| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Niapour, Maryam Abdollahzadeh, Safa Ghaheri Fard, Hakimeh Saadat. The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9. Metabolic brain disease. 2024-07-17. PMID:39017968. |
the neuroprotective influence of calcitriol supplementation (100ng/kg/day for 5 weeks) was assessed through behavioral, electrophysiological, and molecular experiments. cisplatin administration impaired spatial learning and memory and decreased prefrontal brain-derived neurotrophic factor (bdnf). |
2024-07-17 |
2024-07-19 |
rat |
| Ali Niapour, Maryam Abdollahzadeh, Safa Ghaheri Fard, Hakimeh Saadat. The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9. Metabolic brain disease. 2024-07-17. PMID:39017968. |
learning and memory impairments along with bdnf changes caused by cisplatin were amended with calcitriol supplementation. |
2024-07-17 |
2024-07-19 |
rat |
| Forough Radfar, Mehdi Shahbazi, Shahzad Tahmasebi Boroujeni, Elahe Arab Ameri, Maryam Farahmandfa. Moderate aerobic training enhances the effectiveness of insulin therapy through hypothalamic IGF1 signaling in rat model of Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987609. |
we investigated the effects of treadmill exercise and intranasal insulin on learning and memory impairment and the expression of igf1, bdnf, and glut4 in hypothalamus. |
2024-07-10 |
2024-07-13 |
rat |
| Kuang-Min Cheng, Wei-Lun Hsu, Yun-Li Ma, Yen-Chen Liu, Eminy H Y Le. Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-06-20. PMID:38900294. |
whereas knockdown of bdnf, integrin α3 or sgk1 expression impairs spatial learning and memory, it does not affect y-maze performance, suggesting that bdnf, integrin α3 and sgk1 are involved in long-term memory formation, but not short-term memory formation. |
2024-06-20 |
2024-06-22 |
mouse |
| Xiaoyu Wang, Qian Pang, Jiangqi Hu, Bin Luo, Yunping Lu, Xu Sun, Shixiang Meng, Qingsong Jian. Cognitive decline in Sprague-Dawley rats induced by neuroplasticity changes after occlusal support loss. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-20. PMID:38898731. |
the most well-known function of the hippocampus is learning and memory, and the mechanism behind is neuroplasticity, which strongly depends on the level of brain-derived neurotrophic factor (bdnf). |
2024-06-20 |
2024-06-22 |
rat |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Hyo-Sun Choi, Joonki Kim, Sang-Bin Lee, Lijun Zhang, Dowan Kwon, Huynh Nguyen Khanh Tran, Siqi Zhang, Tianqi Huang, Jae Sik Yu, Gakyung Lee, Hyun Ok Yan. Euonymus hamiltonianus Extract Improves Amnesia in APPswe/Tau Transgenic and Scopolamine-Induced Dementia Models. Molecular neurobiology. 2024-05-27. PMID:38801629. |
kgc07eh also improved scopolamine-induced learning and memory impairment in scopolamine-injected mice, and in their cerebral cortex and hippocampus, the expression levels of p-erk, p-creb, p-akt, and bdnf were attenuated. |
2024-05-27 |
2024-05-31 |
mouse |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
both cums and olanzapine can also affect the expression level of brain-derived neurotrophic factor (bdnf) and synaptophysin, the molecular factors involved in synaptic function, and learning and memory. |
2024-05-09 |
2024-05-27 |
rat |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
in this study, we investigated the effect of olanzapine on locomotor activity (using open field test), pain threshold (using hot plate), depressive-like behavior (using forced swim test), spatial learning and memory (using morris water maze), and bdnf and synaptophysin hippocampal expression (using real-time pcr) in both male and female cums rats. |
2024-05-09 |
2024-05-27 |
rat |
| Tareq I Jibril, Karem H Alzoubi, Nizar M Mhaidat, Omar F Khabour, Mohammad A Y Alqudah, Abeer M Rababa'h, Nasr Alrabadi, Doaa Al-Udat. Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor. Current research in pharmacology and drug discovery. vol 6. 2024-05-06. PMID:38706525. |
reduced brain-derived neurotrophic factor (bdnf) levels, increased oxidative stress, and alteration of synaptic plasticity biomarkers are also possible contributors to the negative impact of stress on learning and memory. |
2024-05-06 |
2024-05-08 |
rat |
| Jafar Shahraki, Kaveh Tabrizian, Ramin Rezaee, Behnam Tashakori, Zahra Dadrezaei, Vahideh Ghorani, Gholamreza Bagheri, Hosseinali Jahantigh, Mahmoud Hashemzae. Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-03. PMID:38700797. |
after evaluation of spatial learning and memory using a morris water maze (mwm), animals were sacrificed and oxidative stress status in blood samples, and akt, bax, bcl2, and brain-derived neurotrophic factor (bdnf) expression in brain samples were assessed. |
2024-05-03 |
2024-05-05 |
rat |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
synergistic suppression of bdnf via epigenetic mechanism deteriorating learning and memory impairment caused by mn and pb co-exposure. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
suppression of bdnf is implicated in learning and memory impairment induced by exposure to manganese (mn) or lead (pb) individually. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
our findings reveal that co-exposure to mn and pb leads to severe learning and memory impairment in mice, which correlates with the accumulation of metals in the hippocampus and synergistic suppression of bdnf. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
in summary, our experiments demonstrate that simultaneous exposure to mn and pb results in more severe hippocampus-dependent learning and memory impairment, which is attributed to epigenetic suppression of bdnf mediated by pp2a regulation. |
2024-04-24 |
2024-04-28 |
mouse |
| Yunlin Feng, Jia Qin, Yanfei Lu, Mengdie Wang, Shengqiang Wang, Foquan Lu. Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy. PloS one. vol 19. issue 3. 2024-03-29. PMID:38551911. |
our results showed that maternal propofol exposure during middle pregnancy impaired the water-maze learning and memory of the offspring rats, increased the protein level of hdac2 and reduced the protein levels of p-creb, bdnf and p-trkb in the hippocampus of the offspring, and such effects were exacerbated by surgery. |
2024-03-29 |
2024-04-01 |
rat |
| Matthias Wilhelm Voigt, Jens Schepers, Jacqueline Haas, Oliver von Bohlen Und Halbac. Reduced Levels of Brain-Derived Neurotrophic Factor Affect Body Weight, Brain Weight and Behavior. Biology. vol 13. issue 3. 2024-03-27. PMID:38534429. |
bdnf plays a role in the regulation of body weight and neuronal plasticity and is, therefore, also involved in processes associated with learning and memory formation. |
2024-03-27 |
2024-03-29 |
mouse |
| Raj Katariya, Kartikey Mishra, Shivkumar Sammeta, Milind Umekar, Nandkishor Kotagale, Brijesh Taksand. Agmatine mitigates behavioral abnormalities and neurochemical dysregulation associated with 3-Nitropropionic acid-induced Huntington's disease in rats. Neurotoxicology. 2024-03-07. PMID:38453033. |
agmatine treatment not only improved the 3-np-induced motor incoordination, depression-like behavior, rota-rod performance, and learning and memory impairment but also normalized the gaba/glutamate, bdnf, il-6, and tnf-α levels in discrete brain areas. |
2024-03-07 |
2024-03-10 |
rat |
| Victor Hugo de Oliveira Segundo, Kesley Pablo Morais de Azevedo, Gidyenne Christine Bandeira Silva de Medeiros, Ádala Nayana de Sousa Mata, Grasiela Piuveza. Association between sedentary behavior and Brain-Derived Neurotrophic Factor (BDNF) in children and adolescents: A protocol for systematic review and meta-analysis. PloS one. vol 19. issue 3. 2024-03-05. PMID:38442097. |
there is evidence in the literature suggesting that high time spent in sedentary behavior (sb) can reduce the brain-derived neurotrophic factor (bdnf) levels, an important neurotrophin that plays a role in modulating cognition, learning and memory. |
2024-03-05 |
2024-03-08 |
Not clear |
| Masataka Kiuchi, Tadashi Uno, Tatsuya Hasegawa, Katsuhiro Koyama, Masahiro Horiuch. Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats-A practical implication to human's lost way. Frontiers in behavioral neuroscience. vol 18. 2024-02-21. PMID:38380151. |
the present study aimed to investigate the effects of a short period of normobaric hypoxic exposure on spatial learning and memory, and brain-derived neurotrophic factor (bdnf) levels in the rat hippocampus. |
2024-02-21 |
2024-02-23 |
human |