| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinhua Ni, Mayumi Nagashimada, Lili Zhan, Naoto Nagata, Masuko Kobori, Minoru Sugiura, Kazunori Ogawa, Shuichi Kaneko, Tsuguhito Ot. Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin. Endocrinology. vol 156. issue 3. 2015-04-29. PMID:25562616. |
after 12 weeks of cl diet feeding, β-cryptoxanthin administration attenuated insulin resistance and excessive hepatic lipid accumulation and peroxidation, with increases in m1-type macrophages/kupffer cells and activated stellate cells, and fibrosis in cl diet-induced nash. |
2015-04-29 |
2023-08-13 |
mouse |
| Elisa Lucas, María Jurado-Pueyo, María A Fortuño, Sonia Fernández-Veledo, Rocío Vila-Bedmar, Luis J Jiménez-Borreguero, Juan J Lazcano, Ehre Gao, Javier Gómez-Ambrosi, Gema Frühbeck, Walter J Koch, Javier Díez, Federico Mayor, Cristina Murg. Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. Biochimica et biophysica acta. vol 1842. issue 12 Pt A. 2015-04-28. PMID:25239306. |
notably, we find that cardiac grk2 levels increase in situations where insulin resistance develops, such as in ob/ob mice or after high fat diet feeding. |
2015-04-28 |
2023-08-13 |
mouse |
| Rachel Dorothy Wilson, Md Shahidul Isla. Effects of white mulberry (Morus alba) leaf tea investigated in a type 2 diabetes model of rats. Acta poloniae pharmaceutica. vol 72. issue 1. 2015-04-28. PMID:25850211. |
t2d was induced by feeding a 10% fructose solution in drinking water for 2 weeks to induce insulin resistance, followed by a single injection (i.p.) |
2015-04-28 |
2023-08-13 |
rat |
| Rachel Dorothy Wilson, Md Shahidul Isla. Effects of white mulberry (Morus alba) leaf tea investigated in a type 2 diabetes model of rats. Acta poloniae pharmaceutica. vol 72. issue 1. 2015-04-28. PMID:25850211. |
after 4 weeks feeding of brewed mulberry leaf tea, there were no significant improvements in polyphagia, polydipsia, body weight gain, blood glucose, glucose intolerance, serum insulin, fructosamine, ast, alt, creatinine, albumin and uric acid levels and liver parameters when serum total cholesterol was significantly and ldl-cholesterol and triglyceride concentrations were markedly decreased in the dmth group compared to the dbc and dmtl groups. |
2015-04-28 |
2023-08-13 |
rat |
| Satya Dash, Changting Xiao, Cecilia Morgantini, Khajag Koulajian, Gary F Lewi. Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations. Diabetes. vol 64. issue 3. 2015-04-22. PMID:25288674. |
intranasal insulin (ini) has been shown to modulate food intake and food-related activity in the central nervous system in humans. |
2015-04-22 |
2023-08-13 |
Not clear |
| Hiroyuki Takahashi, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Yamauchi, Shinya Dohgu, Yasufumi Kataok. Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons. Biochemical and biophysical research communications. vol 457. issue 4. 2015-04-17. PMID:25597994. |
insulin signaling in the hypothalamus plays an important role in food intake and glucose homeostasis. |
2015-04-17 |
2023-08-13 |
mouse |
| Zhuqi Tang, Wanlu Zhang, Chunhua Wan, Guangfei Xu, Xiaoke Nie, Xiaohui Zhu, Nana Xia, Yun Zhao, Suxin Wang, Shiwei Cui, Cuifang Wan. TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway. Biochemical and biophysical research communications. vol 457. issue 4. 2015-04-17. PMID:25600807. |
with high-fat feeding (hfd), ffas can activate chronic endoplasmic reticulum (er) stress in target tissues, initiating negative crosstalk between ffas and insulin signaling. |
2015-04-17 |
2023-08-13 |
Not clear |
| Bikash Manandhar, Jung-Mo Ah. Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications. Journal of medicinal chemistry. vol 58. issue 3. 2015-04-14. PMID:25349901. |
produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic β-cells healthy and proliferating. |
2015-04-14 |
2023-08-13 |
Not clear |
| Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Narumi Akiyama-Akanishi, Asako Takenaka, Hisanori Kato, Kazuhiro Chida, Fumihiko Hakuno, Shiro Minami, Shin-Ichiro Takahash. Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats. Endocrine journal. vol 61. issue 5. 2015-04-13. PMID:24621780. |
however, it has not been established whether protein malnutrition up-regulates insulin signaling under physiological conditions, such as feeding. |
2015-04-13 |
2023-08-12 |
rat |
| Yuka Toyoshima, Reiko Tokita, Yusuke Taguchi, Narumi Akiyama-Akanishi, Asako Takenaka, Hisanori Kato, Kazuhiro Chida, Fumihiko Hakuno, Shiro Minami, Shin-Ichiro Takahash. Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats. Endocrine journal. vol 61. issue 5. 2015-04-13. PMID:24621780. |
here, we studied the effects of protein malnutrition on insulin signaling after feeding in rat liver, muscle and white adipose tissue (wat). |
2015-04-13 |
2023-08-12 |
rat |
| Christopher Faulk, Amanda Barks, Brisa N Sánchez, Zhenzhen Zhang, Olivia S Anderson, Karen E Peterson, Dana C Dolino. Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course. PloS one. vol 9. issue 8. 2015-04-13. PMID:25105421. |
perinatal lead (pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course. |
2015-04-13 |
2023-08-13 |
mouse |
| Christopher Faulk, Amanda Barks, Brisa N Sánchez, Zhenzhen Zhang, Olivia S Anderson, Karen E Peterson, Dana C Dolino. Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course. PloS one. vol 9. issue 8. 2015-04-13. PMID:25105421. |
perinatal pb exposure at blood lead levels between 4.1 µg/dl and 32 µg/dl is associated with increased food intake, body weight, total body fat, energy expenditure, activity, and insulin response in mice. |
2015-04-13 |
2023-08-13 |
mouse |
| Wei Chen, Meredith L Howell, Yang Li, Rui Li, Guoxun Che. Vitamin A and feeding statuses modulate the insulin-regulated gene expression in Zucker lean and fatty primary rat hepatocytes. PloS one. vol 9. issue 8. 2015-04-13. PMID:25105869. |
to examine the effects of vitamin a (va), total energy intake and feeding conditions on the insulin-regulated gene expression in primary hepatocytes of zucker lean (zl) and fatty (zf) rats, we analyze the expression levels of hepatic model genes in response to the treatments of insulin and retinoic acid (ra). |
2015-04-13 |
2023-08-13 |
rat |
| Wei Chen, Meredith L Howell, Yang Li, Rui Li, Guoxun Che. Vitamin A and feeding statuses modulate the insulin-regulated gene expression in Zucker lean and fatty primary rat hepatocytes. PloS one. vol 9. issue 8. 2015-04-13. PMID:25105869. |
these results demonstrate that va and feeding statuses modulate the hepatic insulin sensitivity at the gene expression level. |
2015-04-13 |
2023-08-13 |
rat |
| Kathrin Abegg, Caroline Corteville, Neil G Docherty, Camilo Boza, Thomas A Lutz, Rodrigo Muñoz, Carel W le Rou. Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 308. issue 4. 2015-04-09. PMID:25540099. |
in parallel, other groups of animals underwent sham surgery with ad libitum feeding (n = 6), with body weight (n = 8), or glycemic matching (n = 8) to the rygb group, using food restriction or a combination of insulin, metformin, and liraglutide, respectively. |
2015-04-09 |
2023-08-13 |
rat |
| Kathrin Abegg, Caroline Corteville, Neil G Docherty, Camilo Boza, Thomas A Lutz, Rodrigo Muñoz, Carel W le Rou. Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 308. issue 4. 2015-04-09. PMID:25540099. |
sg was, however, associated with higher food intake, weight regain, and higher insulin requirements vs. rygb at study end (p < 0.05). |
2015-04-09 |
2023-08-13 |
rat |
| Hua Jiang, Jueping Feng, Zhongxia Du, Hui Zhen, Mei Lin, Shaohui Jia, Tao Li, Xinyuan Huang, Claes-Goran Ostenson, Zhengwang Che. Oral administration of soybean peptide Vglycin normalizes fasting glucose and restores impaired pancreatic function in Type 2 diabetic Wistar rats. The Journal of nutritional biochemistry. vol 25. issue 9. 2015-03-31. PMID:24985367. |
body weight, food intake, fasting plasma glucose and insulin levels were assayed weekly. |
2015-03-31 |
2023-08-13 |
human |
| Hua Jiang, Jueping Feng, Zhongxia Du, Hui Zhen, Mei Lin, Shaohui Jia, Tao Li, Xinyuan Huang, Claes-Goran Ostenson, Zhengwang Che. Oral administration of soybean peptide Vglycin normalizes fasting glucose and restores impaired pancreatic function in Type 2 diabetic Wistar rats. The Journal of nutritional biochemistry. vol 25. issue 9. 2015-03-31. PMID:24985367. |
the improvement in glucose homeostasis and the increased insulin sensitivity mediated by restored insulin signaling likely contributed to decreased food intake and reduced body weight. |
2015-03-31 |
2023-08-13 |
human |
| Kristin I Stanford, Min-Young Lee, Kristen M Getchell, Kawai So, Michael F Hirshman, Laurie J Goodyea. Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring. Diabetes. vol 64. issue 2. 2015-03-31. PMID:25204976. |
high-fat feeding of sedentary dams resulted in impaired glucose tolerance, increased serum insulin concentrations, and increased percent body fat in offspring. |
2015-03-31 |
2023-08-13 |
mouse |
| Yiming Li, Van H Tran, Bhavani P Kota, Srinivas Nammi, Colin C Duke, Basil D Roufogali. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action. Basic & clinical pharmacology & toxicology. vol 115. issue 2. 2015-03-30. PMID:24428842. |
the hfhc control rats displayed severe insulin resistance, whilst rats treated with ginger extract (200 mg/kg) during hfhc diet feeding showed a significant improvement of insulin sensitivity using the homeostatic model assessment of insulin resistance (homa-ir) after 10 weeks (p < 0.01). |
2015-03-30 |
2023-08-12 |
rat |