All Relations between learning and memory and ca1 field

Publication Sentence Publish Date Extraction Date Species
Jing-Fan Zhang, Qing-Hua Long, Chu-Hua Zeng, Yi-Min Chen, Zhe-Yao Xie, Yuan-Qin Cai, Xi Wan. [Mechanism of Guben Jiannao Liquid on Alzheimer's disease by regulating autophagy based on LKB1/AMPK/mTOR pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929611. morris water maze was used to test the learning and memory ability of rats in each group; hematoxylin-eosin(he) and nissl staining were used to observe the morphological and quantitative changes of neurons and nissl bodies in the ca1 region of rat hippocampus; immunohistochemistry was utilized to detect aβ-positive cell expression in the ca1 region of rat hippocampus; transmission electron microscopy was employed to observe ultrastructural changes in rat hippocampal tissue, and western blot was used to examine the protein expression levels of lkb1, p-ampk/ampk, p-mtor/mtor, beclin1, p62, and lc3-Ⅱ in the hippocampal tissue of the rats. 2025-02-10 2025-02-13 rat
Bo-Lun Chen, Jian-Zheng Lu, Xin-Mei Zhou, Xiao-Dong Wen, Yuan-Jing Jiang, Ning Lu. [Mechanism of Daotan Xixin Decoction in treating APP/PS1 mice based on high-throughput sequencing technology and bioinformatics analysis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929612. compared with the app/ps1 group, daotan xixin decoction at different doses significantly improved the learning and memory abilities of app/ps1 mice, ameliorated the neuropathological damage in the ca1 region of the hippocampus, increased the number of neurons, and decreased the deposition of aβ_(1-42) in the brain. 2025-02-10 2025-02-13 mouse
Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J Kim, Jeiwon Cho, Yeowool Hu. Distinct disruptions in CA1 and CA3 place cell function in Alzheimer's disease mice. iScience. vol 28. issue 2. 2025-02-06. PMID:39911347. these findings elucidate that distinct physiological perturbations in ca1 and ca3 place cells, coupled with disrupted hippocampal theta rhythmicity in ca1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in ad pathogenesis. 2025-02-06 2025-02-08 mouse
Jinghua Shen, Jingjing Gao, Xinyi Wang, Dongying Yan, Ying Wang, Hong Li, Dawei Chen, Jie W. Melatonin attenuates BDE-209-caused spatial memory deficits in juvenile rats through NMDAR-CaMKⅡγ-mediated synapse-to-nucleus signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2025-01-09. PMID:39788477. these resulted in less dendritic spines in ca1 area and poor spatial learning and memory. 2025-01-09 2025-01-13 human
Zeinab Hamidizad, Mehri Kadkhodaee, Farzaneh Kianian, Mina Ranjbaran, Fatemeh Heidari, Behjat Seif. Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway. Neuromolecular medicine. vol 27. issue 1. 2025-01-08. PMID:39775152. snp treatment significantly improved nrf2 (both p < 0.001) /ho-1 (p < 0.001; p < 0.05 respectively) pathways and neuronal injury (p < 0.001 for ca1; ca3; dg) in the hippocampus and prefrontal cortex in ckd rats as well as enhanced learning and memory ability in ckd rats. 2025-01-08 2025-01-13 rat
Yao Tan, Yujing Huang, Weiyan Chen, Tingyuan Lang, Lingqiao Wang, Xiaoling Chen, Haili Yu, Zhiqun Qiu, Ke Cui, Chengwei Guo, Yiqi Wang, Ziyuan Zho. Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R. Environmental pollution (Barking, Essex : 1987). 2024-12-26. PMID:39725202. we found that administration of 10 μg/kg body weight (intraperitoneally) mc-lr impaired learning and memory abilities and induced neuronal damage and apoptosis in the ca1 region of the hippocampus in rats. 2024-12-26 2024-12-29 rat
Steve Mabry, Jessica L Bradshaw, Jennifer J Gardner, E Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J Thomas Cunningham, Rebecca L Cunningha. The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats. Research square. 2024-12-23. PMID:39711575. we quantified protease activity and cleaved spectrin products, along with egr-1 protein expression in hippocampal subregions (ca1, ca3), cortical regions [entorhinal cortex (etc), retrosplenial cortex (rsc), cerebellar cortex (cc)], and subcortical regions [raphe nucleus (rn), locus coeruleus (lc)] associated with learning and memory. 2024-12-23 2024-12-25 rat
Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J Kim, Yeowool Huh, Jeiwon Ch. Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice. bioRxiv : the preprint server for biology. 2024-10-10. PMID:39386433. our results suggest that distinct alteration in the physiological properties of ca1 and ca3 place cells, coupled with disrupted hippocampal theta rhythm in ca1, may collectively contribute to impaired hippocampal-dependent spatial learning and memory in ad. 2024-10-10 2024-10-12 mouse
Rui Wang, Linzhong Zhang, Xia Wang, Wen Li, Tingliang Jian, Pengcheng Yin, Xinzhi Wang, Qianwei Chen, Xiaowei Chen, Han Qi. Electrophysiological activity pattern of mouse hippocampal CA1 and dentate gyrus under isoflurane anesthesia. Frontiers in cellular neuroscience. vol 18. 2024-08-06. PMID:39104439. the ca1 and dentate gyrus (dg), serving as the primary efferent and gateway of the hippocampal trisynaptic circuit facilitating cognitive learning and memory functions, exhibit significant differences in cellular composition, molecular makeup, and responses to various stimuli. 2024-08-06 2024-08-08 mouse
Lei Xia, Junjie Li, Yayan Pang, Mingliang Xu, Yehong Du, Mulan Chen, Boqing Xu, Yiqiong Qiu, Zhifang Don. Dihydroartemisinin promotes tau O-GlcNAcylation and improves cognitive function in hTau transgenic mice. Progress in neuro-psychopharmacology & biological psychiatry. 2024-07-25. PMID:39053763. we reported that dha treatment alleviated the deficits of hippocampal ca1 ltp and spatial learning and memory in the barnes maze and context fear conditioning tests in htau transgenic mice. 2024-07-25 2024-07-28 mouse
Hu-Ping Wang, Yun-Yun Hu, Yu-Jie Lyu, Zhi-Peng Meng, Yi-Qin Chen, Jiao Yan. [Effect of Hei Xiaoyaosan regulating p38MAPK/Beclin-1/Bcl-2 pathway on autophagy level in Alzheimer's disease model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 12. 2024-07-23. PMID:39041098. morris water maze was used to detect the learning and memory ability of rats, and hoechst staining was used to observe the pathological changes of nerve cells in the hippocampal ca1 region. 2024-07-23 2024-07-25 rat
Alicia C Wells, Celina Mojica, Shahrdad Lotfipou. Hypersensitivity of the nicotinic acetylcholine receptor subunit (CHRNA2 Neurobiology of learning and memory. vol 213. 2024-07-05. PMID:38964600. chrna2 encodes for the α2 subunit of nicotinic acetylcholine receptors associated with ca1 oriens lacunosum moleculare gabaergic interneurons and is associated with learning and memory. 2024-07-05 2024-07-08 Not clear
Amelia M Burch, Joshua D Garcia, Heather O'Leary, Ami Haas, James E Orfila, Erika Tiemeier, Nicholas Chalmers, Katharine R Smith, Nidia Quillinan, Paco S Herso. TRPM2 and CaMKII signaling drives excessive GABAergic synaptic inhibition following ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-04-02. PMID:38565288. we previously demonstrated sustained impairment of long-term potentiation (ltp) in hippocampal ca1 neurons correlating with deficits in learning and memory tasks in a murine model of cardiac arrest/ cardiopulmonary resuscitation (ca/cpr). 2024-04-02 2024-04-05 Not clear
Hye-Ji Kim, Eun-A Ko, Oh-Bin Kwon, Sung-Cherl Jun. Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal CA1 neurons of rats. Journal of neuroscience research. vol 102. issue 4. 2024-03-30. PMID:38553948. prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal ca1 neurons of rats. 2024-03-30 2024-04-01 rat
Hye-Ji Kim, Eun-A Ko, Oh-Bin Kwon, Sung-Cherl Jun. Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal CA1 neurons of rats. Journal of neuroscience research. vol 102. issue 4. 2024-03-30. PMID:38553948. these results indicated that the prenatal treatment with corticosterone to elevate cortisol level might potently downregulate the bdnf-mediated signaling critical for the synaptic development of hippocampal ca1 neurons during brain development, and subsequently, induce learning and memory impairment. 2024-03-30 2024-04-01 rat
Heng Kong, Yuan-Yuan Han, Gai-Ling Yang, Kang Li, Lu Yu, Xun-Kai Xie, Guang-Yuan Xia, Peng-Ju Wei, Wan-Rong Zhang, Chu-Hua L. Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice. Behavioural brain research. 2024-03-30. PMID:38554850. tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal ca1 area in healthy female mice but not male mice. 2024-03-30 2024-04-02 mouse
Heng Kong, Yuan-Yuan Han, Gai-Ling Yang, Kang Li, Lu Yu, Xun-Kai Xie, Guang-Yuan Xia, Peng-Ju Wei, Wan-Rong Zhang, Chu-Hua L. Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice. Behavioural brain research. 2024-03-30. PMID:38554850. collectively, the results of the current study showed that ten improved learning and memory by regulating long-term potentiation (ltp) and dendritic structure of hippocampal ca1 area in female mice but not in males. 2024-03-30 2024-04-02 mouse
Zhe Zhao, Hui Ji, Jiamin Pei, Jiaqing Yan, Xiangjian Zhang, Yi Yuan, Mengyang Li. Transcranial Ultrasound Stimulation Improves Memory Performance of Parkinsonian Mice. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. vol 32. 2024-03-22. PMID:38498744. we found that ultrasound stimulation of the pd mice ca1 for 4 days: 1) significantly increased their learning and memory ability, although the learning and memory ability on the 7th day after the stimulation stopped was not significantly different from that before stimulation (p>0.05); 2) significantly increased the relative power of theta, low gamma, and high gamma frequency bands of the local field potential, and the phase amplitude coupling strength between theta and low gamma and between theta and high gamma; and 3) modulated the phase-locking angle between the spike of interneuron and theta wave to a 180°-360° rise cycle. 2024-03-22 2024-03-24 mouse
Zhe Zhao, Hui Ji, Jiamin Pei, Jiaqing Yan, Xiangjian Zhang, Yi Yuan, Mengyang Li. Transcranial Ultrasound Stimulation Improves Memory Performance of Parkinsonian Mice. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. vol 32. 2024-03-22. PMID:38498744. transcranial ultrasound stimulation can improve the learning and memory abilities of pd mice, and evoking neural oscillations in the ca1 is the potential mechanism. 2024-03-22 2024-03-24 mouse
Qiao Ye, Gocylen Gast, Erik George Wilfley, Hanh Huynh, Chelsea Hays, Todd C Holmes, Xiangmin X. Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer's disease mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-03-19. PMID:38503494. significant sex differences for sub inputs are found in 5xfad mice for ca1, ca2, ca3, postsub, prh, lec, and mec: all areas critical for learning and memory. 2024-03-19 2024-03-23 mouse