| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bart Wessels, Nicole M A van den Broek, Jolita Ciapaite, Sander M Houten, Ronald J A Wanders, Klaas Nicolay, Jeanine J Promper. Carnitine supplementation in high-fat diet-fed rats does not ameliorate lipid-induced skeletal muscle mitochondrial dysfunction in vivo. American journal of physiology. Endocrinology and metabolism. vol 309. issue 7. 2016-01-18. PMID:26286868. |
high-fat diet feeding induced insulin resistance and was associated with decreases in muscle and blood free carnitine, elevated levels of muscle lipids and acylcarnitines, and an increased number of muscle mitochondria that showed an improved capacity to oxidize fat-derived substrates when tested ex vivo. |
2016-01-18 |
2023-08-13 |
rat |
| Sho-ichi Yamagishi, Kei Fukami, Takanori Matsu. Crosstalk between advanced glycation end products (AGEs)-receptor RAGE axis and dipeptidyl peptidase-4-incretin system in diabetic vascular complications. Cardiovascular diabetology. vol 14. 2016-01-15. PMID:25582643. |
glucagon-like peptide-1 (glp-1) and glucose-dependent insulinotropic polypeptide (gip) are incretins, gut hormones secreted from the intestine in response to food intake, both of which augment glucose-induced insulin release, suppress glucagon secretion, and slow gastric emptying. |
2016-01-15 |
2023-08-13 |
Not clear |
| R D Ekmay, K Chou, A Magnuson, X G Le. Continual feeding of two types of microalgal biomass affected protein digestion and metabolism in laying hens. Journal of animal science. vol 93. issue 1. 2015-12-31. PMID:25568377. |
feeding dg or fd did not alter plasma concentrations of insulin, glutamine, and uric acid or alkaline phosphatase activity at wk 8 or 14 but decreased plasma 3-methyhistine concentrations (p = 0.03) and tartrate-resistant acid phosphatase (trap) activities (p < 0.001) at wk 14 and improved (p = 0.002) ileal total aa digestibility. |
2015-12-31 |
2023-08-13 |
Not clear |
| A Carreras, S X Zhang, E Peris, Z Qiao, Y Wang, I Almendros, D Goza. Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea. International journal of obesity (2005). vol 39. issue 3. 2015-12-28. PMID:25298275. |
sleep fragmentation (sf) increases food intake and the risk of obesity, and recruits macrophages to visceral white adipose tissue (vwat) promoting tissue inflammation and insulin resistance. |
2015-12-28 |
2023-08-13 |
mouse |
| Lisa E Rasbach, Ashley E Atkins, Kerry M Milaszewski, Joyce Keady, Lisa M Schmidt, Lisa K Volkening, Lori M Laffe. Treatment recommendations following 3-day masked continuous glucose monitoring (CGM) in youth with type 1 diabetes. Journal of diabetes science and technology. vol 8. issue 3. 2015-12-21. PMID:24876612. |
patients/families completed a diary of blood glucose levels, insulin doses, food intake, and exercise during cgm use. |
2015-12-21 |
2023-08-13 |
Not clear |
| Prashanth Anamthathmakula, Maitrayee Sahu, Abhiram Sah. Evidence suggesting phosphodiesterase-3B regulation of NPY/AgRP gene expression in mHypoE-46 hypothalamic neurons. Neuroscience letters. vol 604. 2015-12-21. PMID:26254161. |
hypothalamic neurons expressing neuropeptide y (npy) and agouti related-protein (agrp) are critical regulators of feeding behavior and body weight, and transduce the action of many peripheral signals including leptin and insulin. |
2015-12-21 |
2023-08-13 |
Not clear |
| Prashanth Anamthathmakula, Maitrayee Sahu, Abhiram Sah. Evidence suggesting phosphodiesterase-3B regulation of NPY/AgRP gene expression in mHypoE-46 hypothalamic neurons. Neuroscience letters. vol 604. 2015-12-21. PMID:26254161. |
since phosphodiesterase-3b (pde3b) mediates the hypothalamic action of leptin and insulin on feeding, and is expressed in npy/agrp neurons, pde3b could play a significant role in regulating npy/agrp neuronal activity. |
2015-12-21 |
2023-08-13 |
Not clear |
| Christian Bindesbøll, Qiong Fan, Rikke C Nørgaard, Laura MacPherson, Hai-Bin Ruan, Jing Wu, Thomas Å Pedersen, Knut R Steffensen, Xiaoyong Yang, Jason Matthews, Susanne Mandrup, Hilde I Nebb, Line M Grønning-Wan. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. Journal of lipid research. vol 56. issue 4. 2015-12-18. PMID:25724563. |
lxrs activate lipogenic gene transcription in response to feeding, which is believed to be mediated by insulin. |
2015-12-18 |
2023-08-13 |
mouse |
| Yunfeng Gao, Mengna Zhang, Tianchen Wu, Mengying Xu, Haonan Cai, Zesheng Zhan. Effects of D-Pinitol on Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Rats. Journal of agricultural and food chemistry. vol 63. issue 26. 2015-12-17. PMID:26063468. |
in this investigation, a model of type 2 diabetes mellitus (t2dm) with insulin resistance was established by feeding a high-fat diet (hfd) and injecting streptozocin (stz) to sprague-dawley (sd) rats, targeting the exploration of more details of the mechanism in the therapy of t2dm. |
2015-12-17 |
2023-08-13 |
rat |
| M Ramdas, C Harel, M Armoni, E Karniel. AHNAK KO mice are protected from diet-induced obesity but are glucose intolerant. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 4. 2015-12-15. PMID:25153686. |
taken together, these data demonstrate that (a) ahnak is involved in glucose homeostasis and weight balance (b) under normal feeding ko mice are insulin sensitive yet insulin deficient; and (c) ahnak deletion protects against hfd-induced obesity, but not against hfd-induced insulin resistance and glucose intolerance in vivo. |
2015-12-15 |
2023-08-13 |
mouse |
| A Esteghamati, Z Aryan, Ar Esteghamati, M Nakhjavan. Vitamin D deficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 4. 2015-12-15. PMID:25230322. |
endogenous insulin production in response to food intake and in fasting was significantly lower in vitamin d deficient patients with dm compared to those with serum 25(oh)d>40 ng/ml. |
2015-12-15 |
2023-08-13 |
Not clear |
| S Yamamoto-Kataoka, K Ebihara, M Aizawa-Abe, M Nishio, T Kusakabe, Y Yamamoto, D Aotani, T Sakai, M Zhao, C Ebihara, V M J Gumbilai, K Hosoda, A Suzuki, K Naka. Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 3. 2015-12-15. PMID:25415231. |
leptin infusion effectively reduced liver weight, liver triglyceride content, and glutamate pyruvate transaminase (gpt) concentrations as well as food intake and body weight without the change of plasma insulin concentration in albcreptenff mice. |
2015-12-15 |
2023-08-13 |
mouse |
| S Yamamoto-Kataoka, K Ebihara, M Aizawa-Abe, M Nishio, T Kusakabe, Y Yamamoto, D Aotani, T Sakai, M Zhao, C Ebihara, V M J Gumbilai, K Hosoda, A Suzuki, K Naka. Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 3. 2015-12-15. PMID:25415231. |
the present study clearly demonstrated that leptin improve fatty liver independently of insulin sensitization and suppression of food intake. |
2015-12-15 |
2023-08-13 |
mouse |
| A K Portella, P P Silveira, D P Laureano, S Cardoso, V Bittencourt, C Noschang, I Werlang, F U Fontella, C Dalmaz, M Z Goldan. Litter size reduction alters insulin signaling in the ventral tegmental area and influences dopamine-related behaviors in adult rats. Behavioural brain research. vol 278. 2015-12-14. PMID:25264577. |
however, little is known about its impact on insulin signaling in specific brain regions such as the mesocorticolimbic system, and its putative effects on dopamine-related hedonic food intake in adulthood. |
2015-12-14 |
2023-08-13 |
rat |
| Linkang Zhou, Shi-Young Park, Li Xu, Xiayu Xia, Jing Ye, Lu Su, Kyeong-Hoon Jeong, Jang Ho Hur, Hyunhee Oh, Yoshikazu Tamori, Cristina M Zingaretti, Saverio Cinti, Jesús Argente, Miao Yu, Lizhen Wu, Shenghong Ju, Feifei Guan, Hongyuan Yang, Cheol Soo Choi, David B Savage, Peng L. Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nature communications. vol 6. 2015-12-08. PMID:25565658. |
here we reconcile these data by showing that exposing fsp27-null mice to a substantial energetic stress by crossing them with ob/ob mice or batless mice, or feeding them a high-fat diet, results in hepatic steatosis and insulin resistance. |
2015-12-08 |
2023-08-13 |
mouse |
| Rangachari Balamurugan, Subramanian Ezhil Vendan, Adithan Aravinthan, Jong-Hoon Ki. Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Biochimie. vol 111. 2015-12-04. PMID:25698613. |
oral administration of rhamnoside for 21 days significantly reduced food intake, calorie intake, blood glucose and glycosylated hemoglobin levels, and improved plasma insulin levels. |
2015-12-04 |
2023-08-13 |
rat |
| C Y Le. Adenosine protects Sprague Dawley rats from high-fat diet and repeated acute restraint stress-induced intestinal inflammation and altered expression of nutrient transporters. Journal of animal physiology and animal nutrition. vol 99. issue 2. 2015-12-03. PMID:25196093. |
results showed that hfd feeding increased glucose and insulin levels, and repeated acute restraint stress raised the corticosterone level by 22%. |
2015-12-03 |
2023-08-13 |
rat |
| W Kyle Mitchell, Bethan E Phillips, John P Williams, Debbie Rankin, Jonathan N Lund, Daniel J Wilkinson, Kenneth Smith, Philip J Atherto. The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply. American journal of physiology. Endocrinology and metabolism. vol 309. issue 5. 2015-12-03. PMID:26152764. |
bolus achieved rapid insulinemia (12.7 μiu/ml 25-min postfeed), essential aminoacidemia (∼3,000 μm, 45-65 min postfeed), and mtorc1 activity; pulse achieved attenuated insulin responses, gradual low-amplitude aminoacidemia (∼1,800 μm 80-195 min after feeding), and undetectable mtorc1 signaling. |
2015-12-03 |
2023-08-13 |
Not clear |
| Michael J Keenan, June Zhou, Maren Hegsted, Christine Pelkman, Holiday A Durham, Diana B Coulon, Roy J Marti. Role of resistant starch in improving gut health, adiposity, and insulin resistance. Advances in nutrition (Bethesda, Md.). vol 6. issue 2. 2015-11-30. PMID:25770258. |
in human subjects, insulin sensitivity is increased with the feeding of resistant starch. |
2015-11-30 |
2023-08-13 |
human |
| Scott V Harding, Kevin P Bateman, Brian P Kennedy, Todd C Rideout, Peter J H Jone. Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. BMC research notes. vol 8. 2015-11-30. PMID:25879456. |
high carbohydrate feeding is known to increase plasma triglycerides as well as hepatic de novo lipogenesis (dnl) and may be implicated in the development of hepatic insulin resistance and fatty liver. |
2015-11-30 |
2023-08-13 |
Not clear |