, Mark E Walton, Jill X O'Reilly, Timothy E J Behrens, Matthew F S Rushwort. Effort-based cost-benefit valuation and the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 14. 2009-05-06. PMID:19357278. |
cue-locked activity in the ventral striatum and midbrain reflected the net value of the course of action, signaling the expected amount of reward discounted by the amount of effort to be invested. |
2009-05-06 |
2023-08-12 |
human |
| Shihoko Natori, Kenji Yoshimi, Toshimitsu Takahashi, Maki Kagohashi, Genko Oyama, Yasushi Shimo, Nobutaka Hattori, Shigeru Kitazaw. Subsecond reward-related dopamine release in the mouse dorsal striatum. Neuroscience research. vol 63. issue 4. 2009-05-04. PMID:19367786. |
reward presentation is known to induce transient bursts of midbrain dopamine neurons in monkeys and rats, and the reward-induced dopamine overflow has been detected in the rat ventral striatum. |
2009-05-04 |
2023-08-12 |
mouse |
| Michael J Beckstead, Tamara J Phillip. Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function. The Journal of pharmacology and experimental therapeutics. vol 329. issue 1. 2009-04-28. PMID:19122113. |
midbrain dopamine neurons are thought to be important mediators of both ethanol reward and locomotor stimulation. |
2009-04-28 |
2023-08-12 |
mouse |
| Corey B Puryear, Sheri J Y Mizumor. Reward prediction error signals by reticular formation neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 15. issue 12. 2009-04-08. PMID:19050161. |
as a key part of the brain's reward system, midbrain dopamine neurons are thought to generate signals that reflect errors in the prediction of reward. |
2009-04-08 |
2023-08-12 |
rat |
| Frédéric Brischoux, Subhojit Chakraborty, Daniel I Brierley, Mark A Ungles. Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 12. 2009-04-08. PMID:19261850. |
midbrain dopamine neurons play central roles in reward processing. |
2009-04-08 |
2023-08-12 |
rat |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
we show that neurons in the recently identified gabaergic rostromedial tegmental nucleus (rmtg), which receive a major lhb input, project heavily to midbrain dopamine neurons, and show phasic activations and/or fos induction after aversive stimuli (footshocks, shock-predictive cues, food deprivation, or reward omission) and inhibitions after rewards or reward-predictive stimuli. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
these findings suggest that aversive inputs from widespread brain regions and stimulus modalities converge onto the rmtg, which opposes reward and motor-activating functions of midbrain dopamine neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Jean-Claude Dreher, Philip Kohn, Bhaskar Kolachana, Daniel R Weinberger, Karen Faith Berma. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19104049. |
the main effect of dat1 genotype was seen in robust blood-oxygen-level-dependent response differences in the caudate nucleus and ventral striatum during reward anticipation (p < 0.001) and in the lateral prefrontal cortex and midbrain at the time of reward delivery, with carriers of the dat1 9-repeat allele showing the highest activity. |
2009-02-13 |
2023-08-12 |
human |
| Jean-Claude Dreher, Philip Kohn, Bhaskar Kolachana, Daniel R Weinberger, Karen Faith Berma. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 2. 2009-02-13. PMID:19104049. |
moreover, an interaction between the comt and dat1 genes was found in the ventral striatum and lateral prefrontal cortex during reward anticipation and in the lateral prefrontal and orbitofrontal cortices as well as in the midbrain at the time of reward delivery, with carriers of the dat1 9-repeat allele and comt met/met allele exhibiting the highest activation, presumably reflecting functional change consequent to higher synaptic dopamine availability. |
2009-02-13 |
2023-08-12 |
human |
| Dianne P Figlewicz, Stephen C Benoi. Insulin, leptin, and food reward: update 2008. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 1. 2009-02-06. PMID:18945945. |
specifically, insulin and leptin can decrease food reward behaviors and modulate the function of neurotransmitter systems and neural circuitry that mediate food reward, i.e., midbrain dopamine and opioidergic pathways. |
2009-02-06 |
2023-08-12 |
Not clear |
| Mati Joshua, Avital Adler, Rea Mitelman, Eilon Vaadia, Hagai Bergma. Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 45. 2008-12-31. PMID:18987203. |
midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials. |
2008-12-31 |
2023-08-12 |
monkey |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
age-related changes in midbrain dopaminergic regulation of the human reward system. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
in animals, a substantial body of data indicates that dopamine activity in the midbrain is tightly associated with reward processing. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
here, by using 6-[(18)f]fluorodopa (fdopa) positron emission tomography (pet) and event-related 3t functional magnetic resonance imaging (fmri) in the same subjects, we directly demonstrate a link between midbrain dopamine synthesis and reward-related prefrontal activity in humans, show that healthy aging induces functional alterations in the reward system, and identify an age-related change in the direction of the relationship (from a positive to a negative correlation) between midbrain dopamine synthesis and prefrontal activity. |
2008-10-24 |
2023-08-12 |
human |
| Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, Karen Faith Berma. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 39. 2008-10-24. PMID:18794529. |
taken together, our findings provide an important characterization of the interactions between midbrain dopamine function and the reward system in healthy young humans and older subjects, and identify the changes in this regulatory circuit that accompany aging. |
2008-10-24 |
2023-08-12 |
human |